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Browse the failure-mode index

11,325 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Diagnostic Performance of Diffusion-Weighted Imaging for Evaluation of Breast Lesions: Correlation With Prognostic Factors and Histological Phenotypes.

Konukoglu O, Kaya M, Arslan BC · 2026 · Journal of clinical ultrasound : JCU

Purpose To investigate the role of diffusion-weighted imaging (DWI) in the differential diagnosis of breast lesions and to determine whether there is an association with histological subtypes and prognostic factors. Materials & methods…

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Negative / Null Result ReportOpen accessMedicine

Effects of four weeks of inspiratory muscle training with different resistance modalities on pulmonary function and specialized athletic ability in synchronized swimmers: a randomised trial.

Xu H, Fan Y · 2026 · Scientific reports

This study applies resistance inspiratory muscle training to synchronized swimmers and through two resistance setting methods to explore that the differences in the effects of four weeks of dynamic constant load resistance training versus…

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Negative / Null Result ReportOpen accessMedicine

Impact of combined vascular resection on short and long-term results following radical surgery for hilar cholangiocarcinoma: evidence from a systematic assessment.

Che S, Saad SA, Wang Y et al. · 2026 · World journal of surgical oncology

OBJECTIVE: To analyze the impact of portal vein resection (PVR) and hepatic artery resection (HAR) on the short-term and long-term outcomes of patients with hilar cholangiocarcinoma after surgery. METHODS: A comprehensive literature search…

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Negative / Null Result ReportMedicine

The Coronal Lateral Collateral Ligament Sign Occurs Independent of Generalized Joint Hyperlaxity in Children and Adolescents With ACL-Deficient Knees.

Pedrick EG, Mitchell BC, Bomar JD et al. · 2026 · Journal of pediatric orthopedics

Background The lateral collateral ligament (LCL) sign is known to be correlated with greater anterior tibial translation (ATT) and internal tibial rotation in the setting of anterior cruciate ligament (ACL) tear. The LCL sign has also been…

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Negative / Null Result ReportOpen accessMedicine

β-Glucan training induces stimulus-dependent immune and metabolic modulation in head kidney leukocytes that persists for several days in Atlantic salmon (<i>Salmo salar</i> L.).

Nhan TH, Tort L, Lazado CC · 2026 · Frontiers in immunology

The innate immune system of fish has conventionally been considered incapable of immunological memory, but is now being recognised as exhibiting memory-like features known as trained immunity. This study investigated the induction of…

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Negative / Null Result ReportMedicine

Poller K-Wires versus Screws in Distal Tibial Nailing: Non-Inferior Union with Superior Efficiency and Better Alignment.

Yildirim AM, Bayram S, Karaçam MI et al. · 2026 · Acta chirurgiae orthopaedicae et traumatologiae Cechoslovaca

Purpose of the study To compare the short-term outcomes and complications of the poller screw (PS) and the poller K-wire (PW) in distal tibia nailing. Material and methods In the present study, a retrospective analysis was performed on…

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Negative / Null Result ReportOpen accessMedicine

The role of proinflammatory response and the kynurenine pathway in the association between childhood maltreatment and lifetime substance use disorder.

Östman L, Paul ER, Zhang H et al. · 2026 · Neurobiology of stress

Introduction Childhood maltreatment (CM) is a risk factor for adult psychiatric and substance use disorders (SUD). Retrospectively assessed CM has been linked to increased proinflammatory cytokines, including IL-6. Induced by inflammation,…

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Negative / Null Result ReportOpen accessMedicine

Efficacy of mesotherapy in patients with acute and subacute neck pain: A randomized controlled trial.

Gonultas D, Kulcu DG, Kaymaz EP et al. · 2026 · Turkish journal of physical medicine and rehabilitation

Objectives This study aims to investigate the effectiveness of mesotherapy in patients with acute or subacute neck pain compared to oral medications with the same active ingredients. Patients and methods In this randomized, single-blind…

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Negative / Null Result ReportOpen accessMedicine

Modulation of the gut microbiota as a novel strategy to prevent anastomotic leak after colorectal surgery: Systematic scoping review.

Helliwell JA, Sciberras P, Dosis A et al. · 2026 · Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland

Background Anastomotic leak (AL) remains a major source of morbidity following colorectal surgery. Increasing evidence implicates the gut microbiome in the pathogenesis of AL, with certain microbial species disrupting tissue repair through…

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Negative / Null Result ReportOpen accessMedicine

Fracture Resistance of Mineral Trioxide Aggregate- and Biodentine-Pulpotomized teeth with Different Restorative Techniques: An in vitro Study.

Farhadpour H, Ghahramani Y, Jahani M et al. · 2026 · Journal of dentistry (Shiraz, Iran)

Background Preserving the radicular pulp in traumatically or mechanically exposed teeth through coronal pulpotomy (CP) is an advantageous endodontic procedure. Purpose This study compared the fracture resistance (FR) of mineral trioxide…

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Negative / Null Result ReportOpen accessMedicine

Attentional modulation of sensory gating during a visuomotor task.

Nguyen Van C, Le Trung D, Okamoto T et al. · 2026 · The journal of physiological sciences : JPS

Attention is crucial for motor performance because it enhances task-relevant processing while suppressing distractions. However, physiological markers of attentional engagement during motor activity remain incompletely understood. The…

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Negative / Null Result ReportOpen accessMedicine

Eltrombopag Combined With Cyclosporine A in the Treatment of Pediatric Patients With SAA: Establishing the Range for Eltrombopag Concentrations.

Li F, Li N, Tang X et al. · 2026 · Clinical and translational science

Eltrombopag (ELT), as an oral thrombopoietin receptor agonist, in combination with cyclosporine A (CsA) provides a novel therapeutic option for pediatric severe aplastic anemia (SAA). However, current clinical protocols predominantly adopt…

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Negative / Null Result ReportOpen accessMedicine

Performance of Youth Athletes Is Not Consistently Determined by Maturity or Training Experience: A Cross-Sectional Study.

Lykidis A, Pechlivanos RG, Angelou A et al. · 2026 · Journal of functional morphology and kinesiology

Objective: The purpose of this study was to compare the influence of biological maturity status and training experience on motor performance in young athletes of different sport disciplines. Methods: Youth athletes (n = 84, 23 females)…

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Negative / Null Result ReportOpen accessMedicine

Effects of different intensities of repetitive peripheral magnetic stimulation on corticospinal excitability and motor performance in healthy humans.

Omiya A, Shitara K, Miyazaki D et al. · 2026 · PloS one

Repetitive peripheral magnetic stimulation (rPMS) has been applied in clinical settings to enhance the recovery of motor function following central nervous system lesions. However, the optimal intensity of rPMS for inducing neural…

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Negative / Null Result ReportMedicine

Low Vision Assessment in Virtual Reality (LVAVR): Spatial Computing in Virtual Reality and Real-World.

Bailey E, Roy P, Shifflett K et al. · 2026 · 2026 IEEE Conference on Virtual Reality and 3D User Interfaces Abstracts and Workshops

The Low Vision Assessment in Virtual Reality project aims to create performance assessments of activities of daily living for a broad low vision population in virtual reality. In this study, our goal is to validate representative virtual…

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Negative / Null Result ReportMedicine

Quantitative assessment of tumor burden in multiple myeloma using MY-RADS from whole-body MRI: comparison with established prognostic biomarkers.

Xiong X, Yan Z, Wang J et al. · 2026 · Cancer imaging : the official publication of the International Cancer Imaging Society

Background To explore the value of MY-RADS from whole-body MRI in assessing tumor burden in MM with reference to established prognostic biomarkers. Methods 108 consecutive newly diagnosed MM patients were retrospectively enrolled. Bone…

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Negative / Null Result ReportMedicine

Feasibility and signal quality of the Minder® implantable continuous EEG monitoring® system compared to 10-20 scalp electrodes over extended monitoring periods.

Ganguly TM, Lai A, Niemiec A et al. · 2026 · Epilepsia

Objective To evaluate the signal quality of the Minder implantable continuous EEG monitoring (iCEM) system compared to traditional scalp EEG in the context of long-term, continuous monitoring in individuals with epilepsy. Methods…

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Negative / Null Result ReportOpen accessMedicine

Enhancing wheat bran deconstruction with enzyme cocktails from Penicillium spp. and Trichoderma harzianum: the impact of β-glucosidase supplementation.

Hamann PRV, Martins HS, da Costa PHC et al. · 2026 · Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]

Forests and natural environments are valuable sources of organisms capable of degrading plant cell wall carbohydrates. In the present study, two isolates, Penicillium polonicum and Penicillium chrysogenum, obtained from Brazilian Cerrado…

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Negative / Null Result ReportMedicine

Comparison of 2% lidocaine with epinephrine and 4% articaine with epinephrine in local anesthesia of maxillary molars affected by molar incisor hypomineralization: a randomized controlled trial.

Haidar M, Raslan N · 2026 · Scientific reports

The use of local anesthesia is essential for pain control during the treatment of MIH-affected molars. This study aimed to compare injection-related pain and anesthetic efficacy between 2% lidocaine with epinephrine (LE) and 4% articaine…

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