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Browse the failure-mode index

11,325 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Prognostic impact of time to first recurrence in low-grade serous ovarian carcinoma: A multicentric retrospective study from the French TMRG network.

Montassier, Laas, Hotton et al. · 2026 · Gynecologic oncology

In high-grade serous ovarian carcinoma (HGSOC), time to first recurrence is a major prognostic factor guiding therapeutic management. However, this parameter remains poorly studied in low-grade serous ovarian carcinoma (LGSOC), a rare…

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Negative / Null Result ReportMedicine

Can Knowledge and Motivation for Lymphedema Self-Management Be Improved with the Use of ICG Lymphography? A Prospective Observational Repeated Measures Study.

Trevethan, Doig, Patterson et al. · 2026 · Lymphology

ICG lymphography is a lymphatic imaging tool that can inform lymphedema treatment, including self-management. Self-management requires patient engagement in a multimodal treatment program. However, lack of knowledge about lymphedema,…

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Negative / Null Result ReportMedicine

Search for Double Beta Decays of ^{134}Xe with EXO-200 Phase II.

Al Kharusi, Anton, Badhrees et al. · 2026 · Physical review letters

EXO-200 was a leading double beta decay experiment consisting of a single-phase, enriched liquid xenon time projection chamber filled with an admixture of 80.672% ^{136}Xe and 19.098% ^{134}Xe. The detector operated at the Waste Isolation…

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Negative / Null Result ReportMedicine

A Geospatially Customizable Culturally Tailored Just-in-Time Adaptive Intervention for Violence-Affected People Living With HIV: Mixed Methods Acceptability, Feasibility, and User Experience Study.

Skeen, Tokarz, Gasik et al. · 2026 · JMIR human factors

Posttraumatic stress, along with comorbid mental health challenges and hazardous alcohol use, disproportionately affects people living with HIV. The drivers of these stressors are both intraindividual, rooted in early life adversity and…

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Negative / Null Result ReportMedicine

When performance declines: culturally mediated delay in pediatric knee fracture following traditional healing and scarification-a case report from rural Cameroon.

Npochinto Moumeni, Dikongue · 2026 · Frontiers in pediatrics

Delayed presentation of pediatric musculoskeletal trauma remains a critical yet underexplored challenge in sub-Saharan Africa, where cultural beliefs, socioeconomic constraints, and reliance on traditional healing practices frequently…

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Negative / Null Result ReportMedicine

Effect of Vaginal Palpation on Voluntary Pelvic Floor Muscle Performance During Early Motor Learning in Women with Stress Urinary Incontinence (SUI): A Randomized Controlled Trial.

de Azevedo Ferreira, Fitz, Gimenez et al. · 2026 · International urogynecology journal

Seventy percent of women with pelvic floor muscle (PFM) dysfunction are unable to contract these muscles correctly. Instruction to contract properly is essential for effective PFM training (PFMT). The study aimed to compare two…

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Negative / Null Result ReportMedicine

Chronic Neutropenia in Children: A Single-Center Experience.

Roganović, Zubović, Đorđević et al. · 2026 · Acta medica academica

To analyze the characteristics, etiology, diagnostic evaluation, management, follow-up, and outcomes of children with chronic neutropenia treated at a tertiary care pediatric hospital in Croatia. We retrospectively reviewed the…

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Negative / Null Result ReportMedicine

EXPRESS: Longitudinal evaluation of discordant symmetric dimethylarginine and creatinine as markers of glomerular filtration rate in radioiodine-treated hyperthyroid cats.

Hardy, Hibbert, Tasker et al. · 2026 · Journal of feline medicine and surgery

To determine the frequency and clinical significance of discordant serum symmetric dimethylarginine (SDMA) and creatinine concentrations relative to glomerular filtration rate (GFR) in mature and senior hyperthyroid cats treated with…

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Negative / Null Result ReportMedicine

AMCP Market Insights: Managed care considerations in Barth syndrome.

Flavin, Vernon, Todd Cade et al. · 2026 · Journal of managed care & specialty pharmacy

Barth syndrome is an ultrarare, complex, multisystem, X-linked metabolic and neuromuscular disease, which poses significant and wide-ranging burden to patients and caregivers. Pharmacologic management focuses on treatment of disease…

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Negative / Null Result ReportMedicine

Long-term mortality trends and disparities in renal failure across the United States, 1999 to 2024: A nationwide population-based ecological time-trend study.

Wang, Leng · 2026 · The Journal of international medical research

ObjectiveAlthough renal failure is an important cause of death in the United States, recent mortality trends and subgroup differences remain insufficiently characterized. This nationwide ecological time-trend study examined renal failure…

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Negative / Null Result ReportMedicine

The sound of engagement: assessing the feasibility and acceptability of an AI-generated personalized podcast as a between-session resource for therapy.

Peake, Swirbul, Rodio et al. · 2026 · Frontiers in digital health

Consistent client engagement with between-therapy session activities (i.e., homework) is a strong predictor of positive psychotherapy outcomes. Because traditional homework activities aren't always tailored to the individual, they can fail…

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Negative / Null Result ReportMedicine

Evaluation of electroacupuncture acupoint selection's potential in the treatment of inflammatory bowel disease: an investigation using a mouse gut microbiome and metabolomics model.

Lu, Bi, Gao et al. · 2026 · Frontiers in cellular and infection microbiology

Electroacupuncture (EA) serves as an effective complementary therapy in the treatment of inflammatory bowel disease (IBD) within traditional Chinese medicine, with the therapeutic efficacy significantly influenced by the selection of…

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Negative / Null Result ReportMedicine

Optimising the implementation of adolescent-friendly health services and its effects on contraceptive uptake and adolescent pregnancy in rural Mozambique: an implementation research study of the S-NICE intervention.

Chilundo, Xinavane, Huo et al. · 2026 · Frontiers in reproductive health

Despite national policies promoting adolescent- and youth-friendly health services, implementation gaps hinder improvements in adolescent sexual and reproductive health outcomes in Mozambique. S-NICE is a structured, participatory…

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Negative / Null Result ReportMedicine

Persuasive Gamified Virtual Reality Experience to Enhance Engagement and Focus in Young Adults With Mild Anxiety Symptoms: Randomized Pilot Experimental Study.

Argaw, Jingili, Oyelere et al. · 2026 · JMIR XR and spatial computing

Anxiety-related symptoms are prevalent and can negatively affect concentration, motivation, and overall well-being. Traditional treatments such as cognitive behavioral therapy and medication work well for clinical anxiety disorders.…

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Negative / Null Result ReportMedicine

Association of advanced therapies for intermediate- to high-risk pulmonary embolism with improved right ventricular function on outpatient follow-up among survivors.

Sheikh, Singh, Smith et al. · 2026 · Frontiers in cardiovascular medicine

The impact of catheter-directed thrombolysis (CDT), catheter-directed embolectomy (CDE) and surgical pulmonary embolectomy (SPE) on long term RV function among patients with acute PE remains unclear. We investigated the association of…

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