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Browse the failure-mode index

11,324 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Laboratory evaluation of mixed-species biofilm formation by Streptococcus mutans and Lactobacillus casei on three dental resin-based restorative materials.

Conner, AbdulAzees, Chen et al. · 2026 · American journal of dentistry

To evaluate the biofilm-forming potential of mixed-species bacteria on three commercially available dental restorative composites and compare their resistance to biofilm accumulation. Given the increasing emphasis on bioactive and…

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Negative / Null Result ReportMedicine

Management of Rope Friction Injuries of the Hand.

Evin, Parlak, Okan et al. · 2026 · Annals of plastic surgery

Rope friction injuries result from rapid, repetitive contact with coarse ropes or chains, causing combined mechanical and thermal damage. These injuries commonly affect young individuals during activities such as tug-of-war, climbing, air…

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Negative / Null Result ReportMedicine

Profile of deliberate self-poisoning admissions in KwaZulu-Natal Province, South Africa (2018 - 2023) and the impact of COVID-19.

Pillay · 2026 · South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde

Deliberate self-poisoning (DSP) is a common method of attempted suicide globally, particularly among young adults and women. In South Africa (SA), DSP is the second most frequent method of attempted suicide, after hanging. The COVID-19…

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Negative / Null Result ReportMedicine

Sensory Organization and Postural Control Strategies During Quiet Standing in People with Acute Low Back Pain: A Case-Control Study.

Fatehi Peykani, Saadat, Monjezi et al. · 2026 · The archives of bone and joint surgery

This study aimed to compare posturographic measures between acute low back pain patients (LBP) and healthy controls. A total of 20 participants with acute LBP were compared with a group of matched, healthy participants. Sensory…

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Negative / Null Result ReportMedicine

First Covid-19 Vaccination Rates Among Pregnant Tennessee Women by Month of Conception and Urbanization Level: March 2021 - November 2021.

Valenzuela, Driscoll, Harvey et al. · 2026 · Journal of Appalachian health

Throughout the pandemic, COVID-19 vaccination coverage was lower for the general population living in rural counties than in urban counties. In Tennessee (TN), COVID-19 vaccinations became available to pregnant women in March 2021. Little…

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Negative / Null Result ReportMedicine

MRI Evaluation of Graft Remodeling After Transphyseal Anterior Cruciate Ligament Reconstruction in Pediatric Patients: A 5-Year Follow-up.

de Pesters, Staali, Laval et al. · 2026 · Orthopaedic journal of sports medicine

Anterior cruciate ligament (ACL) reconstruction (ACLR) is increasingly performed in children and adolescents, yet mid- to long-term graft ligamentization remains poorly understood. To characterize the magnetic resonance imaging (MRI)…

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Negative / Null Result ReportMedicine

VR preoperative education with sensory information alleviates perioperative anxiety and enhances delivery experience in primiparas undergoing cesarean section: a randomized controlled trial.

Ran, Wei, Huang et al. · 2025 · Frontiers in psychology

To investigate the effectiveness of a VR preoperative education program with sensory information support in reducing perioperative anxiety and improving the delivery experience among primiparas undergoing cesarean section (CS). A total of…

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Negative / Null Result ReportMedicine

Thoracic Duct Branch Identification Is Comparable Between T2-W 3D Fat-Suppressed Magnetic Resonance Imaging and Computed Tomography Lymphangiography in Normal Dogs.

Griffith, Hecht, Lux et al. · 2026 · Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association

In dogs with chylothorax that are refractory to medical management, surgical intervention is often recommended. Computed tomographic lymphangiography (CTL) is the most commonly used preoperative imaging study, but it has the disadvantages…

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Negative / Null Result ReportMedicine

Does Tibial Tunnel Placement Affect Postoperative Function and Isokinetic Outcomes in Patients Undergoing Anatomical Single-Bundle Anterior Cruciate Ligament Reconstruction with Hamstring Autograft?

Arslantaş, Deveci, Ozdemir et al. · 2026 · The journal of knee surgery

Tunnel malposition is a frequent complication of anterior cruciate ligament (ACL) reconstruction. We evaluated whether the tibial tunnel location of patients who underwent anatomical single-bundle ACL reconstruction with hamstring tendons…

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Negative / Null Result ReportMedicine

Comparison of early-onset and average-onset colorectal cancer in Saudi Arabia: A multicenter retrospective cohort study.

Alessy, Al-Bawardy, Alabdullah et al. · 2026 · Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association

Although overall colorectal cancer (CRC) incidence has stabilized or declined in some regions, early-onset CRC (EO-CRC) is increasing in many countries. We aimed to compare EO-CRC with average-onset CRC (AO-CRC) to inform screening and…

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Negative / Null Result ReportMedicine

Stool Microbiota, Metabolites, and Fecal Incontinence in Women.

Arya, Kashyap, Carnes et al. · 2026 · Urogynecology (Philadelphia, Pa.)

Stool metabolites influencing gut motility and sensation may contribute to fecal incontinence (FI). The objective of this study was to test whether FI is associated with higher levels of butyrate and Clostridiales taxa in stool. Stool…

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Negative / Null Result ReportMedicine

Comparative effectiveness of tirzepatide versus GLP-1 receptor agonists on the risk of venous thromboembolism in patients with obesity: a real-world cohort study.

Wu, Lee, Huang et al. · 2026 · Frontiers in medicine

Venous thromboembolism (VTE), including deep vein thrombosis (DVT) and pulmonary embolism (PE), represents a major cause of morbidity and mortality in patients with obesity. Although glucagon-like peptide-1 receptor agonists (GLP-1 RAs)…

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Negative / Null Result ReportMedicine

An Analysis of Thyrotropin Levels in Patients With Nonscarring Alopecia: A Single-Center Retrospective Comparative Study.

Alomary, Baker, Schell et al. · 2026 · The Journal of clinical and aesthetic dermatology

To compare thyrotropin (TSH) levels across nonscarring alopecia (NSA) subtypes-alopecia areata (AA), telogen effluvium (TE), and androgenetic alopecia (AGA)-in a primary analysis of all patients, a secondary analysis of euthyroid patients…

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Negative / Null Result ReportMedicine

The Influence of Congenital Heart Defect Repair Through a Right Subaxillary Thoracotomy on Postoperative Pulmonary Function and Prognosis in Small Infants.

Wang, Li, He et al. · 2026 · Reviews in cardiovascular medicine

The influence of repair of congenital heart defect (CHD) via a right subaxillary thoracotomy (RSAT) on postoperative pulmonary function and prognosis in small infants is a key consideration. Data were collected from infants who underwent…

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Negative / Null Result ReportMedicine

Comparative efficacy of ripertamab, rituximab, and efgartigimod in chronic inflammatory demyelinating polyneuropathy: an exploratory real-world multicenter cohort study.

Wu, Zhou, Yin et al. · 2026 · Frontiers in immunology

To analyze and compare the efficacy of ripertamab, rituximab, and efgartigimod in patients with chronic inflammatory demyelinating polyneuropathy (CIDP), focusing on treatment response rates, relapse rates, drug safety, long-term clinical…

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Negative / Null Result ReportMedicine

Monitoring cardiac symptoms during teleprehabilitation prior to coronary artery bypass grafting: a digital cardiac counselling trial subanalysis.

van Susante, van Mierlo, Scheenstra et al. · 2026 · European heart journal. Digital health

The purpose of this subanalysis was to explore whether or not teleprehabilitation leads to worsening cardiac symptoms in patients accepted for coronary artery bypass grafting (CABG). A subgroup of patients accepted for CABG (including…

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