11,421 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Lin A, Kutler RB, Schulmeyer L et al. · 2026 · The Laryngoscope
Objectives Hypoxia-related measures are valuable predictors of cardiovascular outcomes in obstructive sleep apnea. This scoping review evaluates existing literature on changes in hypoxia-related measures with hypoglossal nerve stimulation…
View details →Kawano A, Tarukado K, Yokota K et al. · 2026 · Cureus
Introduction The optimal surgical strategy for Clinical and Radiographic Degenerative Spondylolisthesis (CARDS) Type C remains controversial, particularly regarding decompression alone versus fusion surgery. Evidence focusing on outcomes…
View details →Leclair V, Berger C, Bouchard-Marmen M et al. · 2026 · The Journal of rheumatology
Objective Little is known as to whether the American College of Rheumatology/European Alliance of Associations for Rheumatology Total Improvement Score (TIS) reflects how patients in the autoimmune inflammatory myopathies (AIM) spectrum…
View details →Phogat J, Prabha C, Nada M et al. · 2026 · Chinese journal of traumatology = Zhonghua chuang shang za zhi
Purpose To analyze the clinical characteristics, management, and visual outcomes of patients with retained posterior segment intraocular foreign bodies (IOFBs). Methods This was a retrospective, non-comparative, single-institutional case…
View details →Fan KL, Thompson YLE, Chen W et al. · 2026 · Medical decision making : an international journal of the Society for Medical Decision Making
BackgroundAn artificial intelligence (AI)-enabled rule-out device may autonomously remove patient images unlikely to have cancer from radiologist review. Many published studies evaluate this type of device by retrospectively applying the…
View details →Hamada M, Nishiyama K, Ichiyama S et al. · 2026 · Journal of stomatology, oral and maxillofacial surgery
Background Recent advances in generative artificial intelligence (AI) have opened new opportunities in procedural simulation. However, its clinical accuracy for simulating impacted mandibular third molar extraction remains unclear.…
View details →Gur I, Safrai A, Nov Y · 2026 · Clinical toxicology (Philadelphia, Pa.)
Introduction A paucity of evidence exists as to the comparative effectiveness of various hyperbaric oxygen regimens in preventing delayed neuropsychiatric sequelae. We aimed to compare the effect of four such treatment regimens: (1) P O 2…
View details →Paraskevas KI, Zeebregts CJ, Blecha M et al. · 2026 · Seminars in vascular surgery
The Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial (CREST-2) concluded that addition of transfemoral carotid artery stenting to intensive medical therapy (IMT) among patients with high-grade…
View details →Urbaneja A, Martin Laez R, López Gomez P · 2026 · British journal of neurosurgery
Purpose Percutaneous pedicle screw fixation has become a widely adopted technique for treating thoracolumbar burst fractures without neurological deficit, though optimal strategies - particularly regarding anterior support - remain…
View details →Lerhcha H, Chevrier A, Lavertu M · 2026 · NPJ Regenerative medicine
This study evaluated a chitosan-fibrinogen-thrombin (CFT) matrix enriched with autologous skin cells and a fatty acid sodium salt (FASS) to enhance wound closure and regeneration. A rat excisional wound model compared six treatments: CFT…
View details →Kent J, Chao J, Liao W et al. · 2026 · Journal of psoriasis and psoriatic arthritis
Introduction Psoriasis (PsO) and psoriatic arthritis (PsA) are chronic inflammatory conditions treated with primarily immune-modulating medication. However, interest is growing in gut microbiome therapies. Studies have reported altered gut…
View details →Mazurova T, Sengul I, Sengul D et al. · 2026 · Revista da Associacao Medica Brasileira (1992)
Introduction The global burden of peripheral artery disease is increasing worldwide. A subset of 5% of these patients ultimately reach the final stage with trophic defects, a condition clinically defined as critical limb-threatening…
View details →Aragon KE, Vrabec JT · 2026 · Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
Objective To discuss the effect of round window drill-out for otosclerosis cases with radiographic evidence of round window obliteration. Patients Four adult patients (5 ears) were included with audiometric findings of a mixed hearing loss…
View details →Welch HF, Rajendran M, Thorn CA · 2026 · Scientific reports
Stimulation of the left cervical vagus nerve (l-VNS) paired with motor training is FDA-approved to improve upper limb function after stroke. However, recent preclinical studies have revealed a striking asymmetry in engagement of the…
View details →Brand J, Hughes M, Turner KE et al. · 2026 · Orthopedics
Background and objective Locked intramedullary (IM) nails are the primary treatment modality for femoral shaft fractures. This study aimed to determine the risk of developing a femur nonunion as a function of nail-to-bone diameter…
View details →Chang HH, Chun YM, Kim SJ et al. · 2026 · Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association
Purpose To compare clinical and radiologic outcomes among patients undergoing double-row suture bridge (DRSB) repair alone, DRSB with platelet-rich plasma (PRP) augmentation, and DRSB with bone marrow stimulation (BMS) augmentation.…
View details →El Ayat N, Boutalline M, Tannouche A · 2026 · BMC psychiatry
Background Autism Spectrum Disorder (ASD) affects 1 in 100 children globally, yet early detection remains challenging due to reliance on subjective behavioral assessments and limited specialist availability, particularly in…
View details →Schneider BS, Pfaehler CD, Hao KA et al. · 2026 · The Journal of the American Academy of Orthopaedic Surgeons
Background Although os acromiale is often noted on preoperative imaging in patients undergoing reverse total shoulder arthroplasty (rTSA), its clinical significance is ill-defined. The purpose of this study was to compare the clinical…
View details →Cacciatore S, Abbatecola G, Calvani R et al. · 2026 · Medical sciences (Basel, Switzerland)
Background/objectives Ozone therapy has been proposed across multiple clinical conditions based on hormetic, antioxidant, and immunomodulatory effects, but its efficacy and safety remain controversial. We conducted an umbrella review to…
View details →Maseroli E, Alfaroli C, Cirillo M et al. · 2026 · Journal of endocrinological investigation
Purpose To assess whether the Ketogenic Diet (KD) is associated with improvements in biochemical markers of hyperandrogenism in women diagnosed with Polycystic Ovary Syndrome (PCOS) with obesity or overweight. Methods A systematic search…
View details →Cooke T, Soderquist CR, Mansukhani MM et al. · 2026 · The journal of applied laboratory medicine
Background JAK2, CALR, and MPL mutations are defining features of myeloproliferative neoplasms (MPNs). Molecular testing for variants in these genes is standard of care in the diagnosis of MPNs. A high reimbursement denial rate led to…
View details →Magee GA, Mussa FF · 2026 · Seminars in vascular surgery
Dissection morphology is important when considering landing zones for thoracic endovascular aortic repair. Landing proximally in a healthy aorta, free of dissection and intramural hematoma, is generally recommended. For the most common…
View details →Hirai Y, Fujimoto A, Sasaki M et al. · 2026 · Endoscopy international open
Background and study aims It is desirable to develop a safe, cost-effective, and easy approach to prevent strictures after esophageal endoscopic submucosal dissection (ESD). We explored use of a novel rebamipide solution, an anti-ulcer…
View details →Yamaguchi K, Watanabe O, Mitsuki T et al. · 2026 · Transplantation and cellular therapy
The clinical benefit of adding high-dose cytarabine (HDCA) to fludarabine (FLU), busulfan (BU), and melphalan (MEL)-based conditioning for cord blood transplantation (CBT) in acute myeloid leukemia (AML) remains unclear. We aimed to…
View details →Ye L, Yue W, Lin K et al. · 2026 · Scientific reports
Triple therapy combining transarterial chemoembolisation (TACE), tyrosine kinase inhibitors (TKIs), and immune checkpoint inhibitors (ICIs) has shown efficacy in unresectable hepatocellular carcinoma (HCC), but evidence in elderly patients…
View details →Zuo P, Jiang K, Zou W et al. · 2026 · Neurosurgery
Background and objectives Atypical choroid plexus papillomas (ACPPs) are exceedingly uncommon. The treatment strategies for managing this condition remain a topic of debate. The main aim of this study was to elucidate the clinical features…
View details →Kakoudaki T, Poon SS, Kumar P · 2026 · Cardiovascular revascularization medicine : including molecular interventions
Background Surgical ventricular reconstruction (SVR) is not always feasible in patients with ischaemic cardiomyopathy and left ventricular (LV) aneurysm, due to high surgical risk. The Revivent-TC Transcatheter Ventricular Enhancement…
View details →Kang KM, Lee HY, Ahn HM et al. · 2026 · Cancer research and treatment
Purpose The role of adjuvant chemotherapy (ACT) in pathologic T3N0 (pT3N0) rectal cancer, which has a favorable prognosis, remains controversial because high-risk groups for recurrence are not well defined. This study investigated…
View details →Narayan P · 2026 · Indian journal of thoracic and cardiovascular surgery
There has been controversy over the ideal management strategy for asymptomatic carotid artery stenosis. Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trials (CREST-2) evaluated whether adding carotid…
View details →Belgioia L, D'Onofrio I, Filauro M et al. · 2026 · Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale
Objective To evaluate the impact of postoperative radiotherapy (PORT) on survival outcomes in patients with laryngeal cancer treated with partial laryngectomy. Methods In this retrospective multicentre study, 312 patients with supraglottic…
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