Negative / Null Result ReportOpen accessMedicine
CHEN Zhu, LIU Yan, GAO Li-hua, CHEN Bu-you, TANG Ai-hua, LIU Jun · 2021 · Jichu yixue yu linchuang
Objective To evaluate the efficacy and safety of apatinib in the treatment of metastatic colorectal cancer (mCRC). Methods Sixty-five patients with mCRC treated with apatinib were enrolled in this study for retrospective analysis. The factors affecting the recent effective, progression-free survival (PFS) and adverse reactions were evaluated. Results The disease control rate in 63 evaluable patients was 69.9%. The median PFS for patients received first-line, second-line, and third-line and above apatinib treatment were 9.3 months, 5.8 months, and 3.3 months, respectively(P＜0.001). The PFS in t
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Mohammad Reza Zarbakhsh Bahri, Zahra Shoa Hasani, Ziba Zahiri Sorori et al. · 2013 · پژوهان
Introduction: This study aims to evaluate the effectiveness of stress management training and problem-solving training on quality of life and life expectancy of infertile women was conducted.Material and Methods: The method of this study was experimental with pretest – posttest design with a control group. population of 400 infertile women who referred to infertility center in Rasht were randomized to 250 of them were selected and the quality of life and life expectancy of the study were the 45 members of the quality of life and life expectancy lower were more randomly in three groups of 15 pe
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Hanzaleh Jour Ebrahimiyan, Nafise Ansarinejad, Farshid Fardad · 2023 · Disease and Diagnosis
Background: Chemotherapy-induced peripheral neuropathy is one of the most common side effects of chemotherapy. This study aimed to determine the effectiveness of venlafaxine and duloxetine in improving chronic neurotoxicity induced by chemotherapy in cancer patients. Materials and Methods: The study was performed on cancer patients undergoing outpatient chemotherapy or hospitalization in Rasoul Akram hospital. The admitted patients were blindly divided into two groups. The first group was treated with venlafaxine, and the second group was treated with duloxetine. The treatment lasted up until
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Abu Sadat Mohammad Sayeem Bin Shahid, Shahnawaz Ahmed, Tanzina Tazul Renesa et al. · 2022 · PLoS ONE
Background Fibersol-2 has some beneficial effects on human health. We aimed to evaluate the digestive tolerability and acceptability of Fibersol-2 in healthy and diarrheal children, as well as improvement in stool consistencies in young diarrheal children. Methods Sixty children of either sex, aged 1-3 years having four groups (healthy children/low dose, healthy children/high dose, children with diarrhea/low dose and children with diarrhea/high dose) were enrolled into this exploratory study between 1st August to 23rd October 2017. Two presumptive doses, low (2.5g) and high (5g), twice daily w
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Lei Wang, Tingjun Ye, Lianfu Deng et al. · 2014 · PLoS ONE
Up to date, little is known about the repair mode of microdamage in osteonal cortical bone resulting from bone screw implantation. In this study, self-tapping titanium cortical bone screws were inserted into the tibial diaphyses of 24 adult male rabbits. The animals were sacrificed at 1 day, 2 weeks, 1 month and 2 months after surgery. Histomorphometric measurement and confocal microscopy were performed on basic fuchsin stained bone sections to examine the morphological characteristics of microdamage, bone resorption activity and spatial relationship between microdamage and bone resorption. Di
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Arslan A, Benli E, Yüce A et al. · 2026 · BMC urology
Background Erectile dysfunction (ED) is a vascular disease associated with systemic inflammation and endothelial dysfunction. The role of inflammatory markers in the pathogenesis of ED is gaining increasing importance. This study aimed to…
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Barjor Gimi, Lara Leoni, Jose Oberholzer et al. · 2006 · Cell Transplantation
The increasing incidence of diabetes and the need to further understand its cellular basis has resulted in the development of new diagnostic and therapeutic techniques. Nonetheless, the quest to noninvasively ascertain β-cell mass and function has not been achieved. Manganese (Mn)-enhanced MRI is presented here as a tool to image β-cell functionality in cell culture and isolated islets. Similar to calcium, extracellular Mn was taken up by glucose-activated β-cells resulting in 200% increase in MRI contrast enhancement, versus nonactivated cells. Similarly, glucose-activated islets showed an in
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Jeremy Chung Bo Chiang, David Goldstein, Azadeh Tavakoli et al. · 2021 · Scientific Reports
Abstract Immune cell infiltration has been implicated in neurotoxic chemotherapy for cancer treatment. However, our understanding of immune processes is still incomplete and current methods of observing immune cells are time consuming or invasive. Corneal dendritic cells are potent antigen-presenting cells and can be imaged with in-vivo corneal confocal microscopy. Corneal dendritic cell densities and nerve parameters in patients treated with neurotoxic chemotherapy were investigated. Patients treated for cancer with oxaliplatin (n = 39) or paclitaxel (n = 48), 3 to 24 months prior to assessme
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Darpan I. Patel, Kira Abuchowski, Bilal Sheikh et al. · 2019 · European Journal of Translational Myology
The purpose of this study was to examine the effects of exercise in modulating biomarkers of sarcopenia in a treatment naïve transgenic adenocardinoma of the mouse prostate (TRAMP) model. Thirty TRAMP mice were randomized to either exercise (voluntary wheel running) or no-treatment control group for a period of 20 weeks. During necropsy, gastrocnemius muscles and prostate tumors were harvested and weighed. Gastrocnemius concentrations of myostatin, insulin-like growth factor (IGF)-1 and tumor necrosis factor (TNF)-α were quantified. Exercise mice had greater muscle mass than controls (p=0.04).
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Jingjing Zhou, Shanshan Wu, Xiaojing Wu et al. · 2023 · PLoS ONE
The cultural landscape in traditional settlements is an important historical and cultural resource created by human beings in the process of historical evolution, and is an important resource for the development of traditional settlement tourism. This paper selected 21 representative traditional settlements for research using online comments from tourists as data and content analytical methods including high-frequency vocabulary, semantic networks and emotional attitudes to explore the public perspective on the connotations of cultural landscape features in traditional settlements. There are f
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Negar Sheikhdavoodi, Maryam Gheraati, Sima Hashemipour et al. · 2022 · The Journal of Qazvin University of Medical Sciences
Background: Electrolyte disorders, particularly hyponatremia, have been reported in a considerable number of patients with Coronavirus Disease 2019 (COVID-19). Objective: The current study aims to evaluate the risk factors, symptoms, and prognosis of hyponatremia in hospitalized patients with COVID-19. Methods: In this retrospective cohort study, 467 patients with COVID-19 were divided into 4 groups based on the sodium level at the time of admission: normal, mild hyponatremia, moderate hyponatremia, and severe hyponatremia. Symptoms, laboratory findings, and prognosis were compared among these
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Azam Ardeh, Elham Goodarzi, Zahra Madadi et al. · 2025 · BMC Research Notes
Abstract Background Marital relationships, like any other interpersonal bond, encompass both positive and negative dimensions. Central to the success of marriage is the level of satisfaction and commitment experienced by the partners. This study aims to compare the efficacy of cognitive-behavioral couple therapy and schema-based couple therapy in reducing the desire for divorce and marital boredom. Methods This experimental study employed a pre-test-post-test design with a control group. The research sample comprised couples experiencing marital issues who sought counseling at various counseli
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Dandan Chen, Huamin Wu, Feifeng Huang et al. · 2025 · PLoS ONE
Objective This study explored the prognosis of high-grade squamous intraepithelial lesion (HSIL) patients with negative margins, investigating the impact of different distances between lesions and incisal margins in conization specimens. Methods This retrospective cohort study included 240 HSIL patients. Patients with negative incisal margins were divided into 3 groups according to the distance between the lesion and the incisal margin in the conization tissue. Group 1 consisted of a distance of 3 mm (n = 202). For patients with lesions close to the incisal margin (≤3 cm), the decision between
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Van de Vyver A, Taylan O, Peersman G et al. · 2026 · Archives of orthopaedic and trauma surgery
Objectives This study aimed to analyze to what extent a novel intraoperative navigation platform (Next-AR, Medacta) for total knee arthroplasty (TKA) allows to restore the native knee joint kinematics and strains in the medial collateral…
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Hassan Talakesh, Alizamen Salehifard Jouneghani, Karamali Kasiri et al. · 2024 · Journal of Shahrekord University of Medical Sciences
Background and aims: Constipation in children is a serious problem that affects both children and their families. We aimed to compare the clinical efficacy of lactulose and polyethylene glycol in the treatment of constipation in children. Methods: This randomized clinical trial was performed on 92 patients referred to a private gastroenterology clinic in Shahrekord, Iran. The patients were randomly assigned into two groups receiving polyethylene glycol or lactulose. Defecation patterns and complications were assessed 0, 3, 7, and 21 days after the intervention. Data were analyzed using the chi
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Fuengfa Khobkhun, Jenjira Thanakamchokchai · 2023 · Scientific Reports
Abstract Biological sexes (male and female) have been reported to influence postural control and balance due to differences in musculoskeletal structures, hormonal factors, and neuromuscular control. These factors can contribute to the turning performance, potentially leading to an increased incidence of falls, particularly during turning. Therefore, this study aimed to explore the whole-body coordination and stepping characteristics and during standing turns in healthy adults to determine the effects of biological sex and turn speed. Fifty participants (25 males and 25 females) completed 180°
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Andres Montealegre, William Jimenez-Leal · 2019 · PLoS ONE
According to the social heuristics hypothesis, people intuitively cooperate or defect depending on which behavior is beneficial in their interactions. If cooperation is beneficial, people intuitively cooperate, but if defection is beneficial, they intuitively defect. However, deliberation promotes defection. Here, we tested two novel predictions regarding the role of trust in the social heuristics hypothesis. First, whether trust promotes intuitive cooperation. Second, whether preferring to think intuitively or deliberatively moderates the effect of trust on cooperation. In addition, we examin
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Sung Hee Lim, Jong-Mu Sun, Joohyun Hong et al. · 2021 · The Korean Journal of Internal Medicine
Background/Aims Clinical trials have not consistently supported the use of induction chemotherapy (IC) for locally advanced head and neck squamous cell cancer. Hypopharynx and base of tongue (BOT) cancer has shown relatively poor survival. We investigated the role of IC in improving outcome over current chemoradiotherapy (CRT) in patients with hypopharynx and BOT cancer. Methods Treatment-naïve patients with stage III/IV (M0) hypopharynx or BOT cancer were randomly assigned to receive CRT alone (CRT arm: cisplatin 100 mg/m2 on D1 3-weekly, two times plus radiotherapy 68.4 Gy/30 fractions on we
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Derya Sivri Aydın · 2019 · İstanbul Medical Journal
Introduction:To evaluate whether neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR) have diagnostic value in endometrioma, which is a chronic inflammatory disease.Methods:A total of 187 patients who underwent surgery for adnexal mass, 97 patients diagnosed with endometrioma and 90 patients with benign cyst (corpus luteum, serous cysts or functional cysts), were included in this retrospective, comparative case series. NLR and PLR values obtained from preoperative complete blood count parameters were compared between the two groups.Results:There was no statistically significan
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Laura Sterian Ward, Ilda Shizue Kunii, Rui Monteiro de Barros Maciel · 2000 · São Paulo Medical Journal
CONTEXT: Screening programs not only offer the opportunity to trace and treat almost all cases of congenital hypothyroidism but also mean large savings to the health system. However, carefully planned strategies are necessary to extend their benefits and reduce costs. OBJECTIVE: To determine the possible influence of maternal diseases that affect maternal-fetal placenta dynamics on primary thyroid stimulating hormone (TSH) screening for congenital hypothyroidism. DESIGN: Prospective non-randomized clinical trial with at least 3 months of follow-up. SETTING: A public university referral center
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Magdalena Dudek, Marta Kałużna-Oleksy, Jacek Migaj et al. · 2018 · Journal of Medical Science
Background. Coronary artery disease (CAD) is one of the most important causes of death in both men and women. There are many gender differences among patients with CAD, including risk factors and acute coronary syndrome (ACS) outcomes. The latest reports showed that mortality due to CAD is higher in women than in men. Cardiac biomarkers play an important role in risk stratification and choice of treatment strategy in patients with ACS, however some of cardiac biomarkers show worse sensitivity and specificity in women. Aim. The aim was to investigate the sex-related differences in patients with
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Chia Hassan Ali, Rozhan Yassin Khalil · 2025 · Advanced Medical Journal
Background and objectives: Various methods and devices are currently applicable to diagnose endometrial polyps with different outcomes. This study aimed to compare the efficacy of trans-vaginal ultra-sonography in relation to the rigid hysteroscopy in the diagnosis of endometrial polyps in patients with abnormal vaginal bleeding. Methods: This cross-sectional study enrolled 70 female patients with endometrial polyps at Sulaimani Maternity Teaching Hospital, Iraq, from May 01, 2022 to May 01, 2023. A well-designed questionnaire including the patient's age, gender, residency, educational level,
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Nicholette D Palmer, Lingyi Lu, Thomas C Register et al. · 2021 · PLoS ONE
Relative to European Americans, African Americans have lower 25-hydroxyvitamin D (25OHD) and vitamin D binding protein (VDBP) concentrations, higher 1,25-dihydroxyvitamin D (1,25(OH)2D3) concentrations and bone mineral density (BMD), and paradoxically reduced burdens of calcified atherosclerotic plaque (subclinical atherosclerosis). To identify genetic factors contributing to vitamin D and BMD measures, association analysis of >14M variants was conducted in a maximum of 697 African American-Diabetes Heart Study participants with type 2 diabetes (T2D). The most significant association signals w
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Jianxun Fang, Yuze Cao, Jun Ni · 2024 · European Journal of Medical Research
Abstract Background Intracranial aneurysm (IA) accounts for a substantial source of non-traumatic subarachnoid hemorrhage, with inflammation postulated as a potential factor in its pathogenesis. The present study aims at evaluating the association between circulating inflammatory cytokines and risk of IA under a bidirectional two-sample Mendelian randomization (MR) design. Methods For primary analysis, summary statistics of inflammatory regulators was obtained from a genome-wide association study (GWAS) comprising 8293 Finnish participants. Summary data of IA were extracted from a GWAS which c
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Franziska Emmerling, Carolien Martijn, Hugo J E M Alberts et al. · 2017 · PLoS ONE
Cognitive effort and self-control are exhausting. Although evidence is ambiguous, behavioural studies have repeatedly suggested that control-demanding tasks seem to deplete a limited cache of self-regulatory resources leading to performance degradations and fatigue. While resource depletion has indirectly been associated with a decline in right prefrontal cortex capacity, its precise neural underpinnings have not yet been revealed. This study consisted of two independent experiments, which set out to investigate the causal role of the right dorsolateral prefrontal cortex (DLPFC) in a classic d
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Toshiki Saito, Kosuke Motoki, Rui Nouchi et al. · 2019 · PLoS ONE
Emotion plays important and diverse roles across various social relations. Although the social functions of emotion have attracted increased attention, the effects of positive emotions such as pride on impression formation remain poorly understood. Drawing on social projection theory, this study examined how incidental experiences of pride influenced the impressions of those who made a blunder, along with two other characteristics: the person's warmth and competence. Participants were designated randomly to receive inductions of pride, awe, or a neutral emotion. Subsequently, they were asked t
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Nicholas P Carruth, Jairo A Ramos, Akira Miyake · 2023 · PLoS ONE
This article reports a preregistered study in which we attempted to replicate the results of an influential study on the ego-depletion effect reported by Job, Dweck, and Walton in 2010. The original Job et al. study (Study 1, N = 60) provided evidence that the ego-depletion effect-a performance decrease on a self-control task after performing another self-control task-occurs only for individuals who hold a belief that their willpower is limited. This moderation of the ego-depletion effect by one's willpower mindset (limited vs. nonlimited) has been interpreted as evidence against a prevalent l
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Cherubino Paolo, Sala Andrea, Casalone Rosario et al. · 2005 · Journal of Translational Medicine
Abstract Background Local myogenesis, neoangiogenesis and homing of progenitor cells from the bone marrow appear to contribute to repair of the infarcted myocardium. Implantation into heart tissues of autologous skeletal myoblasts has been associated with improved contractile function in animal models and in humans with acute myocardial ischemia. Since heart infarction is most prevalent in individuals of over 40 years of age, we tested whether culture methods available in our laboratory were adequate to obtain sufficient numbers of differentiated skeletal myoblasts from muscle biopsy specimens
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Marta Schirripa, Wu Zhang, Dongyun Yang et al. · 2018 · PLoS ONE
BACKGROUND:Macrophages play a crucial role in the interaction between tumor and immune system, and iNOS is known as a surrogate marker of M1 macrophages activation. The goal of the study was to investigate the role of iNOS polymorphisms as prognostic marker in mCRC patients. MATERIALS AND METHODS:Functional significant polymorphisms in the promoter of INOS gene were analyzed by PCR-based and direct DNA sequencing in 4 cohorts of patients receiving bevacizumab based first-line chemotherapy: two evaluation cohorts (TRIBE ARM A and ARM B) and two validation cohorts (FIRE 3 arm A and MOMA). The re
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Nicholas P. Carruth, Jairo A. Ramos, Akira Miyake · 2023 · PLoS ONE
This article reports a preregistered study in which we attempted to replicate the results of an influential study on the ego-depletion effect reported by Job, Dweck, and Walton in 2010. The original Job et al. study (Study 1, N = 60) provided evidence that the ego-depletion effect—a performance decrease on a self-control task after performing another self-control task—occurs only for individuals who hold a belief that their willpower is limited. This moderation of the ego-depletion effect by one’s willpower mindset (limited vs. nonlimited) has been interpreted as evidence against a prevalent l
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