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Browse the failure-mode index

11,319 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Comparative evaluation of root dentin thickness following hand and rotary instrumentation of primary molar root canals using cone-beam computed tomography - an invitro study.

Thomas RM, Nayak R, Madi M et al. · 2026 · BMC oral health

Remaining Root Dentin Thickness (RRDT) after root canal instrumentation is an important parameter to be assessed with newer file systems. This study aimed to evaluate the root dentin thickness following instrumentation of primary molar…

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Negative / Null Result ReportMedicine

Comparative study of prosthesis implantation, latissimus dorsi flap, and combined reconstruction immediately after breast cancer surgery: A retrospective, single-center, observational cohort study.

Zhang Y, Yu W, Shen W · 2026 · Medicine

This study aimed to explore the effects of 3 immediate reconstruction methods - prosthesis implantation, latissimus dorsi flap (LDF), or their combination - on postoperative outcomes following breast cancer (BC) surgery. A retrospective,…

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Negative / Null Result ReportMedicine

Effect of Remimazolam or Propofol Combined With Esketamine on Anesthesia and Early Perioperative Neurocognitive Disorders in Patients Undergoing Thoracoscopic Partial Lung Resection: A Randomized Clinical Trial.

Yuan W, Liang X, Zhang R et al. · 2026 · Clinical therapeutics

Purpose This study aimed to evaluate the effects of remimazolam in conjunction with esketamine on anesthesia and the incidence of early perioperative neurocognitive disorders (PNDs) in patients undergoing thoracoscopic partial lung…

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Negative / Null Result ReportMedicine

Challenge Under Pressure Contextual Interference or Differential Learning.

Taghizadeh H, Parvizi MJ, Roostaei A et al. · 2026 · Research quarterly for exercise and sport

This study compared the effects of blocked practice, random practice (contextual interference), and differential learning on acquisition, retention, and performance under psychological pressure of a basketball jump shot in novice…

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Negative / Null Result ReportMedicine

Evaluation of Osteomeatal Complex Anatomical Variations, Pathologies and Nasal Cavity Volume in Patients with Cleft Lip and Palate.

Cebeci T, Polat Akmansoy B · 2026 · The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association

ObjectiveTo compare osteomeatal complex (OMC) anatomical variations and nasal cavity airway volume between individuals with cleft lip and palate (CLP) and healthy controls using cone beam computed tomography (CBCT).DesignRetrospective,…

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Negative / Null Result ReportMedicine

The use of partially slatted floor designs as an alternative to littered systems in broiler chickens. II. The effects on welfare and behavioral traits.

Çavdarcı H, Sarıca M, Erensoy K et al. · 2026 · Tropical animal health and production

This study investigated the effects of different flooring designs on the welfare and behavioral traits in fast-growing broilers. A total of 600 day-old Ross-308 chickens were randomly allocated to five treatment groups: fully littered…

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Negative / Null Result ReportMedicine

Sublethal effects and bioaccumulation of "smart" anti-corrosion nanoadditives spiked in sediment in the ragworm Hediste diversicolor.

Bruni M, Perina F, Figueiredo J et al. · 2026 · Aquatic toxicology (Amsterdam, Netherlands)

Metallic corrosion poses an economic problem worldwide and is often mitigated by adding corrosion inhibitors (CIs) to protective coatings. Conventional CIs, such as 2-mercaptobenzothiazole (MBT) and benzotriazole (BTA), exhibit toxicity to…

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Negative / Null Result ReportOpen accessMedicine

Ductus Arteriosus Morphology in Pulmonary Atresia With Ventricular Septal Defect: A Retrospective Case Series Comparing Echocardiography and Digital Subtraction Angiography.

Quan TT, Nguyen HM, Nguyen HT et al. · 2026 · Cureus

Objective This study aims to describe ductus arteriosus (DA) morphology in patients with pulmonary atresia with ventricular septal defect (PA-VSD) and to assess exploratory paired differences between echocardiography and digital…

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Negative / Null Result ReportMedicine

Embryo Euploidy Rates and Reproductive Outcomes Following Ethanol Sclerotherapy, Laparoscopic Cystectomy, or No Intervention for Ovarian Endometriomas Prior to IVF with PGT-A: A Retrospective Cohort Study.

Goc G, Sukur YE · 2026 · Journal of minimally invasive gynecology

Study objective To compare embryo euploidy rates and reproductive outcomes among women with ovarian endometriomas who underwent ethanol sclerotherapy (EST), laparoscopic cystectomy, or expectant management prior to in vitro fertilization…

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Negative / Null Result ReportMedicine

First head-to-head comparison of allograft repair, direct neurorrhaphy and non-surgical management for iatrogenic trigeminal nerve injury: a prospective multicentre cohort study with doubly robust analysis.

Van der Cruyssen F, Willaert R, Palla B et al. · 2026 · International journal of oral and maxillofacial surgery

Trigeminal nerve injuries severely degrade quality of life, yet comparative effectiveness evidence for existing treatments is scarce. The authors prospectively followed 153 adults with iatrogenic lingual or inferior alveolar nerve injuries…

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Negative / Null Result ReportMedicine

Changes in Gait Kinematics with Continuous Intrathecal Baclofen Infusion for Spasticity After Acquired Brain Injury: A Comparison of Implanted and Non-Implanted Cohorts.

Chow JW, Yablon SA, Stokic DS · 2026 · NeuroRehabilitation

BackgroundAlthough several studies have examined gait changes associated with continuous intrathecal baclofen (CITB) infusion for spasticity in ambulatory patients with acquired brain injury (ABI), none has included a control…

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Negative / Null Result ReportOpen accessMedicine

Mid-term outcomes and hemodynamic performance of Edwards 19-mm-labeled aortic valve bioprostheses: a single-center retrospective study.

Gyoten T, Akatsu T, Kuroda T et al. · 2026 · Journal of cardiothoracic surgery

Background This study aimed to evaluate clinical outcomes after surgical aortic valve replacement with third-generation Edwards (Edwards Lifesciences, Irvine, CA, USA) 19-mm-labeled aortic valve bioprostheses, including a rapid-deployment…

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