Negative / Null Result ReportMedicine
Eulenburg C, Celik Y, Redline S et al. · 2023 · Annals of the American Thoracic Society
Rationale: Recent randomized controlled trials did not show cardiovascular benefits of continuous positive airway pressure (CPAP) in adults with coronary artery disease (CAD) and obstructive sleep apnea (OSA) in intention-to-treat…
View details →Negative / Null Result ReportMedicine
Ryser MD, Holloway ST, Morsomme R et al. · 2025 · Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
Background The UK Collaborative Trial of Ovarian Cancer Screening did not detect a reduction in ovarian cancer mortality with either multimodal screening (MMS) or transvaginal ultrasound screening (USS) compared with no screening. The…
View details →Negative / Null Result ReportOpen accessMedicine
Macielak SA, Vollmer NJ, Haddad NA et al. · 2021 · Critical care explorations
In practice, midodrine has been used to reduce IV vasopressor requirements and decrease ICU length of stay. However, recent publications have failed to show clinical success when midodrine was administered every 8 hours. One possible…
View details →Negative / Null Result ReportOpen accessMedicine
Sameed M, Meng Z, Marciniak ET · 2019 · Breathe (Sheffield, England)
In the EOLIA trial, early use of ECMO did not significantly improve mortality at 60 days in patients with severe ARDS, but when used as a rescue modality ECMO might help improve survival http://bit.ly/2XOjwSE.
View details →Negative / Null Result ReportOpen accessMedicine
Bath PM, Howard G, Hacke W · 2025 · Neurological research and practice
Background The majority of randomised controlled trials in acute stroke and many for prevention are neutral, i.e. they failed to reach statistical significance. However, many of these will find apparent benefit in a component of a…
View details →Negative / Null Result ReportMedicine
Galipienso-Eri M, Baraldés-Canals M, Aliaga-Martínez A et al. · 2025 · Indian journal of orthopaedics
Background/purpose Periprosthetic joint infection (PJI) accounts for up to 25% of failed total knee arthroplasties and 15% of the hips. The ICM18 established the criteria for the diagnosis, and the alpha-defensin lateral flow test (ADLT)…
View details →Negative / Null Result ReportOpen accessMedicine
Saqib K, Goel V, Dubin JA et al. · 2026 · International journal of public health
Objective To examine differences in mental health-related healthcare utilization for anxiety and depression between individuals who did and did not undergo COVID-19 PCR testing in Ontario. Background: The COVID-19 pandemic has been…
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Campo-Beamud C, Roig-Ferreruela G · 2026 · Archivos de la Sociedad Espanola de Oftalmologia
Blue light is a physiological component of visible light, essential for daytime vision and circadian synchronization. There is no evidence supporting the routine use of blue-blocking glasses for preventive or therapeutic purposes. The most…
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Marder SR, Eriksson H, Zhao Y et al. · 2020 · Acta neuropsychiatrica
Objective We provide a closer look at the result of a randomised, placebo-controlled, active-reference (quetiapine XR), flexible-dose, 6-week study of brexpiprazole in schizophrenia, which did not meet its primary endpoint - change from…
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Shah R, Das S, Gentile Kruse CF et al. · 2025 · Pediatric neurology
Background Triptans are used to treat migraine attacks, but little to no evidence supports their use for youth with post-traumatic headache (PTH). This study evaluated patterns of use and benefit of triptans in the treatment of acute…
View details →Negative / Null Result ReportMedicine
Park K, Özgüroğlu M, Vansteenkiste J et al. · 2021 · Lung cancer (Amsterdam, Netherlands)
Objectives The JAVELIN Lung 200 phase 3 trial did not meet its primary endpoint of improving overall survival (OS) with avelumab vs docetaxel in patients with platinum-treated PD-L1+ NSCLC. We report post hoc analyses assessing the effects…
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Ponce H, Cordero R, Tran J et al. · 2025 · Journal of patient experience
In a prior study, communication scholar ratings of clinician communication effectiveness did not correlate with perceived clinician empathy, which is one aspect of patient experience. We repeated the analysis with a different rating of…
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Neter E, Youngmann R, Gruper N · 2025 · JMIR formative research
Unlabelled Associations between eHealth literacy and mental health literacy were examined; no significant association was identified between overall eHealth and mental health literacy and only weak associations between specific skills were…
View details →Negative / Null Result ReportOpen accessMedicine
Pienkos S, Swank Z, Hamlin RE et al. · 2025 · Open forum infectious diseases
Plasma samples obtained approximately 3 ( n = 100) and 12 months ( n = 78) after acute SARS-CoV-2 infection were tested for S1, spike, and N antigens. There were no significant differences in plasma proteins or single-cell protein…
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Wesley CD, Strange JE, Holt A et al. · 2025 · European heart journal open
Aims Fluoroquinolones (FQ) have been associated with aortic aneurysm and aortic dissection (AA/AD) resulting in an official warning. Recently, large-scale epidemiological studies failed to confirm this. Methods and results The current…
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Demattio L, Fietz D, Schuler G et al. · 2024 · Tierarztliche Praxis. Ausgabe G, Grosstiere/Nutztiere
A 9.4 mg deslorelin slow-release implant was inserted into an adult, healthy billy goat to achieve temporary infertility and a reduction in sexual behavior. The implant was inserted in late autumn. No significant change in testis size was…
View details →Negative / Null Result ReportOpen accessMedicine
Wang D, Nanavati C, Yang DZ et al. · 2026 · Journal of clinical pharmacology
Impact of concomitant medications (conmeds) on the safety of the investigational agent is often evaluated using subgroup analyses for safety events in patients who received the conmed versus those who did not. Here, we highlight the…
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Choi, Gutman, Iglesia et al. · 2026 · Urogynecology (Philadelphia, Pa.)
Studies have shown that sexual function improves after surgical correction for stress urinary incontinence and pelvic organ prolapse. Current data suggest no significant difference in sexual function between transobturator and retropubic…
View details →Negative / Null Result ReportMedicine
Shaygantabar, Dianati, Ledari et al. · 2026 · BMC pediatrics
Exclusive enteral nutrition (EEN) induces remission in children with active mild to moderate Crohn's disease (CD), while partial enteral nutrition (PEN) with a free diet have failed to be effective in these patients. The effects of CD…
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Caio Gonçalves de Souza, Márcio Passini Gonçalves de Souza, Vanda Jorgetti et al. · 2015 · Acta Ortopédica Brasileira
OBJECTIVE: To determine whether there is a difference on the bone architecture in patients with femoral neck fracture compared to patients with intertrochanteric fractures and assess the importance of aging on bone microarchitecture in patients with proximal femoral fracture.METHODS: Biopsy of the iliac crest was made in seventeen patients between 55 and 90 years old who were admitted to the emergency room with fractures of the proximal end of the femur. After a small fragment was removed, we made a histomorphometric analysis of it.RESULTS: There was no significant difference between patients
View details →Negative / Null Result ReportOpen accessMedicine
Richard R. Chapleau, CharLee A. Martin, Summer R. Hughes et al. · 2019 · BMC Research Notes
Abstract Objective This study sought to determine if there is an association between variants in the apolipoprotein E (ApoE) promoter regions and development of white matter hyperintensities (WMH) in military subjects who have been exposed to high altitude. In an earlier study, we found that ApoE status did not correlate with WMH development, and here we hypothesized that regulation of APOE protein expression may be protective. Results Our cohort of 92 subjects encountered altitude exposures above 25,000 feet mean sea level through their occupations as pilots or altitude chamber technicians. U
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Kencono Viyati, Kinasih Prayuni, Yenni Zulhamidah et al. · 2023 · Makara Journal of Health Research
Background: Asthma is a multifactorial disease that encompasses a multitude of genetic and environmental factors. One such factor is the disintegrin and metalloprotein-33 (ADAM33) gene, which is correlated with asthma and bronchial hyperresponsiveness. Previous studies conducted on Asian populations have reported a significant association between rs2787094 polymorphism in the ADAM33 gene and asthma. Methods: Our study involved 153 Indonesian participants. TaqMan genotyping assay was used to analyze rs2787094 polymorphism in the ADAM33 gene. Results: No significant association was detected betw
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Seyed Mohammadreza Fatemi Khorasgani, Neda Ramezani, Negar Ebrahimi Varnousfaderani · 2020 · Journal of Research in Medical Sciences
Background: Previous studies report an association between joint hypermobility (JH), as a hallmark of connective tissue disorder, and autonomic dysfunction, digestive problems, and irritable bowel syndrome. However, its association with functional constipation (FC) has not been evaluated. This study is run and implemented to justify this theme/topic. Materials and Methods: In this case–control study among 200 subjects, 100 were of FC according to the ROME III Criteria (case group) and each child was matched for age and gender with a healthy control that did not meet criteria for FC (control gr
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Ciaffi J, Bordini B, Cosentino M et al. · 2026 · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
Osteoarthritis patients undergoing THA or TKA were studied to compare the cumulative incidence of revision after perioperative denosumab versus alendronate. Denosumab was not associated with differences in the incidence of revision after…
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LU Yongping, PAN Tingfang · 2025 · Jichu yixue yu linchuang
In order to cultivate interdisciplinary innovative medical talents who can adapt to the development of the needs of national medical care and of global file of medical education, Peking Union Medical College has initiated the project of the “4+4” model, which covers a series of education remodeling like candidate trainees’ enrollment, curriculum integration application of new teaching methods, assessment and evaluation, etc., and has made a great progress. The existing evaluation data show that there is no significant difference between the academic performance of students in the “4+4” trainin
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Azam Abed, Aliasghar Asghar Nezhad, Hamidreza Hatami · 2015 · Iranian Rehabilitation Journal
Objectives: The aim of current study was the evaluation and comparison of compatibility and marital satisfaction between handicapped couples and healthy ones. Methods: In this study, 50 handicapped couples and 50 healthy couples were examined with Enrich’s marital satisfaction questionnaire and Bell’s adjustment questionnaire. The data were analyzed, using SPSS 15, correlation tests and ANOVA. Results: The results showed that there was no significant difference between handicapped and healthy couples in compatibility and marital satisfaction. Discussion: It is concluded that people
View details →Negative / Null Result ReportOpen accessMedicine
Van Weydevelt E, Alrajhi Z, Vannier C et al. · 2026 · Journal of vascular surgery cases and innovative techniques
Objective Fenestrated and branched endovascular aortic repair (F/BEVAR) is increasingly used to treat complex abdominal aortic aneurysms and thoracoabdominal aortic aneurysms (TAAAs) because of their minimally invasive nature compared with…
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Schneider F, Conze T, Büttner K et al. · 2026 · Veterinary sciences
The provision of high-quality colostrum immediately after birth is essential to ensure adequate passive transfer of immunity in neonatal calves. This study evaluated colostrum viscosity as a potential indicator of colostrum quality, its…
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Perrin A, Deillon C, Christe P et al. · 2026 · Parasites & vectors
Arthropod-borne viruses are increasingly reported across Europe, with Culex pipiens serving as the main vector of West Nile and Usutu viruses. The C. pipiens complex comprises two ecologically distinct ecotypes, pipiens and molestus, which…
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Guo Y, Jiang B, Chen H et al. · 2026 · Aquaculture.
Bdellovibrio is a kind of fast-moving bacteria that mainly preys on Gram-negative bacteria. Aeromonas hydrophila is one of the most common pathogenic bacteria for many animals. However, the potential application of freshwater-derived…
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