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Browse the failure-mode index

11,324 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Clinical Strategies to Improve the Accuracy of Articulating Paper for Detecting Occlusal Contact Points in Adults with Natural Dentitions.

Rovira-Lastra, ElOtmani-Sabiri, Ustrell-Barral et al. · 2026 · Diagnostics (Basel, Switzerland)

Background/Objectives : This clinical study assessed the validity of articulating paper for detecting occlusal contacts points, including examining the effects of clinical technique, paper thickness, and the arch. Methods : This…

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Negative / Null Result ReportMedicine

Upper Arm to Upper Leg Length Ratio and Dyslipidemia: A Novel Application of a Fixed Skeletal Proportion Metric in a Nationally Representative U.S. Sample.

Ahmed, Nath, Jahan et al. · 2026 · International journal of environmental research and public health

Conventional anthropometric measures used to predict dyslipidemia, such as body mass index and waist circumference, vary over time and may not fully capture early-life influences on metabolic risk. Fixed skeletal proportions, including…

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Negative / Null Result ReportMedicine

Low-Volume Versus Standard-Volume Pericapsular Nerve Group Block with and Without Dexamethasone for Postoperative Analgesia After Total Hip Arthroplasty: A Randomized Controlled Trial.

Reysner, Ciftci, Alver et al. · 2026 · Journal of clinical medicine

Background: The pericapsular nerve group block provides motor-sparing analgesia after total hip arthroplasty, but the optimal injectate volume and the role of dexamethasone remain unclear. Methods: In this prospective, randomized,…

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Negative / Null Result ReportMedicine

Hope for Romantic Relationships: Validation of a Brief Scale.

Marici, Marina, Cormoș · 2026 · Behavioral sciences (Basel, Switzerland)

This study aimed to develop and validate a brief measure of hope for romantic relationships (HRR), conceptualized as a future-oriented evaluation of relational continuity and quality. The sample consisted of 525 participants. Exploratory…

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Negative / Null Result ReportMedicine

The Effect of Acupressure on Procedural Pain, Anxiety, and Hemodynamic Parameters During Chest Tube Removal in Open-Heart Surgery Patients: A Randomized Sham-Controlled Study.

Kandemir, Yüksel, Çam Yanık et al. · 2026 · Pain management nursing : official journal of the American Society of Pain Management Nurses

Patients undergoing open-heart surgery often experience procedural pain and anxiety during chest tube removal (CTR), which can lead to serious complications, along with potential changes in hemodynamic parameters such as blood pressure,…

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Negative / Null Result ReportMedicine

Effects of Tele-Pilates Exercise on Menopausal and Urogenital Symptoms and Psychosocial Outcomes in Postmenopausal Women: A Randomized Controlled Trial.

Arslan, Tufekci, Acar et al. · 2026 · International urogynecology journal

This study aimed to examine the effects of tele-Pilates exercise on menopausal symptoms, quality of life, depression, and anxiety levels in postmenopausal women. Forty postmenopausal women were separated into two groups: as tele-Pilates…

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Negative / Null Result ReportMedicine

Characterizing the nasal microbiome using a nasal allergen challenge model.

Linton, Sjaarda, Hossenbaccus et al. · 2026 · The Journal of allergy and clinical immunology

The role of the nasal microbiome in allergic rhinitis (AR), particularly following direct allergen exposure using a controlled model, is incompletely understood. Understanding microbiome dynamics after allergen challenge could provide…

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Negative / Null Result ReportMedicine

Three-Season Analysis of Physical Performance in Professional English Football: Influence of Match Outcome, Match Location, and Players' Position During Official Competitions.

Beato, Allen, Jamil et al. · 2026 · Journal of strength and conditioning research

Beato, M, Allen, M, Jamil, M, and Vicens Bordas, J. Three-season analysis of physical performance in professional English football: Influence of match outcome, match location, and players' position during official competitions. J Strength…

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Negative / Null Result ReportMedicine

Systemic Inflammatory and Hematologic Biomarkers in Pediatric Dental Caries: Clear Group Differences with Limited Independent Association with DMFT.

Petrache, Boldeanu, Diaconu et al. · 2026 · Journal of clinical medicine

Background: Dental caries in children has been explored not only as a local oral condition but also in relation to potential systemic inflammatory changes. This study evaluated systemic inflammatory biomarkers and hematologic indices in…

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Negative / Null Result ReportMedicine

Efficacy of a 10-MDP-Containing Cleaner on the Bond Strength to Saliva Contaminated Dentin.

Hayashi-Wells, Phark, Duarte · 2026 · Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.]

To evaluate the effect of saliva contamination and a 10-MDP-containing cleaner (Katana Cleaner; Kuraray Noritake, Japan) on the shear bond strength (SBS) of an ultra-mild universal adhesive applied in self-etch mode to human dentin.…

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Negative / Null Result ReportMedicine

Surgical strategy and prognostic factors in very elderly (≥ 75 Years) patients with stage I NSCLC: insights from a propensity score-matched analysis.

Lee, Chao, Shen et al. · 2026 · BMC pulmonary medicine

BACKGROUND: The optimal surgical strategy for very elderly patients (≥ 75 years) with stage I non–small cell lung cancer (NSCLC) remains uncertain. METHODS: We retrospectively analyzed 390 patients with pathologic…

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Negative / Null Result ReportMedicine

Impact of the risk-treatment paradox on in-hospital and long-term outcomes in patients with very high-risk non-ST-elevation acute coronary syndrome.

Nesova, Vorobeva, Ryabov · 2026 · The Indian journal of medical research

Background and objectives The risk-treatment paradox (RTP) has not been studied in very high-risk patients with non-ST-elevation acute coronary syndrome (NSTE-ACS). We aimed to describe the cohort of very high-risk NSTE-ACS patients,…

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Negative / Null Result ReportMedicine

Adjuvant capecitabine in women with triple-negative breast cancer with residual disease after carboplatin-containing neoadjuvant chemotherapy.

Tavares, Ramalho, da Silva et al. · 2026 · Breast cancer research and treatment

Triple-negative breast cancer (TNBC) is an aggressive subtype characterized by early relapse and limited therapeutic options. Carboplatin added to anthracycline/taxane neoadjuvant chemotherapy (NACT) raises pathologic complete response…

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Negative / Null Result ReportMedicine

Investigating the necessity of preoperative coronary angiography for infection-related cardiac implantable electronic device explantation.

Caldonazo, Scheler, Fischer et al. · 2026 · American heart journal plus : cardiology research and practice

Device-associated endocarditis is a potentially life-threatening condition that typically requires the removal of the cardiac implantable electronic device (CIED). The role of routine coronary angiography (CAG) as part of preoperative…

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Negative / Null Result ReportMedicine

The efficacy of acetic acid and citric acid on calcium silicate based cement removal from root canals and their effect on dentine structure - an in vitro study.

Alzraikat, Al-Hiyasat, Jamous et al. · 2026 · Biomaterial investigations in dentistry

This study evaluated the effectiveness of acids on calcium silicate cement surface hardness, perforation, and their impact on root dentine microstructure. Root dentine discs were exposed to hydrochloric, acetic, and citric acids. Fourier…

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