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Browse the failure-mode index

11,324 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Nailfold capillaroscopy findings after anthracycline-based chemotherapy and their association with subclinical changes in left ventricular ejection fraction.

Kiracı M, Soytürk G, Köş FT et al. · 2026 · BMC cancer

Background Anthracyclines can induce endothelial and microvascular injury that precedes measurable myocardial dysfunction. However, reliable early markers of such injury are lacking. Nailfold capillaroscopy (NFC) is a noninvasive imaging…

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Negative / Null Result ReportMedicine

Changes in female sexual function during the retirement transition.

Virkkunen V, Kero K, Stenholm S et al. · 2026 · Menopause (New York, N.Y.)

Objectives For many women, retirement represents a significant transition in late adulthood, which may result in many alterations in lifestyle habits and behavioral patterns. Several factors known to improve during the retirement…

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Negative / Null Result ReportMedicine

Cross-sectional and prospective relations between dysfunctional cognitive beliefs and obsessive-compulsive symptoms during late childhood and early adolescence: a test of two aetiological models.

Barcaccia B, Cervin M, Borrelli DF et al. · 2026 · Journal of child psychology and psychiatry, and allied disciplines

Background Obsessive-compulsive symptoms (OCS) often emerge during childhood and adolescence, and two aetiological models have been proposed. According to the first model, maladaptive cognitive beliefs facilitate the transformation of…

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Negative / Null Result ReportOpen accessMedicine

The impact of vision care program on the mental health of migrant children in Eastern China: evidence from a cluster-randomized controlled trial.

Wang Y, Li C, Zhang H et al. · 2026 · International journal for equity in health

BACKGROUND: Vision impairment is common among children and is known to affect learning, but its impact on children’s mental health has received less attention, especially in low- and middle-income countries. This study aims to focus on a…

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Negative / Null Result ReportMedicine

A randomized trial of carbon-dioxide flushing to reduce vascular brain injury in patients undergoing TAVI.

Khawaja SA, Hanna L, Singh A et al. · 2026 · EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology

Background Stroke remains a significant concern in patients undergoing Transcatheter Aortic Valve Implantation (TAVI). Despite advances in TAVI technology and techniques, rates have remained unchanged, with trials of Cerebral embolic…

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Negative / Null Result ReportMedicine

FLAMSA versus FLAG-IDA as salvage therapy in adults with relapsed/refractory acute myeloid leukemia and acute lymphoblastic leukemia: A single-center real-world retrospective study.

Savaş EM, Bozkurt HH, Kemer NI et al. · 2026 · Leukemia research

Management of relapsed or refractory acute leukemia remains challenging, as allogeneic transplantation is the only curative option. Although targeted therapies are increasingly incorporated as bridge-to-transplant strategies in both AML…

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Negative / Null Result ReportMedicine

Effects of hydroxychloroquine sulfate combined with aspirin and enoxaparin sodium therapy on perinatal outcomes in patients with undifferentiated connective tissue disease-related recurrent miscarriage: a retrospective clinical study.

Pei LC, Wang T, Guo YJ et al. · 2026 · BMC pregnancy and childbirth

Background To evaluate the association between triple therapy (hydroxychloroquine sulfate, aspirin, and enoxaparin sodium) and pregnancy outcomes in patients with undifferentiated connective tissue disease (UCTD)-related recurrent…

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Negative / Null Result ReportMedicine

Real-world insights on switching aflibercept dosage for enhanced outcomes in age-related macular degeneration (RISE-AMD): Safety data.

Karunainathan MG, Lee C, Zohalinejad KD et al. · 2026 · Acta ophthalmologica

Purpose To evaluate real-world safety experience with aflibercept 8 mg in a large case series of patients with neovascular age-related macular degeneration (nAMD). Methods Due to a high proportion of patients on short treatment intervals,…

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Negative / Null Result ReportMedicine

Closing gaps in urban trauma systems: Outcomes of an inner-city community emergency department multidisciplinary trauma protocol.

London KS, Cherney A, Neupane S et al. · 2026 · The American journal of emergency medicine

Background Non-trauma center (NTC) emergency departments (EDs) play regular but underappreciated roles in the management of severely injured patients, yet many lack formal protocols to guide care. We describe the implementation and…

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Negative / Null Result ReportMedicine

Preoperative computed tomography findings of chest wall or mediastinal invasion in pulmonary metastases among children, adolescents, and young adults.

Shirane K, Kitagawa N, Morishima R et al. · 2026 · Journal of pediatric surgery

Background Pulmonary metastasectomy can improve the survival of children with pulmonary metastases from solid tumors. However, preoperative imaging often suggests chest wall and/or mediastinal invasion, raising concerns about…

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Negative / Null Result ReportOpen accessMedicine

Investigating the lasting effects of SARS-CoV-2 infection and the lung microbiome: no persistent microbial alterations in recovered COVID-19 patients with persistent radiological or respiratory abnormalities.

Teng NMY, Vijayakumar B, Smith DJF et al. · 2026 · Access microbiology

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was a global pandemic where infected individuals experienced mild or severe disease. Unfortunately, some patients who experienced severe disease also had lasting abnormalities.…

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Negative / Null Result ReportMedicine

β2-microglobulin is superior to lactate dehydrogenase and bulky disease for risk stratification in diffuse large B-cell lymphoma patients with IPI 1-2.

Chang H, Hung YS, Kuo MC et al. · 2026 · Annals of hematology

The International Prognostic Index (IPI) is the classical assessment tool to evaluate prognosis of diffuse large B cell lymphoma (DLBCL). Although the IPI is simple, reproducible, well validated and widely utilized, it is not entirely…

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Negative / Null Result ReportMedicine

Field diagnostic performance of the Sysmex XN31 automated hematology analyser for malaria screening among febrile children in a sentinel site for malaria surveillance site in Libreville, Gabon.

Chesly, Patrick, Bedrich et al. · 2026 · International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

To evaluate the diagnostic performance of the Sysmex XN-31 haematology analyser for malaria detection in a sentinel site. A prospective diagnostic assessment study was conducted among febrile children under 15 years of age, attending a…

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Negative / Null Result ReportMedicine

Evaluation of MRCP Findings in Distinguishing Benign from Malignant Causes of Isolated Main Pancreatic Duct Dilation.

Çınar, Uysal, Gürbüz et al. · 2026 · RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin

This study aimed to investigate morphological features on magnetic resonance cholangiopancreatography (MRCP) that may help distinguish benign from malignant causes of isolated main pancreatic duct (MPD) dilation detected without a visible…

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Negative / Null Result ReportMedicine

Synthesis and Biological Evaluation of a PET Probe: 4-Borono-2-[ 18 F]fluoro-l-phenylalanine ([ 18 F]FBPA) via an Iodonium Ylide Method for BNCT.

Li, Hu, Sun et al. · 2026 · The Journal of organic chemistry

Boron neutron capture therapy (BNCT) is a promising radiotherapeutic strategy for cancer treatment that selectively eradicates tumor cells while minimizing damage to surrounding healthy cells. 4-Borono-2-[ 18 F]fluoro-l-phenylalanine ([ 18…

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Negative / Null Result ReportMedicine

Impact of SARS-CoV-2 infection history on the clinical features and outcomes of patients with recurrent pulmonary tuberculosis: a retrospective case-control study.

Tang, Mi, Xue et al. · 2026 · Annals of medicine

The impact of prior SARS-CoV-2 infection on the clinical course of recurrent pulmonary tuberculosis (TB) remains poorly defined. This study aimed to compare clinical features, radiographic evolution, and outcomes in recurrent TB patients…

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Negative / Null Result ReportMedicine

Association Between Temporomandibular Joint Morphology and Mandibular Growth in Adolescents With Facial Asymmetry: An Magnetic Resonance Imaging and Cone-Beam Computed Tomography Study.

Wang, Guo · 2026 · The Journal of craniofacial surgery

To investigate the growth and developmental characteristics of the temporomandibular joint (TMJ) in adolescents with facial asymmetry and its relationship with mandibular morphological changes. A total of 20 patients aged 8 to 20 years…

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