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11,326 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Quality of life and severity of symptoms among patients with various degrees of reflux esophagitis: a prospective study

Amir Mari, Wasef Na’amnih, Loay Ghantous et al. · 2023 · Scientific Reports

Abstract Gastro-esophageal reflux disease (GERD) can cause erosive esophagitis (EE) and compromise the quality of life (QoL). We examined differences in symptom severity and QoL according to EE severity grade. A follow-up study was conducted among GERD patients at the Nazareth Hospital in Israel. Patients underwent a baseline gastroscopy in 2014–2020 during which the EE grade was determined using the Los Angeles classification. Follow-up telephone interviews were conducted during 2019–2020 with a mean time interval of 18.9 months (SD = 14.9) after the baseline gastroscopy to assess GERD sympto

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Negative / Null Result ReportOpen accessMedicine

Food insecurity and early childhood development among children 24-59 months in Nigeria: A multilevel mixed effects modelling of the social determinants of health inequities.

Otobo I Ujah, Omojo C Adaji, Innocent A O Ujah et al. · 2025 · PLoS ONE

Food insecurity (FI) has been identified as a determinant of child development, yet evidence quantifying this association using the newly developed Early Childhood Development Index 2030 (ECDI2030) remains limited. Herein, we provide national estimates of early childhood development (ECD) risks using the ECDI2030 and examined to what extent FI was associated with ECD among children aged 24-59 months in Nigeria. This population based cross-sectional analyses used data from the UNICEF-supported 2021 Multiple Indicator Cluster Survey in Nigeria. The analytic sample comprised children aged 24-59 m

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Negative / Null Result ReportOpen accessMedicine

Performance of Multiple Risk Assessment Tools to Predict Mortality for Adult Respiratory Distress Syndrome with Extracorporeal Membrane Oxygenation Therapy: An External Validation Study Based on Chinese Single-center Data

Lei Huang, Tong Li, Lei Xu et al. · 2016 · Chinese Medical Journal

Background: There has been no external validation of survival prediction models for severe adult respiratory distress syndrome (ARDS) with extracorporeal membrane oxygenation (ECMO) therapy in China. The aim of study was to compare the performance of multiple models recently developed for patients with ARDS undergoing ECMO based on Chinese single-center data. Methods: A retrospective case study was performed, including twenty-three severe ARDS patients who received ECMO from January 2009 to July 2015. The PRESERVE (Predicting death for severe ARDS on VV-ECMO), ECMOnet, Respiratory Extracorpore

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Negative / Null Result ReportOpen accessMedicine

Effectiveness of telemonitoring integrated into existing clinical services on hospital admission for exacerbation of chronic obstructive pulmonary disease: researcher blind, multicentre, randomised controlled trial

H. Pinnock, J. Hanley, L. McCloughan et al. · 2013 · British medical journal

Objective To test the effectiveness of telemonitoring integrated into existing clinical services such that intervention and control groups have access to the same clinical care. Design Researcher blind, multicentre, randomised controlled…

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Negative / Null Result ReportOpen accessMedicine

Statement on chronotherapy for the treatment of hypertension: consensus document from the Korean society of hypertension

Sungha Park, Sang-Hyun Ihm, In-Jeong Cho et al. · 2023 · Clinical Hypertension

Abstract Nocturnal blood pressure (BP) has been shown to have a significant predictive value for cardiovascular disease. In some cases, it has a superior predictive value for future cardiovascular outcomes than daytime BP. As efficacy of BP medications wanes during nighttime and early morning, control of nocturnal hypertension and morning hypertension can be difficult. As such, chronotherapy, the dosing of BP medication in the evening, has been an ongoing topic of interest in the field of hypertension. Some studies have shown that chronotherapy is effective in reducing nocturnal BP, improving

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Negative / Null Result ReportOpen accessMedicine

The Role of Oxidative Stress in Parkinson's Disease

Vera Dias, Eunsung Junn, M. Maral Mouradian · 2013 · Journal of Parkinson’s Disease

Oxidative stress plays an important role in the degeneration of dopaminergic neurons in Parkinson's disease (PD). Disruptions in the physiologic maintenance of the redox potential in neurons interfere with several biological processes, ultimately leading to cell death. Evidence has been developed for oxidative and nitrative damage to key cellular components in the PD substantia nigra. A number of sources and mechanisms for the generation of reactive oxygen species (ROS) are recognized including the metabolism of dopamine itself, mitochondrial dysfunction, iron, neuroinflammatory cells, calcium

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Negative / Null Result ReportOpen accessMedicine

Short-term interval aerobic exercise training does not improve memory functioning in relapsing-remitting multiple sclerosis—a randomized controlled trial

Lisa Baquet, Helge Hasselmann, Stefan Patra et al. · 2018 · PeerJ

Background Only few aerobic exercise intervention trials specifically targeting cognitive functioning have been performed in multiple sclerosis. Objective and Methods This randomized controlled trial with 34 patients in the intervention group (IG) (mean: 38.2 years (±9.6)) and 34 patients in the control group (CG) (mean: 39.6 years (±9.7)) aimed to determine the effects of aerobic exercise on cognition in relapsing-remitting multiple sclerosis (RRMS). The primary outcome was verbal learning assessed by the verbal learning and memory test (VLMT). Patients were randomized to an IG or a waitlist

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Negative / Null Result ReportMedicine

Migraine Features and Nociceptive Profile Do Not Influence Conditioned Pain Modulation in Women With Episodic and Chronic Migraine.

de-la-Llave-Rincón, Ambite-Quesada, Pacho-Hernández et al. · 2026 · Pain research & management

To determine the influence of sensitization-associated and neuropathic-like symptoms and clinical features in conditioned pain modulation (CPM) activity in women with episodic or chronic migraine. A cross-sectional study including 70 women…

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Negative / Null Result ReportMedicine

Do the printing orientation angle and layer thickness influence the radiopacity of 3D-printed dental resins?

Yersel, Ucan, Tekce · 2026 · Journal of prosthodontics : official journal of the American College of Prosthodontists

This in vitro study aimed to evaluate the effect of layer thickness, printing orientation angle, and resin type on the radiopacity of 3D-printed dental resins. Three dental 3D-printed resins (VarseoSmile TriniQ, Crowntec, and Primeprint…

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Negative / Null Result ReportOpen accessMedicine

Identifying early changes in imaging, plasma, and digital cognitive biomarkers that correspond to Alzheimer's disease pathology in the presence of autopsy-confirmed co-pathologies.

Chen CD, Aguero C, Melloni A et al. · 2026 · Alzheimer's & dementia : the journal of the Alzheimer's Association

Introduction Alzheimer's disease (AD) biomarkers are assessed on their ability to detect AD pathophysiology in vivo, with confirmation of AD neuropathology only at autopsy. Methods Positron emission tomography (PET), plasma, and cognitive…

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Negative / Null Result ReportMedicine

Expression patterns of risk genes associated with three evolutionarily relevant syndromes in rhesus macaque and human brains.

Karunakaran KB, Purushottam M, Balakrishnan N et al. · 2026 · Translational psychiatry

Depressive disorder (DD), Alzheimer's disease (AD), and schizophrenia (SZ) are evolutionarily relevant traits that disrupt neural networks supporting affect and cognition. While genome-wide association studies have identified risk-related…

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Negative / Null Result ReportMedicine

Quantification of retinal non-perfusion in eyes with diabetic retinopathy to study the association with retinal neovascularisation: INSPIRED study report 3.

Khalid H, Tsai WS, Lamanna F et al. · 2026 · The British journal of ophthalmology

Background/aims To characterise the distribution of retinal non-perfusion and its relationship with neovascularisation elsewhere (NVE) and visual acuity (VA) in referable diabetic retinopathy (DR) using ultra-widefield fluorescein…

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Negative / Null Result ReportMedicine

Measuring Cognitive Flexibility in Chinese Individuals with Obsessive-Compulsive Disorder: Psychometric Validation and Factor Structure of the Chinese Version of the Flexibility in Daily Life Scale.

Yan Z, Chen T, Ma X et al. · 2026 · Psychology research and behavior management

Purpose Impaired cognitive flexibility is a core feature of obsessive-compulsive disorder (OCD) and may contribute to symptom persistence and variabe therapeutic outcomes. However, traditional measures may adequately capture how cognitive…

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Negative / Null Result ReportMedicine

Predictable modality transitions and meaningful stimuli facilitate sequential statistical learning between sensory modalities.

Pérez-Bellido A, Duato D, Giannelli F et al. · 2026 · Journal of experimental psychology. Learning, memory, and cognition

Statistical learning is the process of extracting regularities from the environment. Although sequential cross-modal regularities are ubiquitous (e.g., the sight of a falling ball followed by the sound of impact), previous research has…

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Negative / Null Result ReportMedicine

Between hope and uncertainty: the elusive evidence on hyperbaric oxygen therapy and radiotherapy.

Cuccia F, Cracchiolo AN, Piras A et al. · 2026 · Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

Background Radiotherapy (RT) is a cornerstone in cancer management, but late radiation tissue injury (LRTI) remains a relevant clinical issue, affecting approximately 5% of patients and significantly impacting quality of life. Hyperbaric…

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Negative / Null Result ReportMedicine

A Review of Trials for Unsuccessful Pediatric Drug Development Programs Submitted to the US Food and Drug Administration 2015-2022.

Samuels S, Seaton M, Abdel-Rahman SM et al. · 2026 · Therapeutic innovation & regulatory science

Background Legislative initiatives have spurred an increase in pediatric drug development programs. However, some drug products studied in the pediatric population have not received an approved pediatric indication, and efforts have been…

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Negative / Null Result ReportOpen accessMedicine

Computer-navigated versus conventional total knee arthroplasty: no difference in implant survival at 15-year follow-up.

Longo G, Pacchiarotti G, Pizzigallo C et al. · 2026 · Journal of orthopaedic surgery and research

Introduction The introduction of computer-assisted navigation (CAS) in total knee arthroplasty (TKA) aimed to improve prosthetic alignment and potentially enhance long-term implant survival. However, the actual clinical benefit beyond 10…

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Negative / Null Result ReportMedicine

Assessment of intraoperative high frequency variability index as a predictor of postoperative pain after open liver or pancreatic surgery under combined general and epidural anesthesia: a prospective observational study.

Yoshida K, Hakozaki T, Hasegawa T et al. · 2025 · Journal of clinical monitoring and computing

The aim of the present study was to investigate the utility of the intraoperative high frequency variability index (HFVI) / Analgesia Nociception Index (ANI) for predicting postoperative pain in patients undergoing open liver or pancreatic…

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Negative / Null Result ReportOpen accessMedicine

Most autophagic cell death studies lack evidence of causality.

Özkaya AB, Ghaseminejad Y · 2025 · FEBS open bio

Autophagy plays a critical role in maintaining cellular homeostasis and is implicated in various physiological and pathological processes, including cancer, neurodegeneration, and metabolic disorders. Although typically associated with…

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Negative / Null Result ReportOpen accessMedicine

Overall survival following treatment of central nervous system meningeal melanocytomas: Insights from the national cancer database (NCDB).

El-Hajj VG, El Choueiri J, Vasella F et al. · 2026 · Brain & spine

Introduction Central nervous system (CNS) melanocytomas are rare, pigmented tumors derived from leptomeningeal melanocytes. Although generally benign, they can exhibit locally aggressive behavior and recur. Despite increasing recognition,…

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Negative / Null Result ReportOpen accessMedicine

Impact of an Anti-infection Double Lumen Bundle on the incidence of central venous catheter-related infections in haematological patients: a retrospective cohort study.

Lazarevic Lindblad M, Pålsson E, Lazarevic V et al. · 2026 · Infection prevention in practice

Background Central venous catheters (CVCs) are commonly used in patients with haematological diseases but are associated with infectious complications. The CVC Anti-infection Double Lumen Bundle was introduced in December 2020 to reduce…

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