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Browse the failure-mode index

11,324 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Avoiding the Umbilical Incision in Obese Patients Undergoing Laparoscopic Cholecystectomy: A Retrospective Cohort Study of Wound-Related Outcomes.

Uesato Y, Inamine S · 2026 · Journal of laparoendoscopic & advanced surgical techniques. Part A

Background The umbilical port is routinely used for camera insertion and specimen retrieval in laparoscopic cholecystectomy (LC). However, the umbilicus is anatomically vulnerable and may be associated with an increased risk of surgical…

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Negative / Null Result ReportMedicine

Comparative Efficacy of Subcutaneous and Sublingual Allergen Immunotherapy for Grass Pollen-Induced Allergic Rhinoconjunctivitis: Pairwise and Adjusted Indirect Treatment Comparison of Standardized ALK Products.

Di Lorenzo G, Melluso M, Rodolico A et al. · 2026 · The journal of allergy and clinical immunology. In practice

Background Allergen immunotherapy (AIT) is the only disease-modifying treatment for grass pollen-induced allergic rhinoconjunctivitis (ARC). Three delivery routes-subcutaneous (SCIT), sublingual drops (SLIT-D), and sublingual tablets…

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Negative / Null Result ReportMedicine

Documented Use of Piperacillin-Tazobactam and Increased 1-Month Mortality in Healthcare-Associated Intra-Abdominal Infections.

Baulier C, Zappella N, Grall N et al. · 2026 · Anaesthesia, critical care & pain medicine

Background Recent studies have increasingly questioned the efficacy and safety of piperacillin-tazobactam (TZP) in septic patients, particularly those with healthcare-associated intra-abdominal infections (hcIAI). This study assessed…

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Negative / Null Result ReportMedicine

Evaluation of Structural and Functional Outcomes After the Application of an Initial Single Dose of Faricimab.

Ariza-Torrado IP, Groman-Lupa S, Martínez-Córdoba CJ et al. · 2026 · Journal of vitreoretinal diseases

Purpose: To evaluate functional and structural outcomes after application of a single intravitreal dose of faricimab in patients with chronic retinal diseases. Methods: In this observational, longitudinal, prospective study, best-corrected…

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Negative / Null Result ReportOpen accessMedicine

Does Maternal Smoking Increase the Risk of Congenital Heart Disease? Insights from a Single-Center Fetal Echocardiography Study.

Kavgacı A, Kaya Ö, Örün UA et al. · 2026 · Journal of clinical medicine

Background : Congenital heart disease (CHD) represents a major cause of perinatal morbidity and mortality, and fetal echocardiography is essential for its early diagnosis and management. Maternal smoking has been suggested as a potential…

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Negative / Null Result ReportMedicine

Does previous neck dissection or irradiation mitigate the response to immunotherapy in advanced/metastatic head and neck squamous cell carcinoma?

Kampel L, Oestreicher-Kedem Y, Horowitz G et al. · 2026 · International journal of oral and maxillofacial surgery

Immunotherapy has brought new hope to patients with locally advanced, recurrent or metastatic (R/M) head and neck squamous cell carcinoma (HNSCC). This study aimed to evaluate the outcomes at our institution, focusing on the response to…

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Negative / Null Result ReportOpen accessMedicine

Underestimation of Prostate Cancer Grade in Transperineal Fusion Biopsy and Its Predictive Factors: Correlation of Biopsy Findings with Post-Da Vinci Radical Prostatectomy Specimens.

Krzepkowski HA, Ząbkowski T, Walędziak M et al. · 2026 · Journal of clinical medicine

Background/Objectives : An accurate preoperative assessment of prostate cancer malignancy is crucial for risk stratification and selection of the optimal treatment strategy. This study assessed the concordance of Gleason scores between…

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Negative / Null Result ReportMedicine

Thyroid disease and breast cancer risk in the Sister Study.

Woo JMP, Chen D, Yarosh R et al. · 2026 · Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

Background Thyroid disease (TD), and its treatments, are suspected risk factors for breast cancer (BC), attributed primarily to alterations in thyroid hormone-related metabolism. Prior literature is inconsistent, in part, due to small…

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Negative / Null Result ReportMedicine

Robot-assisted versus conventional unicompartmental knee arthroplasty: a retrospective comparative study of postoperative complications.

Gonzalez W, Riquelme JP, Arellano J et al. · 2026 · BMC musculoskeletal disorders

Background Unicompartmental knee arthroplasty (UKA) is an established procedure for selected patients with unicompartmental osteoarthritis. Robotic-assisted UKA (RA-UKA) has been introduced to improve accuracy of implant positioning.…

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Negative / Null Result ReportOpen accessMedicine

Associations Between Anemia and Obstructive Sleep Apnea in Patients with Cystic and Non-Cystic Bronchiectasis: A Prospective Cross-Sectional Study.

Balcan B, Vezir D, Ocal R et al. · 2026 · Biomedicines

Background : Anemia and obstructive sleep apnea (OSA) are prevalent comorbidities in bronchiectasis and may share overlapping pathophysiological mechanisms. However, their combined impact on clinical outcomes in bronchiectasis remains…

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Negative / Null Result ReportMedicine

Differential impact of cumulative cerebral small-vessel disease burden on ischemic versus hemorrhagic stroke recurrence in hemorrhage-prone patients.

Park JH, Kwon SU · 2026 · Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

Background Total cerebral small-vessel disease (cSVD) score is a well-established predictor of vascular risks. However, the specific type of recurrent stroke associated with cSVD scores remains unclear in hemorrhage-prone patients-those…

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Negative / Null Result ReportMedicine

Olfactory function in patients with benign paroxysmal positional vertigo (BPPV): a cross-modal sensory analysis.

Tahsin S, Murat K, Gözde OK et al. · 2026 · European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

OBJECTIVE: To investigate the potential interaction between the vestibular and olfactory systems by evaluating olfactory identification performance in patients with BPPV. METHODS: Fifty-two patients with BPPV and 50 age-matched healthy…

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Negative / Null Result ReportMedicine

Postural Stability Changes During the 4 Phases of the Half Squat: Kinematics Profile of the Center of Pressure and Center of Mass in High-Performance Weightlifters-A Pilot Study.

Arrayales-Millán EM, Rodal M, González-Macías ME et al. · 2026 · Bioengineering (Basel, Switzerland)

This study investigated balance control during the half squat by analyzing the relationship between the center of mass (CoM) and the center of pressure (CoP) in five experienced male weightlifters performing segmented squats at five load…

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Negative / Null Result ReportMedicine

(No) attentional biases in obsessive-compulsive disorder? An eye-tracking study using idiosyncratic stimulus material.

Müller CL, Ehring T, Kustermann A et al. · 2026 · Journal of psychopathology and clinical science

Cognitive-behavioral theories propose that attentional biases contribute to the development and maintenance of obsessive-compulsive disorder (OCD). However, research findings have been inconsistent, with some studies supporting vigilance…

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Negative / Null Result ReportMedicine

Pregnancy Hormones and Offspring Psychiatric Problems: Testing Associations Between Placental Corticotropin-Releasing Hormone and Children's Age 8 Internalizing Outcomes.

Sullivan ADW, Barrett ES, Sullivan A et al. · 2026 · Biopsychosocial science and medicine

Objective Placental corticotropin-releasing hormone (pCRH) is a peptide essential for fetal development and birth timing. Prenatal programming frameworks position maternal pCRH as a primary neuroendocrine mediator underlying the…

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Negative / Null Result ReportMedicine

Cross sectional analyses indicated that body fat distribution was not associated with performance-based and self-reported outcomes among ambulatory people with multiple sclerosis.

Kidwell-Chandler A, Jeng B, Motl RW · 2026 · Multiple sclerosis and related disorders

Background Obesity is cited as a relevant factor in multiple sclerosis (MS). To date, there is inconsistent evidence regarding the relationship between total body fat and frequently studied outcomes in MS. Body fat distribution, or the…

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Negative / Null Result ReportMedicine

Efficacy of Watercress (<i>Nasturtium officinale</i> R.Br.) Consumption on Blood Pressure, Oxidative Stress Biomarkers, and Estimated Cardiovascular Risk in Thai Middle-Aged Adults: A Randomized Placebo-Controlled Pilot Study.

Kijkuokool P, Rerkasem K, Fakfum P et al. · 2026 · Antioxidants (Basel, Switzerland)

Watercress ( Nasturtium officinale R.Br.) is a cruciferous vegetable rich in bioactive compounds that may improve cardiovascular disease (CVD) risk factors. However, clinical evidence regarding its direct impact on CVD risk remains…

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Negative / Null Result ReportMedicine

Serum ceramides predict all-cause and cardiovascular mortality in Chinese incident hemodialysis patients: a retrospective cohort study.

Zhang S, Wu YL, Li ZY et al. · 2026 · Kidney research and clinical practice

Background This study explored serum ceramide (Cer) levels' association with all-cause and cardiovascular disease (CVD) mortality in Chinese incident hemodialysis (HD) patients. Methods This retrospective cohort study included 253 adults…

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Negative / Null Result ReportMedicine

Unilateral posterior vertebral column resection versus bilateral approach for post-traumatic thoracic angular kyphosis: a propensity-matched non-inferiority study.

Ghobashy MK, AbdelFatah MA, Youssef ME et al. · 2026 · European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society

Purpose Posterior vertebral column resection (PVCR) for severe post-traumatic thoracic angular kyphosis is effective but carries high morbidity. This study compares unilateral PVCR (UPVCR) with traditional bilateral PVCR (BPVCR),…

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Negative / Null Result ReportMedicine

Face-to-face vs. telerehabilitation for thoracic hyperkyphosis in children- A randomized controlled pilot study.

Gözener Canbülbül S, Canbülbül B, Özcan Şİ et al. · 2026 · Journal of pediatric rehabilitation medicine

PurposeThis pilot study aimed to compare the effects of face-to-face and telerehabilitation approaches on thoracic hyperkyphosis, back extensor muscle strength, and discomfort in children.MethodsA randomized clinical trial was conducted in…

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Negative / Null Result ReportMedicine

The John Charnley Award: A Randomized Controlled Trial of Dual Mobility and Single Bearings for Patients at High Risk of Dislocation Following Primary Total Hip Arthroplasty.

Potluri AS, Yadav AS, Weintraub MT et al. · 2026 · The Journal of arthroplasty

Introduction This multicenter randomized controlled trial (RCT) sought to determine if dual-mobility bearings (DM) reduce dislocations in patients at high-risk for instability undergoing primary total hip arthroplasty (THA) compared to…

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