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Browse the failure-mode index

11,319 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Effect of use of ambient listening technology on patient-reported communication and satisfaction ratings.

Taylor SL, Aizenberg D, Jost M et al. · 2026 · Journal of the American Medical Informatics Association : JAMIA

Objectives Evaluate the impact of ambient listening AI scribe technology for drafting notes on patient-reported communication and satisfaction ratings of their physician during ambulatory visits. Materials and methods We conducted a pilot…

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Negative / Null Result ReportMedicine

The Performance of Large Language Models on Antibiotic Prophylaxis for Endodontic Treatments.

Goker Kamali S, Imamoglu YT · 2026 · Australian endodontic journal : the journal of the Australian Society of Endodontology Inc

This study compared the accuracy and repeatability of responses generated by three advanced language models (ChatGPT-4, Gemini, and DeepSeek) in determining the necessity and appropriate regimen of antibiotic prophylaxis in endodontic…

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Negative / Null Result ReportMedicine

Masseter microvascular perfusion after minimally invasive sagittal split ramus osteotomy: A long-term split-mouth study.

Şahin M, Asan CY, Çukurluoğlu A et al. · 2026 · Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery

Sagittal split ramus osteotomy (SSRO), a widely used mandibular procedure in orthognathic surgery, may affect the masticatory muscles through subperiosteal dissection and soft-tissue manipulation. Although minimally invasive modifications…

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Negative / Null Result ReportMedicine

Clinical roles and workflow characteristics of the 3D 4K exoscope in brain tumor surgery: A single-center retrospective observational study.

Ogiwara T, Sato A, Wakabayashi M et al. · 2026 · Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia

Background The three-dimensional (3D) 4K exoscope has emerged as a practical visualization platform in neurosurgery, offering high-resolution imaging together with ergonomic and workflow-related advantages. The aim of this study was to…

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Negative / Null Result ReportMedicine

Real-World Outcomes of Barbed Versus Interrupted Sutures for Laparoscopic Choledochotomy: A 12-Month Follow-Up in Patients With Choledocholithiasis.

Zhao P, Zhou Y, Zhang C et al. · 2026 · Surgical laparoscopy, endoscopy & percutaneous techniques

Background The optimal suture technique for primary closure after laparoscopic choledochotomy remains uncertain. We compared real-world outcomes of barbed continuous and conventional interrupted sutures in patients with…

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Negative / Null Result ReportMedicine

Do anaerobic bottles add value? A comparative study of blood culture bottle combinations in a tertiary care centre.

Benedict Vinothini A, Mythilipraba S, Punnen SA et al. · 2026 · Indian journal of medical microbiology

Background Bloodstream infections (BSIs) require rapid identification and susceptibility testing to guide timely antimicrobial therapy. Although paired aerobic and anaerobic blood culture bottles are routinely used, the incremental benefit…

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Negative / Null Result ReportMedicine

Sphincter-sparing pre-closure technique-assisted endoscopic papillectomy versus conventional endoscopic papillectomy for duodenal papilla adenomas: a multicenter retrospective cohort study.

Liu FQ, Ren LN, Zhou XR et al. · 2026 · Gastrointestinal endoscopy

Background and aims This multicenter retrospective cohort study aims to evaluate the efficacy and safety of sphincter-sparing pre-closure technique-assisted endoscopic papillectomy (EP) versus conventional EP for duodenal papilla adenomas.…

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Negative / Null Result ReportOpen accessMedicine

Perceived leg length discrepancy after total hip arthroplasty is associated with global spinopelvic coronal flexibility.

Minoji S, Ishikura H, Kudo M et al. · 2026 · Archives of orthopaedic and trauma surgery

Background Perceived leg length discrepancy (pLLD) is a common source of dissatisfaction after total hip arthroplasty (THA), even in the absence of significant radiographic discrepancies. While spinopelvic factors have been increasingly…

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Negative / Null Result ReportOpen accessMedicine

Interfascial Plane Blocks for Perioperative Analgesia in Dogs Undergoing Laparoscopic Ovariectomy: A Retrospective Study (2020-2025).

Paolini A, Serpieri M, Bonaffini G et al. · 2026 · Animals : an open access journal from MDPI

This retrospective study compared three ultrasound-guided locoregional techniques-transversus abdominis plane (TAP), quadratus lumborum (QL), and caudal thoracic paravertebral (C-TPV) blocks-in dogs undergoing laparoscopic ovariectomy.…

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Negative / Null Result ReportMedicine

Determinants of Patient-Reported Experience After Interhospital Transfer Within an Integrated Health System.

Howick V JF, Lugo-Fagundo NS, Umadat G et al. · 2026 · Journal for healthcare quality : official publication of the National Association for Healthcare Quality

Objective To evaluate patient-reported experiences after interhospital transfer (IHT) within an integrated health system and identify communication and coordination domains associated with overall satisfaction. Methods This retrospective…

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Negative / Null Result ReportMedicine

Microfluidic sperm selection versus density gradient centrifugation in ICSI cycles with abnormal semen parameters: a randomized sibling-oocyte study.

Thanapongpibul C, Niransuk P, Sassanarakkit S et al. · 2026 · Scientific reports

Microfluidic sperm selection (MSS) is a centrifugation-free alternative to density gradient centrifugation (DGC) for sperm preparation in intracytoplasmic sperm injection (ICSI). This prospective, randomized sibling-oocyte study included…

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Negative / Null Result ReportMedicine

Association of the mitochondrial regulator PGC-1α with diabetes mellitus and myocardial ischemia-reperfusion injury in coronary artery bypass grafting.

Yildiz A, Yazici S, Yildiz Z · 2026 · BMC cardiovascular disorders

Objectives This study aimed to evaluate whether peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α) could serve as a marker of myocardial ischemia by examining its association with cross-clamp time, which reflects…

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Negative / Null Result ReportOpen accessMedicine

Low-flow oxygen delivery in patients with disturbed consciousness.

Yamada SM · 2026 · Surgical neurology international

Background When low-flow oxygen (O2) delivery is required, a nasal cannula is commonly used. However, no reports have described arterial blood gas analysis in actual patients receiving O2 simultaneously through a mask and a nasal cannula.…

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Negative / Null Result ReportMedicine

Susceptibility of sorghum to infestation by Oryzaephilus surinamensis (Coleoptera: Silvanidae) and Trogoderma variabile (Coleoptera: Dermestidae): influence of variety and temperature.

Gourgouta M, Athanassiou CG, Arthur FH et al. · 2026 · Journal of economic entomology

This study evaluated the effects of sorghum variety and temperature on the population growth, frass production, kernel damage, and weight loss caused by Oryzaephilus surinamensis (L.) and Trogoderma variabile, Ballion, two common…

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Negative / Null Result ReportOpen accessMedicine

Influence of sport mouth-formed type mouthguards on saliva secretion and composition during jaw activity: a pilot study.

van Vliet KE, Lobbezoo F, van Splunter AP et al. · 2026 · BMC oral health

BACKGROUND: We hypothesized that wearing a mouthguard may affect salivary flow and composition. Therefore, we investigated the impact of mouthguard use on saliva secretion rate and some salivary constituents under different jaw activities.…

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Negative / Null Result ReportMedicine

Sacral positioning and interface pressure in the beach-chair position during shoulder surgery: a retrospective, observational study.

Takatori N, Uchiyama Y, Ito H et al. · 2026 · Journal of tissue viability

Background Intraoperative pressure-related skin injuries remain a concern during surgery under general anaesthesia. Although interface pressures have been evaluated in various surgical positions, sacral pressure in the beach-chair position…

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Negative / Null Result ReportMedicine

Migraine is Associated With Altered Preoperative Endodontic Pain Perception and Mechanical Sensory Function but Not Short-Term Postoperative Pain: A Prospective Clinical Study.

Harun AS, Shikder AHMZH, Moni SD et al. · 2026 · Journal of oral rehabilitation

Background Migraine has been associated with altered nociceptive processing and may influence the clinical presentation of odontogenic pain. This study evaluated whether migraine is associated with preoperative endodontic pain,…

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Negative / Null Result ReportMedicine

Source- and land-use-dependent controls on black carbon accumulation in urban soils: A comparison between an industrial city and a megacity in central China.

Zhan C, Liu S, Kang W et al. · 2026 · Environmental pollution (Barking, Essex : 1987)

Black carbon (BC) is an important component of soil organic carbon (SOC), with implications for carbon sequestration and environmental quality, yet its variability across contrasting urban systems remains insufficiently understood. This…

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