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Browse the failure-mode index

11,326 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Steroid with Temporary Stent Versus Steroid Alone for Preventing Stricture After Endoscopic Submucosal Dissection for Early Esophageal Cancer.

Chen Z, Zhang L, Liang Y et al. · 2026 · Digestive diseases and sciences

Background and aims Post-ESD esophageal stricture remains a major complication despite steroid prophylaxis. Temporary stent placement has been proposed as an adjunctive strategy in high-risk cases, yet its independent effect remains…

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Negative / Null Result ReportOpen accessMedicine

Association Between Possible Sarcopenia and Fracture Risk Assessment Tool (FRAX)-Estimated Fracture Risk Without Bone Mineral Density in Institutionalized Older Adults: A Cross-Sectional Study.

Yubaitsa CN, Gani KS, Mitchel M et al. · 2026 · Cureus

Background Musculoskeletal problems in the elderly pose a significant challenge for healthcare providers, as they constitute a vulnerable group. Fractures are often undetected, leading to a reduced quality of life due to increased…

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Negative / Null Result ReportMedicine

FDG PET/CT imaging in recurrent papillary thyroid cancer: does BRAF mutation status matter?

Bastian MB, Kyriakou I, Rosar F et al. · 2026 · The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of...

Background Papillary thyroid carcinoma (PTC) with a BRAFV600E mutation is linked to more aggressive tumor characteristics, as well as a higher likelihood of recurrence and disease-specific mortality. This study aimed to investigate the…

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Negative / Null Result ReportOpen accessMedicine

Effectiveness of Community-Based Breast Cancer Screening Using Full-Field Digital Mammography With Digital Breast Tomosynthesis in an Urban Population in Central India: An Observational Study.

Pande S, Dakhore S, Arora D et al. · 2026 · Cureus

Background Breast cancer is the most common malignancy among women worldwide and remains a leading cause of cancer-related mortality. In India, delayed presentation and limited access to organised screening programmes contribute to poorer…

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Negative / Null Result ReportOpen accessMedicine

Targeting Human Epidermal Growth Factor Receptor 2 in Bladder Cancer: Evaluating Its Role as a More Robust Clinicopathological Biomarker Compared to Programmed Death Ligand 1 Expression.

Mittal A, Malhotra K, Panwar V et al. · 2026 · Urology research & practice

Objective: This retrospective cross-sectional analytical study evaluated the clinicopathological associations of programmed death ligand 1 (PD-L1) and human epidermal growth factor receptor 2 (HER2/neu) expression in 250 patients with…

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Negative / Null Result ReportOpen accessMedicine

Correlation between symptom distress and quality of life in patients with Chronic Kidney Disease Stage 5 undergoing hemodialysis in China: a multi-center cross-sectional study.

Qiao X, Wang Y, Tian Z et al. · 2026 · Frontiers in psychiatry

Aim To explore the symptom distress and quality of life status of patients with Chronic Kidney Disease (CKD) Stage 5 undergoing hemodialysis in China, and their correlation. Methods The Dialysis Symptom Index (DSI) and the Kidney Disease…

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Negative / Null Result ReportOpen accessMedicine

Cephalometric Assessment of Airway-Related Hyoid Position and Velar Morphology Across Skeletal Malocclusions: A Cross-Sectional Study.

Özen GY, Özen AK, Bilge NH · 2026 · Diagnostics (Basel, Switzerland)

Background: The anatomical position of the hyoid bone and the morphological characteristics of the soft palate play a key role in upper airway patency, craniofacial balance, and the coordination of functional structures. These features may…

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Negative / Null Result ReportMedicine

Does ethnicity affect primary palliative care identification and coding? Retrospective cohort study.

Clarke G, Shuweihdi F, Relton SD et al. · 2026 · The British journal of general practice : the journal of the Royal College of General Practitioners

Background Primary palliative care is symptom support and care for people with life-limiting illnesses incorporated within standard primary care. Early identification of needs is best practice. There is limited research concerning…

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Negative / Null Result ReportMedicine

The Moderating Effect of Physical Activity on the Association Between Cognitive Function and Fear of Falling in Low-Income Community-Dwelling Older Adults.

Ojo EO, Xie R, Ng BP et al. · 2026 · Research in gerontological nursing

Purpose The current study aimed to examine the association between cognitive function, fear of falling, and physical activity and assess the moderating effect of physical activity on the association between cognitive function and fear of…

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Negative / Null Result ReportMedicine

Auditory Perception of Neutral Voices in K-Pop Singers.

Dornelas R, Marins I, Rodrigues TS et al. · 2025 · Journal of voice : official journal of the Voice Foundation

Objective To analyze the auditory perception of Korean pop (K-pop) singers' voices to identify vocal characteristics associated with gender neutrality. Study design This is a cross-sectional observational study. Methods The inclusion…

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Negative / Null Result ReportOpen accessMedicine

Tampa scale for kinesiophobia in individuals with knee osteoarthritis: a cross-sectional psychometric evaluation using item-level and exploratory factor analyses.

Sakulsriprasert P, Bunprajun T, Hengsomboon N et al. · 2026 · Scientific reports

This study evaluated floor and ceiling (F/C) effects within the Tampa Scale for Kinesiophobia (TSK) and examined item-level correlations with total TSK scores and pain intensity in individuals with knee osteoarthritis (KOA). A…

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Negative / Null Result ReportOpen accessMedicine

Creatine Supplementation Dose and Duration Are Not Associated with Increased Side Effects: A Structured Review and Study-Level Dose-Response Analysis of Randomized Controlled Trials.

Gonzalez DE, Dickerson BL, Hines K et al. · 2026 · Sports (Basel, Switzerland)

There are concerns that high-dose and/or long-term creatine monohydrate supplementation (CrM) leads to greater side effects (SEs) compared to placebo. This analysis investigated whether the dose or duration of CrM was associated with SEs.…

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Negative / Null Result ReportMedicine

Association between lesion location and symptoms of restless leg syndrome (RLS) among patients with multiple sclerosis (MS).

Aljarallah S, Aldeligan SH, Almarshed A et al. · 2026 · Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

PURPOSE.: Restless legs syndrome (RLS) is a common but under-recognised non-motor symptom in multiple sclerosis (MS), potentially linked to central nervous system lesion distribution. This study aimed to assess the anatomical distribution…

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