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Browse the failure-mode index

11,322 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Effects of Dietary Fermented Black Garlic Powder Supplementation on Performance, Carcass Traits, Serum Parameters, Immune Response and Antioxidant Status of Japanese Male Quails.

Sevim B · 2026 · Tropical animal health and production

This study investigated the effects of dietary supplementation with fermented black garlic powder on performance, carcass characteristics, serum parameters, immunological responses and antioxidant status in male Japanese quail. A total of…

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Negative / Null Result ReportMedicine

Evaluating the need for omentectomy during laparoscopic placement of tunneled peritoneal dialysis catheters in pediatrics: a multicenter comparative study.

Shehata MA, Khirallah MG, Al Nafesa A et al. · 2026 · Pediatric surgery international

Purpose To evaluate whether routine omentectomy improves outcomes during laparoscopic placement of peritoneal dialysis (PD) catheters in children. Methods This multicenter retrospective study included children ≤ 5 years who underwent…

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Negative / Null Result ReportOpen accessMedicine

Mechanistic investigation of flavonoid-mediated inhibition of N-methyl-N-nitrosourea-induced mutagenicity via noncovalent DNA binding.

Matsuoka C, Takatama N, Muraoka T et al. · 2026 · Genes and environment : the official journal of the Japanese Environmental Mutagen Society

Background Previous research using the Ames assay showed that licoricidin (LCD) and isoliquiritigenin (ILTG) can block mutations caused by N-methyl-N-nitrosourea (MNU) in Salmonella typhimurium (S. typhimurium) TA1535. With the aim to…

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Negative / Null Result ReportMedicine

Rigorous Donor Selection for Fecal Microbiota Transplantation in Active Ulcerative Colitis: Key Lessons From a Randomized Controlled Trial Halted for Futility.

Caenepeel C, Deleu S, Vazquez Castellanos JF et al. · 2025 · Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

Background & aims Rigorous donor preselection on microbiota level, strict anaerobic processing, and repeated fecal microbiota transplantation (FMT) administration were hypothesized to improve FMT induction of remission in ulcerative…

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Negative / Null Result ReportOpen accessMedicine

Real-world outcomes in patients with brain metastases secondary to HR+/HER2- MBC treated with abemaciclib and local intracranial therapy.

Gathirua-Mwangi W, Martin H, He D et al. · 2025 · The oncologist

Background Real-world data are limited for patients with brain metastases secondary to metastatic breast cancer (MBC) and treated with cyclin-dependent kinase 4/6 inhibitors (CDK4/6i). This study describes real-world outcomes in patients…

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Negative / Null Result ReportMedicine

The Association of Persistent Fecal White Blood Cell Excretion with Impaired Weight Gain and Food Allergy Among Children with Allergic Proctocolitis.

Fattahi Z, Talakesh T, Kheiri S et al. · 2026 · Recent advances in inflammation & allergy drug discovery

Introduction/objective In children affected by allergic proctocolitis, impaired weight gain and developmental failure to thrive can be a prominent manifestation. However, it remains unclear whether the association between White Blood Cell…

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Negative / Null Result ReportMedicine

Hypothetical Bias in the SG and TTO.

Baillon A, Bleichrodt H, Granic GD · 2026 · Medical decision making : an international journal of the Society for Medical Decision Making

BackgroundHealth state utility measurements are central in health policy and medical decision making. Common methods are the standard gamble (SG) and the time tradeoff (TTO). They typically use hypothetical questions. It is unknown whether…

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Negative / Null Result ReportMedicine

Risk factors of biliary cast syndrome among liver transplant recipients.

Nakamura M, Nishioka Y, Akamatsu N et al. · 2026 · Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society

Biliary cast syndrome (BCS) remains a significant concern that can lead to graft failure and mortality. Data on the etiology and outcomes are limited, particularly with regard to the differences in the risk of occurrence of BCS between…

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Negative / Null Result ReportMedicine

Differential effects of hypothalamic ET<sub>B</sub> receptor blockade in fever, hypolocomotion and serotonin release during systemic inflammation in male and female rats.

Alencar TS, Santos MO, Schneider VMM et al. · 2026 · Brain research

Systemic inflammation triggers a set of physiological and behavioral changes known as sickness behavior, including fever and hypolocomotion. Previous studies demonstrated that lipopolysaccharide (LPS) induces these responses in both sexes,…

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Negative / Null Result ReportOpen accessMedicine

Exhausted olive pomace as a replacement for soybean hulls in corn silage-based diets for late-lactating Holstein cows: Insights from sustainable dairy farming.

Fonseca AJM, Cabrita ARJ · 2026 · JDS communications

This study evaluated the effects of replacing soybean hulls with exhausted olive pomace (EOP) on feed intake, milk production and composition, and rumen fermentation parameters. A cyclical changeover design experiment was used with 4…

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Negative / Null Result ReportMedicine

Revisiting hypocholesterolemia during prolonged sepsis: From targeted cholesterol repletion to unresolved adrenal and muscle dysfunction.

De Bruyn L, Van Beek F, Vander Perre S et al. · 2026 · Molecular and cellular endocrinology

Background Sepsis HDL- and LDL-hypocholesterolemia associate with adverse outcomes, but whether this necessitates supplementation or merely reflects disease severity remains unclear. We hypothesize that sustained hypocholesterolemia can…

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Negative / Null Result ReportMedicine

Effect of different vaccination schedules and administration of a nonsteroidal anti-inflammatory drug around dry-off on inflammation, immunity, and performance of dairy cows.

Gao J, Savegnago CG, Marins TN et al. · 2026 · Journal of dairy science

This study evaluated the effects of different vaccination schedule and oral administrating a nonsteroidal anti-inflammatory drug (NSAID) around dry-off on systemic inflammation, immune responses, behaviors during the early dry period, and…

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Negative / Null Result ReportMedicine

A Performance Evaluation of Bayesian Forecasting for Serum Linezolid Concentrations: Impact of Clinical Factors on Prediction Accuracy.

Hashimoto N, Wakimoto Y, Kusama T et al. · 2026 · Therapeutic drug monitoring

Background Pycsim, a dosing software for linezolid (LZD) based on Bayesian estimation, predicts dosing in the therapeutic drug monitoring (TDM) of LZD. However, its predictive performance, examined using an independent data set with a…

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Negative / Null Result ReportMedicine

Copper regulates the synthesis of steroid hormones through CCS and ATOX1 dependent MEK1-ERK1/2 pathway in follicular granulosa cells of yak (Bos grunniens).

Lou Y, Yang T, Xia C et al. · 2026 · Molecular and cellular endocrinology

Steroid hormone synthesis in granulosa cells (GCs) is crucial for normal follicular development and ovulation. Emerging evidence suggests that copper (Cu), a trace element, influences hormone secretion in yak granulosa cells (YGCs);…

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Negative / Null Result ReportMedicine

Effect of dietary phosphorus and calcium depletion-repletion on pig performance and bone quality.

Palacios-Duchicela R, Létourneau-Montminy MP, Lizardo R et al. · 2026 · Animal : an international journal of animal bioscience

Feeding strategies such as P and Ca depletion and repletion have been proposed to reduce the use of phosphate or improve P utilisation efficiency in pig diets, thereby contributing to the sustainability of the sector. A total of 48 entire…

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