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Browse the failure-mode index

11,322 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Factors Affecting the Intrafollicular Transfer of Immature Oocytes in Beef Heifers: Does the Injection Matter?

de Faria OAC, Kussano NR, de Faria LC et al. · 2026 · Reproduction in domestic animals = Zuchthygiene

This study aimed to evaluate whether the quality of injection and number of oocytes injected during Intrafollicular Transfer of Immature Oocytes (IFIOT) affect ovulation timing, follicle dynamics, oocyte recovery, nuclear maturation and in…

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Negative / Null Result ReportMedicine

Effect of hydrogen peroxide on microcystin-LR from Microcystis sp.

Ng PH, St-Hilaire S · 2025 · Diseases of aquatic organisms

Microcystis spp. blooms in fish ponds can lead to fluctuations in water parameters, and the microcystin-LR (MC-LR) toxin they produce may pose health risks for fish, as well as consumers. Hydrogen peroxide (H2O2) treatment has been…

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Negative / Null Result ReportMedicine

Minimal Movement Restrictions Do Not Increase Hip Dislocations Following Total Hip Arthroplasty: A Before-and-After Study of 10,357 Patients.

Klaassen AD, Willigenburg NW, Musters JWQ et al. · 2026 · The Journal of bone and joint surgery. American volume

Background Hip dislocation is the most common reason for early revision after total hip arthroplasty (THA). To prevent dislocation, patients are often prescribed movement restrictions following THA; however, these restrictions can be…

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Negative / Null Result ReportMedicine

Efficacy and safety of intensive antihypertensive strategy in patients with low diastolic blood pressure: a secondary analysis of a cluster randomised trial.

Xie Z, Yang C, Yin Y et al. · 2025 · Heart (British Cardiac Society)

Background Intensive blood pressure (BP) control Methods This is a post hoc analysis of the China Rural Hypertension Control Project. Mixed-effect Cox proportional regression and generalised estimating equation models were used to…

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Negative / Null Result ReportMedicine

Clinical predictors of overall survival in elderly oligodendroglioma patients: A Surveillance, Epidemiology, and End Results (SEER) database analysis.

Chandan Reddy S, Mao T, Gendreau J et al. · 2026 · Clinical neurology and neurosurgery

Objective Oligodendrogliomas are typically benign tumors that arise within the white matter tracts of the cerebral hemispheres. Surgical resection, radiotherapy (RT), and chemotherapy (CT) are utilized to prolong survival in patients…

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Negative / Null Result ReportMedicine

PolyDeep Advance 3: Randomized Clinical Trial comparing PolyDeep-assisted and conventional colonoscopy for adenoma detection rate in a colorectal cancer screening program.

Davila-Piñón P, Díez-Martín AI, Nogueira-Rodríguez A et al. · 2026 · Endoscopy

Background and study aim The impact of computer-aided detection (CADe) systems remains uncertain. We evaluated whether PolyDeep, a CADe system, improves adenoma detection rate (ADR) in a colorectal cancer (CRC) screening program. Patients…

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Negative / Null Result ReportMedicine

MRI suspicious lesions in patients under active surveillance: Do systematic biopsies still add value?

Savin Z, Ben-David R, Shem-Tov Dlugy A et al. · 2025 · Canadian Urological Association journal = Journal de l'Association des urologues du Canada

Introduction Active surveillance (AS) requires regular monitoring to detect disease progression. Multiparametric magnetic resonance imaging (mpMRI) and targeted biopsies are commonly used to identify clinically significant prostate cancer…

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Negative / Null Result ReportMedicine

Mitigation of nitrous oxide emissions by 3,4-dimethylpyrazole phosphate and 3,4-dimethylpyrazole succinic acid with reduced fertilizer application time while maintaining cabbage yield in Andosol fields

Akiyama H, Sasaki Y, Tago K et al. · 2025 · Agriculture, Ecosystems and Environment.

Previous studies have reported that nitrification inhibitors are effective in reducing nitrous oxide emissions. However, no studies have reported the effectiveness of 3,4-dimethylpyrazole phosphate, and 3,4-dimethylpyrazole succinic acid…

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Negative / Null Result ReportMedicine

A Prospective Interventional Study to Evaluate the Effect of Hypoxia on Healthy Volunteers and Patients With Inflammatory Bowel Disease: The Altitude Inflammatory Bowel Disease Study.

Vavricka SR, Zeitz J, Madanchi M et al. · 2025 · The American journal of gastroenterology

Introduction Retrospective data suggest association of high-altitude exposure and inflammatory bowel disease flares. Knowledge about underlying pathogenesis remains limited. Methods This prospective interventional trial evaluated the…

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Negative / Null Result ReportMedicine

Heavy episodic drinking and intimate partner violence perpetration: Do interpersonal stress perceptions matter?

Hammett JF, Kirwan M, Chen W · 2026 · Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors

Objective Intimate partner violence (IPV) is a major public health concern. Heavy episodic drinking (HED; i.e., drinking 5+ drinks for men or 4+ drinks for women in a 2-hr period) is a contributing cause of IPV, yet HED does not elicit IPV…

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Negative / Null Result ReportMedicine

Decreasing the Use of As-Needed Antihypertensive Therapy in Hospitalized Patients With Asymptomatic Hypertension.

Lipps KM, Samuel AM, Patel D et al. · 2025 · Journal for healthcare quality : official publication of the National Association for Healthcare Quality

Background Hypertension (HTN) is common in the inpatient setting, with many patients receiving as-needed (PRN) antihypertensive medications (anti-HTN) despite lack of benefit and risk of adverse events. We aimed to decrease PRN anti-HTN…

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Negative / Null Result ReportMedicine

Developing more effective phosphorus-loaded iron modified biochar fertilisers for improvement of peanut yield and regulation of soil phosphorus fractions

Zhang J, Wu Q, Chi D et al. · 2025 · Soil & tillage research

Phosphorus-loaded iron-modified biochar (Fe-BP) can be used as farmlands' slow-release phosphorus (P) fertilizer. This study aimed to explore the effects of Fe-BP on soil P composition, phosphatase activity, peanut P accumulation, and P…

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Negative / Null Result ReportMedicine

The influence of the Hunga Tonga-Hunga Ha'apai water vapor on ozone content in the Antarctic and Arctic stratospheric polar vortex in the winter 2023 and 2023–2024

Lukyanov AN, Vargin PN, Yushkov VA · 2025 · Atmospheric research

The eruption of the underwater volcano Hunga Tonga – Hunga Ha'apai (20.54° S, 178.3° W) on January 15, 2022, resulted in the first significant increase in the stratospheric water vapor content in the entire satellite observation era. This…

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Negative / Null Result ReportMedicine

Motivation-informed digital reminders were no more effective than standard reminders for trial task completion in a randomized Study Within A Trial (SWAT).

Ackermann DM, Medcalf E, Bracken K et al. · 2026 · Journal of clinical epidemiology

Objectives Digital reminders are widely used in clinical trials, but their design is rarely evidence-based. We evaluated the effectiveness of two types of digital reminders for trial task completion. Study design and setting This…

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Negative / Null Result ReportMedicine

Breastfeeding-injury link: are concerns warranted?

Jones PAT, Brockwell E, Hassan A et al. · 2025 · British journal of sports medicine

Objective Recreational and elite athletes report avoiding breastfeeding when returning to physical activity following childbirth due to a perceived increased risk of injury; yet, there are no empirical data to support this relationship. We…

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Negative / Null Result ReportMedicine

Cytomegalovirus DNAemia in the lower respiratory tract in nontransplant patients with hematologic malignancies.

Sadowska-Klasa A, Bełdzińska-Gądek K, Klein-Awerjanow K et al. · 2026 · International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

Objectives Cytomegalovirus (CMV) pneumonia is a serious complication in immunocompromised patients, but its role in non-transplant populations remains unclear. Methods We analyzed CMV DNA in bronchoalveolar lavage (BAL) samples from 100…

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Negative / Null Result ReportMedicine

Fine-Scale Variation in Optimal Clutch Size in a Blue Tit Population.

Garrido-Bautista J, Ortega Z, Pérez-Jiménez A et al. · 2025 · Ecological and evolutionary physiology

AbstractClutch size variation may be adaptive in bird populations if parents lay a clutch size that maximizes offspring recruitment. Brood size manipulation experiments allow for testing the optimization of clutch size by studying the…

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Negative / Null Result ReportMedicine

Pictures are not always worth a thousand words: Non-probative pictures did not increase the effectiveness of misinformation corrections.

Whitehead PS, Davis CP, Park JS et al. · 2025 · Journal of applied research in memory and cognition

Much research has focused on the language used for debunking false beliefs: communications should lead with facts, label misinformation as false, and reinforce true information. Pictures are used in debunking messages, but it remains…

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Negative / Null Result ReportMedicine

Evaluating Text Messaging Approaches to Promote Enrollment in Smoking Cessation Treatment Among Latino Adults: A Pragmatic Randomized Clinical Trial.

Cartujano-Barrera F, Catley D, Chávez-Iñiguez A et al. · 2026 · Chest

Background Little is known about the use of text messages to promote enrollment in smoking cessation treatment. Research question What is the impact of the number of outreach messages and monetary incentives on enrollment in smoking…

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