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11,325 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Combination of color-Doppler ultrasound and MRI to improve lacrimal gland lesion characterization: A machine learning approach.

Riehm A, Senicourt L, O'Shaughnessy E et al. · 2026 · Diagnostic and interventional imaging

Purpose The purpose of this study was to develop a machine learning-based algorithm based on a combination of magnetic resonance imaging (MRI) and color-Doppler ultrasound (CDUS) to characterize lacrimal gland lesions. Materials and…

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Negative / Null Result ReportMedicine

Gallic acid as a biointeractive dentin conditioning agent for universal adhesives: bond strength, iron retention, and surface characterization following ferric sulfate hemostatic contamination.

Yılmaz NA · 2026 · Clinical oral investigations

Objectives This study evaluated the effects of two universal adhesives, applied under three protocols, self-etch (SE), conventional total-etch (CTE), and modified total-etch (MTE) with 1% (w/v) gallic acid, on shear bond strength (SBS),…

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Negative / Null Result ReportMedicine

Efficacy evaluation of live attenuated vaccines against Streptococcus agalactiae Ia, administered to Nile tilapia (Oreochromis niloticus) by immersion or intraperitoneal injection.

Fyrand K, Xu C, Evensen Ø · 2026 · Fish & shellfish immunology

Streptococcus agalactiae serotype Ia is a major bacterial pathogen in Nile tilapia (Oreochromis niloticus), and vaccines for juvenile fish, especially immersion vaccines, remain unavailable. We evaluated live attenuated vaccine candidates…

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Negative / Null Result ReportMedicine

Validating ICD code case definitions for condition case ascertainment in multimorbidity measurement: a retrospective chart review.

Kang AJ, Tseng CH, Wei MY · 2026 · The journals of gerontology. Series A, Biological sciences and medical sciences

Background Accurate case ascertainment of chronic conditions is critical for research, clinical decision-making, and population health management, especially for older adults with high multimorbidity. However, validation of ICD-based case…

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Negative / Null Result ReportMedicine

The development of a universal screening measure for young children: Assessing social and emotional competencies in early childhood.

Wadington M, Eklund K, Kilgus SP et al. · 2026 · School psychology (Washington, D.C.)

Research highlights the importance of the early identification of social, emotional, and behavioral concerns in young children; however, there are limitations regarding the usability and technical adequacy of available measures. The…

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Negative / Null Result ReportMedicine

Association Between Urinary Heavy Metals and Developmental Disorders in Children Aged 6-15 Years: A Study Based on the NHANES Database.

Liao Y, Zhan L, Li H · 2026 · Basic & clinical pharmacology & toxicology

This cross-sectional study utilized data from the National Health and Nutrition Examination Survey (NHANES) collected between 1999 and 2018, enrolling a total of 4525 children and adolescents aged 6-15 years. Weighted logistic regression,…

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Negative / Null Result ReportMedicine

Phytochemical investigation of Phyllanthus emblica (Amla) for therapeutic application in urinary tract infection (UTI) management and development of functional tea.

Ashraf S, Ismail T, Akhtar S et al. · 2026 · Ultrasonics sonochemistry

Phyllanthus emblica L. (amla) is a medicinal fruit, rich in secondary metabolites with reported anti-inflammatory and antimicrobial effects. The current study aimed to assess the impact of drying and extraction techniques on phytochemical…

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Negative / Null Result ReportMedicine

Unveiling glomerulonephritis in the Pacific: a Fijian cohort study.

Krishna J, Khan Z, Chandra Y et al. · 2026 · Journal of nephrology

The epidemiology of kidney diseases is poorly known in several settings, including the Pacific Islands. To contribute to filling this gap, the current study aims to explore the incidence, distribution and patterns of biopsy-proven…

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Negative / Null Result ReportMedicine

Associations of Fasting Glucagon and the Glucagon-Alanine Index With Hepatic Steatosis and Liver Stiffness in Japanese Individuals With Type 2 Diabetes.

Hattori T, Hamaguchi M, Hashimoto Y et al. · 2026 · Diabetes, obesity & metabolism

Background In type 2 diabetes, impaired glucagon action in the liver (hepatic glucagon resistance) may disrupt the liver-α-cell axis. We examined the associations of fasting glucagon and a modified glucagon-alanine index (GAI) with…

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Negative / Null Result ReportMedicine

Comparative morbidity and outcomes for adult spinal deformity corrections spanning C2-pelvis compared to T4-pelvis: a propensity score-matched analysis.

Yahanda AT, Joseph K, Bui TT et al. · 2026 · Spine deformity

Purpose Surgical corrections for adult spinal deformity (ASD) often extend from T4-pelvis. Certain patients may require fusion from C2-pelvis. Comparisons are necessary to guide surgical decision-making, particularly for frailer patients…

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Negative / Null Result ReportMedicine

Implicit Global-Local Learning in Young People With and Without Autism.

Ziva A, Ziori E, Pothos EM · 2026 · Quarterly journal of experimental psychology (2006)

Implicit (unconscious) learning ostensibly affects cognitive and social skills in both typical and atypical populations, such as those on the autism spectrum. Research into implicit learning in autism has yielded conflicting results,…

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Negative / Null Result ReportMedicine

End-to-end multimodal attention fusion for drug-target interaction prediction with cold-scaffold validation on the Davis kinase benchmark.

Agboola OE, Agboola SS, Shaleye AB et al. · 2026 · Journal of molecular graphics & modelling

Predicting drug-target interactions computationally is a practical strategy for prioritizing candidate compounds in early drug discovery, but the reliability of published models is often limited by small resampled datasets, warm-only…

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Negative / Null Result ReportMedicine

Statistical Learning in Dynamic Assessment to Identify Developmental Language Disorder in Spanish-English-Speaking Preschoolers: A Feasibility Study.

Neiling SL, Alt M, Kapa LL · 2026 · Language, speech, and hearing services in schools

Background The current project was a prospective feasibility study using a dynamic assessment of statistical learning of a novel morpheme for the identification of developmental language disorder (DLD) in Spanish-English-speaking…

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Negative / Null Result ReportMedicine

A cumulative-morbidity plasma proteomic architecture of critical-illness susceptibility: a UK biobank proteome-wide study of critical-care exposure, in-hospital death, and sex-specific signals.

Ren X, Dai Q, Jin C · 2026 · Journal of intensive care

Background Existing biomarker studies profile plasma during acute illness, leaving pre-illness proteomic susceptibility to critical care largely uncharacterised. We mapped the baseline proteomic architecture of critical-care outcomes in UK…

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Negative / Null Result ReportMedicine

Developing and Validating a Machine Learning Model to Predict Brain Injury in Preterm Infants Using Multisource Data from the Early Postnatal Period.

Xu P, Li Y, Chen Y et al. · 2026 · Children (Basel, Switzerland)

Background Moderate-to-severe preterm brain injury (PBI), including intraventricular hemorrhage (IVH) and periventricular leukomalacia (PVL), remains an important cause of adverse neurodevelopmental outcomes in preterm infants. Early risk…

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Negative / Null Result ReportMedicine

Tailoring Grammatical Test Items in English According to Language Experience for the Classification of Developmental Language Disorder in Bilinguals.

Pratt AS, Ramos MN, Peña ED et al. · 2026 · Journal of speech, language, and hearing research : JSLHR

Purpose This study attempts to discriminate developmental language disorder (DLD) in bilinguals using only the child's second language (L2), English. We grouped bilinguals by their current weekly language experience (high English…

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Negative / Null Result ReportMedicine

Molecular Basis of Synergistic Causal Effect of Dual GLP-1R and GIPR Agonists for Risk Reduction in Diabetic Retinopathy, Alzheimer Disease, and Coronary Artery Disease in Diabetic Patients.

Xu J, Ashebir YA, Shao Y · 2026 · Genes

Background: The dual agonism of glucagon-like peptide-1 receptor (GLP-1R) and glucose-dependent insulinotropic polypeptide receptor (GIPR) becomes a groundbreaking treatment for type 2 diabetes (T2D) that achieves robust glycemic control…

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Negative / Null Result ReportMedicine

Comparative evaluation of tigecycline susceptibility testing methods for carbapenem-resistant Klebsiella pneumoniae and Acinetobacter baumannii.

Shi Y, Li S, He L et al. · 2026 · Annals of clinical microbiology and antimicrobials

Background In this study, we aimed to evaluate the performance of different tigecycline susceptibility testing methods for CRKP and CRAB using the broth microdilution (BMD) method as the gold standard, under different breakpoint criteria.…

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Negative / Null Result ReportMedicine

The Diagnostic Value of English Language Sample Measures for Identifying Developmental Language Disorder in Bilingual Children.

Ramos MN, Bedore LM, Peña ED · 2026 · American journal of speech-language pathology

Purpose This study examines the diagnostic accuracy of four measures derived from English narrative language samples for identifying developmental language disorder (DLD) in 5- and 6-year-old Spanish-English bilinguals. Method Ninety-two…

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Negative / Null Result ReportMedicine

Development of a Prognostic Prediction Model for Clinically Significant Prostate Cancer Based on Lesion Zone and Apparent Diffusion Coefficient Value Quantification.

Ashouri R, Reynolds PS, Rajavel S et al. · 2026 · Urology

Objective To guide biopsy decision making via a predictive model for clinically significant prostate cancer (csPCa) in men with positive imaging (PI-RADS 3-5). We aim to elucidate the influence of zone on the predictive accuracy of PI-RADS…

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