11,322 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Choi JY, Joo H, Kim JS et al. · 2026 · Public health
Objective In February 2024, over 90% of South Korea's resident physicians resigned in protest of government medical school expansion policies, creating an unprecedented healthcare crisis. This study examined whether this mass exodus…
View details →Pazos J, Fox DJ, Devi A et al. · 2026 · Food chemistry
Cabernet Sauvignon grapes were harvested at three different maturities (unripe, ripe, overripe, represented by Harvest 1, 2 and 3) and used for winemaking, adjusting total soluble solids of each harvest to three concentrations (∼11 %, 14…
View details →Orbell SL, Lund BC, Kim N et al. · 2026 · Diabetes technology & therapeutics
The impacts of the rapid transition to telehealth care among Veterans on insulin pumps (VIPs) at the onset of the COVID-19 pandemic have not yet been studied. We performed a longitudinal analysis of VIP outcomes from October 1, 2018 to…
View details →DeFrancesco CJ, Cavendish E, Kocher MS · 2026 · The American journal of sports medicine
Background Lateral extra-articular tenodesis (LET) can reduce the risk of graft failure after anterior cruciate ligament (ACL) reconstruction in adolescents and young adults. It is unclear whether the use of this procedure increases risks…
View details →Lytchiér JVC, Okur MI, Rutkowski W et al. · 2026 · European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
Introduction Neoadjuvant immune checkpoint inhibitors (ICI) have recently entered clinical practice in management of melanoma, yet its impact on surgical outcomes remains unclear. This study evaluated the influence of neoadjuvant ICI on…
View details →Tonegawa-Kuji R, Kanaoka K, Takemoto S et al. · 2026 · Brazilian journal of cardiovascular surgery
Surgical left atrial appendage occlusion (S-LAAO) is increasingly performed during cardiac surgery, but perioperative outcomes remain uncertain. Using a nationwide Japanese inpatient database, we analyzed 25,059 adults undergoing valve or…
View details →Gong W, Chen X, Zhao W et al. · 2026 · Sleep medicine
Background Obstructive sleep apnea (OSA) and age are strongly associated with recurrent events following acute coronary syndrome (ACS), but their interaction is unclear. This study was designed to evaluate the age-dependent impact of OSA…
View details →Wong ES, Taylor LL, Rojas J et al. · 2026 · Healthcare (Amsterdam, Netherlands)
Background In the Veterans Health Administration (VHA), primary care is delivered through a team-based medical home called the Patient Aligned Care Team (PACT). Increasing team panel size is one approach to addressing staffing challenges…
View details →Soares EMKVK, da Cruz CJG, Ives SJ et al. · 2026 · Nutrients
Objectives : To determine whether caffeine supplementation and its expectancy influence muscle strength (ST) and muscle endurance (ME) using a balanced-placebo design. Methods: Using a randomized, double-blind, balanced-placebo design,…
View details →Yang HS, Atkins LT, James CR · 2026 · Journal of applied biomechanics
Gait symmetry is often assumed in healthy individuals, yet functional asymmetries arise from biomechanical and neurophysiological factors. Although light upper body loading can improve walking performance, its effect on lower limb joint…
View details →Karataş ŞN, Çağan E, Demirören K et al. · 2025 · Turkish archives of pediatrics
Objective Increased intestinal permeability is associated with the development of allergic and autoinflammatory diseases. Zonulin is a key physiological regulator of tight junctions in the intestinal epithelium. Thymus-expressed chemokine…
View details →Kerlin MP, Harhay MO, Li F et al. · 2026 · Implementation science : IS
Background "Nudges" embedded in the electronic health record (EHR) facilitate desired decisions while preserving autonomy and may provide a scalable strategy to overcome the common implementation barrier of lack of knowledge about a best…
View details →Kloosterman R, Dinh T, Michaeli J · 2026 · Journal of assisted reproduction and genetics
Purpose The purpose of this study is to assess whether discontinuing routine serum hormone testing following gonadotropin-releasing hormone (GnRH) agonist trigger affects the incidence of empty follicle syndrome (EFS) and embryological…
View details →Tsai PH, Hsieh CI, Kuo YC et al. · 2026 · Journal of the National Comprehensive Cancer Network : JNCCN
Background The safety of immune checkpoint inhibitors (ICIs) in patients with cancer and preexisting or acquired autoimmune rheumatic diseases (ARDs) remains unclear. This study aimed to evaluate the safety of ICIs in patients with cancer…
View details →Litvina EA, Illarionova AR, Potapova OM · 2026 · Vestnik oftalmologii
The combination of age-related cataract and neovascular age-related macular degeneration (nAMD) presents a clinically challenging scenario, as it requires continuation of anti-angiogenic therapy during the perioperative period. The impact…
View details →Hochstenbach LMJ, Verbeek JGE, Brokken-Peters MBJ et al. · 2026 · Rheumatology (Oxford, England)
Objectives To evaluate MyRA, a web-based self-monitoring application for RA, on patient empowerment, usability and perceived usefulness. Methods MyRA was co-developed with patients and used at their own discretion during a 4-month…
View details →Song M, Mao M, Zhao H et al. · 2025 · Infectious agents and cancer
Objective To investigate the oncogenic risks of distinct high-risk human papillomavirus (HR-HPV) genotypes and whether multiple infections exacerbate pathogenicity, with analysis of age stratification and viral load impact. Methods…
View details →Yamano Y, Shimizu Y, Inata Y et al. · 2026 · Clinical nutrition ESPEN
Background & aims Lipid emulsions are key components of parenteral nutrition (PN); however, concerns persist that soybean oil-based lipid emulsions may increase the risk of infection and catheter occlusion. In pediatric intensive care…
View details →Matsumura M, Yasuda A, Murakami M et al. · 2025 · Biochemical genetics
Hepcidin centrally regulates systemic iron status. We previously revealed that activities of trans-factor to induce hepcidin expression are distinct between cattle and humans/mice in which regulation of hepcidin expression is…
View details →Ruiz-Palacios GM, Cahn PE, Halperin SA et al. · 2026 · Vaccine
Background There is a concern about the potential increased risk of acquiring HIV infection after vaccination with adenovirus type 5 (Ad5) vector-based vaccines. We aimed to investigate whether Ad5-nCoV increases the risk of HIV infection.…
View details →Li RQ, Su S, Zhan LP et al. · 2026 · Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology
Objective: To investigate the differences in the changes of periodontal ligament area (PDLA) and related clinical indicators before and after maxillary central incisor movement under different orthodontic treatment regimens. Methods: This…
View details →Zhang XR, Yang GJ, Jiang LC et al. · 2026 · The New phytologist
Nitrogen (N) inputs generally benefit grassland biomass production. Supporting evidence, however, comes mainly from experiments with high N input rates and from grasslands without utilization. Using a 10-yr field experiment in temperate…
View details →Liang XS, Ning Y, Wang HY et al. · 2026 · The New phytologist
Nitrogen (N) enrichment is expected to exacerbate plant phosphorus (P) limitation, yet this assumption has seldom been empirically tested. We investigated the effects of 7-9 yr of N and P addition on grassland aboveground net primary…
View details →Schaefer N, Kelaher BP, Bishop MJ · 2026 · Marine environmental research
Climate warming is exposing intertidal species to increasing temperatures, threatening the survival of those already experiencing conditions close to their upper thermal limit. On intertidal rocky shores, habitat-forming seaweeds can…
View details →Dupla X, Bertagni MB, Grand S · 2025 · Environmental science & technology
Enhanced rock weathering (ERW) is a CO 2 removal technology that involves spreading finely ground silicate rock on fields. The chemical weathering of this rock powder removes atmospheric CO 2 in the form of bicarbonate ions and secondary…
View details →Hernigou P, Caton J · 2025 · International orthopaedics
Purpose Calcium pyrophosphate dihydrate (CPPD) deposition, often visible radiographically as chondrocalcinosis, frequently accompanies knee osteoarthritis and is usually encountered at the time of arthroplasty. Whether its presence…
View details →Grummon AH, Zeitlin AB, Lee CJY et al. · 2026 · American journal of preventive medicine
Introduction As of 2025, 9 states have adopted Universal Free School Meal programs. The success of these programs depends in part on high participation. This study tested whether a social media campaign promoting school meal participation…
View details →Sazuka T, Habu Y, Matsusaka K et al. · 2026 · International journal of clinical oncology
Background Pelvic lymph-node dissection is performed across multiple surgical specialties. However, inconsistent terminology and unclear anatomical boundaries hinder standardization. This study established a multidisciplinary team with a…
View details →Hamrick MW, Fulzele S, Isales CM et al. · 2025 · Biochimie
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that is thought to play important roles in aging, oxidative stress, and cellular senescence. We have previously shown that the AhR agonist kynurenine (Kyn), a…
View details →Busse A, Müller J, Benbow ME et al. · 2025 · Journal of Applied Entomology
Understanding the dispersal ability of insects is critical for conservation efforts, as well as for preventing economic and health risks, such as the spread of bluetongue disease or African swine fever (ASF). However, knowledge of the…
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