11,326 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Zhang D, Eurich J, Pitz-Goncalves L et al. · 2026 · Journal of orthopaedic trauma
Objectives To determine the rate of occult vascular abnormalities in high-energy tibial plateau fractures using Computed Tomography Angiography (CTA). Methods Design Prospective Cohort Study. Setting Single Academic Level I Trauma Center.…
View details →Bilen YE, Sinanoğlu N, Külekci Ç · 2026 · European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
Purpose Total laryngectomy disrupts nasal airflow, often resulting in significant olfactory and gustatory dysfunction. While these sensory losses may adversely affect patients' quality of life and psychological well-being, they typically…
View details →Akıncıoğlu P, Dağlı Ü, Koca E · 2026 · The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology
Background/aims Inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, is a chronic inflammatory disorder commonly associated with iron deficiency anemia and anemia of chronic disease. Hepcidin is a key…
View details →Cigdem-Karacay B, Bayramoglu-Demirdogen E, Konar NM et al. · 2026 · Irish journal of medical science
AIM: The effectiveness of EMG-BF in SUI has not yet been proven. This study aimed to the effectiveness of EMG-BF on pelvic floor muscle activity, pad test, severity of complaints, and quality of life in female patients with Stress Urinary…
View details →Gosset M, Coquart A, Delaval B et al. · 2026 · Journal of strength and conditioning research
Abstract Gosset, M, Coquart, A, Delaval, B, Catalano, J, Huou, G, Boufflers, M, Bozok, D, Bellanger, L, Douchet, T, Viroux, P, Jaffré, C, and Abaïdia, A-E. Compression garments and adaptations to plyometric training in soccer players: A…
View details →Fernando H, Vito I, Santillan N et al. · 2026 · Journal of neuroendocrinology
As peptide receptor radionuclide therapy (PRRT) maintains a key role in the treatment of neuroendocrine tumours (NETs), there is growing recognition of the importance of evaluating patient-reported health related quality of life (HRQoL).…
View details →Shigehara K, Shinzawa R, Sakatoku N et al. · 2026 · International journal of urology : official journal of the Japanese Urological Association
Objectives We assessed the efficacy of testosterone replacement therapy (TRT) combined with exercise on body composition in hypogonadal men. Methods Two hundred-fourteen patients were enrolled. All patients were divided into four groups:…
View details →Kassem S, Gressel O, Samuels N et al. · 2026 · Journal of pain and symptom management
Context and objective Integrative oncology (IO) programs address quality of life (QoL)-related concerns within palliative and supportive cancer care. This study examined adherence to and outcomes of an IO program among patients with both…
View details →Yadav R, Shukla U, Yadav U et al. · 2026 · Annals of African medicine
Background Improvement in neurological function has been reported in stroke patients after hyperbaric oxygen therapy (HBOT) administration. Although the majority of spontaneous neurological recovery occurs within the first 90 days…
View details →Zhang Y, Wang J, Hao M et al. · 2026 · Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie
PURPOSE: This proof-of-concept study aimed to detect preliminary signals of efficacy and assess the short-term safety of Esculin and Digitalis glycoside eye drops for the management of presbyopia. METHODS: This study was a 30-day,…
View details →Bovenberg C, Keeler JL, Cardi V et al. · 2026 · Journal of eating disorders
Background Anorexia nervosa (AN) is a severe psychiatric disorder (ED) with high mortality, marked functional impairment, and substantial phenotypical heterogeneity. Despite extensive research, treatment outcomes remain poor, and it is…
View details →Abbas Amanat M, Srichana T, Takahashi Yupanqui C et al. · 2026 · Pakistan journal of pharmaceutical sciences
Background Dry mouth is a condition associated with significant morbidity. It not only causes discomfort but also increases risk of many health and oral health problems. Objectives This study compared the efficacy and patient satisfaction…
View details →Rajendiran A, Maharjan A, Gerrard AD et al. · 2026 · Techniques in coloproctology
Introduction Radiofrequency ablation (RFA) for haemorrhoids has emerged as a minimally invasive treatment for grade II-III haemorrhoids, offering reduced postoperative pain and faster recovery compared with conventional surgery. However,…
View details →Kluckner M, Hitzl W, Enzmann FK et al. · 2026 · Journal of clinical medicine
Background/Objectives : Hyperspectral imaging (HSI) facilitates noninvasive assessment of tissue perfusion in patients with peripheral arterial disease. However, available studies are either based on small cohorts and provide no comparison…
View details →Wang J, Chen J, Zhao Y et al. · 2026 · Bone & joint research
Aims Ankle sprain (AS), a prevalent sports injury, often progresses to chronic ankle instability (CAI) and post-traumatic arthritis if inadequately treated. Despite known clinical manifestations, the molecular mechanisms driving poor…
View details →Seok HG, Park SG · 2026 · Archives of orthopaedic and trauma surgery
INTRODUCTION: The recovery patterns following arthroscopic rotator cuff repairs are influenced by several factors, including the size of the tear and the degree of patient compliance. This study aimed to ascertain whether a correlation…
View details →Ikuma H, Hirose T, Kawasaki K et al. · 2026 · Acta medica Okayama
We evaluated the clinical outcomes and limitations of anterior and posterior combined surgery with a mini-open corpectomy applying an expandable cage (Xcore®) and percutaneous pedicle screw (PPS) fixation using single-position surgery in…
View details →Patil S, Raju KN, S Kotnoor S et al. · 2026 · Bioinformation
The additional clinical benefit of diode laser irradiation as an adjunct to open flap debridement (OFD) in the treatment of chronic periodontitis remains uncertain. Therefore, it is of interest to evaluate the impact of diode laser…
View details →Pimouguet C, Kret M, Francis-Oliviero F et al. · 2026 · Journal of Alzheimer's disease : JAD
BackgroundThere is increasing interest in non-pharmacological approaches to address the needs of patients with Alzheimer's disease and other dementia. However, previous research highlighted the need to adapt interventions to the healthcare…
View details →Hansel NN, Putcha N, Woo H et al. · 2026 · American journal of respiratory and critical care medicine
Rationale Indoor particulate matter (PM) is linked to worse respiratory outcomes in adults with chronic obstructive -pulmonary disease (COPD). It is unclear if reducing indoor pollutants can improve respiratory health among current…
View details →Wong ECH, Lo RWM, Kwan RLC et al. · 2026 · Healthcare (Basel, Switzerland)
Background : COVID-19 can have adverse effects on individuals' lung functions for up to 6 months or more after the episode. As a result, people may be reluctant to exercise, and this can have further adverse effects on their lung capacity…
View details →Maldonado DR, Schab AR, Sikligar D et al. · 2026 · Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association
Purposes To compare minimum 2-year patient-reported outcomes measures (PROMs) between adolescents undergoing primary and revision hip arthroscopy. Methods Data were prospectively collected and retrospectively reviewed for adolescents who…
View details →Topan YE, Bayar Muluk N, Yavuz R et al. · 2026 · The Journal of craniofacial surgery
Objective To determine whether biological therapy is a viable option for individuals with recurrent chronic rhinosinusitis with nasal polyps (CRSwNP), we will assess the clinical outcomes of maximal conventional therapy (MCT). Methods For…
View details →Da Costa M, Seitz B, Munteanu C et al. · 2026 · Die Ophthalmologie
Background In Germany, each surgical corneal center defines individual criteria for the indications for Descemet membrane endothelial keratoplasty (DMEK). Clinical experience shows a clear discrepancy between best corrected visual activity…
View details →Eldesoqui M, Al-Batati A, Erfan OS et al. · 2026 · Clinical anatomy (New York, N.Y.)
Generation Z has different requirements, problems, expectations, and attitudes that they bring into the educational environment. Teachers have unprecedented challenges in addressing their needs and aspirations. Gamification involves…
View details →Hassan AM, Elgarem HF, Sheta E et al. · 2026 · Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
Objective Balloon dilation of the Eustachian tube (BDET) is increasingly used to treat pediatric obstructive Eustachian tube dysfunction (OETD); however, its broader adoption is limited by the cost of commercially available devices.…
View details →Metry M, Bernard S · 2026 · JAAPA : official journal of the American Academy of Physician Assistants
Abstract Heart failure (HF) is one of the most common and consequential conditions encountered in clinical practice. It frequently coexists with chronic kidney disease (CKD), a highly prevalent and economically burdensome condition. The…
View details →Flores Rodríguez JC, Morán Ortega MJ, Jimenez Ordoñez AC et al. · 2026 · Cureus
Postbiotics, defined as non-viable microbial cells and their metabolites, have emerged as topical therapies for inflammatory dermatoses and provide more clinical benefits than live postbiotics by eliminating infection risk and stability.…
View details →Cangemi DJ, Laitman AP, Faiman O et al. · 2026 · Annals of medicine
Introduction Constipation and bloating are common bothersome gastrointestinal (GI) symptoms that frequently occur concurrently. It is important to recognize the underlying condition(s) and tailor therapeutic interventions appropriately.…
View details →Gozde Ozdemir B, Avci F, Huseynli L et al. · 2026 · Pakistan journal of pharmaceutical sciences
Background Persistent infection with human papillomavirus (HPV) is a key factor in cervical carcinogenesis. Immune-mediated mechanisms play a central role in viral clearance, leading to interest in immunomodulatory supportive therapies.…
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