Negative / Null Result ReportOpen accessMedicine
Arturo Arrona-Palacios, Jung-Hie Lee, Charles A. Czeisler et al. · 2023 · Clocks & Sleep
The main aim of this study was to explore how melatonin onset timing and phase angle to bedtime in healthy older adults are impacted by prior light exposure. A total of 13 healthy older (ages 56–74) individuals were studied on two successive evenings. Prior to the first evening, the participants were in self-selected lighting conditions for the first 4–6 h of the day and then were in dim light (3 lux) until their scheduled bedtime. On the second day, individuals from Project A remained in the dim lighting conditions throughout the entire day but those in Project B were in more typical indoor l
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Wejpisit Wongwiwattananon, Jatuporn Pakpirom, Raviwan Akarapatima · 2020 · Journal of Health Science and Medical Research (JHSMR)
Objective: This study aimed to determine the risks of propofol-based total intravenous anesthesia (TIVA) compared to local anesthesia (LA) in patients undergoing percutaneous transluminal angioplasty (PTA) in a lower extremity. Material and Methods: A retrospective cohort study was conducted in 231 patients who underwent PTA in the lower extremity using either propofol-based TIVA or LA between January 2016 and September 2018. The outcomes of interest included perioperative major adverse cardiac events (MACE) and minor perioperative complications. Risk factors analysis was performed using a uni
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Laura Emanuelle da Rosa Carlos Monteiro, Sheila Piccoli Garcia, Leonardo Grabinski Bottino et al. · 2022 · Archives of Endocrinology and Metabolism
ABSTRACT Objective: To evaluate the precipitating factors of diabetic ketoacidosis (DKA) in patients with type 1 diabetes hospitalized through the emergency department of a tertiary hospital. Materials and methods: Individuals with type 1 diabetes hospitalized for DKA from January 2005 to March 2010 (first period [P1], n = 75) and from April 2010 to January 2017 (second period [P2], n = 97) were identified through a query of electronic medical records. Data were collected by reviewing medical records. Only the first hospitalization of each participant in each period was included. Results: In P
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Matthias Huber, Till Treutler, Peter Martus et al. · 2013 · PLoS ONE
Unlabelled Treatment of hypertension in hemodialysis (HD) patients is characterised by lack of evidence for both the blood pressure (BP) target goal and the recommended drug class to use. Telmisartan, an Angiotensin receptor blocker (ARB) that is metabolised in the liver and not excreted via HD extracorporeal circuit might be particularly suitable for HD patients. We designed and conducted a randomised, placebo-controlled, double-blind and cross-over trial for treatment of dialysis-associated hypertension with telmisartan 80 mg once daily or placebo on top of standard antihypertensive treatmen
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Thaiz Ferraz Borin, Debora A P C Zuccari, Bruna V Jardim-Perassi et al. · 2014 · PLoS ONE
A selective inhibitor of 20-HETE synthesis, HET0016, has been reported to inhibit angiogenesis. 20-HETE has been known as a second mitogenic messenger of angiogenesis inducing growth factors. HET0016 effects were analyzed on MDA-MB-231 derived breast cancer in mouse and in vitro cell line. MDA-MB-231 tumor cells were implanted in animals' right flank and randomly assigned to early (1 and 2), starting treatments on day 0, or delayed groups (3 and 4) on day 8 after implantation of tumor. Animals received HET0016 (10 mg/kg) treatment via intraperitoneal injection for 5 days/week for either 3 or 4
View details →Negative / Null Result ReportOpen accessMedicine
Wishyar Jamal Al-Bazzaz, Nihad Rifaat Jawad2 Ali W. AlKhayat · 2020 · Zanco Journal of Medical Sciences
Background and objective: Prostate Thulium laser vaporization is a novel treatment option for a bladder outlet obstruction caused by benign prostate enlargement. However, this surgical technique has not yet been standardized. We present our finding of using Tm vaporesection of the prostate. This study aimed to assess the efficacy and safety of thulium laser versus bipolar transurethral resection of the prostate for treating patients with benign prostatic obstruction. Methods: Sixty three consecutive patients with benign prostatic hyperplasia attending public and private clinics in Erbil city w
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Elham Naghshineh, Safoura Rouholamin, Zahra Derakhshandeh · 2023 · Advanced Biomedical Research
Background: Asherman syndrome is a controversial issue in obstetrics and gynecology without any consensus on its management and treatment. It is characterized by variable lesions inside the uterine cavity and also causes menstrual irregularities, infertility, and placental abnormalities. The study aimed to assess the platelet-rich plasma (PRP) effect in women with intrauterine adhesions by evaluating the improvement of the menstrual cycle and intrauterine adhesion (IUA) stage. Materials and Methods: This clinical trial study was performed on 60 women with Asherman syndrome in two groups of 30.
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Makkar RR, Chakravarty T, Gupta A et al. · 2025 · Journal of the American College of Cardiology
Background In the ACURATE IDE (Safety and Effectiveness Study of ACURATE Valve for Transcatheter Aortic Valve Replacement) randomized controlled trial, ACURATE neo2 failed to show noninferiority to commercially available balloon-expandable…
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Mohammed Abdul, Bernard, Yates · 2026 · Cureus
Background The optimal choice of polyethylene insert in total knee arthroplasty (TKA) continues to cause contention. Rotating platform bearings (RP) have theoretical advantages but have failed to demonstrate a functional difference…
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Geysenbergh, Debrock, Lie Fong et al. · 2026 · Human reproduction (Oxford, England)
Does a natural cycle result in higher clinical pregnancy rates (CPR) with foetal heartbeat compared to an artificial cycle for frozen-thawed embryo transfer (FET) preparation in ovulatory women? The CPR with foetal heartbeat did not differ…
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El-Tanani, Wali, Rabbani et al. · 2026 · Pharmaceuticals (Basel, Switzerland)
In spite of plausible biology, the majority of oncology trials involving drug repurposing have failed to demonstrate any efficacy. Numerous factors can potentially cause failure, including issues with dosing, drug strength, the trial…
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Diptasree Maitra Ghosh, Dinesh Kumar, Sridhar Poosapadi Arjunan et al. · 2017 · PLoS ONE
This study has described and experimentally validated the differential electrodes surface electromyography (sEMG) model for tibialis anterior muscles during isometric contraction. This model has investigated the effect of pennation angle on the simulated sEMG signal. The results show that there is no significant effect of pennation angle in the range 0° to 20° to the single fibre action potential shape recorded on the skin surface. However, the changes with respect to pennation angle are observed in sEMG amplitude, frequency and fractal dimension. It is also observed that at different levels o
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Suzuki Y, Matsui M, Munir M et al. · 2025 · Zoological science
Using mitochondrial DNA and genome-wide SNP, phylogenetic relationships in Chalcorana were investigated. Phylogenetic analyses based on subregions of mtDNA found possible lineages of several cryptic species, but did not support the…
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Sabrina Lorenz, Birte Alex, Thomas Kammer · 2020 · PLoS ONE
Recently, modulatory effects of static magnetic field stimulation (tSMS) on excitability of the motor cortex have been reported. In our previous study we failed to replicate these results. It was suggested that the lack of modulatory effects was due to the use of an auditory oddball task in our study. Thus, we aimed to evaluate the role of an oddball task on the effects of tSMS on motor cortex excitability. In a within-subject-design we compared 10 minutes tSMS with and without oddball task. In one of the two sessions subjects had to solve an auditory oddball task during the exposure to the ma
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Haley Appel, Rogger P Carmen-Orozco, Clayton P Santiago et al. · 2025 · eLife
The RNA-binding protein Ptbp1 has been proposed as a master regulator of neuronal fate, repressing neurogenesis through its effects on alternative splicing and miRNA maturation. While prior studies using RNA interference suggested that Ptbp1 loss promotes neurogenesis, recent genetic studies have failed to replicate glia-to-neuron conversion following Ptbp1 loss of function. To evaluate the role of Ptbp1 in developmental neurogenesis in vivo, we conditionally disrupted Ptbp1 in mouse retinal progenitors. Ptbp1 was robustly expressed in both retinal progenitors and Müller glia but absent from p
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Abraham D. Flaxman, Riley Hazard, Ian Riley et al. · 2020 · BMC Medicine
Abstract We recently published in BMC Medicine an evaluation of the comparative diagnostic performance of InSilicoVA, a software to map the underlying causes of death from verbal autopsy interviews. The developers of this software claim to have failed to replicate our results and appear to have also failed to locate our replication archive for this work. In this Correspondence, we provide feedback on how this might have been done more usefully and offer some suggestions to improve future attempts at reproducible research. We also offer an alternative interpretation of the results presented by
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Mykolow G, Guyodo J, Cartigny MC · 2026 · Soins. Psychiatrie
The randomized SIPRéS study, conducted at Montpellier University Hospital, compares an outpatient nursing follow-up program aimed at preventing post-hospitalization suicide recurrence with standard care. Although it has no significant…
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Katie Finning, David A Richards, Victoria A Goodwin et al. · 2019 · BMJ Open
Objectives Physical rehabilitation is a complex process, and trials of rehabilitation interventions are increasing in number but often report null results. This study aimed to establish treatment success rates in physical rehabilitation trials funded by the National Institute of Health Research Health Technology Assessment (NIHR HTA) programme and examine any relationship between treatment success and the quality of intervention development work undertaken.Design This is a mixed methods study.Setting This study was conducted in the UK.Methods The NIHR HTA portfolio was searched for all complet
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Alexis David James Makin, Afzal Rahman, Marco Bertamini · 2020 · PLoS ONE
Previous work has shown that symmetrical stimuli are judged as lasting longer than asymmetrical ones, even when actual duration is matched. This effect has been replicated with different methods and stimuli types. We aimed to a) replicate the effect of symmetry on subjective duration, and b) assess whether it was further modulated by the number of symmetrical axes. There was no evidence for either effect. This null result cannot be explained by reduced statistical power or enhanced floor or ceiling effects. There is no obvious stimulus-based explanation either. However, we are mindful of the r
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Suda Y, Ishida K, Shibanuma N et al. · 2026 · BMC musculoskeletal disorders
Background Previously, it was reported that preoperative medial tibial bone marrow lesions (BMLs) were not associated with worse postoperative outcomes after medial unicompartmental knee arthroplasty (UKA). However, the effect of BMLs in…
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Fontaine E · 2025 · Current opinion in clinical nutrition and metabolic care
Purpose of review Many clinical trials have failed to demonstrate the superiority of one nutritional protocol over another. This raises questions about the assessment tools used. In particular, intention-to-treat data analysis can mask…
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Shi-gui Yang, Bin Cao, Li-rong Liang et al. · 2012 · PLoS ONE
BACKGROUND: There is limited data on the clinical outcome of patients with pandemic H1N1 (pH1N1) pneumonia who received oseltamivir treatment, especially when the treatment was administered more than 48 hours after symptom onset. METHODS: During the pandemic in 2009, a cohort of pH1N1 influenza pneumonia was built in China, and their clinical information was collected systematically, and analyzed with Cox models. RESULTS: 920 adults and 541 children with pneumonia who didn't receive corticosteroids were analyzed. In-hospital mortality was higher in adults who did not receive antiviral therapy
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Yang G, Milne GL, Nogueira MS et al. · 2026 · International journal of cancer
Despite widespread interest, large randomized controlled trials have failed to demonstrate chemopreventive benefits of antioxidant supplementation, raising concerns about its efficacy and safety. Building on our prior observation of a…
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Samaniego-González E, Podlipnik S, Ribero S et al. · 2026 · Actas dermo-sifiliograficas
Background Management of patients with cutaneous melanoma and positive sentinel lymph node biopsy (SLNB) has shifted toward surveillance rather than complete lymph node dissection (CLND), because CLND has failed to demonstrate a survival…
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Emma T L Cheng, Mohammad Cheik-Hussein, Noelle Lin et al. · 2023 · PLoS ONE
Background Pregabalin is a drug used to treat neuropathic pain, and its use has increased substantially since 2007. Early trials found a strong treatment effect on pain for post-herpetic neuralgia and diabetic neuropathy. However more recent studies have failed to replicate these results. Methods This meta-epidemiological study aimed to assess change in the reported effectiveness of pregabalin in neuropathic pain trials over time, and if a change is present, determine any associated factors. Data sources We performed electronic searches for published trials in Medline, Embase and Cochrane Cent
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M.Ghasemi, Z. Hajheidari, M. Golpour · 2007 · Journal of Mazandaran University of Medical Sciences
AbstractPemphigus Erythematosus specially its localized form is a rare autoimmune blistering disease combining features of Pemphigus Foliaceus and Lupus Erythematosus. We reported a 60 years old woman with skin lesion which presented Erythemato squamo plaque with oozing in the right cheek. The chief compliant was burning and pruritus. Skin biopsy was obtained and discoid Lupus Erythemato was reported. She was prescribed with topical steroid but did not improve. All of the lab tests such as Anti DNA, ESR, RF, CRP, CH50, C3, C4, ANA were normal. The biopsy repeated and Pemphigus Erythematosus wa
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Xavier Jannot, Alpha Oumar Diallo, Judicaelle Didierjean et al. · 2025 · European Journal of Case Reports in Internal Medicine
We report the case of a 75-year-old woman admitted to the emergency department for confusion, gait disturbances and mutism associated with an inflammatory syndrome occurring 3 weeks after acute carbon monoxide intoxication. The main hypothesis upon arrival was infectious meningoencephalitis, and the patient was put on acyclovir and antibiotics in meningeal doses. After a short stay in intensive care, the patient’s condition did not improve, and the revaluation of her case history and imaging studies led to the diagnosis of post-interval syndrome secondary to carbon monoxide intoxication after
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Beck QM, Sachet J, Cargnelli C et al. · 2026 · The Journal of clinical psychiatry
Objectives: Unwanted intrusive thoughts (UITs) of intentional infant-related harm are common among birthing parents. Evidence to date has failed to find any association with physical aggression toward the infant. However, the relationship…
View details →Negative / Null Result ReportOpen accessMedicine
Chaudhari A, Rosenstein ZM, Kamal R et al. · 2026 · Stroke (Hoboken, N.J.)
Background Intracranial atherosclerotic disease is associated with up to 10% of ischemic strokes and a high risk of recurrence. Endovascular treatments including percutaneous transluminal angioplasty and stenting have failed to demonstrate…
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Mazdarani, Miles · 2026 · Veterinary research communications
Cranial cruciate ligament (CCL) rupture is uncommon in cats but may cause persistent stifle instability. Previous ex vivo assessments of tibial plateau levelling osteotomy and tibial tuberosity advancement have failed to restore stability…
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