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Browse the failure-mode index

11,319 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Effectiveness of a standardized patient simulation training programme on nursing students' skill in dementia screening in Malawi: A quasi-experimental study.

Chiona BC, Mbakaya BC, Liu MF · 2026 · Nurse education in practice

Aim To evaluate the effectiveness of Standardized Patient Simulation (SPS) compared with lecture-based teaching in improving dementia knowledge, dementia screening skills and mild cognitive impairment (MCI) classification accuracy among…

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Negative / Null Result ReportMedicine

Marginal Bone Loss Around Bone-Level Fully Guided Implants With Direct Implant Connection Versus Intermediate Abutment: A Randomized Clinical Trial.

Gargallo-Albiol J, Zilleruelo-Pozo MJ, Treserra-Parra A et al. · 2026 · Clinical oral implants research

Objective To determine the influence of an intermediate prosthetic abutment on peri-implant marginal bone loss (MBL) around two implant-supported fixed restorations in the posterior area. Material and methods This study included patients…

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Negative / Null Result ReportMedicine

Comparison of visual performance among three higher-order aspheric enhanced monofocal intraocular lenses and a standard aspheric monofocal lens.

Hayashi S, Yoshida M, Hayashi K et al. · 2025 · Journal of cataract and refractive surgery

Purpose To compare visual performance among 3 types of higher-order aspheric enhanced monofocal intraocular lenses (IOLs) and a standard aspheric monofocal IOL. Setting Hayashi Eye Hospital, Fukuoka, Japan. Design Randomized comparative…

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Negative / Null Result ReportMedicine

Day-case versus conventional inpatient artificial urinary sphincter implantation: A single-center comparative study of 177 patients.

Youssef MW, Perrin L, Denormandie AC et al. · 2026 · The French journal of urology

Purpose Ambulatory artificial urinary sphincter (AUS) implantation has been proposed as an alternative to conventional inpatient surgery, but comparative data remain limited. We aimed to compare early postoperative outcomes between…

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Negative / Null Result ReportMedicine

Evaluating junior medical staff confidence in assessment and management of mental health presentations in an Australian paediatric emergency department.

Daoud J, Greenwood J, Botha T et al. · 2026 · Australasian psychiatry : bulletin of Royal Australian and New Zealand College of Psychiatrists

ObjectiveTo evaluate confidence levels of junior doctors working in the paediatric emergency department (ED) in the assessment and management of acute mental health presentations.MethodsThis cross-sectional study invited 89 eligible junior…

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Negative / Null Result ReportMedicine

Retrospective study on diagnostic yield and medical impact of diagnostic imaging in dogs with immune-mediated haemolytic anaemia in Belgium.

Vlassenbroek R, Peeters D, Matthewman L et al. · 2026 · The Journal of small animal practice

Objectives To assess the incidence of associative immune-mediated haemolytic anaemia in dogs diagnosed with immune-mediated haemolytic anaemia and to evaluate whether performing diagnostic imaging, specifically thoracic radiographs and…

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Negative / Null Result ReportMedicine

Stabilizing Segmental Le Fort I Osteotomy Using Clear Thermoplastic Retainers Versus Arch Bars With Occlusal Splints: A Retrospective Analysis.

Wu L, Xu X, Liu X et al. · 2026 · The Journal of craniofacial surgery

In patients receiving segmental Le Fort I osteotomy as part of a clear aligner treatment regimen, this study aimed to compare the clinical effectiveness of clear thermoplastic retainers as a postoperative stabilization technique and…

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Negative / Null Result ReportMedicine

Midterm Clinical and Echocardiographic Outcomes After Transcatheter Aortic Valve Replacement in Patients With Severe Bicuspid Aortic Valve Stenosis.

Nienaber S, Krabichler K, Fahlbusch D et al. · 2026 · Journal of the American Heart Association

Background Outcomes >2 years after transcatheter aortic valve replacement (TAVR) for bicuspid aortic valves (BAV) are scarce, and differences between balloon-expandable transcatheter heart valves (THVs) and self-expandable (SE-THVs) are…

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Negative / Null Result ReportMedicine

Increased Retinol Levels in Patients with Cardiac Surgery-Associated Acute Kidney Injury-A Prospective Single-Center Exploratory Study.

Olasińska-Wiśniewska A, Swora-Cwynar E, Urbanowicz T et al. · 2026 · Nutrients

Background Acute kidney injury (AKI) is a frequent and prognostically important complication of cardiac surgery, yet early risk stratification remains challenging. The purpose of this prospective exploratory study was to determine whether…

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Negative / Null Result ReportMedicine

Comparative Analysis of Clinically Meaningful Recovery Trajectories Following Unicompartmental Arthroplasty and Patello-Femoral Arthroplasty.

Singh R, Williams DL, Alexander J et al. · 2026 · The Journal of arthroplasty

Background Medial unicompartmental knee arthroplasty (UKA), lateral UKA, and patello-femoral arthroplasty (PFA) are established treatments for isolated compartmental knee osteoarthritis. Despite its growing popularity, the comparative…

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Negative / Null Result ReportMedicine

No serological association between Porphyromonas gingivalis or Prevotella intermedia and early spondyloarthritis: analysis from the DESIR cohort.

Zekre F, Neel T, Paul M et al. · 2026 · Clinical and experimental medicine

Porphyromonas gingivalis and Prevotella intermedia are key oral pathogens implicated in periodontal disease and have been associated with rheumatoid arthritis and specific categories of juvenile idiopathic arthritis. Whether oral dysbiosis…

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Negative / Null Result ReportOpen accessMedicine

Residential radon exposure and lung cancer histology and stage: a population-based ecological study in Central Germany.

Ernst P, Rachow T, Henn S et al. · 2026 · Journal of cancer research and clinical oncology

Purpose Residential radon exposure is recognised as one of the leading environmental risk factors for lung cancer and acts synergistically with tobacco smoking. Thuringia, Germany, exhibits high geogenic radon potential; however,…

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Negative / Null Result ReportMedicine

The impact of drains on postoperative seroma and infection after mastectomy: A retrospective study in Danish women with breast cancer.

Palshof FK, Korsholm RHR, Duriaud HM et al. · 2026 · European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

Introduction Postoperative drains are commonly used after mastectomy to reduce seroma formation, but evidence of the benefit remains unclear. We evaluated the effect of postoperative drains on seroma formation and infection after…

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