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Browse the failure-mode index

11,326 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Longitudinal Estimation of Adequate Physical Activity Levels to Reduce the Risk of Alzheimer's Disease and Other Dementias in Older Adults With Mild Cognitive Impairment.

Lee J, Kim J, Lee K · 2026 · Journal of physical activity & health

Background Although previous studies have identified a positive relationship between physical activity (PA) participation and cognitive function in older adults, further research is needed to determine the level of PA necessary to…

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Negative / Null Result ReportMedicine

Recurrence patterns and adjuvant therapy strategies in patients with esophageal squamous cell carcinoma who achieved pathological complete response after neoadjuvant immunochemotherapy: A high-volume retrospective study.

Zhu J, Ma Y, Xiong Y et al. · 2026 · European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

Background Studies investigating recurrence patterns and adjuvant therapy strategies in patients with esophageal squamous cell carcinoma (ESCC) who achieve pathological complete response (pCR) following neoadjuvant immunochemotherapy…

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Negative / Null Result ReportMedicine

Prospective evaluation of nonporous wrap fails to minimize inadvertent perianesthetic hypothermia in healthy canine patients undergoing ovariohysterectomy.

Bartels CM, Ranganathan B, Spinner M · 2025 · Journal of the American Veterinary Medical Association

Objective To prospectively evaluate a nonporous wrap's ability to prevent inadvertent perianesthetic hypothermia (IPH) in canines undergoing ovariohysterectomy. Methods All client-owned canines and felines undergoing ovariohysterectomy…

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Negative / Null Result ReportMedicine

Growth Hormone's Impact on Oxidative Stress, Ovarian Response, and <i>In Vitro</i> Fertilization in Polycystic Ovary Syndrome Across Different Ages.

Zhao P, Wang X, Zhang Q et al. · 2025 · British journal of hospital medicine (London, England : 2005)

Aims/Background Growth hormone (GH) supplementation contributes to improved reproductive and pregnancy outcomes in in vitro fertilization (IVF)-embryo transfer (ET) in polycystic ovary syndrome (PCOS) women. This study aimed to explore the…

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Negative / Null Result ReportOpen accessMedicine

Preoperative 15 mg of melatonin for reducing anxiety and post-traumatic stress disorder symptoms in mandibular third molar surgery: A randomized double-blind placebo-controlled clinical trial.

Rosa HH, Ruppel C, Trappel ND et al. · 2026 · Medicina oral, patologia oral y cirugia bucal

Background This study evaluated the efficacy of a single 15 mg preoperative sublingual dose of melatonin in reducing anxiety as the primary outcome, and its effects on psychomotor performance, postoperative sleep quality, and early…

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Negative / Null Result ReportMedicine

Quality of life effects of renal artery stenting versus medical therapy for atherosclerotic renal-artery stenosis: results from the randomized CORAL trial.

Arnold SV, Wang K, Kirtane AJ et al. · 2025 · European heart journal. Quality of care & clinical outcomes

Background Renal-artery stenosis can be associated with difficult to control hypertension, although renal-artery stenting has not been shown to improve clinical outcomes. Alternative antihypertensive medications could potentially result in…

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Negative / Null Result ReportMedicine

Comprehensive Analysis of a Single-Center Inpatient Posttransplant Physical Therapy Program in High-Acuity Patients: Is It Worth the Effort?

Ugarte R, Noguchi D, Jaeger C et al. · 2025 · Journal of the American College of Surgeons

Background High-acuity post-liver transplantation (LT) patients often have a prolonged hospital course. In response, we developed a novel, intensive inpatient group physical therapy (PT) program and sought to evaluate its impact on…

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Negative / Null Result ReportOpen accessMedicine

The combination of atezolizumab and BCG in high-risk non-muscle invasive bladder cancer: results of the phase Ib/II BladderGATE clinical trial.

Guerrero-Ramos F, Gómez-Cañizo C, Rodríguez-Izquierdo M et al. · 2026 · The oncologist

Background BladderGATE evaluated the safety, tolerability, and efficacy of intravenous (IV) atezolizumab combined with intravesical Bacillus Calmette-Guérin (BCG) in patients with BCG-naïve high-risk non-muscle invasive bladder cancer…

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Negative / Null Result ReportMedicine

Editorial Commentary: Shoulder Abduction Braces Are Unnecessary After Rotator Cuff Repair: A Simple Sling Confers No Clinically Important Disadvantages.

Saithna A · 2025 · Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association

Evaluations of practice patterns after rotator cuff repair reveal that both simple slings and abduction braces are commonly used, with the latter most frequently preferred in the United States. A preference for a shoulder abduction brace…

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Negative / Null Result ReportOpen accessMedicine

Efficacy of a low-FODMAP diet in children with irritable bowel syndrome and functional abdominal pain-not otherwise specified: a randomized controlled trial with early termination.

Stróżyk A, Horvath A, Kozłowska-Jalowska A et al. · 2026 · Frontiers in pediatrics

Objective Evidence supporting the effectiveness of a low fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (low-FODMAP) diet in treating functional abdominal pain disorders remains limited. We aimed to assess the…

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Negative / Null Result ReportMedicine

Long-term effects of statin and anticoagulant therapy on restenosis after drug-coated balloon angioplasty for femoropopliteal artery disease: results from the POPCORN registry.

Tsubakimoto Y, Takahara M, Soga Y et al. · 2025 · Cardiovascular intervention and therapeutics

Drug-coated balloon (DCB) angioplasty is an effective endovascular therapy for femoropopliteal artery (FPA) disease in patients with peripheral artery disease (PAD). However, the long-term impact of statin and anticoagulant therapy on…

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Negative / Null Result ReportOpen accessMedicine

Evaluating Food and Drug Administration approved gastrointestinal cancer drugs: clinical benefit and trial endpoints over the past two decades.

Jamal F, Sahvan O, Junior PLSU et al. · 2025 · The oncologist

Background The increasing reliance on accelerated approvals and surrogate endpoints for Food and Drug Administration (FDA) approvals of gastrointestinal (GI) cancer therapies raises concerns about their clinical benefit and long-term…

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Negative / Null Result ReportMedicine

Patient-reported outcomes with paclitaxel and ramucirumab switch maintenance in advanced gastroesophageal cancer: A secondary endpoint of the ARMANI phase 3 trial.

Cristarella E, Ambrosini M, Di Maio M et al. · 2025 · European journal of cancer (Oxford, England : 1990)

Background In the ARMANI trial, switch maintenance with paclitaxel plus ramucirumab improved progression-free survival and overall survival versus continuation of oxaliplatin-based chemotherapy in patients with HER2-negative advanced…

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Negative / Null Result ReportMedicine

Evaluating patients on immune checkpoint inhibitors for cardiac adverse events: The EPICC study.

Vang K, Panich J, Folz C et al. · 2025 · Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners

IntroductionImmune checkpoint inhibitors (CPIs) work by engaging the patient's immune system against tumor cells and have demonstrated a significant benefit in the treatment of cancers. Activation of the patient's immune system can lead to…

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