11,326 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Akhtar, Ghaloo, Pasha et al. · 2026 · JPMA. The Journal of the Pakistan Medical Association
To investigate the prevalence, utilisation and association of diagnostic delay, tumour stage and recurrence with alternative medicine among head and neck cancer patients having undergone surgical resection. The retrospective,…
View details →Zember, Turkbey, Chu et al. · 2026 · Pediatric radiology
Radiologic findings associated with SARS-CoV-2 infection have been well described since its emergence. However, long-term clinical and radiologic complications of pediatric SARS-CoV-2 infection are less defined, including radiologic…
View details →Sun Tae Ahn, Ji Sung Shim, Woong Jin Bae et al. · 2022 · The World Journal of Men's Health
Purpose: We aimed to evaluate the efficacy and safety of penile girth enhancement (PGE) using hyaluronic acid (HA) filler with different physical properties from previous studies. Additionally, we evaluated the clinical impact on ejaculation after PGE. Materials and Methods: This was a prospective, patient/evaluator-blinded, randomized, active-controlled, multicenter trial. Patients recruited between December 2017 and March 2018 were randomly assigned to the HA filler or control group (polylactic acid [PLA] filler). Penile girth, satisfaction level, Premature Ejaculation Profile (PEP), and sel
View details →Funda Yetkin, Sibel Altunisik Toplu · 2017 · Medicine Science
Despite the advances and a wide range of studies conducted, sepsis is one of the most frequent causes of death in patients with critical health condition. Early diagnosis, rapid and effective treatment are extremely important. Use of procalcitonin (PCT) for this purpose has become widespread and notable recently. Procalcitonin is an important test as point-of-care testing (POCT) just like C-reactive protein (CRP). Procalcitonin is the prohormone of calcitonin. It is released from the parenchymal cells of the liver, kidneys and muscles, and in response to bacterial toxins, it is released from
View details →Riddhi Vyas, Santhosh Kumar, C M Manasa · 2026 · Saudi Dental Journal
Abstract Periodontal wound dressings have advanced from passive protectants to bioactive agents. This study compared the efficacy of Blue®m gel and a hyaluronic acid (HA) gel in promoting wound healing and controlling postoperative pain after functional crown lengthening surgery. A prospective, randomized, patient and outcome assessor-blinded study was conducted on 40 systemically healthy patients (aged 20–60 years) requiring crown lengthening of posterior teeth. Participants were divided into two groups: Blue®m gel (Group A) and custom-formulated HA gel (Group B). Both gels were applied to th
View details →gehad Abd algaliel, Amani Abo alhassein, Sarah Omar · 2024 · Minia Journal of Medical Research
BACKGROUND: Hydroxyzine is an antihistamine that belongs to the first generation of H1 Antihistamines and used in medicine for a variety of purposes. It was introduced into the field of anesthesia for a variety of reasons, including its sedative, antiemetic and anti-allergic properties. Therefore, it's critical to understand how hydroxyzine premedication affects hemodynamic changes in individuals, particularly in younger ones undergoing surgery OBJECTIVES: The objective of this study was to identify the impact of administering hydroxyzine orally before surgery on hemodynamics prior to inductio
View details →Nilgün Solmaz, Onur Yaya, Feyza Önder · 2014 · Türk Oftalmoloji Dergisi
Objectives: Evaluation of structural alterations of the optic nerve head (ONH) and the retinal nerve fiber layer (RNFL) in patients with ocular hypertension (OHT) and early-stage glaucoma and assessment of the discriminatory diagnostic performance of spectral-domain optical coherence tomography (SD-OCT) Copernicus (Optopol Technology S.A.). Materials and Methods: This study included 59 eyes of a total of 59 patients, 29 of whom were diagnosed with OHT (Group 1) and 30 with early-stage glaucoma (Group 2). The differentiation of early-stage glaucoma and OHT was carried out on the basis of standa
View details →Olvera-Maneu S, Regidor M, Serres-Corral P et al. · 2026 · Animals : an open access journal from MDPI
Fecal glucocorticoid metabolites (FGM) are widely used to assess hypothalamic-pituitary-adrenal (HPA) activity in vertebrates, but their applicability to reptiles, and more specifically to snakes, remains poorly explored. The objective of…
View details →Pola farhad hassan, Hamdia Mirkhan Ahmed · 2019 · Diyala Journal of Medicine
Background: Benefits of minimally invasive or laparoscopic procedures include less post operative discomfort. Objective: This study aimed to identify the early postoperative complications of laparscopic cholecystectomy and their association with age, occupation and previous laparatomy. Patients and Methods: 60 female patients diagnosed with having symptomatic gallstone underwent laparscopic cholecystectomy in Pirmam General Hospital, during the period from Jan 2015 to Jul 2015. Surgery done by researchers and after 10 days, the patient interviewed and examined for finding the complications, th
View details →Xuetao Zhu, Yixiang Zhao, Kaiwen Liu et al. · 2024 · Scientific Reports
Abstract To compare the clinical efficacy of interlaminar endoscopic surgical system delta (iLESSYS-Delta) discectomy with that of classical fenestration discectomy for treating lumbar disc herniation. Patients who underwent iLESSYS-Delta or fenestration discectomy were enrolled in this study. Baseline information and clinical indicators were collected. The baseline data were matched using propensity score matching. Fifty-two patients were in each group. In the iLESSYS-Delta cohort, the volume of intraoperative bleeding was 18.17 ± 4.20 ml, the length of postoperative hospital stay was 4.16 ±
View details →Fereshteh Baygi, Theis Bitz Trabjerg, Lars Henrik Jensen et al. · 2025 · JMIR Formative Research
BackgroundEnhancing care coordination and sharing information in cancer care improves patient experiences by promoting clarity and satisfaction. ObjectiveThis study aims to assess the impact of cross-sectoral video consultation on patient perceptions of care coordination and satisfaction with received information compared to usual care. MethodsThis study presents secondary outcomes on patient perceptions of care coordination and satisfaction with received information from a 7-month follow-up of the Partnership Project. In this randomized controlled trial, patients with cancer were allocated to
View details →Anthime Flaus, Armand Pattée, Guillaume Criton et al. · 2026 · Scientific Reports
Abstract [11C]Methionine ([11C]MET) PET provides high sensitivity to localize corticotroph pituitary neuroendocrine tumors (PitNETs) in de novo Cushing’s disease but remains inconclusive in up to 20% of cases. Current PET protocols rely on late acquisitions (20–40 min post-injection). Since other endocrine tumors present earlier peak tracer uptake, corticotroph PitNETs might also exhibit early differential amino acid uptake, compared to the normal pituitary gland. This exploratory study based on data derived from a previously registered prospective multicenter cohort study (ClinicalTrials.gov
View details →Amirsaeed Hosseini, Mohammad Yousofpour, Faranak Zaker et al. · 2026 · Journal of Mazandaran University of Medical Sciences
Background and purpose: Osteoarthritis is the most common cause of knee pain and has various treatment modalities. The Ferfion plant is a significant medicinal plant in traditional medicine used worldwide. This study aimed to investigate the effect of Ferfion herbal ointment on the clinical symptoms of patients with primary knee osteoarthritis. Materials and methods: This double-blind, randomized clinical trial was conducted on 50 patients with primary knee osteoarthritis at Baghban Clinic. Patients were divided into two groups of 25, receiving either Ferfion ointment or a placebo. The first g
View details →Meera Niranjan Khadilkar, Nitin Ankle, Sheetal Harakuni · 2017 · Bengal Journal of Otolaryngology and Head Neck Surgery
Introduction Controversy regarding treatment of tonsillitis based on throat culture report still persists. If surface culture is a determinant of bacteriology of the core, then rational therapy could be aimed at organisms cultured by surface swab. Materials and Methods A Cross-sectional study was conducted on 100 patients of chronic tonsillitis who underwent tonsillectomy. Tonsil surface and core swabs were studied for aerobic and anaerobic growth. Result Eighty seven percent patients had aerobic growth on tonsil surface and ninety percent in tonsil core. Staphylococcus aureus was the commones
View details →Jinmann Chon, Hee-Sang Kim, Jong Ha Lee et al. · 2018 · Annals of Rehabilitation Medicine
ObjectiveTo evaluate the association between balance function and asymmetry of knee extension strength in an elderly Korean population.MethodsThe strength of the knee extensors in each leg was measured in 306 community-dwelling elderly subjects (age, 76.70±4.85 years) and 25 young healthy subjects (age, 34.23±8.93 years). Based on the difference in strength of both legs, the elderly subjects were divided into symmetric (n=128) and asymmetric (n=178) strength groups using an asymmetry cutoff 20%. We determined the postural control ability of the subjects using InBody posturography, Berg Balance
View details →Ullal Anand Nayak, Reena Sharma, Nilotpol Kashyap et al. · 2016 · Journal of Clinical and Diagnostic Research
Introduction: Chewing Side Preference (CSP) is said to occur when mastication is recognized exclusively/consistently or predominantly on the same side of the jaw. It can be assessed by using the direct method - visual observation and indirect methods by electric programs, such as cinematography, kinetography and computerized electromyography. Aim: The present study was aimed at evaluating the prevalence of CSP in deciduous, mixed and permanent dentitions and relating its association with dental caries. Materials and Methods: In a cross-sectional observational study, 240 school going children a
View details →Hasan Demirkan, Mehmet Ozgur Kuzdan · 2022 · Haseki Tıp Bülteni
Aim:There is still a lack of sufficient evidence-based data on the standardized urodynamic patterns of urological disorders worldwide, particularly in the childhood age group. With this study, we sought to investigate the outcomes of urodynamic studies of common disorders frequently encountered in pediatric urology practice.Methods:Children who underwent urodynamic studies in a pediatric urology unit between March 2019 and September 2020 were included in the study. A retrospective review of data on demographic characteristics and cystometrogram findings of 266 children from the urodynamic labo
View details →Mehmet Mahir Fersahoğlu, Ahmet Çakmak, Hüseyin Çiyiltepe et al. · 2022 · İstanbul Tıp Fakültesi Dergisi
Objective: To evaluate the effects of using different doses of ursodeoxycholic acid (UDCA) for six months in prevention of gallstones after Laparoscopic Sleeve Gastrectomy (LSG) on the formation of gallstones in the 6th and 12th months. Materials and Methods: The data of patients who underwent LSG for morbid obesity were analyzed. Three groups of 20 people were formed. These were the control group, Group I who were treated with UCDA 500 mg/day for six months after LSG, and Group II who were treated with UCDA 1000 mg/day for 6 months after LSG. Demographic characteristics, co-morbid diseases, c
View details →Videnović Nebojša, Mladenović Jovan, Pavlović Aleksandar et al. · 2019 · Srpski Arhiv za Celokupno Lekarstvo
Introduction/Objective. In this study, the effects of applied anesthetic techniques were investigated in a retrospective analysis of obese patients and those with normal body mass index undergoing in vitro fertilization, using bispectral index as an indicator of anesthetic depth. Methods. In total 116 patients with normal body mass index were allocated to group N. Another 116 patients with body mass index > 30 kg/m2 were allocated to group O. Anesthetic protocol comprised midazolam for premedication, diclofenac for pre-emptive analgesia, propofol for induction and maintenance, alfentanil for a
View details →Ryogo Minamimoto, Toshiyuki Saginoya, Chisato Kondo et al. · 2015 · PLoS ONE
The aim of this multi-center study was to assess the diagnostic capability of visual assessment in L-methyl-11C-methionine positron emission tomography (MET-PET) for differentiating a recurrent brain tumor from radiation-induced necrosis after radiotherapy, and to compare it to the accuracy of quantitative analysis.A total of 73 brain lesions (glioma: 31, brain metastasis: 42) in 70 patients who underwent MET-PET were included in this study. Visual analysis was performed by comparison of MET uptake in the brain lesion with MET uptake in one of four regions (around the lesion, contralateral fro
View details →Mayuri Biccodu Shivashankar, Nandini Thippannanavar Niranjan, Arun Jayasheel et al. · 2016 · Journal of Clinical and Diagnostic Research
Introduction: Complete cleaning and shaping of root canal system is of paramount importance to achieve a successful root canal treatment. There are various rotary Ni-Ti systems available in the market to achieve mechanical goal of root canal preparation. But aggressive preparation of root canal with such systems would result in canal transportation and excess root dentin removal that would be one of the major reasons to decide the prognosis of root canal treated tooth. Aim: The present study was conducted to compare the root canal preparation in terms of canal transportation and volumetric cha
View details →Wang Z, Yang J, Duan L · 2026 · Cognitive neurodynamics
Based on the important function of the thalamic reticular nucleus(TRN) in epileptic seizures, we explore how changes in TRN information affect epileptic seizures across the entire brain nervous system by adjusting the excitatory coupling…
View details →Mahdiyeh Harati-Sadegh, Leila Kohan, Batool Teimoori et al. · 2019 · Journal of Biomedical Science
Abstract Background Preeclampsia (PE), as a multisystem disorder, is associated with maternal hypertension and proteinuria. Apoptosis seems to be involved in the pathophysiology of PE, although its precise pathogenic mechanisms are not well established. In this study, we aimed to identify the association between maternal TP53-rs1042522, P21-rs1801270, and P21-rs1059234 polymorphisms and PE. In addition, we examined the effects of promoter methylation and TP53 and P21 polymorphisms on placental mRNA expression in PE women. Methods The blood of 226 PE women and 228 normotensive pregnant women wa
View details →Oliver Hendricks, Mikkel Østergaard, Susanne Juhl Pedersen et al. · 2026 · RMD Open
Introduction Evidence of treat-to-target strategies including secukinumab dose escalation in patients with axial spondyloarthritis (axSpA) remains limited. We investigated the effect of a treat-to-target approach aiming for Axial Spondyloarthritis Disease Activity Score (ASDAS) remission, assessed by clinical and MRI outcomes over 24 weeks.Methods TRACE was a multicentre study including biologic-naïve patients with active axSpA. Sixteen weeks after secukinumab 150 mg initiation, patients in ASDAS remission (<1.3)(week 16 remitters) continued the same dose, while non-remitters (week 16 non-remi
View details →Serkan Oner, Yusuf Secgin, Zulal Oner et al. · 2022 · Medicine Science
The aim of this study was to evaluate the correlation between triiodothyronine (T3), thyroxine (T4), and thyroid-stimulating hormone (TSH) hormones and thyroid gland volume with volumetric analysis performed by using computed tomography (CT) images. In this retrospective study, IV contrasted thoracic CT images taken for different indications between 2019 January and 2020 January were scanned from the archive system of the hospital. 67 (31F, 36M) individuals chosen randomly among patients whose CT results were reported as normal and who had taken thyroid hormone tests within the past week were
View details →Roman Panovský, Martina Doubková, Mary Luz Mojica-Pisciotti et al. · 2021 · Orphanet Journal of Rare Diseases
Abstract Background Sarcoidosis is a systemic granulomatous disease affecting different organs including the heart. Myocardial strain analysis could potentially detect the early stages of cardiac dysfunction in sarcoidosis patients. The present study aims to assess the use of cardiac magnetic resonance (CMR) strain analysis using feature tracking (FT) in the detection of early cardiac involvement in asymptomatic patients with sarcoidosis. Methods One hundred and thirteen CMR studies of patients with sarcoidosis of the respiratory tract and/or extrapulmonary sarcoidosis without pre-existing kno
View details →Huang C, Wu M, Li Y et al. · 2026 · Clinical, cosmetic and investigational dermatology
Background Androgenetic alopecia (AGA) is the most common type of hair loss, and platelet-rich plasma (PRP) has emerged as a promising therapy. However, preparation methods may influence clinical outcomes. Objective To compare buffy coat…
View details →Pramitra B, Al Musadieq M, Afrianty TW et al. · 2026 · F1000Research
Although digital transformation in port management has been widely discussed, previous studies have not extensively examined how organizational capabilities translate into performance through digital adoption at ports. This study addresses…
View details →Mehrabi A, Mohamadi-Nejad A, Ghorbani M et al. · 2026 · Brazilian journal of biology = Revista brasleira de biologia
Contract farming has gained popularity in recent years. Understanding farmers' preferences for contracts can help make contracts more sustainable and profitable. Therefore, the present study aimed to investigate farmers' preferences for…
View details →Kim J, Cho Y · 2026 · Archives of environmental & occupational health
This study explored the impact of exposure to nonstandard work on workers' depression and suicidal ideation. Using data from the 12th to 18th waves of the Korea Welfare Panel Study, longitudinal analyses were conducted employing cox…
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