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Browse the failure-mode index

11,421 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Impact of red propolis addition on the color stability and surface roughness of glass ionomer cements.

Sampaio GKML, Sette-de-Souza PH, Vieira BR et al. · 2026 · Biomaterial investigations in dentistry

Objective The present study aimed to evaluate the surface roughness (SR) and color stability of conventional restorative glass ionomer cements (GICs) modified with the addition of red propolis ethanolic extract (RPEE) as an antimicrobial…

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Negative / Null Result ReportMedicine

Phthalocyanine-based mouth gel as an adjunct to non-surgical periodontal treatment: a randomized controlled trial.

Neto SOP, Rosalen PL, da Cruz Pegoraro JV et al. · 2026 · Naunyn-Schmiedeberg's archives of pharmacology

This study aimed to evaluate the effect of topical application of a mouth gel formulation containing iron tetracarboxyphthalocyanine (FeTcPc) during non-surgical periodontal treatment. Forty-seven individuals with periodontitis underwent a…

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Negative / Null Result ReportMedicine

Effects of Live and Heat-Treated Bifidobacterium longum CECT 7347 in Adults With Allergic Rhinitis: A Randomised, Double-Blind, Placebo-Controlled Trial.

Cardoso A, Naghibi M, Climent E et al. · 2026 · Allergy

Background Allergic rhinitis (AR) is an increasingly common chronic inflammatory condition of the nasal mucosa. While conventional anti-allergy treatments are widely used, they can come with side effects and are not always effective. As a…

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Negative / Null Result ReportMedicine

Effects of Extended-Release Liposomal Bupivacaine on Postoperative Mechanical and Thermal Hypersensitivity in C57BL/6 Mice (Mus musculus).

Wang AI, Duong MP, Frohlich JR et al. · 2026 · Journal of the American Association for Laboratory Animal Science : JAALAS

Systemic analgesics, such as opioids and nonsteroidal anti-inflammatory drugs, may be contraindicated in certain studies due to their mechanisms of action and risk for systemic effects. Local anesthetics (LAs) are therefore crucial in…

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Negative / Null Result ReportMedicine

Hemidesmosomal Proteins in Oral Cancer Progression: An Immunohistochemical Study of Human and Mouse.

Mongia N, Mohammed AI, McCullough M et al. · 2026 · Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology

Background Hemidesmosomal subunits have gained attention for their potential role in the progression of oral squamous cell carcinoma (OSCC). However, formal analysis of quantitative expression patterns correlating with OSCC disease…

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Negative / Null Result ReportOpen accessMedicine

AIDS patients with Talaromycosis Marneffei exhibit inflammatory activation and depletion in their peripheral blood monocytes.

Guo P, Yang Y, Chen X et al. · 2026 · PLoS neglected tropical diseases

Objectives This study seeks to investigate the characteristics, dynamics, and association with disease progression of monocyte inflammation in patients with AIDS/Talaromycosis Marneffei (TSM). The findings are expected to contribute to a…

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Negative / Null Result ReportMedicine

In Silico Morphometric Analysis of the Tibia Following Four Virtual Proximal Levelling Osteotomies for the Treatment of Canine Cranial Cruciate Ligament Rupture.

de Marcos Carpio I, de Vicente F, Vallefuoco R · 2026 · Veterinary and comparative orthopaedics and traumatology : V.C.O.T

Objectives (1) To describe and compare the morphometric changes of the tibia following four virtual proximal tibial osteotomies for treatment of canine cranial cruciate ligament deficiency and (2) to determine how these changes are…

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Negative / Null Result ReportMedicine

Mindful-Compassion Art-Based Therapy for Dementia Care (MCAT-DC): A multicomponent approach to enhancing resilience in dementia family caregivers.

Tan-Ho G, Choo PY, Ma SHXY et al. · 2026 · Psychological trauma : theory, research, practice and policy

Objective Caring for a loved one with dementia imposes significant physical strain, emotional burden, and psychological trauma on family caregivers. Singaporean caregivers face added pressures under cultural norms that emphasize familial…

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Negative / Null Result ReportMedicine

Topical lidocaine spray for reducing pain during paracervical block administration in postmenopausal women undergoing manual vacuum aspiration: A randomized trial.

Ortíz Aguirre MJ, Barrientos Chinchilla AC, León-Velásquez M et al. · 2026 · Journal of gynecology obstetrics and human reproduction

Objective To assess the efficacy of topical lidocaine versus placebo in reducing pain during manual vacuum aspiration (MVA) for endometrial sampling in patients with endometrial thickening, as measured by the visual analog scale (VAS).…

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Negative / Null Result ReportOpen accessMedicine

Spatial lipidomic and neuron-specific transcriptomic signatures in the nucleus accumbens reveal phospholipid dyshomeostasis in depression-related maladaptations.

Camargo A, Kaya I, Sturchio A et al. · 2026 · Translational psychiatry

Lipid systems play a substantial role in the pathophysiological mechanisms underlying several brain disorders. However, the mechanisms underlying the lipid profile in stress-induced maladaptations and how these changes can impact distinct…

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Negative / Null Result ReportMedicine

Impact of aromatherapy neck massage on resting cardiovascular parameters in patients with chronic kidney disease and secondary hypertension: A self-controlled study.

Deepa Y, Vijay A, Padmavathi K et al. · 2026 · Journal of bodywork and movement therapies

Objective Chronic kidney disease (CKD) is characterized by kidney damage persisting for 3 months or more. Hypertension (HTN) is a common cause of CKD progression. Previous studies had shown that aroma massage can effectively reduce…

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Negative / Null Result ReportMedicine

Transitions to old age: a multidimensional poverty approach for Chile.

Amarante V, Colacce M · 2026 · Longitudinal and life course studies : international journal

Evaluating deprivation among individuals transitioning to older ages requires a multidimensional approach to evaluate their diverse needs. Despite its importance, research on this topic remains limited in the developing world, particularly…

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Negative / Null Result ReportMedicine

Stroke mortality in patients with mental health disorders; a cohort study from the Spanish hospital discharge records.

Ayerbe L, Barbero-Pablos E, Foguet-Boreu Q et al. · 2026 · Journal of psychosomatic research

Introduction Evidence on the clinical outcomes of stroke for patients with psychiatric disorders is poor. It is also unclear if the prognosis of stroke has improved over the last two decades for those with mental health conditions. The…

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Negative / Null Result ReportMedicine

Changes in functional connectivity of the default mode network and thalamus may be a therapeutic mechanism for the treatment of major depressive disorder with vortioxetine.

Song Z, Wang H, Jin M et al. · 2026 · Psychiatry research. Neuroimaging

This study investigates the pathogenic mechanisms underlying major depressive disorder (MDD) and the therapeutic mechanisms of vortioxetine in treatment-naive, first-episode MDD patients. 22 treatment -naive, first-episode MDD patients and…

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Negative / Null Result ReportOpen accessMedicine

Pilot study of the use of ezetimibe in dogs with hyperlipidemia.

de Lima Wachholz P, Bierhals ES, de Lima CM et al. · 2026 · Veterinary research communications

The aim of this study was to evaluate the tolerance and efficacy of ezetimibe in reducing cholesterol and/or triglycerides in dogs with hyperlipidemia. Twenty-three dogs with hyperlipidemia were randomly distributed into three groups:…

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Negative / Null Result ReportOpen accessMedicine

The effect of labor epidural analgesia on uterine activity using electrohysterography monitoring: A follow-up study.

Berben PBQ, Smolders YL, de Vries IR et al. · 2026 · Acta obstetricia et gynecologica Scandinavica

Introduction Labor epidural analgesia (LEA) is widely used for intrapartum pain management, but its effects on uterine activity (UA) remain unclear. Electrohysterography (EHG) is a promising non-invasive method for intrapartum UA…

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Negative / Null Result ReportMedicine

Effects of maternal peripartum supplementation with Schizochytrium oil on metabolic status, colostrum quality, and neonatal calf performance and immunity in dairy cows.

Song JM, Li SH, Peng WT et al. · 2026 · Journal of dairy science

The periparturient period in dairy cattle is characterized by significant metabolic stress, often involving a state of negative energy balance, heightened oxidative stress, and systemic inflammation. Supplementation with n-3 PUFA, such as…

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Negative / Null Result ReportMedicine

Transforming clinical pharmacy practice models: the impact of a transitions of care model on patient outcomes.

Espinoza Ramirez J, Durango M, Santalo O et al. · 2026 · Journal of the American Pharmacists Association : JAPhA

Background Many organizations have developed criteria for pharmacy practice models; however, most of these models are not based on studies evaluating clinical outcomes. Currently, there is no consensus on the ideal pharmacy practice model.…

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Negative / Null Result ReportMedicine

Assessment of the Impact of Two-Jaw Orthognathic Surgery on Three-Dimensional Airway Volume in Patients with Skeletal Class III Patterns.

Chang YJ, Hsu TC, Chan CH et al. · 2026 · The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association

ObjectiveTo evaluate 3-dimensional pharyngeal airway changes following 2-jaw orthognathic surgery in skeletal Class III patients and to assess their association with surgical movements.DesignRetrospective observational study.SettingSingle…

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Negative / Null Result ReportMedicine

The activation of thematic semantic relation representations is intrusive but modulated by thematic association strength: evidence from the Think/No-Think paradigm.

Shi K, Li J · 2026 · Psychological research

This study adopts the Think/No-Think (TNT) paradigm for the first time to examine whether activation of thematic semantic relation representations is intrusive. In Experiment 1, during the learning phase, participants memorized cue–target…

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Negative / Null Result ReportMedicine

Effects of inpatient and outpatient cardiac rehabilitation on the 5-year prognosis in patients with acute myocardial infarction.

Suematsu Y, Minei A, Sumita Y et al. · 2026 · European journal of preventive cardiology

Aims Cardiac rehabilitation (CR) has been shown to improve the prognosis of patients with acute myocardial infarction (AMI). In Japan, the duration of hospitalization has shortened, resulting in a lower participation rate in CR among…

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