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Browse the failure-mode index

11,325 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Angelica dahurica alleviates peripheral nerve injury-induced muscle atrophy via the Phlpp2-Akt-FoxO3α axis independently of analgesia.

Wu, Wang, Liu et al. · 2026 · Phytomedicine : international journal of phytotherapy and phytopharmacology

Peripheral nerve injury frequently causes refractory neuropathic pain and muscle atrophy. While clinical care focuses on analgesia, effective therapies for muscle wasting are lacking. Angelica dahurica (BZ) is known for its analgesic…

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Negative / Null Result ReportMedicine

VC-VTON: Toward Across-View and Multi-Posture-Driven Virtual Try-On via Spatiotemporal-Aware View-Consistency Training.

Ma, Wei, Cai et al. · 2026 · IEEE transactions on image processing : a publication of the IEEE Signal Processing Society

Virtual try-on (VTON) aims to synthesize specific fashion images dressed in given garments, which possesses great potential in real-world scenarios. Existing methods generally stand on the shoulder of the single-view VTON to train a…

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Negative / Null Result ReportMedicine

Defective inducible T cell costimulator signalling drives neuropilin-1 hi CD4 + T cell-mediated non-germinal centre B cell activation via impaired regulatory T cell maintenance in a lupus model.

Kang, Kim, Kim et al. · 2026 · Experimental & molecular medicine

Inducible T cell costimulator (ICOS) signalling is essential for follicular helper T (Tfh) cell activation and has emerged as a therapeutic target in B cell-dependent autoimmune diseases such as systemic lupus erythematosus (SLE). However,…

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Negative / Null Result ReportMedicine

The Indian Smell Identification Test for Parkinson's Disease: Limitations of Binary Scoring and Proposal of a Modified Graded Approach.

Nagaraj, Prasad, Bhat et al. · 2026 · Annals of Indian Academy of Neurology

Olfactory dysfunction is a common nonmotor symptom and prodromal marker of Parkinson's disease (PD). Despite its early occurrence, hyposmia is frequently underrecognized, emphasizing the need for objective, culturally appropriate tools.…

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Negative / Null Result ReportMedicine

Clinical and radiological outcomes of a cartilage-preserving pinhole transtibial technique versus standard pull-out repair for traumatic posterior meniscal root tears.

Gezer, Demir · 2026 · Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES

Traumatic posterior meniscal root tears disrupt normal load transmission, resulting in meniscal extrusion and accelerated osteoarthritis. Although transtibial pull-out repair is widely used, creation of a 4.5-mm tibial tunnel at the joint…

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Negative / Null Result ReportMedicine

Peripherally located type I vestibular hair cells are required for several motor behaviors and stimulus-evoked brainstem neural responses in adult mice.

Ciani Berlingeri, Phillips, Mejia Bibriesca et al. · 2026 · The Journal of neuroscience : the official journal of the Society for Neuroscience

The mammalian vestibular system has two types of sensory receptors (hair cells), type I and type II. Understanding the roles of type I and II hair cells in the vestibular system's control of motor behaviors is difficult because most…

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Negative / Null Result ReportMedicine

Finite-size effects and energy alignment in molecular XANES under periodic boundary conditions: A systematic comparison of core-hole treatments.

Fujikata, Muramatsu, Mizoguchi · 2026 · The Journal of chemical physics

X-ray absorption near-edge structure (XANES) provides element-specific insights into local electronic and structural environments, but quantitative interpretation of molecular XANES under periodic boundary conditions (PBC) remains…

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Negative / Null Result ReportMedicine

Decreased posterior tibial slope is not a risk factor for posterior cruciate ligament reconstruction failure: A multicentric analysis of 173 cases.

Pizza, Perelli, Grassi et al. · 2026 · Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA

To investigate whether posterior tibial slope (PTS) is associated with failure after posterior cruciate ligament reconstruction (PCLR) in a cohort of patients undergoing isolated PCLR and PCL-based multiligament knee injuries (MLKI)…

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Negative / Null Result ReportMedicine

Bedside transcranial Doppler as a diagnostic bridge for suspected intracranial hypertension after traumatic brain injury surgery: A case report.

Prandani, Fuadi, Halimi et al. · 2026 · Surgical neurology international

Early recognition of postoperative neurologic deterioration in patients with traumatic brain injury (TBI) is essential but remains challenging, as clinical assessment may lack sensitivity and computed tomography (CT) imaging is not always…

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Negative / Null Result ReportMedicine

The prognostic value of the early neutrophil-to-lymphocyte ratio for 28-day mortality in sepsis patients: A machine learning-based investigation of the MIMIC database.

Liao, Xiang, Chen et al. · 2026 · PloS one

The neutrophil-to-lymphocyte ratio (NLR) has shown inconsistent prognostic value in individuals with sepsis. This study aimed to clarify its ability to predict 28-day mortality via a machine learning-based analysis of a large ICU database.…

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Negative / Null Result ReportMedicine

Complement C5 inhibitors as add-on rescue treatment in severe AQP4-antibody neuromyelitis optica spectrum disorder attacks: a case series and literature review.

Gan, Abu Hassan, Tan et al. · 2026 · Therapeutic advances in neurological disorders

Acute attacks of aquaporin-4 antibody neuromyelitis optica spectrum disorder (AQP4-Ab NMOSD) are typically managed with intravenous methylprednisolone, with therapeutic plasma exchange (PLEX) reserved for severe episodes. Despite these…

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Negative / Null Result ReportMedicine

Posterior circulation stroke secondary to atlantoaxial instability-induced vertebral artery dissection and pseudoaneurysm in a paediatric patient.

Bedia Cadelo, García Feijoo, Zamorano-Fernandez et al. · 2026 · BMJ case reports

A boy in his early teens presented with transient visual disturbances and headache. Brain imaging revealed bilateral occipital infarctions, while vascular studies demonstrated bilateral V3 vertebral artery wall abnormalities with…

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