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Browse the failure-mode index

11,325 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Comparison of perioperative chemotherapy and neoadjuvant chemoradiotherapy (CRT) in locally advanced resectable distal esophageal/esophagogastric junction (EGJ) adenocarcinomas.

Şahin Çelik B, Ağdaş G, Genç V · 2026 · BMC cancer

Objective To compare the real-world outcomes of perioperative chemotherapy (ChT) and neoadjuvant chemoradiotherapy (CRT) in patients with locally advanced resectable distal esophageal and esophagogastric junction (EGJ) adenocarcinomas,…

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Negative / Null Result ReportOpen accessMedicine

Anti-inflammatory and antioxidative stress effects of <i>Sclerocarya birrea</i> (Anacardiaceae) trunk bark aqueous extract on acetic acid-induced ulcerative colitis in rats.

Dongmo F, Kom B, Akiki À Tsang G et al. · 2026 · Annals of medicine and surgery (2012)

Background Sclerocarya birrea is used in traditional medicine for the treatment of many diseases, including gastritis, diarrhea, dysentery, and hemorrhoids. The objective of this study was to evaluate the efficacy of Sclerocarya birrea…

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Negative / Null Result ReportMedicine

The effect of podcasts delivered to female university students on HPV knowledge, awareness, and anxiety levels: A randomized controlled trial.

Çi̇men HN, Uğur S, Çıralı A et al. · 2026 · Nurse education in practice

Aim The aim of this study was to evaluate the effect of podcast-based educational content delivered to students on their knowledge, awareness and anxiety levels regarding Human Papillomavirus (HPV). Method This randomized controlled…

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Negative / Null Result ReportMedicine

[Study on stability of elastic fixation with TightRope button-loop titanium plate in the reconstruction of the lower tibiofibular joint].

Wang S, Ma J, Ma S et al. · 2026 · Zhongguo gu shang = China journal of orthopaedics and traumatology

Objective To compare clinical efficacy of TightRope button-loop titanium plate elastic fixation and hollow tension screw fixation in treating ankle fractures with accompanying tibiofibular syndesmosis injury. Methods A retrospective…

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Negative / Null Result ReportOpen accessMedicine

A Botanical Mixture of Boswellia serrata, Commiphora myrrha, Propolis and Scutellaria baicalensis Reduces Expression of Inflammatory Chemokines in Canine Keratinocytes In Vitro.

Ha D, Jung K, Choi H et al. · 2026 · Veterinary medicine and science

Background Botanical ingredients can function as adjunctive therapies for managing inflammatory skin diseases. Objectives This study aimed to investigate the anti-inflammatory effects of a mixture of Boswellia serrata, Commiphora myrrha,…

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Negative / Null Result ReportOpen accessMedicine

'To improve is to change'-but is it safe? A single surgeon's transition from lateral to vertical hemispherotomy.

Salim O, Chari A, Tahir MZ · 2026 · Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery

Purpose Hemispherotomy is an established treatment for children with drug-resistant epilepsy. Recent reports have suggested a superiority of outcomes with the vertical approach compared to the traditional lateral approach. This study…

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Negative / Null Result ReportOpen accessMedicine

Assessment and Correlation of the Vitamin D Level With Growth Status as Measured by the Cervical Vertebral Maturation Index and Insulin-Like Growth Factor 1 Level in 10-14-Year-Old Patients.

Jaiswal M, Hazare A, Karia H et al. · 2026 · Cureus

Introduction Growth assessment is a fundamental process in orthodontics as accurate determination of skeletal maturity guides the timing of treatment intervention. Biochemical and radiographic indicators can be used to evaluate growth…

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Negative / Null Result ReportMedicine

Sirolimus-based treatment regimens for antinuclear antibody (ANA)-positive immune thrombocytopenia: a retrospective single-center cohort study.

Tan A, Liu J, Chen X et al. · 2026 · Hematology (Amsterdam, Netherlands)

Objectives To evaluate the efficacy and safety of sirolimus-based treatment regimens in patients with antinuclear antibody (ANA)-positive immune thrombocytopenia (ITP). Methods This retrospective single-center study enrolled patients with…

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Negative / Null Result ReportOpen accessMedicine

Melody vs. message: Effects of traditional song and concise social media communications on iodine knowledge, attitudes, behaviors, and biomarkers in pregnant women-A randomized controlled trial.

Ruengsiriphakakul S, Bumrerraj S, Thaenkham T · 2026 · Journal of education and health promotion

Background Iodine deficiency remains a global public health problem. Urinary iodine concentration (UIC) in pregnant women is a key indicator of iodine status in the population. Knowledge (K), attitude (A), and practice (P) levels of…

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Negative / Null Result ReportOpen accessMedicine

Novel Taiwan-I-type infectious bronchitis virus: First evidence of testicular atrophy and efficacious protection with strain-matched oil-emulsified inactivated vaccine.

Zhang T, Xie Y, Yang C et al. · 2026 · Virulence

The Taiwan-I-type infectious bronchitis virus (IBV) has become one of the most dominant and threatening genotypes circulating in China poultry farms. In this study, we characterized the Taiwan-I-type IBV strain GX-NN200723 and evaluated…

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Negative / Null Result ReportOpen accessMedicine

A comparative evaluation of apical sealing ability of NeoPutty, Biodentine, and Bio-c repair using a radioactive isotope method - An <i>in vitro</i> study.

Rathore S, Bhushan J, Uppal AS et al. · 2026 · Journal of conservative dentistry and endodontics

Background Treatment of teeth with immature apices is difficult to manage by conventional endodontics. Apical barrier formation using bioceramic materials offers a biologically favorable solution, providing a hermetic seal that supports…

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Negative / Null Result ReportMedicine

The Effect of Virtual Simulation of Parenteral Medication Administration on Nursing Students' Knowledge and Skills: A Randomized Controlled Experimental Study.

Biyik Bayram S, Gülnar E, Çalişkan N et al. · 2026 · Computers, informatics, nursing : CIN

This study investigated the effect of virtual simulation of parenteral medication administrations on nursing students' knowledge and skills. This randomized controlled experimental study adopted a pretest-posttest research design. The…

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Negative / Null Result ReportOpen accessMedicine

Evaluation of Time-Dependent Chemical Alterations in Sodium Hypochlorite Solution Kept on the Unit Tray During an Average Root Canal Treatment Period.

Bastug Guven E, Genc Sen O · 2026 · Medical science monitor : international medical journal of experimental and clinical research

BACKGROUND Sodium hypochlorite (NaOCl) is the most commonly used irrigant in root canal treatment because of its antimicrobial activity and tissue-dissolving capacity. Since these properties are related to its physicochemical…

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Negative / Null Result ReportOpen accessMedicine

Impact of hyperbaric oxygen as initial treatment on idiopathic sudden sensorineural hearing loss prognosis: a propensity scores matching analysis.

Xie S, Hong W, Huang L et al. · 2026 · Brazilian journal of otorhinolaryngology

Objective This study aimed to evaluate the effect of Hyperbaric Oxygen Therapy (HBOT) combined with steroids as initial treatment on the prognosis of patients with Idiopathic Sudden Sensorineural Hearing Loss (ISSNHL) by using propensity…

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Negative / Null Result ReportOpen accessMedicine

Effects of Norbixin on Growth Performance, Immunomodulation, Antioxidant Systems, and Metabolic Alterations in the Oriental River Prawn (Macrobrachium nipponense): An Integrative Analysis.

Ettefaghdoost M, Haghighi H, Haghdoost A · 2026 · Veterinary medicine and science

Background Natural carotenoids have gained considerable attention in aquaculture due to their potential to enhance growth performance, physiological status, and product quality in crustaceans. However, limited information is available…

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Negative / Null Result ReportOpen accessMedicine

Identical versus compatible blood typing: investigating best practices in lung transplantation.

Bugacov H, Cusmai C, Li K et al. · 2026 · Transplant international : official journal of the European Society for Organ Transplantation

This study investigated acute rejection in ABO-compatible versus ABO-identical lung transplants from 2005-2023, with a secondary objective of comparing 5-year survival. Lung transplantation improves quality of life and survival; however,…

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Negative / Null Result ReportMedicine

The effect of midwife-led education based on Pender's health promotion model (MidLed-PHPM) on the perinatal mental health of immigrant women.

Cevik A, Alan S · 2026 · Women and birth : journal of the Australian College of Midwives

Background Perinatal mental health issues are a global problem that constitutes a significant part of the burden on maternal and infant health. This situation could pose a risk, especially for immigrant women, who are a vulnerable group.…

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Negative / Null Result ReportOpen accessMedicine

Physical performance responses to match venue and outcome in elite soccer.

Nobari H, Kamis O, Atıcı AR et al. · 2026 · BMC sports science, medicine & rehabilitation

Background It is widely accepted that match venue influences technical, tactical, fitness, nutrition, the importance of the match, sleep, and psychological factors. This study investigates the impact of match venue (i.e., home vs. away)…

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