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Browse the failure-mode index

11,326 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Maltodextrin as sucrose replacer: Effect of dextrose equivalence and sucrose/maltodextrin ratio on physical and sensory properties of non-fat whipped cream analogue

Yang J, Han Y · 2026 · Food Hydrocolloids.

The development of non-fat whipped cream analogue (NFWCA) addresses the demand for low-fat and reduced-sucrose foods. This study systematically evaluated how the dextrose equivalent (DE) value of maltodextrin (MD) and the sucrose/MD ratio…

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Negative / Null Result ReportMedicine

Efficacy of multimodal therapy for sudden sensorineural hearing loss: a propensity score-matched analysis of 1632 patients.

Li G, Wang C, Gao Y et al. · 2026 · European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

OBJECTIVE: This study evaluated the efficacy and safety of multimodal outpatient therapy compared with conventional inpatient therapy during the initial treatment of sudden sensorineural hearing loss (SSNHL). The goal was to provide…

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Negative / Null Result ReportMedicine

Outcomes of secondary interventions in treatment of post-traumatic stiff shoulder in conservatively managed proximal humeral fractures: a scoping review.

Zhang Y, Sadeh N, Mitchell O et al. · 2026 · Irish journal of medical science

Aims There is no current gold standard in treating post-traumatic stiff (PTS) shoulder complicating conservatively managed proximal humeral fractures (PHFs). This scoping review seeks to present available outcome evidence in this cohort of…

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Negative / Null Result ReportMedicine

Postoperative syphilitic scleritis following strabismus surgery.

Parunakian E, Yehezkeli V, Khitri M et al. · 2026 · Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus

Syphilis can present with a wide range of ocular manifestations; however, scleritis is exceedingly rare. Although various infectious and noninfectious causes of scleritis following strabismus surgery have been documented, syphilitic…

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Negative / Null Result ReportMedicine

Comparative Outcomes of the Modified Woodward Procedure Versus Conservative Management in Sprengel Deformity: A Retrospective Cohort Study.

Jia Y, Dong Y, Jiang R et al. · 2026 · Journal of pediatric orthopedics

Background Sprengel deformity is a rare congenital malformation of the scapula. To date, there have been limited reports analyzing the clinical outcomes of the modified Woodward procedure and conservative management in the treatment of…

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Negative / Null Result ReportMedicine

Fortitude as a Key to Reducing Burnout: Its Critical Role in Influencing the Relationship Between Organizational Support and Burnout.

Weinzimmer LG, Hippler SE · 2026 · Journal of healthcare management / American College of Healthcare Executives

Goal Burnout in healthcare remains a significant problem, with implications not only for physicians and advanced practice providers but also for the entire US healthcare system, including patients and payers. Significant work has been done…

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Negative / Null Result ReportMedicine

Editorial Commentary: Lumbar Pathology Likely Negatively Affects Surgical Outcomes in Patients With Femoroacetabular Impingement Syndrome, Though the Strength of the Relationship is Unclear.

Kaplan DJ · 2026 · Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association

A complex interplay exists between the hip joint and the lumbosacralpelvis. As a patient moves from a standing to seated position, the lower back, pelvis, and hips must move in concert to properly function. Conceptually, any deviation from…

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Negative / Null Result ReportMedicine

Comparative Evaluation of Unilateral Recession-Plication Versus Bilateral Three-Muscle Surgery for Large-Angle Exotropia.

Anand K, Nagpal V, Dutta P et al. · 2026 · Journal of pediatric ophthalmology and strabismus

Purpose To evaluate and compare unilateral recession-plication versus bilateral three-muscle surgery for large-angle exotropia. Methods A prospective interventional non-randomized comparative study was conducted involving 66 patients with…

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Negative / Null Result ReportOpen accessMedicine

Precision in Medial pivot total knee arthroplasty: A retrospective study on mechanical axis alignment and functional outcomes with CT-guided patient-specific instrumentation.

Mat Salleh F, Nizam I · 2026 · SICOT-J

Background Total Knee Arthroplasty (TKA) is the standard treatment for end-stage osteoarthritis, with optimal outcomes dependent on precise mechanical alignment and accurate implant positioning. Patient-specific instrumentation (PSI),…

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Negative / Null Result ReportMedicine

Olfactory outcomes after primary endoscopic sinus surgery and dupilumab for post-operative recurrence in eosinophilic chronic rhinosinusitis.

Saito T, Hirose T, Haruna T et al. · 2026 · The Journal of laryngology and otology

Objective. To compare subjective and psychophysical olfactory outcomes in patients with eosinophilic chronic rhinosinusitis controlled after primary functional endoscopic sinus surgery (FESS) alone versus those treated with dupilumab for…

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Negative / Null Result ReportOpen accessMedicine

The association between cognitive function trajectories and all-cause mortality in middle-aged and older Chinese adults with cardiovascular disease: A longitudinal study from CHARLS.

Song X, Wang Y, Chen H · 2026 · International journal of cardiology. Cardiovascular risk and prevention

Objective To identify distinct multi-year cognitive function trajectories in middle-aged and older Chinese adults with established cardiovascular disease (CVD) and evaluate their independent associations with all-cause mortality. Methods…

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Negative / Null Result ReportMedicine

Investigating the Effect of Tumour Necrosis Factor Antagonist on Olfaction.

Espehana A, Macfarlane G, Garden EM et al. · 2026 · Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery

Objectives Tumour Necrosis factor antagonists is a potent anti-inflammatory medication and has shown to improve olfactory function in murine models. The primary aim was to determine the effect of TNF antagonists on olfactory performance in…

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Negative / Null Result ReportMedicine

Asialoglycoprotein receptor-1 promotes hyperandrogenism in polycystic ovary syndrome through direct interaction with FSHR, leading to the cAMP-PKA-CREB pathway inhibition.

Liu X, Shi J, Wang T · 2026 · Reproduction (Cambridge, England)

Polycystic ovary syndrome (PCOS) is a prevalent multifactorial disorder characterized by hormone dysregulation and follicular development defects. Asialoglycoprotein receptor 1 (ASGR1), a C-type lectin predominantly expressed on the…

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Negative / Null Result ReportOpen accessMedicine

No Difference Between Open and Arthroscopic ATFL Repair, Both Yielding Clinically Significant Improvement in Chronic Ankle Instability: A Randomized Controlled Trial.

Vuurberg G, Maria PA, Baalbaki R et al. · 2026 · Orthopaedic journal of sports medicine

Background Lateral ligament repair is a reliable surgical approach for the treatment of chronic ankle instability (CAI). Although the open technique has shown success over time, technological advancements have enabled the increasing use of…

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Negative / Null Result ReportMedicine

Effects of Photobiomodulation Therapy in Lateral Luxation of Anterior Permanent Teeth: A Randomized, Double-Blind Clinical Trial.

Belmonte FM, Soares PC, Azevedo LH et al. · 2026 · Dental traumatology : official publication of International Association for Dental Traumatology

Background Among the traumatic dental injuries (TDIs), lateral luxation may present poor prognosis due to frequent root resorption and consequent tooth loss. Photobiomodulation therapy (PBMT) modulates cellular activities (proliferation,…

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Negative / Null Result ReportOpen accessMedicine

Mid-Term Outcomes of Posterior Pelvic Reconstruction Combined with Lateral Abdominal Wall Suspension versus Sacrocolpopexy for Advanced Pelvic Organ Prolapse: A Retrospective Comparative Study.

Chu G, Hu C, Deng Q · 2026 · International journal of women's health

Purpose To compare mid-term efficacy, safety, and functional outcomes of laparoscopic sacrocolpopexy (LSC) versus laparoscopic lateral abdominal wall suspension (LAWS), both combined with standardized posterior repair, for advanced…

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Negative / Null Result ReportMedicine

The Effects of Personalized Observation, Execution, and Mental Imagery (POEM) Therapy in Logopenic Primary Progressive Aphasia: A Telepractice-Based Single-Case Study.

Basaglia-Pappas S, Solignac H, Durand É · 2026 · Brain sciences

Background/Objectives: Verb anomia is a common symptom of primary progressive aphasia (PPA), particularly in the logopenic variant (lvPPA). Despite the central role of verbs in sentence construction, interventions specifically targeting…

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Negative / Null Result ReportMedicine

Practice Effects and the Lanthony D15.

Ho J, Ng JS · 2026 · Vision (Basel, Switzerland)

Purpose Recent studies have shown that subjects with congenital colour vision deficiency (CVD) can pass the saturated Farnsworth D15 (FD15) through practice. The Lanthony D15 (LD15) uses desaturated colours and is a difficult test even for…

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Negative / Null Result ReportMedicine

Enhancing Resilience and Well-Being Among Nurse Leaders: A Randomized Controlled Trial of Mindfulness and Narrative Interventions.

Kim M, Owens R, Tucker S et al. · 2026 · The Journal of nursing administration

Objective Evaluate the short-term effectiveness of interventions to address nurse leader resilience and well-being. Background Nurse leaders face unique stressors in their role. Evidence-based, feasible interventions are urgently needed.…

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Negative / Null Result ReportOpen accessMedicine

Preliminary Evidence of Motor Outcomes in Children with Autism Spectrum Disorder Following Equine-Assisted Therapy and Dual-Task Training: A Pilot Study.

Della Valle C, Di Martino G, Melis A et al. · 2026 · Sports (Basel, Switzerland)

Background Equine-assisted therapy (EAT) is a supportive intervention for children with autism spectrum disorder (ASD). Aim This pilot study evaluated the feasibility of a cognitive-motor EAT intervention to explore its preliminary effects…

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Negative / Null Result ReportOpen accessMedicine

Long-Term Results of Medial Fixed-Bearing Unicompartmental Knee Arthroplasty with Miller-Galante Prosthesis: A Minimum 10-Year Follow-Up Study.

Lim S, Kim TH, Park DY et al. · 2026 · Medicina (Kaunas, Lithuania)

Background and Objectives : Medial unicompartmental knee arthroplasty (UKA) has emerged as an effective surgical option for isolated medial compartment osteoarthritis (OA), offering advantages in bone preservation, knee kinematics, and…

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