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Browse the failure-mode index

11,325 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Healing Integrity Determines Meniscal Extrusion After Isolated Medial Meniscus Posterior Root Repair in Knees With No Lower Limb Malalignment.

Kim JS, Hwang UJ, Woo CW et al. · 2026 · Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association

Purpose To investigate changes in meniscal extrusion and meniscal healing status following root repair, and the relationship between meniscal extrusion and healing conditions. Methods Patients who underwent isolated root repair between…

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Negative / Null Result ReportOpen accessMedicine

Evaluating poultry by-product meal, tomato pomace, and azolla with or without Natuzyme supplementation as sustainable alternatives to fish meal for Nile tilapia (Oreochromis niloticus).

Kamel AM, Mahmoud MM, Ibrahim MT et al. · 2026 · Tropical animal health and production

Several studies have predicted that developing countries will be unable to afford fish meal as a primary aquafeed protein source in the future. This experiment evaluated the effect of replacing fish meal (FM) with poultry by-product meal…

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Negative / Null Result ReportOpen accessMedicine

Monitoring the Adverse Implications of Coronavirus 2019-induced Pulmonary Complications on Patients' Respiratory Capacity and Physical Abilities with Moderate and Severe Signs during Interval Follow-up.

Aali F, Habibi Z, Aali F et al. · 2026 · Journal of medical signals and sensors

Background The respiratory system of individuals with coronavirus 2019 (COVID-19) experiences significant strain due to the body's immunological response and inflammation, leading to organ failure. Over time, patients have improvement in…

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Negative / Null Result ReportOpen accessMedicine

Endometrial HOXA-10, HOXA-11, ß-1 integrin, ECM-1, FAK, and CD44 immunohistochemical expressions in endometriosis-related recurrent IVF failure: a retrospective case-control study.

Toruk EŞ, Kaplan EA, Sarıbaş GS et al. · 2026 · Journal of ovarian research

BACKGROUND: Endometriosis is a common cause of infertility and is frequently associated with recurrent implantation failure in assisted reproductive technologies. Impaired endometrial receptivity, mediated by altered transcription factors,…

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Negative / Null Result ReportOpen accessMedicine

Efficacy of Normobaric High-Flow Oxygen Therapy Combined with Low Molecular Weight Heparin in the Management of Fetal Growth Restriction: A Prospective Cohort Study.

He M, Zhao K, Wei Q et al. · 2026 · International journal of women's health

Objective This study investigated the clinical efficacy of adding normobaric high-flow oxygen therapy (NHFOT) to low molecular weight heparin (LMWH) and standard supportive care for the management of the present FGR cohort, idiopathic…

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Negative / Null Result ReportMedicine

Single antiplatelet therapy vs oral anticoagulation monotherapy in patients with atrial fibrillation and coronary artery disease after successful catheter ablation: A target trial emulation.

Li F, Zhao Y, Peng X et al. · 2026 · Heart rhythm

Background The optimal long-term antithrombotic strategy in patients with atrial fibrillation (AF) and coronary artery disease (CAD) after successful catheter ablation (CA) remains uncertain. Objective This study aimed to compare the…

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Negative / Null Result ReportOpen accessMedicine

Evaluating the Effectiveness of Age Simulation Gloves.

Lüleci EH, Kedgley AE · 2026 · Human factors

ObjectiveThis study evaluated the effectiveness of age simulation gloves in replicating age-related declines in hand function.BackgroundCommercially available age simulation gloves are increasingly used. However, their ability to replicate…

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Negative / Null Result ReportOpen accessMedicine

A comparative analysis of the performance of leading large language models on the endodontics section of the dentistry specialization exam in Türkiye.

Başkan B, Başkan HK, Koç N · 2026 · PloS one

Objective This study aimed to evaluate and compare the performance of eight contemporary LLMs on the endodontics section of the DUS, assessing their accuracy in both theoretical knowledge and simulated clinical scenarios from historical…

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Negative / Null Result ReportMedicine

Artificial intelligence-generated patient information on shoulder instability remains suboptimal: DeepSeek outperforms ChatGPT in completeness of content while ChatGPT is more readable.

Öğümsöğütlü E, Bozgeyik B, Huri G · 2026 · Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA

Purpose This study aimed to evaluate and compare the performance of the Chat Generative Pre-Trained Transformer (ChatGPT) and DeepSeek artificial intelligence (AI) models for patient information on shoulder instability. Methods Sixteen…

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Negative / Null Result ReportOpen accessMedicine

Vitamin D receptor gene polymorphism and its association with the susceptibility to Helicobacter pylori infection in the Egyptian population with hepatocellular carcinoma.

Ibrahim A, Abdelhady SA, Rageh F et al. · 2026 · BMC gastroenterology

OBJECTIVE: This study aimed to estimate the frequency of H. pylori infection in patients with liver disorders, and identify the relationship between vitamin D receptor gene variants and susceptibility to H. pylori infections and HCC in…

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Negative / Null Result ReportOpen accessMedicine

CBCT in Evaluation of Root Canal Preparation-A Scoping Review.

Vidal A, Teles AM, Cardoso M et al. · 2026 · Dentistry journal

Cone-beam computed tomography (CBCT) is widely utilized in endodontics for evaluating root canal shaping outcomes, offering critical three-dimensional imaging capabilities. This study aims to assess the differences in apical and root canal…

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Negative / Null Result ReportMedicine

Postoperative antibiotic prophylaxis following cardiac implantable electronic device implantation and the risk of device infection.

Mandler I, Krutik T, Biham O et al. · 2026 · Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing

BACKGROUND AND AIMS: Cardiac implantable electronic devices (CIEDs) are essential for the management of cardiac arrhythmias. Device infection is one of the most dismal complications of CIED implantation. The aim of this study is to assess…

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Negative / Null Result ReportOpen accessMedicine

Are Skip Laminectomy and Oblique Corpectomy Effective Options to Treat Degenerative Cervical Myelopathy While Preserving Motion? Results of a Scoping Review.

Lomax JL, Mehta A, Vedantam A et al. · 2026 · Global spine journal

Study DesignScoping Literature Review.ObjectiveThe aim of this literature review is to examine the results of both skip laminectomy and oblique corpectomy in the setting of degenerative cervical myelopathy (DCM).MethodsA scoping review of…

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Negative / Null Result ReportOpen accessMedicine

Health-related quality of life scores of ultralow rectal cancer patients after conformal sphincter preservation operation compared to newly derived preoperative EORTC QLQ-C30, CR38 reference values and EORTC QLQ-C30 norm.

Ding HB, Sun G, Yu GY et al. · 2026 · Frontiers in oncology

Background Postoperative quality of life (Post-QoL) is the key to measuring the effectiveness of sphincter-preserving operation such as Conformal sphincter preservation operation (CSPO) for ultralow rectal cancer. This study aimed to…

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Negative / Null Result ReportMedicine

Correlation Between Morphology of Reinke's Edema and Disease Regression After Office-Based Laser Therapy and Steroid Injection.

Hamdan AL, Abou Raji Feghali P, Lababidi G et al. · 2026 · Journal of voice : official journal of the Voice Foundation

Objective To investigate the association between the morphology and the severity of Reinke's edema (RE) and disease regression following office-based blue laser therapy (OBLT) and steroid injection. Study design Retrospective Review…

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Negative / Null Result ReportOpen accessMedicine

Retrograde Intrarenal Renal Surgery versus Supine Mini Percutaneous Nephrolithotripsy in Treatment of Renal Pelvic Stones Less than 2 cm, Randomized Clinical Study.

Abdelgawad AH, Elhawy MA, Hussein AAHF et al. · 2026 · Urology research & practice

Objective Retrograde intrarenal surgery (RIRS) is the first-line treatment for kidney stones between 1 and 2 cm and can serve as an alternative to percutaneous nephrolithotomy for larger stones in high-risk patients, including those with…

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Negative / Null Result ReportOpen accessMedicine

Protein Creatinine ratio versus 24-h test in HIV-positive and HIV-negative women with pre-eclampsia.

Mkhize SF, Moodley J, Khaliq OP et al. · 2026 · South African family practice : official journal of the South African Academy of Family Practice/Primary Care

Background Pre-eclampsia (PE) is a major contributing factor to high rates of maternal and perinatal morbidity and mortality in South Africa. Early diagnosis is currently a challenge. The objective is to assess the diagnostic accuracy of…

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Negative / Null Result ReportMedicine

Low-Dose Aspirin is Not Associated with Increased Risk of Postpartum Hemorrhage.

Ali M, Higginbotham A, Sabri E et al. · 2026 · Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC

Objectives Aspirin (ASA) is recommended for preeclampsia prophylaxis, but it is uncertain whether higher doses, such as the 150 mg/day used in the ASPRE trial, increase the risk of postpartum hemorrhage (PPH). In Canada, the available…

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