11,326 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Kaushik A, Jaiswal A, Priya B et al. · 2025 · Journal of family medicine and primary care
Background Breast cancer is the most common cancer in women across the world. Immune cells can detect and destroy cancer cells. However, cancer cells acquire certain immune evasion mechanisms such as PD-1+ T-cells, to combat immune…
View details →Zhou X · 2026 · Translational psychiatry
Low titers of blood circulating natural anti-NMDAR1 autoantibodies were reported in ~10% of the general human population. Their potential effects on NMDAR functions in the brain, however, remain unknown. We developed a new method to more…
View details →Hiroshimaya T, Iwai K, Marutani M et al. · 2026 · Scientific reports
This study aimed to clarify the relationship between periodontitis and non-alcoholic fatty liver disease (NAFLD). A survey was conducted with 2,453 participants who visited the dental clinic at the Asahi University Hospital. Periodontitis…
View details →Haddad A, Zabari Parnis E, Stein N et al. · 2026 · Vaccines
Background/Objective : The emergence of the COVID-19 pandemic has raised significant concerns regarding its impact on immune-mediated diseases, particularly with respect to disease induction and exacerbation. We aimed to investigate the…
View details →Wu Z, He S, Zhu F et al. · 2026 · Frontiers in endocrinology
Objective Copper overload has been implicated in impaired β -cell function and insulin resistance through oxidative stress and inflammatory pathways. As a major lipoprotein component involved in lipid oxidation, apolipoprotein B (apoB) may…
View details →Macian N, Dualé C, Delay M et al. · 2026 · European journal of pain (London, England)
Background Fibromyalgia is a syndrome characterised by widespread chronic pain, which is believed to be mediated by a state of central sensitisation (CS). Based on the hypothesis that CS itself could have genetic determinants, our aim was…
View details →Alharthy N, Alreefi M, Alsenani M et al. · 2026 · Pediatric health, medicine and therapeutics
Background Among children younger than 5 years, infectious conditions account for the majority of pediatric emergency department visits. Due to nonspecific presentation, early identification of Sepsis and serious bacterial infection is…
View details →Önder N, Muratoglu K · 2026 · Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment
Peanuts are among the most clinically important food allergens and may cause severe reactions even at very low exposure levels. This study investigated the presence of peanut residues in packaged baby biscuits marketed on the European side…
View details →Mirmosayyeb O, Barzegar M, Rezaei M et al. · 2026 · Neurologia
Purpose Multiple sclerosis (MS) is a debilitating disease accompanied by physical and mental comorbidities. Little is known about the relation between different comorbidities and health-related quality of life (HRQOL) in people with MS…
View details →Kanani P, Shinde V, Bhimani K et al. · 2026 · Annals of African medicine
Background Shock is a critical, life-threatening syndrome defined by a state of global hypoperfusion that results in inadequate oxygen and nutrient delivery to tissues, leading to cellular dysfunction and ultimately, organ failure. Despite…
View details →Kądziela M, Migdalska-Sęk M, Domańska-Senderowska D et al. · 2026 · International journal of molecular sciences
Vitiligo is a chronic autoimmune skin disorder characterized by progressive melanocyte loss and depigmented skin lesions, whose pathogenesis has been attributed to genetic and immunological factors. The aim of this exploratory study was to…
View details →Anderson N, Kimlin K, O'Rourke JL et al. · 2026 · Pediatric research
Background Congenital hearing loss can significantly affect childhood development, yet more than half of affected infants present without identifiable risk factors. A possible association between maternal diabetes and congenital hearing…
View details →Li Y, Zhu YX, Qiu Y et al. · 2026 · Clinical nephrology
Objective The association between the atherogenic index of plasma (AIP) and chronic kidney disease (CKD) among individuals with different metabolic syndromes remains inadequately characterized. The aim of this study is to assess the…
View details →Mostofi K, Caragliano G · 2026 · The Journal of hospital infection
Background Surgical site infections (SSIs) are a major complication of spinal surgery. The influence of tattoos overlying the operative incision has not been previously evaluated as a risk factor in this context. Methods Retrospective…
View details →Karabulut Ü, Yolaçan R, Ebik B et al. · 2026 · BMC gastroenterology
Background Duodenogastric reflux (DGR), defined as the retrograde flow of duodenal contents into the stomach, has an incompletely understood pathophysiology. This study aimed to evaluate the relationship between DGR and clinical,…
View details →Maher AA, Maad AH, Al-Jaufy AY et al. · 2026 · Frontiers in medicine
Background Burn wound infections (BWIs) represent a major cause of morbidity and mortality among hospitalized burn patients. Pseudomonas aeruginosa is recognized for its ability to acquire multidrug resistance (MDR) and form biofilms that…
View details →Böckels L, Lisnic V, Alexa D et al. · 2026 · Journal of clinical medicine
Background/Objectives: Relapsing-remitting multiple sclerosis (RRMS) is frequently associated with anxiety and depressive symptoms, which significantly impact quality of life and clinical outcomes. The Hospital Anxiety and Depression Scale…
View details →Shimada H, Lee S, Doi T et al. · 2026 · Gerontology
Introduction Walking speed is widely recognized as an informative indicator of physical capability in later life and is frequently used to evaluate mobility and functional health in older adults. Although the measurement of community…
View details →Rosi Júnior J, Telles JPM, Santana LS et al. · 2026 · Arquivos de neuro-psiquiatria
Background Alpha 1-antitrypsin (A1AT) helps maintain vascular-wall integrity, but its role in the formation and rupture of intracranial aneurysms is unclear. Objective To compare A1AT levels between patients with ruptured and unruptured…
View details →Kavrul Kayaalp G, Balcı MC, Kürkçü Güneş D et al. · 2026 · Cardiology in the young
Background Early identification of familial hypercholesterolaemia is critical to prevent long-term cardiovascular complications. This study assessed diagnostic features and age at diagnosis in children with familial hypercholesterolaemia…
View details →Shinkawa K, Yoshida S, Nakao YM et al. · 2026 · Clinical and experimental nephrology
Introduction The clinical characteristics of patients with nephrotic syndrome undergoing in-hospital rehabilitation are not well-understood, and the effects of exercise on acute kidney injury (AKI) or venous thromboembolism (VTE) in this…
View details →Kim T, Oh SB, Choi HJ et al. · 2025 · Genes
Objective Suicide attempts have become one of the most serious problems worldwide in recent years. Suicide attempts are known to be genetically highly associated with serotonin and BDNF in international studies. Methods In this study, we…
View details →Devi Krishna RB, Mathews SG, Agarwal P et al. · 2026 · Biochemical genetics
To assess the potential association between LRP1 (rs715948) and PAI1 (rs2227631, rs1799889) gene variation and ovarian cancer (OC) susceptibility. This study evaluated the genotypic and allelic distributions of LRP1 gene and PAI1 gene…
View details →Majmudar IP, Aggarwal S, Hamzeh N et al. · 2026 · Clinical ophthalmology (Auckland, N.Z.)
Purpose To determine if there is an association between surgeon-patient sex concordance and post-surgical complications for cataract surgeries. Patients and methods In this 16-year retrospective cohort study, data was collected from the…
View details →Foo JF, Haddow K, Jones S et al. · 2026 · The Journal of laryngology and otology
Objectives To investigate whether socioeconomic deprivation is associated with residual or recurrent cholesteatoma following primary mastoidectomy. Methods A retrospective cohort study included all patients undergoing primary mastoidectomy…
View details →Peng P, Guo Y, Zhu Y · 2026 · Advances in clinical and experimental medicine : official organ Wroclaw Medical University
Background Given that long-term anticoagulant therapy is required in many clinical scenarios, continuous safety monitoring of direct factor Xa inhibitors is of great importance. To date, the renal safety of these agents remains a subject…
View details →Zhai L, Fang C, Wang L et al. · 2026 · Scientific reports
There is little evidence about the susceptible exposure window of maternal depression during pregnancy and preterm birth in China. We aimed to assess the trimester-specific association of depression during pregnancy with preterm birth, and…
View details →Metwally YF, Zahran RF, El Sadda RR et al. · 2026 · Discover oncology
Background Lung cancer remains the leading cause of cancer-related deaths worldwide. Despite advances in diagnostics and treatment, most patients are diagnosed at advanced stages. Genetic variants such as single nucleotide polymorphisms…
View details →Aryal SB, Raj Joshi D · 2026 · Journal of Nepal Health Research Council
Background Homocysteine (Hcy) contributes to oxidative stress and renal injury by generating reactive oxygen species and reducing heme oxygenase-1 levels. Elevated Hcy (Hhcy) may worsen outcomes after acute renal failure(ARF), promoting…
View details →Bellos I, Marinaki S, Benetou V · 2026 · Journal of clinical medicine
Background/Objectives : Composite endpoints are commonly used in chronic kidney disease (CKD) trials to enhance statistical efficiency but may not reflect clinically meaningful outcomes. We assessed agreement between composite endpoints…
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