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Browse the failure-mode index

11,417 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Effects of glucose ingestion on blood flow in the small intestine and exercising limbs during endurance exercise.

Endo MY, Kashima H, Miura A et al. · 2026 · Journal of applied physiology (Bethesda, Md. : 1985)

Performance during endurance exercise depends on the balance between the blood flow (BF) to active muscles and their energy use. We compared the acute cardiovascular regulation after the ingestion of a 300-mL drink containing 50 g glucose…

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Negative / Null Result ReportMedicine

Clinical Characteristics and Management for Flares in Patients With Rheumatoid Arthritis Treated With Biologic and Targeted Synthetic Disease-Modifying Antirheumatic Drugs.

Kim YE, Ahn SM, Oh JS et al. · 2026 · International journal of rheumatic diseases

Objective To evaluate the frequency and management of flares in rheumatoid arthritis (RA) patients treated with biologic or targeted synthetic disease-modifying antirheumatic drugs (b/tsDMARDs). Methods Data were analyzed from the KOrean…

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Negative / Null Result ReportMedicine

Factors influencing time to speech processor upgrades.

Hung C, Spitzer ER, Waltzman SB · 2026 · Cochlear implants international

Objective Cochlear implant (CI) speech processors have undergone technological advancements. Therefore, patients upgrade speech processors when new features are available or when their previous device becomes broken and is no longer…

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Negative / Null Result ReportMedicine

Non-alcoholic beverage provision reduces alcohol consumption and improves health-related outcomes, with no effect on presenteeism: a randomized controlled trial.

Dobashi S, Hotoge S, Kikuchi A et al. · 2026 · Scientific reports

Excessive alcohol consumption contributes to mortality and productivity losses, yet evidence for workplace-based substitution interventions remains limited. This randomized controlled trial examined whether providing non-alcoholic…

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Negative / Null Result ReportMedicine

Reliability of Noninvasive Blood Pressure Monitoring During Atrial Fibrillation Ablation Under General Anesthesia.

Schwartz J, Al-Sadawi M, Mattimore D et al. · 2026 · Journal of cardiothoracic and vascular anesthesia

Objectives To evaluate the accuracy and reliability of noninvasive blood pressure (NIBP) monitoring compared to invasive blood pressure (IBP) measurements during atrial fibrillation (AF) ablation under general anesthesia, and to determine…

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Negative / Null Result ReportMedicine

The effect of eggshell translucency on egg weight, embryonic development, hatching traits, chick quality, post-hatch growth, carcass, and organ traits in Ross 308 fast growing broiler strains at 7 days of age.

Abdallah N, Kursun K, Baylan M · 2026 · Tropical animal health and production

This study investigated the effect of eggshell translucency on egg weight, embryonic development, hatching traits, chick quality, post-hatch growth, carcass, and organ traits at 7 days of age in broiler chickens. A total of 300 hatching…

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Negative / Null Result ReportOpen accessMedicine

[Corrigendum] Associations between Huwe1 and autophagy in rat cerebral neuron oxygen‑glucose deprivation and reperfusion injury.

He GQ, Chen Y, Liao HJ et al. · 2026 · Molecular medicine reports

Following the publication of the above article, the authors have contacted the Editor to explain that, regarding the immunofluorescence experiments shown in Fig. 3 on p. 5089, the data correctly shown in Fig. 3I (for the 'V‑ctrl+DMSO+R 24…

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Negative / Null Result ReportMedicine

Source of lateralization in reverse total shoulder arthroplasty matters: a comparison of glenoid and humeral lateralization on rotator cuff biomechanics.

Brusalis CM, Glenday J, Fu MC et al. · 2026 · Journal of shoulder and elbow surgery

Background Compared with the traditional Grammont design, modern reverse total shoulder arthroplasty (rTSA) implant designs often introduce lateralization of the glenoid and/or humeral components. This study aimed to evaluate the impact of…

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Negative / Null Result ReportMedicine

Does the Combination of Calcium Hydroxide and Chlorhexidine Gel Affect Dentinal Tubule Penetration of Epoxy Resin and Tricalcium Silicate-Based Sealers?

Baran EK, Oncu A, Celikten B · 2026 · Australian endodontic journal : the journal of the Australian Society of Endodontology Inc

This study evaluated effect of calcium hydroxide (CH) medicaments prepared with distilled water, glycerin and chlorhexidine (CHX) gel on dentinal tubule penetration of epoxy resin- and tricalcium silicate-based sealers using confocal laser…

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Negative / Null Result ReportMedicine

Design and Preliminary Evaluation of a Hand-Held Surgical Robot for Enhanced Intuitive Control in Laparoscopy.

Kong K, Qiang Z, Yang Y et al. · 2026 · The international journal of medical robotics + computer assisted surgery : MRCAS

Background Surgical robots offer improved precision and stability for laparoscopy; nevertheless, their limited portability and high cost impede broader clinical applications. Methods This paper proposes a hand-held surgical robot with an…

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Negative / Null Result ReportMedicine

EEG activities and connectivities associated with surtitle presentation during live opera viewing: an exploratory analysis of cognitive absorption.

Boasen J, Giroux F, Duchesneau MO et al. · 2026 · Scientific reports

Characterizing brain activities underlying text availability in an ecologically valid context and identifying whether aspects of these activities are influenced by one's state of cognitive absorption (CA) are important yet unexplored lines…

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Negative / Null Result ReportMedicine

Transdermal versus oral hormone replacement therapy and bone mass density in Turner syndrome patients: a pilot study.

Widmann K, Hager M, Windischbauer LM et al. · 2026 · Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology

Objective Women with Turner syndrome (TS) are at increased risk of reduced bone mineral density (BMD) due to primary ovarian insufficiency. This study aimed to assess longitudinal changes in BMD in TS patients receiving oral or transdermal…

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Negative / Null Result ReportMedicine

Effects of probiotics on alcohol-conditioned behaviors and hippocampal morphology in male rats.

Eraghi NG, Sefati N, Ghaffari MK et al. · 2026 · Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

Alcohol Use Disorder (AUD) is a complex condition marked by physical and psychological dependence, often accompanied by lasting changes in brain regions such as the hippocampus that contribute to memory and cognitive impairments. Emerging…

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