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Browse the failure-mode index

11,326 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Impact of hearing aid use on cognitive function in elderly individuals with hearing loss: a prospective study.

Velho HC, Schichi MASC, da Silveira Sassi TS et al. · 2026 · Brazilian journal of otorhinolaryngology

Objective To evaluate the cognition and the depressive symptoms of elderly individuals with hearing impairment before and after the use of Hearing Aids (HA), in order to determine whether auditory rehabilitation can influence cognition and…

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Negative / Null Result ReportMedicine

Developing facilitative interpersonal skills: A randomized controlled study of an apprenticeship training for first-year clinical psychology students.

Fagerbakk SA, Brattland H, Laugen NJ et al. · 2026 · Psychotherapy research : journal of the Society for Psychotherapy Research

Objective This study aimed to evaluate whether apprenticeship training could enhance facilitative interpersonal skills (FIS) in first-year students enrolled in a six-year integrated clinical psychology study program, compared to…

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Negative / Null Result ReportMedicine

Development of virtual reality in the upper extremities function in children with Cerebral Palsy. A pilot randomized controlled trial.

Iamchaimongkol A, Sangkrai S, Alberts P et al. · 2026 · Journal of neuroengineering and rehabilitation

Objective To evaluate the effect of the Virtual Reality (VR) in upper extremities function in children with Cerebral Palsy (CP). Study design Pilot randomization study. Methods A total of 42 children with CP, aged 10 to15 years, were…

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Negative / Null Result ReportOpen accessMedicine

Functional and Radiological Benefits of Adding Fibular Osteotomy to Supramalleolar Osteotomy in Ankle Osteoarthritis.

Li P, Liu H, Huang F et al. · 2026 · Medical science monitor : international medical journal of experimental and clinical research

BACKGROUND Ankle arthritis is a chronic degenerative disease; its typical symptom is pain in the ankle joint. This retrospective study of 65 patients with mid-stage ankle osteoarthritis aimed to compare clinical outcomes from…

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Negative / Null Result ReportMedicine

Short-Term Effects of Four Common Semioccluded Vocal Tract Exercises in Primary Muscle Tension Dysphonia: A Randomized Controlled Trial.

Aziz R, Khoddami SM, Jalaie S et al. · 2026 · Journal of voice : official journal of the Voice Foundation

Objectives This study investigated the effects of four common semioccluded vocal tract exercises (SOVTEs)-tongue trill, lip trill, straw phonation, and water resistance therapy (WRT)-in primary muscle tension dysphonia (MTD). Study design…

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Negative / Null Result ReportOpen accessMedicine

Types of physical activity and applied outcome measures in physical activity interventions among patients with inflammatory bowel disease: a scoping review.

Fromberg EB, Brink MT, Villumsen M et al. · 2026 · BMC gastroenterology

BACKGROUND: While pharmacological treatments remain essential in inflammatory bowel disease (IBD), complementary approaches such as physical activity are increasingly being explored for their potential benefits. This scoping review aimed…

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Negative / Null Result ReportMedicine

Bridging the Gap from "Paper" to "Patient": An Overview and Quality Assessment of PET/CT-Based Radiomics for Prostate Cancer Using the Updated RQS 2.0.

Bian S, Yang Y, Wang Z et al. · 2026 · Academic radiology

Rationale and objectives To apply the updated Radiomics Quality Score (RQS 2.0) and the Radiomics Readiness Level (RRL) framework to systematically evaluate the methodological quality and clinical translation maturity of Positron-emission…

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Negative / Null Result ReportMedicine

Comparison of the Efficacy of Intra-Articular Polyacrylamide Hydrogel and the Cross-Linked Hyaluronic Acid/Chondroitin Sulfate Combination in Treating Advanced-Stage Knee Osteoarthritis.

Altıntaş M, Ateş O, Soy F et al. · 2026 · Medicina (Kaunas, Lithuania)

Background and Objectives : Polyacrylamide hydrogel (PAAG) is still underresearched, and few human studies have validated its efficacy in knee osteoarthritis (OA), particularly in advanced stages. The aim of this study was to compare the…

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Negative / Null Result ReportMedicine

Improving Operative Note Documentation in Vascular Surgery: A Two-Cycle Closed-Loop Audit Following Introduction of Standardised Procedure-Specific Templates.

Mersal M, Amin A, Embaby OM et al. · 2026 · Annals of vascular surgery

Objective To evaluate completeness of operative note documentation in a vascular surgery service and to assess whether introduction of standardised procedure-specific templates was associated with improved documentation in a repeat audit…

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Negative / Null Result ReportMedicine

The effect of glandular frenulectomy on refractory lifelong premature ejaculation: a pilot study.

Roaiah MF, El Khayat YI, Saad El Din OA et al. · 2026 · Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica

Purpose Premature ejaculation (PE) is one of the most common male sexual disorders and is influenced by both psychological and biological factors. Despite available treatments, including psychosexual therapy and pharmacological…

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Negative / Null Result ReportMedicine

Impact of an 8-Week Targeted Potentiation Phase in the RAMP Warm-Up Protocol on Agility Performance in Female Police Officers.

Janković D, Kukić F, Radić I et al. · 2026 · Journal of strength and conditioning research

Abstract Janković, D, Kukić, F, Radić, I, Čvorović, A, Dawes, J, and Dopsaj, M. Impact of an 8-week targeted potentiation phase in the RAMP warm-up protocol on agility performance in female police officers. J Strength Cond Res XX(X):…

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Negative / Null Result ReportMedicine

ST-Elevation Myocardial Infarction Complicated by Ventricular Septal Defect Is Associated With Very High Mortality Without Improvement Over Time.

Movahed MR, Rasti A, Hashemzadeh M · 2026 · Reviews in cardiovascular medicine

Background This study aimed to examine mortality trends among patients who presented with ST-elevation myocardial infarction (STEMI) complicated by ventricular septal defect (VSD) between 2016 and 2022. Methods Using the Nationwide…

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Negative / Null Result ReportMedicine

Prediction of Clinically Significant Improvements During the Interdisciplinary Intensive Outpatient Program for Traumatic Brain Injury Using Machine Learning.

Srikanchana R, Samuel D, Powell J et al. · 2025 · Annals of biomedical engineering

Purpose The aim of this research was to assess the potential for machine learning to predict clinically significant patient improvement during a four-week interdisciplinary Intensive Outpatient Program (IOP) for traumatic brain injury…

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Negative / Null Result ReportOpen accessMedicine

Non-Pharmacological Interventions for Symptom Cluster Management in Women with Cancer: A Scoping Review of Multicomponent and Mechanism-Based Approaches.

Irmala N, Solehati T, Sukmawati S · 2026 · International journal of women's health

Background Women with cancer frequently experience co-occurring symptoms, including cancer-related fatigue, sleep disturbance, and psychological distress, which negatively impact quality of life. Despite the increasing use of…

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Negative / Null Result ReportMedicine

Similar performance with electrochemically deposited hydroxyapatite coating versus plasma porous spray in press-fit acetabular components for primary total hip arthroplasty: a randomised controlled study of early outcomes with DEXA.

Liu D, Turner D, Cadman J et al. · 2026 · Hip international : the journal of clinical and experimental research on hip pathology and therapy

Background Hydroxyapatite (HA) is an osteo-inductive material commonly added to the surface of components to enhance bone implant fixation; however, clinical studies have demonstrated inferior performance of HA coated acetabular cups in…

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Negative / Null Result ReportMedicine

Absent Bone Marrow Edema on MRI in a Patient with Acute Vertebral Compression Fractures: Implications for Vertebral Augmentation.

Singh S, Galperin M, Waghray-Penmetcha T · 2026 · Pain medicine case reports

Background Vertebral compression fractures (VCFs) are a common and debilitating consequence of multiple myeloma (MM). Acute VCFs often benefit from percutaneous vertebral augmentation (PVA), indicated by bone marrow edema (BME) on MRI. We…

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Negative / Null Result ReportMedicine

No clinical and functional benefit after medial congruent compared to ultra congruent total knee arthroplasty at 1 year: A prospective randomized controlled study.

Schrednitzki D, Sina J, Lamarche A et al. · 2026 · Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA

Purpose Various conforming bearing designs are used during total knee arthroplasty (TKA), yet their impact on clinical outcomes remains uncertain. In recent years, the use of medial congruent (MC) and ultra congruent (UC) onlays has gained…

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Negative / Null Result ReportOpen accessMedicine

Clinical and Radiographic Factors Affecting the Outcomes of Decompression Surgery in Clinical and Radiographic Degenerative Spondylolisthesis (CARDS) Classification Type C Degenerative Lumbar Spondylolisthesis.

Kawano A, Tarukado K, Yokota K et al. · 2026 · Cureus

Introduction The optimal surgical strategy for Clinical and Radiographic Degenerative Spondylolisthesis (CARDS) Type C remains controversial, particularly regarding decompression alone versus fusion surgery. Evidence focusing on outcomes…

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Negative / Null Result ReportMedicine

Does the ACR/EULAR Total Improvement Score reflect how individuals with autoimmune inflammatory myopathies feel and function?

Leclair V, Berger C, Bouchard-Marmen M et al. · 2026 · The Journal of rheumatology

Objective Little is known as to whether the American College of Rheumatology/European Alliance of Associations for Rheumatology Total Improvement Score (TIS) reflects how patients in the autoimmune inflammatory myopathies (AIM) spectrum…

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Negative / Null Result ReportMedicine

Intraocular foreign bodies in the posterior segment: Clinical characteristics, management, and visual outcomes.

Phogat J, Prabha C, Nada M et al. · 2026 · Chinese journal of traumatology = Zhonghua chuang shang za zhi

Purpose To analyze the clinical characteristics, management, and visual outcomes of patients with retained posterior segment intraocular foreign bodies (IOFBs). Methods This was a retrospective, non-comparative, single-institutional case…

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Negative / Null Result ReportMedicine

Use of Expected Utility to Evaluate Artificial Intelligence-Enabled Rule-out Devices for Mammography Screening.

Fan KL, Thompson YLE, Chen W et al. · 2026 · Medical decision making : an international journal of the Society for Medical Decision Making

BackgroundAn artificial intelligence (AI)-enabled rule-out device may autonomously remove patient images unlikely to have cancer from radiologist review. Many published studies evaluate this type of device by retrospectively applying the…

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