11,325 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Cai, Qu, Feng et al. · 2026 · Journal of thoracic disease
Lung squamous cell carcinoma (LUSC) is associated with poor prognosis and low 5-year survival rates, and effective targeted therapies remain unavailable in clinical practice. To investigate the expression levels and clinical significance…
View details →Mann, Sharma, Jhamb et al. · 2026 · Journal of conservative dentistry and endodontics
Esthetics are in high demand in modern dentistry; conservative dentistry offers tooth-colored restorative materials; however, drawbacks such as polymerization shrinkage can lead to microleakage. To minimize this problem, cavity liners are…
View details →Mahardika, Rakhmawati, Sulijaya et al. · 2026 · Frontiers in cellular and infection microbiology
To determine the differences in periodontal status-Probing Depth (PD), Clinical Attachment Loss (CAL), Bleeding on Probing (BOP); oral inflammatory biomarkers-Tumor Necrosis Factor Alpha (TNF-α), Interleukin 1 Beta (IL-1β),…
View details →Kato, Ngonzi, Byamukama et al. · 2026 · Cureus
The burden of pelvic organ prolapse (POP) is the highest among elderly women compared to their young and middle-aged counterparts. These women are also faced with various medical comorbidities. Surgery in these women presents a…
View details →Gupta, Madan, Dutta et al. · 2026 · Journal of clinical and experimental hepatology
Human epidermal growth factor receptor 2 (HER2) overexpression is a critical therapeutic target in gallbladder cancer (GBC), but detection requires invasive sampling. We developed a fully automated computed tomography (CT)-based framework…
View details →Reason, Rizvi, Chawla et al. · 2026 · Canada communicable disease report = Releve des maladies transmissibles au Canada
Language concordant care can influence patient outcomes. The level of language concordant care and its impact on adherence to infection prevention protocols has not been well described. To assess whether patients' preferred language…
View details →Zhao, He, Li et al. · 2026 · Experimental and therapeutic medicine
Retroperitoneal laparoscopic resection is the preferred minimally invasive surgery for adrenal tumors. Patients vary greatly in postoperative drain output, but no clear criteria exist to select candidates for a drainage-free strategy. The…
View details →Ben Haberou, Bard, Gibier et al. · 2026 · Kidney international reports
The predictive value of Banff classification in protocol transplant biopsies without specific lesions is limited. Morphometry provides precise data on microstructures, surpassing semiquantitative scores but is time-consuming. This study…
View details →Li, Chen, Zhou et al. · 2026 · Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions
Moderate/severe mitral regurgitation (MR) can affect the prognosis of patients with transcatheter aortic valve replacement (TAVR). However, few studies have focused on the role played by papillary muscles (PMs). We intend to explore the…
View details →Bodur, Küçükekenci̇ · 2026 · BMC oral health
This study investigated how different access cavity designs and irrigation solutions influence the removal of calcium hydroxide from root canals. Eighty-four mandibular molars were divided into three groups according to their access…
View details →Zhai, Zhu, Lan et al. · 2026 · Annali italiani di chirurgia
This study aimed to explore the clinical application of surgical methods based on different lung segments and pathological subtypes in the treatment of T1b lung adenocarcinoma. A total of 207 patients with T1b lung adenocarcinoma admitted…
View details →Sun, Gong, Zhu et al. · 2026 · Annali italiani di chirurgia
This study aims to explore the critical risk factors associated with surgical site infection (SSI) in patients with type 2 diabetes mellitus (T2DM) undergoing oral and maxillofacial surgery, and to develop a predictive model to support…
View details →Shu, Jin, Peng · 2026 · Annali italiani di chirurgia
Given the high incidence of postoperative cognitive decline and reduced self-efficacy in lung cancer patients undergoing radical thoracoscopic surgery, this study aimed to investigate the effect of evidence-based nursing combined with…
View details →Kavakli, Bozkurt, Diri et al. · 2026 · Surgical endoscopy
Conventional abdominal wall blocks primarily target somatic afferent nerves and may therefore provide limited relief for the peritoneal component of postoperative pain. This study aimed to investigate whether a laparoscopic-guided deep…
View details →Calkins, Alaei, Winkler et al. · 2026 · Scientific reports
Tendons are essential for force transmission, yet the influence of menstrual cycle phase on upper-limb positional tendon mechanics is unknown. This exploratory study investigated biceps brachii tendon mechanics across the menstrual cycle.…
View details →Nakashima, Iguchi, Sugimoto et al. · 2026 · Clinical nuclear medicine
Chronic lung allograft dysfunction (CLAD) is a major cause of late morbidity after lung transplantation, and spirometry lacks the ability to detect regional lung changes. Thus, in this study, we investigated whether quantitative perfusion…
View details →Muto, Ohtake · 2026 · Journal of occupational and environmental medicine
To evaluate whether nudge emails increased early registration for an occupational health support program among employees advised to act after annual health checkups. In this stratified randomized controlled trial, 871 employees with no…
View details →Jimbih, Mazlan, Waran et al. · 2026 · PloS one
Traumatic brain injury (TBI) resulting from road traffic accidents (RTAs) is a leading cause of morbidity in children globally. However, paediatric TBI outcomes are understudied in Southeast Asia. To examine functional outcomes and…
View details →Kibak, Mouritsen · 2026 · Journal of helminthology
The concept of 'ecology of fear' recognises the importance of non-consumptive effects of predators inspiring fear in their prey, but has subsequently been broadened to include the non-consumptive effects of parasites on their hosts. Here,…
View details →Tc, S, J et al. · 2026 · Chronic respiratory disease
BackgroundDysregulated breathing is a major cause of persisting breathlessness for many people following acute COVID-19 illness. There is little evidence to support the use of breathing interventions within this population.MethodsA…
View details →Darwich, Yassine, Weiss et al. · 2026 · Surgical endoscopy
This prospective randomized study compared the efficacy of articulated ArtiSential® instruments with that of conventional straight laparoscopic instruments in minimally invasive left-sided colorectal resections. The primary endpoint…
View details →Xing, Hu, Liu et al. · 2026 · Medicine
Laparoscopic duodenum-preserving pancreatic head resection avoids complicated organ resection and reconstruction. In recent years, it has replaced laparoscopic pancreaticoduodenectomy as the first choice for treating benign and low-grade…
View details →Somura, Sato, Takakura et al. · 2026 · Medicine
Seizures are serious complications of awake craniotomy (AC), and generalized clonic seizures are problematic because they require pharmacologic termination and emergency airway management. Although associations between seizure onset and…
View details →Castillo Ortiz, Barrera Rodriguez · 2026 · Reumatologia clinica
Biologic therapy withdrawal in inflammatory rheumatic diseases is a frequent event with direct consequences on disease control, safety, and care costs. Real-world data from southeastern Mexico remain scarce. The objective of this study was…
View details →McShane, Olivera, Candido et al. · 2026 · Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
The optimal sequencing of therapy following anti-tumor necrosis factor (TNF) inhibitor failure in Crohn's disease (CD) remains uncertain. We compared the effectiveness of upadacitinib (UPA) versus risankizumab (RSZ) in patients with active…
View details →Shahzadi, Reimann, Schneider et al. · 2026 · RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin
To retrospectively evaluate the diagnostic performance and confidence of photon-counting computed tomography (PCCT) for detecting bone marrow edema (BME) in trauma patients, using magnetic resonance imaging (MRI) as the reference standard.…
View details →Chiriani, Fiorillo, Song et al. · 2026 · Applied ergonomics
The evolution of autonomous vehicle interiors presents both opportunities and challenges in optimizing space for Non-Driving Related Activities (NDRAs). Previous research explored the reconfiguration of interiors in autonomous vehicles to…
View details →Badi, Yilmaz, Odabasi Tezer et al. · 2026 · European endodontic journal
This study evaluated tooth discolouration potential of triple antibiotic paste (TAP) containing either minocycline or cefuroxime, Ledermix and Odontopaste using spectrophotometric analysis. Sixty extracted human maxillary central incisors…
View details →Sajatovic, Still, Burant et al. · 2026 · International journal of aging & human development
This 6-month randomized controlled trial compared TEAM, a group intervention to reduce stroke risk versus a 6-month wait-list control in Black men with stroke or transient ischemic attack. The primary outcome was the change from baseline…
View details →Ozaki, Inoue, Mishima et al. · 2026 · Journal of the American Heart Association
The potential value of low-voltage area (LVA) ablation for persistent atrial fibrillation (AF) has been suggested. However, its efficacy determinants remain unclear. We investigated the impact of diabetes on the outcomes of LVA ablation in…
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