11,325 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Canning C, McCormack T, Clifford E et al. · 2024 · The British journal of developmental psychology
Previous studies have failed to show an effect of episodic future thinking (EFT) on children's delay of gratification (DoG), contrasting strikingly with adult findings. Recent findings from a sample of 8-11-year-old children by Canning et…
View details →Danahay H, McCarthy C, Schofield T et al. · 2025 · Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society
Background Inhibiting ENaC in the airways of people with cystic fibrosis (pwCF) is hypothesized to enhance mucociliary clearance (MCC) and provide clinical benefit. Historically, inhaled ENaC blockers have failed to show benefit in pwCF…
View details →Cornell CA, Norman KA, Griffiths TL et al. · 2024 · Psychological science
We often use cues from our environment when we get stuck searching our memories, but prior research has failed to show benefits of cuing with other, randomly selected list items during memory search. What accounts for this discrepancy? We…
View details →Wan H, Myerson J, Green L et al. · 2025 · The journals of gerontology. Series B, Psychological sciences and social sciences
Objectives Previous studies failed to find age-related differences in the discounting of delayed, monetary losses, potentially due to their failure to examine the effects of income and their use of relatively small loss amounts.…
View details →Gibb RD, Brum JM, Sloan KJ et al. · 2025 · Journal of travel medicine
What can be concluded from a clinical trial that spanned 5 years yet failed to achieve target enrollment, generated flat results that contradict the existing body of knowledge and has a primary efficacy endpoint confounded by a…
View details →Chevalley S, Wängberg V, Åhlén M et al. · 2024 · The Journal of hand surgery
Purpose There is no consensus on the optimal postoperative rehabilitation program following flexor tendon repair. Some studies suggest a faster recovery after active mobilization, whereas other studies have failed to find any differences…
View details →Madill-Thomsen KS, Gauthier PT, Abouljoud M et al. · 2025 · Transplantation
Background Initial analysis of liver transplant biopsies in the INTERLIVER study ( ClinicalTrials.gov ; unique identifier NCT03193151) using rejection-associated transcripts failed to find an antibody-mediated rejection state (ie, rich in…
View details →Stone BM, Hammersley JJ, Rabinovich NE et al. · 2024 · Experimental and clinical psychopharmacology
In contrast to overnight deprivation versus satiety studies, a small number of placebo-controlled studies have failed to find that nicotine administration reduces attentional bias (AB) to smoking cues. To assess the reliability of this…
View details →Catling FJR, Nagendran M, Festor P et al. · 2024 · Critical care explorations
Large randomized trials in sepsis have generally failed to find effective novel treatments. This is increasingly attributed to patient heterogeneity, including heterogeneous cardiovascular changes in septic shock. We discuss the potential…
View details →Saki F, Shams M, Dastghaib S et al. · 2023 · BioMed research international
Background Recent researches have failed to uncover a clear explanation for proton pump inhibitors' bone-loss effects. In light of pantoprazole's effects on gastrin secretion, the goal of this study was to see if it caused bone loss…
View details →Platts CR, Groh AM, Runze J et al. · 2026 · Attachment & human development
Initial molecular genetic studies identified specific genes that contribute to variation in associations between maternal sensitivity and infant attachment, but these findings from small samples failed to replicate in larger-sample…
View details →Kong SH · 2026 · Endocrinology and metabolism (Seoul, Korea)
For decades, vitamin D has been a cornerstone of preventive medicine. However, recent large-scale randomized controlled trials have failed to replicate the broad benefits previously observed in epidemiological studies, particularly with…
View details →Salwei M, Tang LA, Vogus TJ et al. · 2026 · Health care management review
Background Health care organizations have failed to replicate the performance of high-reliability organizations (HROs), systems that operate nearly error-free despite inherently complex, interdependent, and time-pressured environments.…
View details →Zhang X, Gunderson EA · 2025 · Developmental psychology
Spatial skills in early childhood are key predictors of mathematical achievement. Previous studies have found that training mental rotation can transfer to arithmetic skills; however, some studies have failed to replicate this transfer…
View details →Odintsova VV, van Dongen J, van Beijsterveldt CEM et al. · 2023 · Twin research and human genetics : the official journal of the International Society for Twin Studies
In studies of singletons, a range of early-life characteristics have been reported to be associated with handedness, but some of these associations have failed to replicate. We examined associations between 23 early life characteristics…
View details →Legendre M, Sabourin S, Bégin C · 2022 · Eating and weight disorders : EWD
Purpose A higher risk of food addiction (FA) in individuals reporting childhood sexual abuse (CSA) has been well demonstrated with community samples, but studies including clinical samples failed to replicate this relation. This study…
View details →Zhang J, Whitehurst LN, Mednick SC · 2022 · Neurobiology of learning and memory
Prior studies suggest a role for sleep in memory consolidation, with specific contributions from slow oscillations and sleep spindles (Rasch & Born, 2013). However, recent studies failed to replicate sleep's superiority over wake in…
View details →Aitken-Buck HM, Moore MK, Bingham KT et al. · 2024 · Forensic science, medicine, and pathology
Epicardial adipose tissue (EAT) deposition has been long associated with heart weight. However, recent research has failed to replicate this association. We aimed to determine the association of EAT volume with heart weight in post-mortem…
View details →Taheri F, Tanha AS, Aboutorabi RB et al. · 2026 · Clinical nuclear medicine
A 78-year-old woman with medullary thyroid carcinoma (MTC) demonstrated persistently elevated serum calcitonin despite prior surgery and radiotherapy. 99mTc-octreotide imaging failed to detect skeletal metastases, while 68Ga-FAPI PET/CT…
View details →Huang Y, Huang X, Ling L et al. · 2024 · Kardiologiia
Aim Elevated levels of pro-inflammatory factors in plasma have been linked to worse prognosis after on-pump cardiac surgery, yet interventions that reduce the levels in patients have failed to improve prognosis. Therefore, we explored…
View details →Hanazawa R, Sato H, Hirakawa A · 2025 · Therapeutic innovation & regulatory science
Background Alzheimer's disease (AD) is a neurodegenerative disease for which many clinical trials failed to detect treatment effects, possibly due to the heterogeneity of disease progression among the patients. Predicting and clustering a…
View details →Knappich C, Bohmann B, Kirchhoff F et al. · 2025 · European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery
Objective Various studies have failed to detect a difference in outcomes between carotid endarterectomy (CEA) with patch angioplasty and eversion CEA. This study aimed to assess whether surgical technique and related department policy are…
View details →Ledesma V, Vanbaelen T, Gestels Z et al. · 2024 · FEMS microbiology letters
The ResistAZM randomized controlled trial found that the receipt of ceftriaxone/azithromycin, compared to ceftriaxone was not associated with an increase in the proportion of oral commensal Neisseria spp. and streptococci with azithromycin…
View details →Petr V, Tichanek F, Liu SL et al. · 2025 · American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Targeting peritransplant inflammation via tumor necrosis factor alpha blockade failed to improve kidney transplantation outcomes in the CTOT-19 trial that tested infliximab (IFX) induction. As natural antibodies (nAbs) to cardiolipin and…
View details →Lähteenmäki EI, Lehti S, Jauhiainen M et al. · 2025 · American journal of physiology. Endocrinology and metabolism
Although high-density lipoprotein (HDL) has cardiometabolic protecting properties, interventions to raise HDL cholesterol concentration have failed to improve cardiometabolic health. Hence, HDL composition and functionality might be key…
View details →El Jalkh J, Obeid PM, Guermazi D et al. · 2025 · Dermatopathology (Basel, Switzerland)
A 64-year-old patient presented for management of symptomatic skin-colored papules symmetrically distributed over the lateral neck over the past two years, which failed to improve on multiple topical corticosteroids, antifungal creams, and…
View details →Mohammed SA, Gorica E, Albiero M et al. · 2025 · Diabetes
Revascularization strategies failed to improve outcome in patients with diabetes with peripheral artery disease (PAD). Histone modifications are key modulators of gene expression and could play a role in angiogenic response. This study…
View details →Zhang H, Yang Y, Sun S · 2024 · Acta psychologica
In response to the public's puzzle about why maternity leave has unexpectedly failed to improve fertility problem in the Chinese context of a widespread extension of maternity leave, our study concentrates on a prevailing stigmatization…
View details →Sanabria A, Rodrigo JP, Araújo ALD et al. · 2025 · Cancers
Background/Objectives : Oropharyngeal squamous cell carcinoma (OPSCC) management has shifted following recognition of HPV-driven disease. Neoadjuvant chemotherapy (NAC) has historically failed to improve overall survival (OS) in mixed head…
View details →Li H, Man X, Cai T · 2024 · Journal of Environmental Management
Despite decades of recovery, soil carbon in heavily burned areas has failed to reach pre-fire levels. It is unclear whether stand management practices can promote soil organic carbon accumulation at such sites. This study evaluated the…
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