11,322 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Li X, Wei X, Liu H · 2026 · Acta psychologica
The detrimental effect of demotivation on language learning engagement and achievement highlights the necessity to explore its antecedents. This research specifically delves into the intricate interplay between demotivation, self-esteem,…
View details →Chen X, An Z, Li C et al. · 2026 · Clinical and experimental medicine
Anti-citrullinated peptide/protein antibodies (ACPAs) are specific serological markers for rheumatoid arthritis (RA), but their direct role in promoting osteoclastogenesis remains controversial. This study aims to determine whether…
View details →Song Z, Liu Y, Liu H et al. · 2026 · Animals : an open access journal from MDPI
Bile acids are important for lipid digestion and metabolic regulation, but the roles of individual bile acids in crustaceans remain unclear. This study evaluated the effects of six dietary monomeric bile acids on growth and lipid…
View details →Manole C, Shet S, O Apos Brien A et al. · 2026 · Cerebrovascular diseases extra
Introduction In acute ischaemic stroke secondary to a large vessel occlusion, endovascular thrombectomy (EVT) is the standard of care. However, prediction of functional outcomes following EVT remains challenging. We sought to determine…
View details →Matheron G, Pearse R, Dellis S et al. · 2026 · Foot and ankle surgery : official journal of the European Society of Foot and Ankle Surgeons
Background Nonunion remains a major complication after ankle and hindfoot arthrodesis. Biologic augmentation is frequently used to mitigate this risk, but incremental benefit remains unproven. This study evaluated CT-verified union rates…
View details →Valizadeh S, Moshfeghi M, Bahrani Z et al. · 2026 · International journal of dentistry
Objective Artifacts from dental implants impact the clarity of cone-beam computed tomography (CBCT) scans, posing challenges to radiographic detection in adjacent areas. The aim of this in vitro study is to examine the effect of angling a…
View details →Irimie AI, Dinescu SN, Novac MB et al. · 2026 · Journal of clinical medicine
Background . Hematological inflammatory indices from the complete blood count have been proposed as inexpensive prognostic markers in sepsis. The systemic immune-inflammation index (SII) and neutrophil-to-lymphocyte ratio (NLR) are the…
View details →Sengoku M, Ogawa H, Nakamura Y et al. · 2026 · Journal of orthopaedic surgery (Hong Kong)
BackgroundDuloxetine is a potent analgesic that reduces pain associated with knee osteoarthritis. This study aimed to evaluate the analgesic effects of regular postoperative duloxetine after high tibial osteotomy (HTO) and its influence on…
View details →Couturier I, Denis S, Rossary A et al. · 2026 · Food chemistry
Cooked High Amylose Wheat (HAW) products are dietary sources of resistant starch (RS). While its effects on gut microbiota are known, links to immune responses remain unclear. This study evaluated the antioxidant and anti-inflammatory…
View details →Płuciennik K, Bukowska B, Sicińska P · 2026 · Nanotoxicology
The widespread presence of polystyrene nanoparticles (PS-NPs) in the human body has raised concerns about their potential biological toxicity. When assessing the safety of nanoparticles and other xenobiotics, a key aspect is their effect…
View details →Masood M, Lane B, Maghfour J et al. · 2026 · Clinical and experimental dermatology
Post-inflammatory hyperpigmentation (PIH) is a common complication following trauma or cutaneous inflammation, particularly affecting individuals with skin of colour. Tranexamic acid (TXA) is a lysine analogue with antifibrinolytic…
View details →Banjoko A, Harris N, Mousavi S et al. · 2026 · Journal of clinical medicine
Background/Objectives: Shift work is a form of circadian dysregulation, which has been associated with adverse reproductive health outcomes. However, the association between circadian dysregulation and ovarian reserve remains uncertain.…
View details →Zhao Y, Peng Z, Cao D et al. · 2026 · BMC health services research
Background The Chinese government piloted the public hospital's compensation system reform in 2017. It is important for policymakers to understand how this reform has affected the health workforce's compensation and its structure. We…
View details →Zazzeron L, Grancini V, Trombetta M et al. · 2026 · Frontiers in endocrinology
Background Cystic fibrosis-related diabetes (CFRD) is the most common extra-pulmonary complication in adults with cystic fibrosis (CF) and is primarily driven by progressive beta-cell dysfunction. The impact of CFTR modulators,…
View details →Tapescu I, Brody RM, Cao AC et al. · 2026 · Oral oncology
Objectives To determine the incidence of pathologic retropharyngeal lymph node (RPLN) metastases, evaluate the accuracy of preoperative imaging, identify predictors for RPLN involvement, and assess the impact of pathologic RPLN metastases…
View details →Prasad D, Feltham G, De Giorgi R et al. · 2026 · Journal of psychopharmacology (Oxford, England)
Introduction Cognitive flexibility, defined as the ability to shift mental strategies when environmental demands change, may influence psychological well-being and psychiatric treatment outcomes. Research increasingly implicates the renin…
View details →Miño V, Bacigalupo F, Quezada-Scholz VE et al. · 2026 · Acta psychologica
The present study investigated whether cognitive reappraisal modulates conditioned responding during extinction in a socially relevant fear-conditioning paradigm and whether these effects vary as a function of 5-HTTLPR genotype and…
View details →Gajula SNR, Kallam JS, Kanukolanu A et al. · 2026 · Biopharmaceutics & drug disposition
Echinacea is a widely used herbal supplement and is frequently co-administered with antiviral drugs, raising concerns regarding potential herb-drug interactions. This study evaluated the effect of repeated Echinacea administration on the…
View details →Zhang P, Iskandarani ME, Riggs S · 2026 · IEEE transactions on visualization and computer graphics
Optical see-through head-mounted displays (OST-HMDs) allow users to interact with both physical and virtual displays overlaid in the real world within augmented reality (AR) environments. When arranging these displays in space, spatial…
View details →Hoshiyama K, Hirano T, Sekiya E et al. · 2026 · Scientific reports
This prospective observational study evaluated short-term intraocular pressure (IOP) changes and safety following intravitreal injection of aflibercept 8 mg versus 2 mg in diabetic macular edema (DME). We included 40 eyes from 36 patients…
View details →Bektaş B, Ulusoy CO, Uslu H et al. · 2026 · International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics
Objective In the present study, we aimed to evaluate the impact of vaginal birth after cesarean (VBAC) on quality of life, sexual function, sleep quality, and urinary incontinence and compare the results with those of vaginal birth (VB)…
View details →Avalos MA, Shah S, Rosenblatt NJ · 2026 · Experimental brain research
Following a loss of balance, proper reactive responses are needed to avoid a fall. Efforts have focused on how physiological factors affect these responses, but few have addressed psychological states. One psychological factor of…
View details →Burgazli AY, Avuloglu Yilmaz E, Mamur S et al. · 2026 · Toxicology mechanisms and methods
Hyperoside (HYP), a plant-derived flavonoid, was evaluated for its cytotoxic, anti-cancer, genotoxic, antigenotoxic, and antioxidant properties, and potential mechanisms of action using an integrated in vitro and in silico approach.…
View details →Wu Y, Zhu L, Lin G et al. · 2026 · Bioresource technology
Antibiotic resistance genes (ARGs) are an increasing environmental and public health concern in wastewater treatment systems due to their persistence, mobility, and links to human bacterial pathogens (HBPs). In this study, aerobic…
View details →Li H, Zhao B, Wang J et al. · 2026 · Theriogenology
Ovum pick-up and in vitro embryo production (OPU-IVP) in Holstein cows is influenced by donor characteristics, yet quantitative selection criteria for optimizing oocyte developmental competence remain limited. In this study, data from 600…
View details →Vukovic V, Karan-Djurasevic T, Antic D et al. · 2026 · Biomolecules & biomedicine
Fludarabine treatment in patients with chronic lymphocytic leukemia (CLL) has been associated with immune dysregulation and the development of autoimmune hemolytic anemia (AIHA). Prior research indicates a potential correlation between the…
View details →Gutierrez AM, Robinson JO, Allen-Rhoades WA et al. · 2026 · Pediatric blood & cancer
Background Decision-making (DM) dynamics between adolescents and young adults (AYAs) with cancer, parents, and oncologists remain underexplored in diverse populations. We examined cancer treatment DM preferences among an ethnically and…
View details →Halawi H, Matar A, Wang I et al. · 2026 · American journal of physiology. Gastrointestinal and liver physiology
Visceral hypersensitivity is a pivotal mechanism in pain associated with irritable bowel syndrome (IBS). Calcitonin gene-related peptide (CGRP) is expressed by visceral afferents. The aim of this study was to evaluate the efficacy of…
View details →Wan L, Xie B, Shuda M et al. · 2026 · Molecular therapy : the journal of the American Society of Gene Therapy
CD8+ T cell targeting of the conserved SARS CoV2 RNA-dependent RNA polymerase (RdRp, nsp12) may offer a means for cross-protection against diverse coronavirus strains. Native RdRp, however, displays primary sequence immunoevasion (PSI)…
View details →Abbasi D, Schall M, Acosta-Sojo Y et al. · 2026 · Applied ergonomics
Shoulder disorders have been associated with repetitive overhead work and manual lifting. Passive exoskeletons may reduce exposure to physical risk factors associated with shoulder injuries. This repeated-measures study evaluated the…
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