11,326 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Guo P, Yang Y, Chen X et al. · 2026 · PLoS neglected tropical diseases
Objectives This study seeks to investigate the characteristics, dynamics, and association with disease progression of monocyte inflammation in patients with AIDS/Talaromycosis Marneffei (TSM). The findings are expected to contribute to a…
View details →de Marcos Carpio I, de Vicente F, Vallefuoco R · 2026 · Veterinary and comparative orthopaedics and traumatology : V.C.O.T
Objectives (1) To describe and compare the morphometric changes of the tibia following four virtual proximal tibial osteotomies for treatment of canine cranial cruciate ligament deficiency and (2) to determine how these changes are…
View details →Tan-Ho G, Choo PY, Ma SHXY et al. · 2026 · Psychological trauma : theory, research, practice and policy
Objective Caring for a loved one with dementia imposes significant physical strain, emotional burden, and psychological trauma on family caregivers. Singaporean caregivers face added pressures under cultural norms that emphasize familial…
View details →Ortíz Aguirre MJ, Barrientos Chinchilla AC, León-Velásquez M et al. · 2026 · Journal of gynecology obstetrics and human reproduction
Objective To assess the efficacy of topical lidocaine versus placebo in reducing pain during manual vacuum aspiration (MVA) for endometrial sampling in patients with endometrial thickening, as measured by the visual analog scale (VAS).…
View details →Camargo A, Kaya I, Sturchio A et al. · 2026 · Translational psychiatry
Lipid systems play a substantial role in the pathophysiological mechanisms underlying several brain disorders. However, the mechanisms underlying the lipid profile in stress-induced maladaptations and how these changes can impact distinct…
View details →Kilaru KR · 2026 · Journal of conservative dentistry and endodontics
Background Postoperative sensitivity (POS) and marginal integrity (MI) are common concerns in Class V restorations because of dentin exposure and polymerization shrinkage stress. Composite-reinforced glass ionomer liners have been…
View details →Deepa Y, Vijay A, Padmavathi K et al. · 2026 · Journal of bodywork and movement therapies
Objective Chronic kidney disease (CKD) is characterized by kidney damage persisting for 3 months or more. Hypertension (HTN) is a common cause of CKD progression. Previous studies had shown that aroma massage can effectively reduce…
View details →Hendy J, Bereznicki H, Lundin RM · 2026 · Frontiers in psychiatry
Addictive disorders remain important contributors to the overall burden of disease, and although many have established treatments, stimulant use disorders (StUDs) still lack effective management options. Neurostimulation techniques, such…
View details →Kosys V, Streimikyte G, Sidlauskas M · 2026 · Cureus
Background Fluoride-containing mouth rinses are widely used in orthodontic patients to prevent enamel demineralization. However, fluoride exposure may influence the mechanical properties of nickel-titanium (NiTi) orthodontic archwires,…
View details →Ronaldson A, Henderson C · 2026 · BJPsych open
Using data from the Attitudes to Mental Illness (AMI) survey, we previously reported positive change in mental health stigma in England between 2008 and 2019. However, following the conclusion of the Time to Change campaign in 2021, 2023…
View details →Amarante V, Colacce M · 2026 · Longitudinal and life course studies : international journal
Evaluating deprivation among individuals transitioning to older ages requires a multidimensional approach to evaluate their diverse needs. Despite its importance, research on this topic remains limited in the developing world, particularly…
View details →Kim J, Lee J, Kim J · 2026 · International journal of aging & human development
Objectives: We investigated whether participating in moderate-intensity leisure-time physical activity (MLTPA) or vigorous-intensity leisure-time physical activity (VLTPA) moderate the relationship between alcohol consumption and…
View details →Kocamış Ö, Sütiçen H · 2026 · BMC ophthalmology
To evaluate corneal endothelial morphology and anterior segment parameters in patients with vitiligo and to investigate the potential impact of periocular involvement on endothelial characteristics. In this cross-sectional observational…
View details →Gadapani Pathak B, Vats P, Manna S et al. · 2026 · BMJ open
Objectives To collate and appraise evidence from existing systematic reviews and meta-analyses on interventions to prevent stillbirth and reduce perinatal mortality across the reproductive continuum, including preconception, antenatal,…
View details →Celik C, Celik MS · 2026 · Human psychopharmacology
Background and objective Isotretinoin is a systemic agent widely used in the treatment of severe acne vulgaris. Previous studies have reported that isotretinoin use may be associated with depression, anxiety, and sleep disorders. The aim…
View details →Ayerbe L, Barbero-Pablos E, Foguet-Boreu Q et al. · 2026 · Journal of psychosomatic research
Introduction Evidence on the clinical outcomes of stroke for patients with psychiatric disorders is poor. It is also unclear if the prognosis of stroke has improved over the last two decades for those with mental health conditions. The…
View details →Silberlust J, Roberts B, Leybov V et al. · 2026 · Journal of telemedicine and telecare
Virtual urgent care (VUC) has become an increasingly utilized resource for acute care delivery. Frequent utilization of VUC may reflect unmet longitudinal care needs and contribute to fragmented care. While high-utilizer patterns are well…
View details →Song Z, Wang H, Jin M et al. · 2026 · Psychiatry research. Neuroimaging
This study investigates the pathogenic mechanisms underlying major depressive disorder (MDD) and the therapeutic mechanisms of vortioxetine in treatment-naive, first-episode MDD patients. 22 treatment -naive, first-episode MDD patients and…
View details →de Lima Wachholz P, Bierhals ES, de Lima CM et al. · 2026 · Veterinary research communications
The aim of this study was to evaluate the tolerance and efficacy of ezetimibe in reducing cholesterol and/or triglycerides in dogs with hyperlipidemia. Twenty-three dogs with hyperlipidemia were randomly distributed into three groups:…
View details →Berben PBQ, Smolders YL, de Vries IR et al. · 2026 · Acta obstetricia et gynecologica Scandinavica
Introduction Labor epidural analgesia (LEA) is widely used for intrapartum pain management, but its effects on uterine activity (UA) remain unclear. Electrohysterography (EHG) is a promising non-invasive method for intrapartum UA…
View details →Song JM, Li SH, Peng WT et al. · 2026 · Journal of dairy science
The periparturient period in dairy cattle is characterized by significant metabolic stress, often involving a state of negative energy balance, heightened oxidative stress, and systemic inflammation. Supplementation with n-3 PUFA, such as…
View details →Espinoza Ramirez J, Durango M, Santalo O et al. · 2026 · Journal of the American Pharmacists Association : JAPhA
Background Many organizations have developed criteria for pharmacy practice models; however, most of these models are not based on studies evaluating clinical outcomes. Currently, there is no consensus on the ideal pharmacy practice model.…
View details →Chang YJ, Hsu TC, Chan CH et al. · 2026 · The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
ObjectiveTo evaluate 3-dimensional pharyngeal airway changes following 2-jaw orthognathic surgery in skeletal Class III patients and to assess their association with surgical movements.DesignRetrospective observational study.SettingSingle…
View details →Shi K, Li J · 2026 · Psychological research
This study adopts the Think/No-Think (TNT) paradigm for the first time to examine whether activation of thematic semantic relation representations is intrusive. In Experiment 1, during the learning phase, participants memorized cue–target…
View details →Suematsu Y, Minei A, Sumita Y et al. · 2026 · European journal of preventive cardiology
Aims Cardiac rehabilitation (CR) has been shown to improve the prognosis of patients with acute myocardial infarction (AMI). In Japan, the duration of hospitalization has shortened, resulting in a lower participation rate in CR among…
View details →Omerovic E, Råmunddal T, Jha S et al. · 2026 · European heart journal. Cardiovascular pharmacotherapy
Two contemporary randomized trials of β-blocker therapy after myocardial infarction (MI) reached apparently conflicting conclusions. REBOOT, conducted in Spain and Italy, found no reduction in death or major cardiovascular events among…
View details →Mittal H, Thattaruthody F, Akella M et al. · 2026 · Indian journal of ophthalmology
Abstract This experiment was designed to study the effect of mitomycin C (MMC) on conjunctival lymphatics and the lymphangiogenesis potential of synthetic retinoic acid (ec23) in rat eyes. This prospective animal experimental study…
View details →Royo M, Jiménez Á, Molina-Martin A et al. · 2026 · European journal of ophthalmology
PurposeTo analyze the amplitude of accommodation and its changes at a 6-month follow-up in healthy subjects implanted with an anterior chamber pIOL, assessing whether accommodative function is affected. Additionally, changes in visual…
View details →Temizel KA, Dursun P, Ikizoglu G · 2026 · Postepy dermatologii i alergologii
Introduction Chronic spontaneous urticaria (CSU) and urticarial vasculitis (UV) are chronic inflammatory skin disorders. Monoclonal anti-IgE therapy is widely approved for CSU and is increasingly investigated for its broader…
View details →Siqueira RC, Pinho TS, Brandao CC · 2026 · Cureus
Objective The objective of this study was to evaluate the short-term ocular safety, feasibility, and exploratory functional signals associated with intravitreal adalimumab (ADA) in patients with retinitis pigmentosa (RP). Methods This…
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