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Browse the failure-mode index

11,325 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Effect of baseline characteristics on mortality in the SURVIVE trial on the effect of levosimendan vs dobutamine in acute heart failure: Sub-analysis of the Finnish patients.

M. Kivikko, P. Pollesello, Tuukka Tarvasmäki et al. · 2016 · International Journal of Cardiology

BACKGROUND In the SURVIVE trial, including 1327 acute heart failure patients, no statistically significant difference between levosimendan and dobutamine in the 180-day all-cause mortality was seen. Country-specific differences in outcome…

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Negative / Null Result ReportOpen accessMedicine

Grading angiogenesis in oral squamous cell carcinoma: a histomorphometric study.

V. Wadhwan, Preeti Sharma, Chitrapriya Saxena et al. · 2015 · Indian Journal of Dental Research

CONTEXT Like normal tissues, tumors require an adequate supply of oxygen, metabolites and an effective way to remove waste products. This is achieved by angiogenesis, which is defined as the process by which new blood vessels are produced…

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Negative / Null Result ReportOpen accessMedicine

Successful weight loss maintenance in relation to method of weight loss

Angela Marinilli Pinto, A. A. Gorin, Hollie A Raynor et al. · 2008 · Obesity

This study examined the relation between method of weight loss and long‐term maintenance among successful weight losers enrolled in a weight‐loss maintenance trial. Participants were 186 adults (mean age = 51.6 ± 10.7 years, mean BMI =…

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Negative / Null Result ReportMedicine

Comparative Pathologic Analysis of Breast Cancers Classified as HER2/neu-Amplified by FISH Using a Standard HER2/CEP17 Dual Probe and an Alternative Chromosome 17 Control Probe

Somaye Y. Zare, Leo I. Lin, Abrar Alghamdi et al. · 2018 · American Journal of Surgical Pathology

At our institution, breast cancer cases that generate an equivocal HER2/neu (HER2) result by fluorescence in situ hybridization (FISH) using the dual HER2/chromosome enumeration probe (CEP17) are reflexed to an assay that utilizes an…

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Negative / Null Result ReportMedicine

Accuracy comparison of 3D printed tooth-supported implant surgical guides: A prospective observational clinical study.

A. Rezaei, Farnoush Fotovat, Ali Heidari et al. · 2026 · The Journal of prosthetic dentistry (Print)

STATEMENT OF PROBLEM Implant-supported prostheses provide a reliable method of replacing missing teeth. To avoid complications, their accurate placement is critical. Advances in static computer-aided implant surgery (sCAIS), which uses…

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Negative / Null Result ReportMedicine

Impact of Moderate‐Intensity Multicomponent Training on Cardiometabolic Health‐Related Outcomes in Older Adults With Overweight and Obesity: A 9‐Month Quasi‐Experimental Single‐Arm Pretest‐Posttest Study

Enzo Berbery, Vitor de Salles Painelli, Paulo Vitor Suto Aizava et al. · 2026 · Australasian Journal on Ageing

ABSTRACT Objective The aim of this study was to investigate the effects of a moderate‐intensity multicomponent training (MCT) program on body composition, physical function, glycaemic control and lipid profiles in overweight and obese…

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Negative / Null Result ReportOpen accessMedicine

Perbandingan Pemberian Informasi Verbal dengan Presentasi Video Terhadap Pengetahuan Prosedur Anestesi Umum pada Pasien yang Akan Menjalani Operasi di RSUP DR Hasan Sadikin Bandung

Yodi Suryo Arnanto, Ruli Herman Sitanggang, Nurita Dian Kestriani Saragi Sitio · 2018 · Jurnal Anestesi Perioperatif

Informasi mengenai indikasi, tujuan, prosedur, risiko, manfaat, dan alternatif tindakan anestesi yang akan dilakukan harus disampaikan kepada pasien. Pemberian informasi dilakukan secara verbal atau lisan pada saat proses persetujuan…

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Negative / Null Result ReportOpen accessMedicine

The effect of photobiomodulation on histamine and Mucuna pruriens-induced pruritus, hyperknesis and alloknesis in healthy volunteers: A double-blind, randomized, sham-controlled study

K. Lang-Illievich, C. Klivinyi, Heike Schulze-Bauer et al. · 2024 · PLoS ONE

Background Photobiomodulation, also referred to as Low-Level Light Therapy (LLLT), has emerged as a promising intervention for pruritus, a prevalent and often distressing symptom. Objectives This study investigated the efficacy of…

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Negative / Null Result ReportOpen accessMedicine

Repeatability of Pentacam-derived intraocular lens decentration measurements and the level of agreement with OPD-Scan III: A prospective observational case series

Xiaobao Liu, Wenjie Wu, Yulong Huang et al. · 2024 · PLoS ONE

Purpose This study aimed to assess the repeatability of intraocular lens (IOL) decentration measurements obtained through Pentacam, based on corneal topographic axis (CTA) and pupillary axis (PA), and to evaluate the level of agreement…

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Negative / Null Result ReportOpen accessMedicine

Posterior Tracheopexy for Severe Tracheomalacia Associated with Esophageal Atresia (EA): Primary Treatment at the Time of Initial EA Repair versus Secondary Treatment

H. Shieh, C. Smithers, Thomas E. Hamilton et al. · 2018 · Frontiers in Surgery

Purpose We review outcomes of posterior tracheopexy for tracheomalacia in esophageal atresia (EA) patients, comparing primary treatment at the time of initial EA repair versus secondary treatment. Methods All EA patients who underwent…

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Negative / Null Result ReportOpen accessMedicine

Physical Activity and Sedentary Behavior in Children With Congenital Heart Disease

C. Voss, S. Duncombe, Paige H. Dean et al. · 2017 · Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease

Background Children with congenital heart disease (CHD) are thought to have low levels of physical activity (PA), but few studies have used objective measures of PA in this population. Methods and Results We recruited patients with mild,…

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Negative / Null Result ReportMedicine

Study on Normal Laryngeal Electromyography of Thyroarytenoid Muscle, Cricothyroid Muscle, and Posterior Cricoarytenoid Muscle

Xinlin Xu, Pan Yang, P. Zhuang et al. · 2018 · Annals of Otology, Rhinology and Laryngology

Objective: The aim of this study was to investigate the physiological activity of intrinsic laryngeal muscle under different functional states of larynx by measuring the normal laryngeal electromyography parameters. Methods: Laryngeal…

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Negative / Null Result ReportOpen accessMedicine

GlideScope® versus C-MAC®(D) videolaryngoscope versus Macintosh laryngoscope for double lumen endotracheal intubation in patients with predicted normal airways: a randomized, controlled, prospective trial

P. Huang, Renlong Zhou, Zhi-juan Lu et al. · 2020 · BMC Anesthesiology

Background The double lumen endotracheal tube (DLT) is the most widely-used device for single lung ventilation in current thoracic anesthesia practice. In recent years, the routine application of the videolaryngoscope for single lumen…

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Negative / Null Result ReportOpen accessMedicine

Discrepancies between leg-to-leg bioelectrical Impedance analysis and computerized tomography in abdominal visceral fat measurement

Hsueh-Kuan Lu, Yu-Ywan Chen, Chin-Jung Yeh et al. · 2017 · Scientific Reports

The aim of this study was to evaluate leg-to-leg bioelectrical impedance analysis (LBIA) using a four-contact electrode system for measuring abdominal visceral fat area (VFA). The present study recruited 381 (240 male and 141 female)…

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Negative / Null Result ReportOpen accessMedicine

Comparison of corneal changes after phacoemulsification using BSS Plus versus Lactated Ringer's irrigating solution: a prospective randomised trial

D. R. Lucena, M. S. Ribeiro, A. Messias et al. · 2010 · British Journal of Ophthalmology

Background/aims To compare two intraocular irrigating solutions, Balanced Salt Solution Plus (BSS Plus) versus Lactated Ringer's (Ringer), for the preservation of corneal integrity after phacoemulsification. Methods 110 patients undergoing…

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Negative / Null Result ReportMedicine

Repeatability and comparability of a new swept-source optical coherence tomographer in optical biometry.

C. E. Monera Lucas, J. Escolano Serrano, C. T. Tarazona Jaimes et al. · 2022 · Archivos de la Sociedad Española de Oftalmología

PURPOSE To evaluate the reproducibility in the measurement of ocular biometric parameters using a new swept-source optical coherence tomographer and its comparability with an optical low coherence reflectometry biometer. DESIGN An…

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Negative / Null Result ReportOpen accessMedicine

Early stage adrenocortical carcinoma—what contributes to poor prognosis after adrenalectomy? A retrospective cohort study

Douk Kwon, C. Rah, Byung-Chang Kim et al. · 2024 · Annals of Surgical Treatment and Research

Purpose Adrenocortical carcinoma (ACC) is a rare primary carcinoma originating in the adrenal gland with a poor prognosis and a high recurrence rate. This study evaluated the risk factors associated with recurrence in patients with early…

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