11,325 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Zanco B, Mirth CK, Sgrò CM et al. · 2026 · npj aging
Dietary restriction may extend lifespan by improving late-life gut health. Because micronutrients mediate the effects of macronutrient ratios on longevity, we examined how cholesterol limitation affects gut health in female Drosophila…
View details →Julie Labrosse, Marie Osdoit, Anne-Sophie Hamy et al. · 2020 · PLoS ONE
Although identified to be at a higher risk of relapse, no consensus exists on the treatment of breast cancer (BC) patients with no pathological complete response after neoadjuvant chemotherapy (NAC). The benefit of adjuvant chemotherapy (ADJ) in this context has scarcely been studied. We evaluated the benefit of administrating adjuvant chemotherapy in a real life cohort of BC patients with invasive residual disease after NAC. 1199 female BC patients with T1-3NxM0 invasive tumors receiving NAC at Institut Curie from 2002 to 2012 were included in the analysis. 1061 had been treated by NAC only,
View details →Yong Xue, Ai Zhao, Li Cai et al. · 2015 · PLoS ONE
OBJECTIVE:To explore the associations between picky eating behaviour and pre-schoolers' growth and development. Corresponding potential mechanisms, such as nutrient and food subgroup intake, as well as micronutrients in the blood, will be considered. METHODS:Picky eating behaviour was present if it was reported by parents. From various areas of China, 937 healthy children of 3-7 years old were recruited using a multi-stage stratified cluster sampling method. Children and their mothers' socio-demographic information and children's anthropometry, intelligence, blood samples, one 24-hour dietary
View details →Amr Almaz Abdel-aziem, Amira Hussin Draz · 2013 · Medicine Science
The purpose of this study was to examine the effect of chronic ankle instability (CAI) on eccentric peak torque of the ankle musculature. The study included fifty participants divided into two groups; the first group consisted of twenty five subjects suffering from CAI, the second group consisted of twenty five subjects with no prior history of ankle injury as control group. Eccentric peak torque of invertors, evertors, plantar-flexors and dorsiflexors was recorded for each participant at angular velocities 30 and 90o/sec by using (Biodex Medical Systems, Inc, Shirley, NY, USA). Analysis of va
View details →XUE Bing, XI Hualei, YAO Lihong, XU Wanqiu, XU Xiaohang, LIN Song, PIAO Guiyan, WANG Xiumei · 2025 · 口腔疾病防治
Objective To investigate the effect of neurite outgrowth inhibitor extracellular peptide residues 1-40 (NEP1-40) combined with poly (lactic-co-glycolic acid) (PLGA) and gelatin electrospun fiber membrane on facial nerve repair in rats. Methods According to the principle of random grouping, 108 male SD rats were divided into four groups ( n = 27 in each group, approved by the ethics committee), namely, the sham group, control group, PLGA group, and NEP1-40 + PLGA group. A facial nerve fracture model was established for all of the groups except for the sham group. The control group received no f
View details →Hulya Colak, Ismail Sert, Yusuf Kurtulmus et al. · 2014 · Saudi Journal of Kidney Diseases and Transplantation
The objective of the study is to evaluate the relationship between serum testos-terone levels and cardiovascular risk factors (CVRF) in patients after kidney transplantation and with chronic kidney disease (CKD). Seventy-five male patients, aged between 18 and 68 years, who had kidney transplantation at least six months earlier, were enrolled into the study. Only renal transplant recipients and CKD patients with a creatinine level of 0.05). Serum testosterone levels were independent risk factors affecting IVC collapse index, systolic BP and LA. m-TORi and CNIs drugs might have no negative effe
View details →Zeyi Deng, Takayuki Uehara, Hiroyuki Maeda et al. · 2014 · PLoS ONE
To investigate the prevalence, genotypes, and prognostic values of Epstein-Barr virus (EBV) and human papillomavirus (HPV) infections in Japanese patients with different types of head and neck cancer (HNC).HPV and EBV DNA, EBV genotypes and LMP-1 variants, and HPV mRNA expression were detected by PCR from fresh-frozen HNC samples. HPV genotypes were determined by direct sequencing, and EBV encoded RNA (EBER) was examined by in situ hybridization.Of the 209 HNC patients, 63 (30.1%) had HPV infection, and HPV-16 was the most common subtype (86.9%). HPV E6/E7 mRNA expression was found in 23 of 60
View details →Fatemeh Samiei Siboni, Zainab Alimoradi, Tahereh Sadegi · 2013 · مجله دانشگاه علوم پزشکی بیرجند
Background and Aim: Life style can cause stress and anxiety and consequently, hypertension. Regarding nurses' influencial role in implementing educational programs to increase patients’ self-control, the present research was designed to study the impact of a lifestyle promoting educational programs on controlling stress, anxiety, depression, and hypertewnsion in Qazvin Mino area in 2010. Materials and Methods: after the present study was a pre/post semi-experimental one conducted on 55 hypertensives. Living in Qazvin Minodar region. DAS (Depression, Anxiety, Stress)-21 general questionnaire an
View details →Yu-Hsuan Wu, Yi-Huei Chen, Ming-Hong Chang et al. · 2018 · PLoS ONE
To evaluate the association between Parkinson's disease (PD) prognosis and the patient's onset of depression.A total of 353 patients with newly-diagnosed PD and a history of depression were enrolled. On the basis of the onset of depression before or after PD diagnosis, we divided participants into PD patients with pre- or post-diagnostic depression. Cox's regression analysis was used to detect risks between the onset of depression and outcomes (including death, accidental injury, dementia, and aspiration pneumonia). The association between the onset of depression and levodopa equivalent dosage
View details →WANG Yibo, HAN Yingdong, XIE Tiange, WU Juan, DI Hong, ZHANG Yun, ZENG Xuejun · 2025 · Jichu yixue yu linchuang
Objective To characterize the clinical features of the group of gout patients to facilitate earlier identification, and optimize the diagnosis and treatment of the condition. Methods The retrospective study analyzed 24 gout patients with shoulder joint(s) involved and consulted by physicians of Peking Union Medical College Hospital from March 2021 to April 2025, while 70 outpatient gout patients matched by clinical course duration and sex were enrolled as control group. Clinical data including medical history, laboratory tests, therapeutic interventions. Prognosis was systematically collected
View details →Dilek Agircan, Ozlem Ethemoglu, Mustafa Calik et al. · 2024 · Haseki Tıp Bülteni
Aim: Previous studies have shown that the cerebrospinal fluid (CSF) protein level correlates with the number of demyelination criteria in electromyography in adult patients with Guillain-Barré syndrome (GBS), which is a potentially life-threatening postinfectious disease. We aimed to assess the association between CSF protein level, inflammatory markers, and electrophysiological values in the diagnosis of pediatric patients to act quickly in treating GBS. Methods: In this cross-sectional study, thirty-nine children with GBS were retrospectively analyzed from the medical records of patients who
View details →Hessling, Martin, Gierke, Anna-Maria, Sicks, Ben et al. · 2022 · GMS Hygiene and Infection Control
Background: The measures implemented against the coronavirus pandemic also led to a sharp decline in influenza infections in the 2020/2021 flu season. In the meantime, however, the number of influenza infections has risen again; it is known from history that influenza viruses can also trigger severe pandemics. Therefore, we investigated the efficacy of ultraviolet radiation in the spectral range of 200–40 for inactivating influenza viruses.Materials and methods: The scientific literature was searched for published ultraviolet (UV) irradiation experiments with influenza viruses and the results
View details →Elif Özdemir, Şeyda Türkölmez · 2020 · Ankara Medical Journal
INTRODUCTION: This study aims to disclose the frequency and clinical significance of incidental prostatic uptake during FDG PET imaging. METHODS: FDG PET images of 1839 male patients undergoing imaging for non-prostate and non-urinary bladder malignancy indications were retrospectively reviewed for the presence of incidental prostatic FDG uptake. Prostatic volume, calcification and the presence and pattern of FDG uptake were evaluated. Further follow-up prostatic evaluation results were comparatively assessed. RESULTS: Incidental prostatic FDG uptake was detected in 41 out of 1839 patients(2.2
View details →J Neves, P J Santos, I Azevedo et al. · 1999 · Acta Médica Portuguesa
Labour is very important in breech presentation and it is associated to significant morbidity and mortality enhancement in recent years. The authors made a retrospective study of breech presentation and labour with this kind of fetal presentation, in Santa Maria Hospital in 1993 and analysed the following data: maternal age, parity, gestational age, the mode of delivery, the fetal weight, the maternal and fetal morbidity and mortality. The authors also reviewed the Literature on the incidence, the most frequent complications and the management in labour to compare with the results of the study
View details →Leela McKinnon, David R Samson, Charles L Nunn et al. · 2022 · PLoS ONE
Sleep duration, quality, and rest-activity pattern-a measure for inferring circadian rhythm-are influenced by multiple factors including access to electricity. Recent findings suggest that the safety and comfort afforded by technology may improve sleep but negatively impact rest-activity stability. According to the circadian entrainment hypothesis, increased access to electric lighting should lead to weaker and less uniform circadian rhythms, measured by stability of rest-activity patterns. Here, we investigate sleep in a Maya community in Guatemala who are in a transitional stage of industria
View details →Philipp Fuelkell, Soenke Langner, Nele Friedrich et al. · 2018 · PLoS ONE
OBJECTIVES:To investigate acoustic noise reduction, image quality and white matter lesion detection rates of cranial magnetic resonance imaging (MRI) scans acquired with and without sequence-based acoustic noise reduction software. MATERIAL AND METHODS:Thirty-one patients, including 18 men and 13 women, with a mean age of 58.3±14.5 years underwent cranial MRI. A fluid-attenuated inversion recovery (FLAIR) sequence was acquired with and without acoustic noise reduction using the Quiet Suite (QS) software (Siemens Healthcare). During data acquisition, peak sound pressure levels were measured wit
View details →Mujda Nooristani, Maxime Maheu, Marie-Soleil Houde et al. · 2019 · PLoS ONE
Noisy galvanic vestibular stimulation (nGVS) has been shown to enhance postural stability during stimulation, and the enhancing effect has been observed to persist for several hours post-stimulation. However, these effects were observed without proper control (sham condition) and the possibility of experimental bias has not been ruled out. The lasting effect of nGVS on postural stability therefore remains in doubt. We investigated the lasting effect of nGVS on postural stability using a control (sham) condition to confirm or infirm the possibility of experimental bias. 28 participants received
View details →Hamide Abbaspour kasgari, Maria Tavakoli Ardakani, Abdollah Farhadinasab · 2019 · Journal of Mazandaran University of Medical Sciences
Background and purpose: Memantine is a medication used to treat moderate to severe Alzheimer’s disease. Memantine targeting the glutamatergic system specifically N-Methyl-D-Aspartate offer a novel approach in treatment of psychiatric disorders such as schizophrenia and schizoaffective disorder. The purpose of this study was to evaluate the efficacy and safety of memantine in combination with antipsychotics in patients with schizophrenia and schizoaffective disorder. Materials and methods: A double-blind, placebo-controlled trial was performed in patients aged 18-65 years old with confirmed dia
View details →Hasan M. Al-Dorzi, Abdulaziz Al-Dawood, Fahad M. Al-Hameed et al. · 2022 · Scientific Reports
Abstract There are contradictory data regarding the effect of intermittent pneumatic compression (IPC) on the incidence of deep-vein thrombosis (DVT) and heart failure (HF) decompensation in critically ill patients. This study evaluated the effect of adjunctive use of IPC on the rate of incident DVT and ventilation-free days among critically ill patients with HF. In this pre-specified secondary analysis of the PREVENT trial (N = 2003), we compared the effect of adjunctive IPC added to pharmacologic thromboprophylaxis (IPC group), with pharmacologic thromboprophylaxis alone (control group) in c
View details →Jae-Hong Kim, Chang-Su Na, Myoung-Rae Cho et al. · 2022 · PLoS ONE
This study aimed to provide preliminary evidence for the efficacy of invasive laser acupuncture (ILA) for chronic non-specific low back pain (CNLBP). This was a single-center, randomized, patient and assessor-blinded, placebo-controlled, parallel-arm, clinical trial with a 1:1:1 allocation ratio that included a full analysis set. Forty-five participants with CNLBP were randomly assigned to the control group (sham laser), 650 group (650 nm-wavelength ILA), or 830 group (830 nm-wavelength ILA) (n = 15/group). All participants received ILA for 10 min, followed by electroacupuncture for 10 min on
View details →Sadan Soyyigit, Onur Baykara, Nur Buyru et al. · 2013 · Medicine Science
Chronic obstructive pulmonary disease (COPD) is a disease which genetic and environmental factors play an important role in COPD development. VDBP (Vitamin D Binding Protein ) gene might be responsible for COPD development. The purpose of this study to investigate the possible effect of VDBP on progression of COPD. We studied VDBP genotypes in 75 COPD patients, 36 smoker healthy subjects and 19 non-smoker healthy subjects with PCR-RFLP method to analyze the association between VDBP and COPD. In our study, the most frequently seen genotype was 1S-2 with a frequency of 32% in COPD group; and 1F-
View details →Joan Hermosura, Everett Lohman, Brenda Bartnik-Olson et al. · 2024 · PLoS ONE
Objectives The main purpose of this research study was to compare mean modified straight-leg raise test (mSLR) and hamstring muscle length (HL) between chronic non-specific low back pain (LBP) and healthy subjects to understand the possibility of neuropathic causes in LBP population as it may impact the diagnosis and treatment of LBP. Another purpose was to compare mean mSLR between those with lumbar nerve root impingement and those without as determine by magnetic resonance imaging (MRI). Methods The design of the study is cross sectional and included 32 subjects with ages ranging from 18-50
View details →Rudhir Jaga, Dinell Behari, Anton P Doubell et al. · 2022 · African Journal of Emergency Medicine
Introduction: Intended for use by prehospital first responders, the Lubo TM cervical collar is an adjustable, radiolucent, single-use device that incorporates a mechanical jaw thrust mechanism. The combination enables non-invasive airway management in cases of trauma where cervical motion restriction is necessary. The potential benefits include use as an airway adjuvant maintaining upper airway patency, reducing provider task loading. The limited research on the device efficacy and safety requires further investigation.Methods: A randomized, crossover, interventional study was performed to com
View details →Bejo Utomo Handayani, Luwih Bisono, Dadik Wahyu Wijaya et al. · 2025 · JAI (Jurnal Anestesiologi Indonesia)
Background: Antiseptics or germicides are chemical compounds used to kill or inhibit the growth of microorganisms on living tissue such as the surface of the skin and mucous membranes. Objective: To determine the comparative effectiveness of povidone iodine 10% antiseptic compared to octenidine hydrochloride 0.1% in neuraxial blockade in patients undergoing surgery at Haji Adam Malik General Hospital, Medan. Methods: This study is an experimental study of the two-group pre-test - post-test study type. This design is a design that groups patients into certain groups that receive different treat
View details →Omar Mustafa, Ebtehal Mohamed, Ahmed Omer et al. · 2022 · Sudan Journal of Medical Sciences
Abstract Background: Tuberculosis (TB) is a major healthcare burden in Sudan and other developing countries, it is considered the second most common cause of death from infectious diseases after those due to AIDS. In Sudan, TB lymphadenitis (TBLA) remains one of the major health problems. This descriptive cross-sectional study was conducted at the University of Medical Sciences and Technology (UMST) and Total Labcare Diagnostic Center (TDC). The study aims to compare the sensitivity of Fine Needle Aspiration Cytology (FNAC) smears with that of the Polymerase Chain Reaction (PCR) for the diagno
View details →Hadi Ghaedi, Siamak Takesh, Ebrahim Banitalebi · 2020 · Journal of Shahrekord University of Medical Sciences
Background and aims: Exercise training is a well-established therapeutic tool for treating type 2 diabetes. The purpose of this study is to examine the beneficial effects of personalized sprint interval training (SIT) and combined aerobic endurance and resistance training (Com) on insulin resistance and glycated hemoglobin A1c (HbA1c) concentration in women with type 2 diabetes. Methods: Fifty-two overweight female type 2 diabetic patients (age 45-60 years and body mass index [BMI] > 30) with HbA1c value of 6.5% or higher and fasting blood glucose (FBG) ≥ 126 mg/dL (7.0 mmol/L) were selected.
View details →Seyed Jalal Hashemi, Hamidreza Shetabi, Shayan Saki et al. · 2018 · مجله دانشکده پزشکی اصفهان
Background: The purpose of this study was to compare the effect of endotracheal intubation in three methods of oral, and nasal with and without the help of Magill forceps, on heart rate and blood pressure in patients undergoing maxillofacial surgery. Methods: In this single-blind randomized clinical trial study, 96 patients who underwent facial and maxillofacial surgery, were randomly divided into three groups of oral, and nasal (with or without the use of Magill forceps) endotracheal intubation. Heart rate and blood pressure were studied in patients before the intubation, and 0, 1, 2, 5, and
View details →Erkal Bilgiç, Orhan Balta, Mehmet Burtaç Eren et al. · 2021 · Journal of Contemporary Medicine
Predictive scoring systems are designed to predict patients' discharge status, patient mortality, Intensive Care Unit(ICU) mortality and lenght of hospital stay. These scoring systems, which are aimed to standardize and form a common language in terms of evaluating patient general health situation, are used in the evaluation of patients in many ICU.In this study, we aimed to evaluate the ability of the scoring systems that can be used to predict the mortality of the patients who will be followed up in the ICU after orthopedic surgery and predict the mortality that occurs in the first year outs
View details →Mohammadreza Zarei, Mozhgan joker, Negin Larti et al. · 2020 · مجله دانشکده پزشکی اصفهان
Background: This study aimed to investigate and compare the characteristics of abdominal pain after bariatric surgery with two techniques of Laparoscopic One-Anastomosis Gastric Bypass (LOAGB) and Laparoscopic Roux-en-Y Gastric Bypass (LRYGB) in patients with morbid obesity. Methods: This prospective descriptive-analytical study was conducted on 114 patients who were candidates for bariatric surgery. Patients were entered to study in one of two groups of LOAGB and LRYGB by convenient and continuous sampling. The characteristics of abdominal pain of patients were investigated and compared at ce
View details →Can Konca, Ali Abbas Yılmaz, Süleyman Utku Çelik et al. · 2018 · Balkan Medical Journal
Background: Staple-line leak is the most frightening complication of laparoscopic sleeve gastrectomy and several predisposing factors such as using improper staple sizes regardless of gastric wall thickness, narrower bougie diameter and ischemia of the staple line are asserted. Aims: To evaluate the effects of different bougie diameters on tissue oxygen partial pressure at the esophagogastric junction after sleeve gastrectomy. Study Design: A randomized and controlled animal experiment with 1:1:1:1 allocation ratio. Methods: Thirty-two male Wistar Albino rats were randomly divided into 4 group
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