11,324 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Chen, Ma, Zhang · 2026 · Accident; analysis and prevention
Automated vehicles (AVs) are designed to improve traffic safety, mobility, and driver comfort; however, their benefits depend on the widespread adoption of AVs. As full market penetration remains unlikely in the near term, AVs will…
View details →Atef Abdelsattar Ibrahim, Gouda Kamal, Zid et al. · 2026 · World journal of clinical pediatrics
Obesity and overweight are major public health challenges and are associated with autonomic imbalance and decreased heart rate variability (HRV), a non-invasive indicator of cardiovascular risk. Omega-3 polyunsaturated fatty acids have…
View details →Ahmed, AbuMostafa · 2026 · Scientific reports
This investigation sought to evaluate the comparative influence of different irrigation activation protocols-ultrasonic, sonic, XP-Endo Finisher, and manual dynamic activation (MDA)-on the nanohardness, elastic modulus, flexural strength,…
View details →Zhan, Hao, Li et al. · 2026 · Frontiers in medicine
Currently, there are few reports on the impact of preoperative anticoagulant administration on perioperative coagulation function and blood loss. Therefore, this study observed the effects of preoperative anticoagulant administration on…
View details →Qin, Liu, Cheng et al. · 2026 · Ecology letters
Although habitat area and isolation are considered key factors influencing plant disease and herbivory, their specific mechanisms remain underexplored within island biogeography. We investigated the direct and indirect effects (via…
View details →Genel, Alzarouni, Mirza et al. · 2026 · Neuro-oncology advances
Recent evidence has demonstrated a tight relationship between neuronal activity and glioblastoma (GBM) growth, involving novel mechanisms such as neuron-glioma synapses and tumor microtube networks. Seizure activity and antiepileptic drug…
View details →Da Silva Souza, De Souza, Dos Santos et al. · 2026 · Frontiers in public health
Children with low motor coordination tend to engage in less physical activity. They are more likely to gain weight, establishing a bidirectional relationship, as weight gain may further restrict their participation in physical activity.…
View details →Liang, Zhu, Han et al. · 2026 · Zhongguo shi yan xue ye xue za zhi
To explore the effect of body mass index (BMI) on the efficiency of hematopoietic stem cell (HSC) mobilization. A retrospective analysis was conducted on the clinical data of 158 healthy donors who underwent peripheral blood HSC…
View details →Cummings, Hodges, Theodore · 2026 · Psychonomic bulletin & review
Listeners can use lexical information to accommodate ambiguity in speech input. Some evidence suggests that lexically guided perceptual learning persists over time. However, other evidence suggests that lexically guided perceptual learning…
View details →Schwarz, Watzenboeck, Stuempflen et al. · 2026 · European radiology
Prenatal alcohol exposure (PAE) of the fetus may result in physiognomic alterations and/or impediment of cognitive development, summarized as fetal alcohol spectrum disorders (FASDs). Although alcohol is metabolized in the liver, the…
View details →Razmeh, Karimi, Dashti et al. · 2026 · Journal of neurology
Hypoxic ischemic encephalopathy (HIE) is a severe brain injury that can lead to death and long-term disability. HIE can be treated with therapeutic hypothermia, and various adjuvant treatments (such as melatonin) are also utilized.…
View details →van Amstel, Simons, Kooreman et al. · 2026 · Breast (Edinburgh, Scotland)
In clinically node-positive (cN+) patients, radioactive iodine ( 125 I) seeds can be considered to mark metastatic axillary lymph nodes before neoadjuvant therapy (MARI-procedure) but potential therapeutic effects remain unclear. This…
View details →Yıldız, Top, Yıldız et al. · 2026 · Mediterranean journal of hematology and infectious diseases
Stenotrophomonas maltophilia ( S. maltophilia ) is a multidrug-resistant pathogen frequently isolated in hospital-acquired pneumonia and represents a significant clinical challenge. This study aimed to investigate the risk factors…
View details →Timothee, Bliss, Blumenthal et al. · 2026 · Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
The primary objective is to determine whether patients undergoing osseous microvascular free flap reconstruction of head and neck defects have higher inpatient pain requirements than those undergoing nonosseous reconstruction. Secondary…
View details →Kacar, Ayaz-Alkaya · 2026 · Journal of pediatric nursing
Internet addiction is a growing problem among children and adolescents. Pathological internet use may lead to psychological and social issues. More effective and innovative interventions are needed to promote the mental health of children.…
View details →Lopes, Costa, Nociti Junior et al. · 2026 · Brazilian oral research
This study investigated the effects of incorporating 3wt% titanium dioxide nanotubes (nTiO2) into calcium hydroxide [Ca(OH)2]-based intracanal medicament (ICM) formulations on the proliferation, viability, and mitochondrial metabolic…
View details →Linke, Mayer, Suttkus et al. · 2026 · Pediatric research
This study examined parental stress indicators during outpatient pediatric surgery and whether intraoperative text messaging could alleviate stress. This randomized trial assigned parents of children aged 6 months to 6 years undergoing…
View details →Melnikova · 2025 · Bulletin of experimental biology and medicine
Using in vivo microscopy, changes in the diameter of pial arterial microvessels were studied in rats with modeled moderate acute blood loss followed by whole-body cooling against the background of a single administration of tranexamic acid…
View details →Nazki, Tennakoon, Reddy et al. · 2026 · The Journal of general virology
Infectious bursal disease virus (IBDV) causes an endemic immunosuppressive disease in chickens. Prior exposure to IBDV influences the pathogenesis and shedding of chicken strains of influenza A virus (IAV), but its effect on waterfowl…
View details →Tuncekin, Toprak · 2026 · Iranian journal of immunology : IJI
Rheumatoid arthritis (RA) and ankylosing spondylitis (AS) are chronic autoimmune inflammatory disorders in which TNF-α plays a key role. Anti-TNF agents are widely used in the management of these diseases. Since TNF-α is also…
View details →Xu, Hu, Zhao et al. · 2026 · Obesity (Silver Spring, Md.)
HDM1002, a small-molecule agonist of glucagon-like peptide-1 receptors, was evaluated for safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD). Chinese participants (18-60 years) with…
View details →Shen, Yan, Yan et al. · 2026 · Journal of environmental sciences (China)
Diazotrophs play a crucial role within the rhizosphere by fixing atmospheric nitrogen and promoting plant growth. However, the diversity of diazotrophic communities and the influences of human activity are largely unclear. This study…
View details →Uludag, Uludag · 2026 · Current medicinal chemistry
Recently, there has been growing interest in the roles of vitamin D and certain platelet characteristics, such as mean platelet volume (MPV). However, the influence of vitamin D levels on these platelet traits is still under discussion.…
View details →Estaji, Ahmadizadeh · 2026 · Journal of psychiatric research
Based on neurocognitive models, the development and maintenance of post-traumatic stress disorder (PTSD) are correlated with cognitive biases, including attention and memory biases, which are associated with imbalanced activation of…
View details →Cazalis-Henry, Seuront, Spilmont · 2026 · Biology letters
Brown macroalgae like Fucus serratus are key ecosystem engineers in intertidal environments and are increasingly threatened by anthropogenic pollution and global change. This study examined how the combined effects of conventional and…
View details →Grub, Naab · 2026 · Digital health
To examine user perceptions of human advisors versus chatbots in mental health apps and assess the impact of algorithm literacy interventions. In an online experiment, participants engaged in simulated chats about digital stress. A…
View details →Maureen, Budiardjo, Wahono · 2026 · Journal of the Indian Society of Pedodontics and Preventive Dentistry
Down syndrome is a genetic condition caused by trisomy 21, often accompanied by orofacial hypotonia and anomalies in stomatognathic development. A hypotonic tongue may alter oral cavity morphology, particularly palatal depth, anterior…
View details →Goh, Sud, Chau et al. · 2026 · Medicina (Kaunas, Lithuania)
Background and Objectives : Renin-angiotensin system inhibitors (RASIs) are recommended to preserve residual kidney function (RKF) in patients on peritoneal dialysis (PD); however, evidence of benefit is inconsistent. This study evaluated…
View details →Ptáček, Musil, Guarnieri et al. · 2026 · International journal of molecular sciences
Amyotrophic lateral sclerosis (ALS) is a common neurodegenerative disorder; to date, there is no long-term effective treatment. Recently, a relationship has been discovered between the human intestinal microbiome and the pathogenesis of…
View details →Deng, Xiang, Li et al. · 2026 · Animals : an open access journal from MDPI
Due to the lack of corn and soybean meal in animal feeding, rice bran meal (RBM) has been proposed as a beneficial substitute for these feedstocks' ingredients. Its fermentation by using diverse microbes has been adopted as a beneficial…
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