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Browse the failure-mode index

11,325 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Intermittent hemodialysis with regional citrate anticoagulation vs. priming heparin and pre-dilution HDF in patients at Risk Of Bleeding in Nephrology (the ROBIN randomized control trial).

Moranne O, Gerbal M, Chkair S et al. · 2026 · Blood purification

Introduction This single center randomized controlled trial (NCT03562754) compared pre-diluted IHDF (PIHDF) without systemic anticoagulation and the Prometheus system with regional citrate anticoagulation (IHD-RCA) in high-bleeding-risk…

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Negative / Null Result ReportMedicine

Association between short (≤ 30-day) dual antiplatelet therapy and 1-year major adverse cardiac events after drug-coated balloon-based non-stent percutaneous coronary intervention following optimal lesion preparation: a propensity score-based cohort study.

Kuroda S, Sawada T, Yui R et al. · 2026 · Cardiovascular intervention and therapeutics

Drug-coated balloon (DCB)-based non-stent percutaneous coronary intervention (PCI) may allow shorter dual antiplatelet therapy (DAPT), but whether a ≤ 30-day regimen is associated with worse outcomes remains unclear, particularly in…

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Negative / Null Result ReportOpen accessMedicine

The influence of different skeletal patterns on TMJ anatomy: a comprehensive CBCT study across various sagittal and vertical skeletal patterns in adults.

Eslami S, Sayahpour B, Tashakor A et al. · 2026 · Clinical oral investigations

Objective This study aimed to evaluate the impact of sagittal and vertical skeletal patterns as well as gender on temporomandibular joint (TMJ) morphology using Cone Beam Computed Tomography (CBCT). Methods A cross-sectional analysis was…

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Negative / Null Result ReportMedicine

Phacoemulsification Combined With 360° Gonioscopy-Assisted Transluminal Trabeculotomy: Prospective 12-Month Outcomes in Primary Open-Angle and Primary Angle-Closure Glaucoma.

Maheshwari D, Nagdev NG, Pillai MR et al. · 2026 · Journal of glaucoma

Precis This study concludes that combined gonioscopy assisted transluminal trabeculotomy-phacoemulsification have similar efficacy in terms of intraocular pressure and antiglaucoma medication reduction in primary open angle and primary…

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Negative / Null Result ReportMedicine

The Effect of Smoking History on Inflammatory Biomarkers in Synovial Fluid of Patients Undergoing Arthroscopic Knee Surgery for Meniscal Injury.

Kurtz JL, Ehlers M, Montgomery SR Jr et al. · 2026 · The American journal of sports medicine

Background Smoking has been linked to alterations in cellular inflammatory pathways and adverse outcomes in orthopaedic procedures. It is unclear how patient smoking affects the intra-articular microenvironment in the setting of…

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Negative / Null Result ReportOpen accessMedicine

Nano-magnolol enhances the modulatory effects of magnolol on cognitive performance and BACE1-related biochemical changes in an STZ-induced rat model of Alzheimer's disease.

Youssef B, Ibrahim EA, Moselhy SS et al. · 2026 · Discover nano

Background The Late-onset Alzheimer's disease (LOAD) is progressive cognitive deficits associated with different abnormalities as cholinergic dysfunction, amyloid accumulation, inflammation, and oxidative stress. Magnolol is a polyphenolic…

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Negative / Null Result ReportOpen accessMedicine

Clinical study on the efficacy comparison between ileotransverse colon overlap anastomosis and π-shaped anastomosis in laparoscopic radical right hemicolectomy.

Fangxin W, Bin L, Haocheng Z et al. · 2026 · Frontiers in surgery

Objective To compare the safety and efficacy of ileotransverse colon Overlap and π-shaped anastomosis in laparoscopic radical right hemicolectomy (LRRH). Methods A prospective RCT enrolled 120 right colon cancer patients (Dec 2022-Dec…

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Negative / Null Result ReportMedicine

Vision-related quality of life following trabeculectomy versus Baerveldt glaucoma implant: Five-year results from a randomized clinical trial.

Popescu-Giovanitsas I, Woudstra-de Jong JE, Vingerling JR et al. · 2026 · Acta ophthalmologica

Purpose To assess the vision-related quality of life (VRQoL) in glaucoma patients over 5 years after primary Baerveldt glaucoma implant (BGI) or trabeculectomy (TE) using a secondary analysis of a randomized clinical trial. Methods…

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Negative / Null Result ReportOpen accessMedicine

Comparative efficacy and safety of different posterior surgical approaches for Intra-articular distal humerus fractures.

Yao H, Chen W, Lin Z et al. · 2026 · Journal of orthopaedic surgery and research

Objective To systematically compare the clinical efficacy and safety of four posterior surgical approaches-olecranon osteotomy (OO), triceps-reflecting approach (TRA), triceps-splitting approach (TS), and triceps tongue approach (TT)-for…

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Negative / Null Result ReportOpen accessMedicine

Reporting of patient-reported outcomes (PROs) in randomized controlled trials of anemia treatments for people with CKD: a scoping review.

Patel DM, Wilson RF, Gharibani T et al. · 2026 · Journal of patient-reported outcomes

BACKGROUND: Patient-reported outcomes (PROs) are key outcomes of importance for people with chronic kidney disease (CKD), and may be of even higher relevance for patients with concomitant anemia which can often be symptomatic. Thus, PROs…

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Negative / Null Result ReportOpen accessMedicine

Amniotic Membrane Versus Platelet-Rich Fibrin for the Treatment of Gingival Recession Using the Vestibular Incision Subperiosteal Tunnel Access Technique: A Randomized Controlled Clinical Trial.

Advani H, Dixit A, Kumar S et al. · 2026 · Cureus

Background Gingival recession (GR) results in significant functional and cosmetic concerns and manifests as a disintegration of soft and hard tissues. Recently, clinical research has increasingly focused on the development of minimally…

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Negative / Null Result ReportOpen accessMedicine

Accuracy of Marginal and Internal Adaptation of Advanced Lithium Disilicate Crowns Using Different Margin Designs (In Vitro Study).

Mohamed HA, Azer A, AboElHassan RG · 2026 · International journal of dentistry

Background Advanced lithium disilicate glass ceramics offer excellent esthetics, but conservative crown preparations are not always the preferred choice. Various margin designs are available; however, more conservative vertical…

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Negative / Null Result ReportOpen accessMedicine

Daily supplementation of D-ribose shows no therapeutic benefits in the MHC-I transgenic mouse model of inflammatory myositis.

William Coley, Sree Rayavarapu, Jack H van der Meulen et al. · 2013 · PLoS ONE

BACKGROUND: Current treatments for idiopathic inflammatory myopathies (collectively called myositis) focus on the suppression of an autoimmune inflammatory response within the skeletal muscle. However, it has been observed that there is a poor correlation between the successful suppression of muscle inflammation and an improvement in muscle function. Some evidence in the literature suggests that metabolic abnormalities in the skeletal muscle underlie the weakness that continues despite successful immunosuppression. We have previously shown that decreased expression of a purine nucleotide cycle

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Negative / Null Result ReportOpen accessMedicine

Comparative response of platelet fV and plasma fV to activated protein C and relevance to a model of acute traumatic coagulopathy.

James E Campbell, Michael Adam Meledeo, Andrew P Cap · 2014 · PLoS ONE

BACKGROUND: Acute traumatic coagulopathy (ATC) has been linked to an increase in activated protein C (aPC) from 40 pM in healthy individuals to 175 pM. aPC exerts its activity primarily through cleavage of active coagulation factor Va (fVa). Platelets reportedly possess fVa which is more resistant to aPC cleavage than plasma fVa; this work examines the hypothesis that normal platelets are sufficient to maintain coagulation in the presence of elevated aPC. METHODS: Coagulation responses of normal plasma, fV deficient plasma (fVdp), and isolated normal platelets in fVdp were conducted: prothromb

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Negative / Null Result ReportOpen accessMedicine

Effect of Curcumin on Odontogenic/Osteogenic Differentiation of Dental Pulp Stem Cells

Masoud Seifi, Shirin Farivar, Malihe Sadat Mirhosseini et al. · 2020 · Regeneration, Reconstruction & Restoration

Introduction: Stem cells have gained great attention in tissue engineering and curcumin is a natural phenolic product that had showed some positive effects on these cells. The aim of this study was to evaluate the effect of curcumin on the differentiation of human dental pulp stem cells (hDPSCs). Materials and Methods: In this experimental study, hDPSCs were isolated from human third molars and treated without and with different concentrations (5, 10 and 15 µM) of curcumin and dimethyl sulfoxide (DMSO) as solvent for curcumin. Proliferation of the cells was measured by methyl-thiazol-tetrazoli

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Negative / Null Result ReportOpen accessMedicine

Optimization of technological parameters for durum wheat pasta production with carrot powder and ion-ozonated water

Galiya Iskakova, Bauyrzhan Iztayev, Auyelbek Iztayev et al. · 2025 · Scientific Reports

Abstract The quality of food products and a balanced diet play a key role in maintaining health and improving the quality of life. Due to the high popularity of pasta, a promising direction is the development of recipes that include whole grain flour, carrot powder and ion-ozonated water, which increase the nutritional value of the product and improve its chemical composition. The aim of this study was to optimise the technological modes of production of durum wheat pasta using carrot powder and ion-ozonated water to minimise the loss of dry matter (DM) during cooking and increase the protein

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Negative / Null Result ReportOpen accessMedicine

Exploring cyberbullying and cybervictimization among sports fans on Sina Weibo: the roles of personality traits and fan identity

Mengting Chen, Eng Wah Teo, Sau Cheong Loh · 2026 · Scientific Reports

Abstract Cyberbullying and cybervictimization have become widespread phenomena on social media platforms, particularly in emotionally charged environments such as sports fandom. While prior research has emphasized the role of individual personality traits, the influence of social identification—specifically, fan identity—on these behaviors remains underexplored, especially within Chinese digital communities, such as Sina Weibo. Grounding the study in the Social Identity Model of Deindividuation Effects, we theorize that platform affordances, such as anonymity and group salience, amplify identi

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Negative / Null Result ReportOpen accessMedicine

THE INTEGRATING EFFECT OF ACUPUNCTURE ON ABNORMAL SHORT-LATENCY SOMATOSENSORY EVOKED POTENTIALS IN HUMAN

Dong Chengtung · 1987 · 针刺研究

Somatosensory evoked potentials(SEPs)were recorded simultaneously from the cervical spine and scalp in 10 normal subjects and 22 patients with cerebrovascular attack(9)and syringomelia(13)using median nerve stimulation.Patients were considered as having abnormal studies,if either N_(18) were absent or if their peak latencies were prolonged more than 21.1 msec,or if the difference of (N_(13)-N_(18))conduction time was more than 7.53 msec.In addition,side-to-side value for(N_(13)-N_(18))were compared, these normally differ by less than 1.38 msec. The results may be summarized as followings: Acup

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Negative / Null Result ReportOpen accessMedicine

Effect of Probiotic Dietary Intervention on Calcium and Haematological Parameters in Geriatrics

Manisha Kalpesh Gohel, Jashbhai B. Prajapati, Sreeja V. Mudgal et al. · 2016 · Journal of Clinical and Diagnostic Research

Introduction: Probiotics are live microorganisms which when administered in adequate amounts confer a health benefit on the host. Sufficient calcium intake has been reported to support bone growth and prevent bone loss during the ageing process. Aim: To determine the effect of Lactobacillus helveticus MTCC 5463 probiotic dietary intervention on serum calcium & haematological parameters in geriatric population. Materials and Methods: Healthy volunteers with age ranging from 64-74 years were recruited from the nearby residential areas in and around Anand, Gujarat. Study duration was from 2012 to

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Negative / Null Result ReportOpen accessMedicine

HEART RATE VARIABILITY DURING PHYSICAL EFFORT IN PATIENTS WITH METASTATIC OVARIAN CANCER AND CONCOMITANT OBESITY

Viktoriia V. Yevsieieva, Volodimyr I. Cherniy, Kateryna V. Kharchenko et al. · 2023 · Клінічна та профілактична медицина

Introduction. One of the main factors affecting postoperative outcomes in patients with advanced ovarian cancer is the cardiopulmonary status. Several studies have reported that preoperative multifactorial rehabilitation and physical fitness can lead to reduced postoperative morbidity, mortality, shorter length of stay, and improved quality of life in cancer patients. The issue of adaptability to physical activity of overweight and obese patients who undergoing debulking surgery is insufficiently studied. The study of compensatory changes that occur in physically inactive obese patients remain

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Negative / Null Result ReportOpen accessMedicine

Photon-counting CT: image quality evaluation in patients with tibial plateau fracture treated with metallic osteosynthesis material.

Björkman AS, Malusek A, Persson A et al. · 2026 · European radiology experimental

Objective The aim was to compare the image quality of photon-counting detector CT (PCD-CT) and energy-integrating detector CT (EID-CT) in patients with tibial plateau fractures treated with metallic osteosynthesis material, and to identify…

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