11,417 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Iwagami S, Yamamoto H, Miyai H et al. · 2026 · Lower urinary tract symptoms
Objectives To evaluate whether frailty at treatment initiation is associated with treatment-related adverse events in patients with newly diagnosed overactive bladder (OAB). Methods This retrospective, single-center cohort study included…
View details →Mattar YA, Refaat O, El-Makawi S et al. · 2026 · The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry
Background Family history and APOE ε4 carriage represent the strongest non-modifiable Alzheimer's disease (AD) risk factors after advancing age. Early identification of cognitive markers in individuals at risk is essential for effective…
View details →Schwanitz von Keitz P, Liebau KH, Mittelmeier W et al. · 2026 · Children (Basel, Switzerland)
Background: Developmental dysplasia of the hip (DDH) is the most common congenital musculoskeletal disorder in newborns. Flexion-abduction orthoses are widely used in early treatment; however, in vivo data on their biomechanical load…
View details →Hansen BK, Sandefur EP, Garcia AR et al. · 2026 · The journal of knee surgery
Abstract Cyclops lesions are a common postoperative complication that occurs in up to 47% of patients after anterior cruciate ligament reconstruction (ACLR), often resulting in painful extension loss. While risk factors for cyclops lesions…
View details →Espinoza-Abad R, Gogeascoechea-Trejo MDC, García-García F · 2026 · Sleep medicine
Objective To examine the associations of chronotype and sleep quality with psychoactive substance use among adolescents attending schools with different schedules and patterns associated with chronotype-school schedule combinations.…
View details →Kabra NS, Umate SS, Halder P et al. · 2026 · Journal of tropical pediatrics
This study compared the safety and efficacy of double-walled incubators versus radiant warmers in extremely low-birth weight (ELBW: birth weight < 1000 g) preterm infants, hypothesizing that incubator care would reduce the time to regain…
View details →Miller JJ, Duggal M, Bahnson BJ · 2026 · Protein science : a publication of the Protein Society
A growing number of enzymes demonstrate deviations from typical linear kinetic temperature dependencies as modeled by the Arrhenius and Eyring equations. These deviations may manifest as biphasic temperature dependencies consisting of two…
View details →Kanehira M, Nozaki Y, Ogasawara K et al. · 2026 · The international journal of medical robotics + computer assisted surgery : MRCAS
Introduction Robot-assisted partial nephrectomy (RAPN) using the da Vinci Surgical System (DVSS) is broadly performed globally. In Japan, the Hinotori Surgical Robot System (HSRS) has recently been developed. However, few studies have…
View details →Gilmore LK, Russ C · 2026 · Critical care nurse
Background Mechanical ventilation increases patients' risk for ventilator-associated events. Nursing unit councils can help mitigate these events through shared governance. Local problem The medical critical care unit at the project site…
View details →Cebulla C, Hamdan A, Poonawala H et al. · 2026 · Diagnostic microbiology and infectious disease
Background Coagulase-negative Staphylococci (CoNS) are common blood culture contaminants, yet distinguishing true infection from contamination remains challenging. In January 2023, we implemented routine species-level CoNS reporting. This…
View details →Askarian F, Karimizadeh Z, Kalantari A et al. · 2026 · Pediatric nephrology (Berlin, Germany)
Background Acute kidney injury (AKI) is an understudied complication in pediatric Fanconi anemia (FA) patients undergoing hematopoietic stem cell transplantation (HSCT). This study evaluates AKI incidence, risk factors, renal trajectories,…
View details →Shuto H, Hagiwara A, Kudoh R et al. · 2026 · Respiratory medicine and research
Background Acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) carries a high risk of short-term mortality, and optimal management strategies remain unclear. Although recent studies have suggested that antifibrotic therapy…
View details →Bhagat S, Kaur K, Petronglo JR et al. · 2026 · Infection and immunity
Staphylococcus aureus ( S. aureus ) is a highly virulent pathogen responsible for chronic infections such as osteomyelitis. Although its interaction with the host immune system has been widely studied, the specific role of inflammasomes in…
View details →He CZ, Qiu Q, Lai H et al. · 2026 · BMC ophthalmology
This study aimed to evaluate whether a combination of optical coherence tomography (OCT) and OCT angiography (OCTA) parameters could improve the discrimination between clinically diagnosed normal-tension glaucoma (NTG) and non-glaucomatous…
View details →Tawhari I, Park S, Yamani F et al. · 2026 · Frontiers in nephrology
Objective Calcineurin inhibitors, such as tacrolimus, are associated with long-term nephrotoxicity and renal allograft dysfunction despite evidence of improved kidney transplantation outcomes. Consequently, minimizing calcineurin inhibitor…
View details →Stepanichev M, Peregud D, Manolova A et al. · 2026 · Cell biochemistry and function
Chronic stress is often a precursor to depression. Multiple brain mechanisms underlying the development of depression involve alterations in neurotrophin signaling. In the present study, male Wistar rats were exposed to chronic mild…
View details →Momma T, Okayama H, Hasegawa M et al. · 2026 · BMC gastroenterology
Background The global incidence of early-onset colorectal cancer (EOCRC) is increasing. The prognostic impact of EOCRC remains controversial, as it is largely confounded by hereditary syndromes and mismatch repair deficient…
View details →Coombs EL, Cillcott R, McEwan NR · 2026 · Journal of veterinary dentistry
A variety of factors which might potentially affect the severity score of rabbits' teeth were investigated. These included the age, breed and gender of the animal as well as its cephalic index and dietary factors such as type of bowl feed…
View details →Chen J, Zhu Y, Zheng D et al. · 2026 · Journal of magnetic resonance imaging : JMRI
Background MRI is sensitive for detecting hepatocellular carcinoma (HCC), but its routine use is hindered by low accessibility. Purpose To evaluate the performance of non-contrast abbreviated MRI (NC-AMRI) alone and in combination with…
View details →Khan HA, Khan A, Rosenberg A et al. · 2026 · Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA
Purpose To compare the career longevity of professional soccer players after achilles tendon rupture (ATR) with that of an uninjured matched control cohort. Methods A retrospective analysis of ATR cases in professional male athletes from…
View details →Schemel-Suarez M, Egido-Moreno S, Martínez-Lizan I et al. · 2026 · Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons
Background Dental anxiety frequently compromises patient cooperation and outcomes during third molar (3M) extraction prompting the use of nonpharmacological strategies such as detailed written information. Evidence on reducing preoperative…
View details →González-Cruces T, Carrillo-Pulido M, Aguilar-Salazar FJ et al. · 2026 · Eye & contact lens
Objective This study aimed to develop supervised machine learning (ML) models to predict ocular sagittal height (OC-SAG), using anterior eye data derived from topography and tomography. Method ology: A retrospective cohort of 100 eyes…
View details →Chen R, Li D, Jia B et al. · 2026 · PeerJ
Background This study examined whether ischemic preconditioning (IPC) improves lower-limb anaerobic performance and neuromuscular function in female athletes. Methods Twenty-two female second-level athletes were randomly assigned to an IPC…
View details →Amini S, Alshammari M, Abdulhameed N et al. · 2026 · Journal of prosthodontics : official journal of the American College of Prosthodontists
Purpose The aim of this in vitro study was to investigate the effect of print orientation and printing technology on the accuracy of static computer-aided implant surgery (s-CAIS). Materials and methods A cone beam computed tomography…
View details →Broughton MC, Bunzli E, Pagel S et al. · 2026 · Journal of paediatrics and child health
Aim This study explored whether a single music therapy session could reduce 22q11.2 deletion syndrome (DS) children and adolescents' clinic-related anxiety when visiting the hospital outpatient clinic for health appointments. Methods The…
View details →Armah L, Tan L, Branning R et al. · 2026 · Epilepsy & behavior : E&B
Aims To evaluate whether improvements in depressive symptoms, epilepsy self-efficacy, and perceived stigma mediate the association between the SMART intervention and epilepsy self-management. Methods 160 people with epilepsy were enrolled…
View details →Mahat G, Zha P · 2026 · Journal of pediatric health care : official publication of National Association of Pediatric Nurse Associates & Practitioners
Evidence highlights rising mental health concerns among youth. This study investigated the relationship between protective behaviors, including physical activity, regular breakfast, sleep, and parental monitoring, and adolescent mental…
View details →Yukishima T, Kobayakawa T, Hirano Y et al. · 2026 · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
This multicenter retrospective cohort compared romosozumab outcomes between oral glucocorticoid users and non-users. Bone turnover marker responses and lumbar spine bone mineral density gains were similar, whereas total hip bone mineral…
View details →Aslan G, Eggers K · 2026 · Folia phoniatrica et logopaedica : official organ of the International Association of Logopedics and Phoniatrics (IALP)
Introduction This pilot study investigated whether attention skills influence speech disfluencies in school-aged children, comparing monolingual Dutch (MONO) speakers and bilingual Dutch-Turkish speakers (BIL). Disfluencies frequently…
View details →Marschal V, Ziebart A, Abdoullahi M et al. · 2026 · Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
While ventriculostomy-associated hemorrhages are well-documented in spontaneous subarachnoid hemorrhage (SAH), the impact of external ventricular drainage (EVD) placement accuracy on puncture channel bleeding (PCB) remains underexplored.…
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