11,322 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Ott A, Gül AZ, Löber U et al. · 2026 · Brain research bulletin
High-fat diet (HFD) consumption contributes to obesity, yet its impact on females of (pre)reproductive age and the effects of dietary modification after adolescence remain underexplored. This study examined how continuous HFD exposure or…
View details →Lagacé JC, St-Martin P, Avino M et al. · 2026 · Experimental physiology
Prolonged bed rest and immobilization have deleterious effects on skeletal muscle mass and function, especially in older adults. These can lead to reduced physical capacity and quality of life. Previous experiments in younger individuals…
View details →Stadie N, Heinzer R, Marques-Vidal P · 2026 · European journal of nutrition
PURPOSE: Many individuals turn to supplements like magnesium, believing them to offer a natural way to improve sleep quality. Yet, research on magnesium’s effects has produced inconsistent results. We assessed the relationships between…
View details →Thomas S, Ben-Davies R, Cetinkaya-Fisgin A et al. · 2026 · Journal of the peripheral nervous system : JPNS
Background and aims Recent preclinical studies have shown that nicotinamide adenine dinucleotide (NAD + ) plays a critical role in molecular mechanisms of axon degeneration, and reductions in NAD + levels are associated with axonal…
View details →Battistelli LS, Moraes RM, Santos YC et al. · 2026 · Journal of periodontology
Background Recent findings have associated alveolar bone loss (ABL) with the presence of senescent cells. Aging and the accumulation of senescent cells are associated with a pro-inflammatory environment which may exacerbate tissue damage.…
View details →Spormann S, Lebre M, Moutinho-Pereira J et al. · 2026 · Journal of plant physiology
Wild tomato species (WTS) have long been attracting the attention of plant researchers due to their ability to tolerate harsh environmental conditions in their natural habitats. In this context, their use in grafting procedures, where they…
View details →Espelta JM, Viana‐Soto A, Molowny‐Horas R et al. · 2026 · Journal of Applied Ecology.
While disturbances are essential for biodiversity, their escalation driven by climate change may threaten forest ecosystems. Contrasting approaches to adapt forests to disturbances-intensifying management versus encouraging natural…
View details →Ruocco-Vetucci V, Chaves RAC, Ballan ACF et al. · 2026 · General dentistry
Considering that osteonecrosis of the jaw may be due to the antiangiogenic effect of bisphosphonates and that leukocyte- and platelet-rich fibrin (L-PRF) releases proangiogenic factors, this study hypothesized that L-PRF could prevent…
View details →Al-Haddad C, Kobeissi H, Wehbi Z et al. · 2026 · Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus
Purpose To assess the driving performance and visual attention of amblyopic drivers using a driving simulator integrated with eye tracking technology in an urban setting. Methods A total of 30 participants were enrolled: 14 amblyopic…
View details →Cao X, Francisco CO, TaghiBeyglou B et al. · 2026 · Sleep & breathing = Schlaf & Atmung
PURPOSE: The recumbent posture during sleep increases small airway narrowing and nocturnal asthma despite optimal asthma treatment. Fluid accumulation in the chest can narrow the airway lumen, contributing to small airway narrowing. We…
View details →Lu X, Han Y, Song J et al. · 2025 · Frontiers in endocrinology
Background Recent studies have focused on investigating the role of cellular senescence in ovarian aging. Targeting cellular senescence has been proposed as a potential strategy to improve ovarian aging. p16 and p21 are classical molecules…
View details →Rodríguez-Arias M, Malaguarnera M, Ribes-Catalá M et al. · 2026 · Behavioral neuroscience
Social defeat (SD) is a well established model that increases addiction vulnerability accompanied by depressive- and anxiety-like behaviors. Environmental enrichment (EE) has been shown to enhance resilience and mitigate stress-induced…
View details →Leitão EPT, Del Rosario H, Hernández I et al. · 2026 · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
By 2030, the incidence of new cases of cancer worldwide is expected to have increased by 18.1%, with a 22% increase in mortality. Leukaemia is the most common childhood cancer, and drug resistance remains a major therapeutic challenge.…
View details →Zhang H, Patton HN, Nagahawatte ND et al. · 2026 · Neurogastroenterology and motility
Background Stomach contractions are coordinated in part by bioelectric slow waves (SW). Dysfunctional SWs are associated with motility disorders. Electrical pacing is a potential strategy for managing motility disorders but remains poorly…
View details →Song JH, Kim SY, Lee YJ et al. · 2026 · Surgery
Background The use of postoperative antibiotics in patients with nonperforated appendicitis remains controversial, with limited evidence supporting routine administration. However, certain intraoperative findings, such as gangrenous,…
View details →Barbarot S, Aubert H, Boivin M et al. · 2026 · The British journal of dermatology
Background New primary preventive therapeutic strategies for atopic dermatitis (AD) are needed. Atopic diseases are associated with disrupted gut microbial balance in early life, suggesting that optimizing microflora through intervention…
View details →Amthor L, Jaeckle A, Kampmeier J et al. · 2025 · Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association
Sitagliptin, an inhibitor of dipeptidyl peptidase-4 widely used in type 2 diabetes therapy, impairs the barrier formed by retinal endothelial cells (REC) during prolonged exposure. Because diabetic macular edema is treated with inhibitors…
View details →Caltabiano A, Voruganti A, Nesi J et al. · 2026 · JMIR serious games
Background Exposure and response prevention is a first-line intervention for obsessive-compulsive disorder (OCD), yet many individuals with contamination concerns do not access care. Virtual reality exposure-based therapy (VRET) may…
View details →Kik OE, Zaviska F, Lesage G et al. · 2026 · Water research
This study investigated the electro-oxidation (EO) of three priority micropollutants: carbamazepine (CBZ), diuron (DIU), and perfluorooctane sulfonate (PFOS), in secondary-treated wastewater using boron-doped diamond (BDD) anodes. Although…
View details →Bidon M, Saito T, Skjaerven KH et al. · 2026 · Aquatic toxicology (Amsterdam, Netherlands)
Methylmercury (MeHg) is a pervasive neurotoxicant threatening aquatic ecosystems. Selenium (Se) has been reported to protect fish against the adverse MeHg toxicity, yet molecular investigations of their interaction in the brain remain…
View details →Birsen I, Erdogan K, Ozsoy O et al. · 2026 · Tissue & cell
Inflammatory bowel disease (IBD) is a systemic condition that can also lead to extraintestinal complications, including liver damage. Disruptions in the gut-liver axis and inflammatory mediators play a key role in this process. Apelin, a…
View details →Dai T, Dai Q, Ding Y et al. · 2026 · Neurochemical research
Conversion of microglia to a branching state is considered a potential strategy to ameliorate neuroinflammation. Inhibition of histone deacetylases (HDACs) may convert microglia to a branching state and thus prevent neuroinflammation.…
View details →de Boer N, Vučko Z, Koster DI et al. · 2026 · European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology
Antipsychotic-induced weight gain (AiWG) is a common, burdensome adverse effect. Switching to antipsychotics with lower metabolic risks, such as aripiprazole, is recommended, but long-term data is limited. Long-acting injectables (LAIs)…
View details →Sholikah TA, Septyaningtrias DE, Sumiwi YAA et al. · 2025 · Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft
Background this study aimed to examine the impact of a TNF-α antagonist on markers of neuronal death, the total number of myenteric neurons, and the volume of each colonic layer in diabetic rats. Methods thirty male rats were divided into…
View details →Carmon L, Nassar M, Idan D et al. · 2026 · Journal of clinical medicine
Background/Objectives : Mucopolysaccharidoses (MPS) are lysosomal storage disorders characterized by impaired glycosaminoglycan degradation, leading to multisystem involvement and progressive growth impairment. Longitudinal growth data in…
View details →Cedeno Escobar AM, Walstrom KM · 2025 · microPublication biology
Imbalances between pathogenic and commensal bacteria cause microbial dysbiosis that disrupts host development. Streptococcus mutans ' virulence factors promote human oral cell colonization, leading to dysbiosis if unchecked. When grown…
View details →Goldberg TS, Shalem Y, Fujinaga D et al. · 2025 · Journal of insect physiology
Juvenile hormones (JHs) are key insect endocrine signals regulating pre-adult development and adult life history strategies, physiology, and behavior. The importance of this endocrine signal has led to the development of insecticides…
View details →Kitaoka Y, Tsukahara C, Fujita N et al. · 2025 · International ophthalmology
Purpose Intravitreal injections of some drugs such as anti-VEGF antibodies are available for certain human ocular diseases. Meanwhile, inhibition of SARM1 has been reported to exert neuroprotection in several neurodegenerative disease…
View details →Garofolo IC, Santos PF, Silva MF et al. · 2026 · Nutrition and health
Background: Type 2 Diabetes Mellitus is a metabolic disease characterized by hyperglycemia and hyperinsulinemia, closely linked to obesity. According to the International Diabetes Federation, in 2021, almost 6.7 million adults aged 20-79…
View details →Lee SU, Choi SK, Song JM et al. · 2025 · Taiwanese journal of obstetrics & gynecology
Objective Aspirin is recommended for women with pregestational diabetes mellitus (PGDM) because they are at a high risk for preeclampsia. However, previous studies have predominantly examined the effect of aspirin on high-risk groups, with…
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