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Browse the failure-mode index

11,325 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Interplay of anemia in inborn errors of energy metabolism.

Shetye S, Bhat YR, Lewis LES et al. · 2026 · Scientific reports

Inborn errors of energy metabolism (IEEM) are inherited conditions that typically present with impaired mitochondrial energy production and multisystem involvement, leading to adverse developmental outcomes. Iron is essential for…

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Negative / Null Result ReportMedicine

Repurposing traditional cerclage and suture techniques for the reduction of comminuted patellar fractures.

Pan Y, Wang T, An M et al. · 2026 · European journal of orthopaedic surgery & traumatology : orthopedie traumatologie

Purpose This study aimed to compare the cerclage and suture reduction technique with the point-type reduction technique in the management of comminuted patellar fractures using the modified Kirschner wire tension band. Methods We conducted…

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Negative / Null Result ReportOpen accessMedicine

Impact of Sensory Re-education Paradigm on Quality of Life, Tactile Sensation, and Proprioceptive Acuity in Patients with Post-COVID-19 Polyneuropathy: A Randomized Controlled Trial.

Alsaid HM, Khadour YA, Zakaria HM et al. · 2026 · Journal of musculoskeletal & neuronal interactions

Objectives This study evaluated the effect of sensory re-education on quality of life and sensation in patients with post-COVID-19 polyneuropathy. Methods Forty patients with post-COVID-19 polyneuropathy were randomly assigned to a study…

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Negative / Null Result ReportMedicine

The effect of stress ball use on stress, sleep quality, and comfort in individuals receiving hemodialysis: a randomized controlled trial.

Kacaroglu Vicdan A, Gibyeli Genek D · 2026 · BMC complementary medicine and therapies

Background Hemodialysis often leads to various physiological, psychological, and social challenges for individuals receiving this treatment. This study was conducted to determine the effects of stress ball use on stress, sleep quality, and…

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Negative / Null Result ReportOpen accessMedicine

Carboxymethyl cellulose-based edible coatings emulsified with Lemongrass oil for enhancing the storage stability of refrigerated broiler meat.

Ahmad U, Ishaq A, Khalid N · 2026 · Food science of animal resources

The present study aimed to analyze the effects of lemongrass essential oil emulsified with carboxymethyl cellulose (CMC) based edible coating on the physicochemical characteristics, microbial status, and oxidation level of raw chicken meat…

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Negative / Null Result ReportOpen accessMedicine

Synergistic effect and resistance prevention activity of antimicrobial peptide MPX with Tulathromycin against <i>Actinobacillus pleuropneumoniae</i>.

Wang H, Wang L, Zhang W et al. · 2026 · Frontiers in microbiology

Introduction The emergence and dissemination of multidrug-resistant Actinobacillus pleuropneumoniae (APP) have significantly hindered the advancement of the swine industry. The combination of antimicrobial peptides (AMPs) with conventional…

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Negative / Null Result ReportOpen accessMedicine

Hyperaldosteronism in Mice Lacking the Distal Polybasic Tract of the γ-Subunit of the Epithelial Sodium Channel During Sodium Restriction.

Essigke D, Kalo MZ, Wörn M et al. · 2026 · Acta physiologica (Oxford, England)

Aims The epithelial sodium channel ENaC consists of the subunits α, β, and γ and is activated at an individual channel level by proteolytic processing. Murine γENaC contains a distal polybasic tract 186 RKRK mediating proteolytic ENaC…

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Negative / Null Result ReportOpen accessMedicine

Development of engineered magnetic liposome/exosome hybrid as a novel caffeine nanocarrier for restraining liver fibrosis induced in rats.

Elakkad YE, Refai H, Ahmed HH et al. · 2026 · Scientific reports

Liver fibrosis, a severe health issue linked to liver injury, inflammation, and cell death, often progresses to liver cancer without effective treatments. In this study, an exosome-nanoliposome hybrid loaded with caffeine (Caff) was…

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Negative / Null Result ReportOpen accessMedicine

Determining the Optimal Volume of Ropivacaine Combined with Dexmedetomidine for Programmed Intermittent Epidural Bolus in Labor Analgesia: A Randomized Dose-Response Study.

Song C, Ni J, Liu C et al. · 2026 · Drug design, development and therapy

Background The programmed intermittent epidural bolus (PIEB) technique is effective for labor analgesia. Although ropivacaine combined with dexmedetomidine is used for epidural labor analgesia, the optimal PIEB volume for this regimen…

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Negative / Null Result ReportMedicine

Comparison of Outcomes after Minimally Invasive Transverse Distal Metatarsal Osteotomy (MITO) and Proximal Phalangeal Osteotomy for Hallux Valgus With and Without Rheumatoid Arthritis: A Matched Cohort Study.

Yoon YK, Shim DW, Kim JH et al. · 2026 · Foot & ankle international

Background There is an increasing role for joint-preserving surgery in hallux valgus (HV) management among patients with rheumatoid arthritis (RA). We compared radiologic and clinical outcomes after minimally invasive transverse distal…

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Negative / Null Result ReportOpen accessMedicine

Comparative evaluation of <i>Calotropis gigantea</i> latex and sodium hypochlorite as tissue-dissolving agents - an <i>in vitro</i> study on concentration and time-dependent proficiency.

Ravi M, Annadurai P, Gupta R · 2026 · Biomaterial investigations in dentistry

Background Complete removal of organic tissue and microorganisms from the root canal system is essential for successful endodontic therapy. Sodium hypochlorite (NaOCl) remains the gold standard irrigant for its tissue-dissolving and…

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Negative / Null Result ReportOpen accessMedicine

Some carcass and meat quality characteristics of Anatolian local and Mast geese in semi-intensive conditions.

Ürer H, Yıldırım İ, Asker G et al. · 2026 · Tropical animal health and production

In this study, meat quality characteristics of Anatolian local geese (Anser anser domesticus) and Mast geese (Anser anser) reared under semi-intensive conditions were compared. A total of 100 geese were used: 50 from each breed, 25 males…

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