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11,326 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Associations of physical fitness with sleep quality and anxiety Among university students: a cross-sectional regression analysis.

Xu G, Li X, Song G et al. · 2026 · Frontiers in sports and active living

Background Poor sleep quality and anxiety are prevalent among university students and pose growing public health concerns. Physical fitness is often assumed to be associated with better sleep and mental health outcomes; however, evidence…

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Negative / Null Result ReportMedicine

Changes in myeloid-derived suppressor cells and cytokine expression during mother-to-child transmission prevention in HBeAg-positive pregnant women with chronic hepatitis B.

Pan S, Xiao L, Li Y et al. · 2026 · BMC infectious diseases

Objective The objective of this study was to investigate the changes of Myeloid-derived suppressor cells (MDSCs) and cytokines expression during mother-to-child blockade in chronic HBV infected patients. Method This was a single-center,…

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Negative / Null Result ReportMedicine

The diameter of malformation capillaries does not influence the efficacy of photodynamic therapy for facial port-wine stains: a pilot study.

Hao L, Ju W, Huang Y · 2026 · The Journal of dermatological treatment

Background Photodynamic therapy (PDT) is an effective treatment for port-wine stains (PWS). However, the relationship between the diameter of malformed capillaries and the efficacy of PDT in PWS has been rarely studied. Objective This…

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Negative / Null Result ReportMedicine

Emotion Perception in Behavioral Variant Frontotemporal Dementia and Alzheimer Disease: The Parahippocampal Conundrum.

Morais RF, Duro D, Pires R et al. · 2026 · Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology

Background Emotion perception is the capacity that enables humans to correctly identify the cues that guide interpersonal interactions, forming the basis for social behavior. The parahippocampal cortex may contribute to emotion perception…

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Negative / Null Result ReportOpen accessMedicine

Changes in Upper Airway Anatomy and Apnea-Hypopnea Index in Patients with Obstructive Sleep Apnea Undergoing Bariatric Surgery: A Pilot Study.

Nithya M, Titiyal R, Ajayababu A et al. · 2026 · Journal of clinical medicine

Background: Obstructive sleep apnea (OSA) is common in individuals with obesity, largely due to increased soft tissue causing upper airway narrowing. However, mechanisms of OSA improvement following weight loss are incompletely understood,…

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Negative / Null Result ReportMedicine

Direct and indirect assessment: comparison of different methods to estimate staff equivalent dose to the lens during different interventional procedures.

Fedeli L, Magistrelli A, Vaiano A et al. · 2026 · Journal of radiological protection : official journal of the Society for Radiological Protection

The reduction of the annual equivalent dose limit to the lens of the eye from 150 to 20 mSv has increased the need for reliable assessment of occupational eye lens exposure, particularly in interventional radiology. Lens absorbed dose is…

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Negative / Null Result ReportMedicine

Immunohistochemical Assay Variability and Human Epidermal Growth Factor Receptor 2 (HER2)-Low Breast Cancer Detection: A Laboratory Comparison in the Netherlands.

Kain ZE, Schuurman E, Baez-Navarro X et al. · 2026 · Laboratory investigation; a journal of technical methods and pathology

Purpose HER2-low breast cancer has gained clinical relevance owing to the efficacy of trastuzumab deruxtecan. However, variability in detecting low HER2 expression may affect patient eligibility. This nationwide study in the Netherlands…

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Negative / Null Result ReportMedicine

Dynamic navigation system accuracy in orthodontic miniscrew insertion in the palatal vault: a prospective single-arm clinical study.

Brilli D, Giansanti M, Bertoldo S et al. · 2026 · International journal of computerized dentistry

Aim The aim of the present study was to evaluate the accuracy of dynamic navigation (DN) in miniscrew insertion in the palatal vault by comparing the deviation between planned and placed miniscrew positions. The secondary outcome was to…

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Negative / Null Result ReportOpen accessMedicine

Discordance in diagnostic assessment of Achilles tendon thickening between soft X-ray radiography and ultrasonography among patients with coronary artery disease.

Itagaki T, Ueki Y, Oyama Y et al. · 2026 · Scientific reports

Achilles tendon (AT) xanthomas are characteristic manifestations of familial hypercholesterolemia (FH). Although soft X-ray radiography (XR) and ultrasonography (US) are used to assess AT thickness, data comparing their diagnostic…

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Negative / Null Result ReportOpen accessMedicine

p53 Immunohistochemistry Expression in Epithelial Ovarian Tumors.

Madini S, Suresh TN, Kattepur AK · 2026 · Cureus

Introduction Epithelial ovarian carcinoma usually has TP53 expression. The TP53 gene is the most frequently mutated gene in ovarian cancer and therapies targeting these mutations may improve treatment outcomes, but there are only few…

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Negative / Null Result ReportMedicine

Pd-L1 Expression in Oral Cavity Squamous Cell Carcinomas.

Nalwa A, Visakhan A, Elhence PA et al. · 2026 · Indian journal of surgical oncology

Programmed cell death ligand-1 (PD-L1) is involved in T-cell regulation by acting as an immune checkpoint inhibitor, and its expression is being widely studied in various malignancies. The following study was designed to examine the role…

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Negative / Null Result ReportMedicine

Significant Correlation Between White Matter Hyperintensity Volume and Rare NOTCH3 Variants in the General Japanese Population.

Mizuta I, Yamashita F, Sutoh Y et al. · 2026 · Geriatrics & gerontology international

Aim Cerebral small vessel disease (CSVD)-related MRI findings, including white matter hyperintensities (WMHs), are not rare in general elderly populations. The aim of this study was to elucidate the contribution of hereditary CSVD-related…

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Negative / Null Result ReportMedicine

Chondrolabral junction pathology in Femoroacetabular Impingement Syndrome is underestimated by pre-operative MRI and have no significant correlation with baseline outcomes.

Samim M, Jardon M, Vonck C et al. · 2026 · Journal of orthopaedics

Purpose To assess correlation of pre-operative symptoms, labral damage and chondrolabral junction pathology on MRI with intra-operative findings in patients undergoing hip arthroscopy for femoroacetabular impingement (FAI). Methods…

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Negative / Null Result ReportOpen accessMedicine

Exploratory Analysis of the Neutrophil-to-Lymphocyte Ratio (NLR) and Mucositis Severity in Head and Neck Cancer Patients Undergoing Radiotherapy-Based Treatment: A Retrospective Study.

Santo B, Romanello M, De Franco P et al. · 2026 · Journal of clinical medicine

Background/Objectives: The neutrophil-to-lymphocyte ratio (NLR) is a simple biomarker reflecting systemic inflammatory status and has been investigated in head and neck cancer (HNC) as a potential prognostic indicator. Its role in relation…

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