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11,319 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Supervised exercise and pelvic floor muscle training eases current pelvic and genital pain but not worst pelvic and genital pain in women with endometriosis: a randomised trial.

Gabrielsen R, Tellum T, Bø K et al. · 2025 · Journal of physiotherapy

Question How much does adding supervised group and independent individual exercise including pelvic floor muscle training (PFMT) to multidisciplinary pain management affect pelvic and genital pain in women with endometriosis? How much does…

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Negative / Null Result ReportMedicine

Utility of RB1 immunohistochemistry for prognostic subtyping of pulmonary large cell neuroendocrine carcinoma.

Minkley M, Ravasia K, Nghiem T et al. · 2026 · Virchows Archiv : an international journal of pathology

Pulmonary large cell neuroendocrine carcinoma (LCNEC) is an aggressive and molecularly heterogenous cancer with poorly defined treatment strategies. We aimed to (i) assess whether RB1 immunohistochemistry alone can prognostically stratify…

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Negative / Null Result ReportMedicine

Macular Optical Coherence Tomography Angiography Biomarkers Predict Regional Retinal Nonperfusion Patterns on Ultrawidefield Angiography in Diabetes.

Kakihara S, Busza AM, Duffy BV et al. · 2026 · American journal of ophthalmology

Objective To determine whether foveal avascular zone (FAZ) enlargement and geometric perfusion deficits in the deep capillary plexus (GPDd) are independently associated with retinal nonperfusion in different regions of ultrawidefield…

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Negative / Null Result ReportMedicine

Toward Earlier Bedtimes: Randomized Trial of Multi-Method Interventions in a Community Cohort of Adolescents.

Kuula L, Pesonen AK · 2026 · The Journal of adolescent health : official publication of the Society for Adolescent Medicine

Purpose Many adolescents develop very late circadian rhythms, indicating delayed sleep phase. Interventions are sparse, and the stability of any improvements is rarely reported. To evaluate how late sleep patterns can be improved, we…

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Negative / Null Result ReportMedicine

Clinical evaluation of obturator nerve involvement following a supra-inguinal fascia iliaca compartment block: A randomized, double-blind trial.

Miao Y, Zhang H, Wu J et al. · 2026 · Journal of clinical anesthesia

Background Clinical evidence on obturator nerve involvement after supra-inguinal fascia iliaca compartment block (SFICB) is limited. This study aimed to investigate whether a 40-mL SFICB reliably anesthetizes the obturator nerve and…

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Negative / Null Result ReportMedicine

Treatment outcomes of Mycobacterium simiae pulmonary disease: a retrospective multicenter cohort study.

Najjar-Debbiny R, Cohen R, Arbel A et al. · 2026 · European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology

BACKGROUND: Mycobacterium simiae is an emerging cause of non-tuberculous mycobacterial pulmonary disease (NTM-PD) in the Middle East, yet treatment outcomes remain unclear. We aimed to evaluate clinical and microbiologic outcomes of M.…

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Negative / Null Result ReportMedicine

Minimum 10-year Results of Cementing a Polyethylene Liner Into an Acetabular Cup With a Deficient Locking Mechanism: Is It a Reliable Option?

Rhyu KH, Cho YJ, Chun YS et al. · 2026 · Clinical orthopaedics and related research

Background Cementing a new liner into a well-fixed acetabular cup with a deficient locking mechanism has been reported as a viable option, but concerns remain regarding complications such as dislocation and late loosening.…

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Negative / Null Result ReportMedicine

Population pharmacokinetic/pharmacodynamic modelling to evaluate favipiravir in combination with lopinavir-ritonavir in patients with COVID-19.

Agyeman AA, Buggiotti L, Brown LK et al. · 2026 · British journal of clinical pharmacology

Aims The repurposed use of favipiravir in COVID-19 has been reported to have limited clinical efficacy, yet it has been widely used in some countries. Favipiravir causes mutagenesis in RNA viruses, and it is currently unknown whether it…

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Negative / Null Result ReportMedicine

Vocal Fundamental Frequency and Generalized Anxiety Disorder: Insights from a Large Multi-Country Cohort in Africa.

Khoshnevis A, Zayernouri M, Malete L et al. · 2026 · Journal of voice : official journal of the Voice Foundation

Objective Voice-based biomarkers have been proposed as objective tools for anxiety assessment, yet existing research relies on small, demographically homogeneous samples and shows inconsistent associations between fundamental frequency (F…

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Negative / Null Result ReportMedicine

Inter-joint coordination and coordination variability during gait differentiate copers from noncopers in males with anterior cruciate ligament deficiency.

Golparian A, Anbarian M, Golparian M · 2026 · Journal of biomechanics

Anterior cruciate ligament deficiency (ACLD) leads to knee instability and altered gait patterns. Individuals with ACLD can be classified as copers or noncopers. Lower-limb coordination and coordination variability may reflect compensatory…

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Negative / Null Result ReportMedicine

Impact of application repetition on Joule heating and lesion formation using a circular-shaped pulsed field catheter.

Okumura M, Yamagami S, Akiyama M et al. · 2026 · Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing

Introduction Pulsed field ablation (PFA) is a non-thermal ablation modality, but repeated high-voltage applications can still cause Joule heating at the electrode-tissue interface. We evaluated the effects of application repetition and…

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Negative / Null Result ReportMedicine

Clinical study of the superthin anterolateral thigh flap for reconstruction of post-traumatic ankle joint soft-tissue defects.

Xiang F, Lin J, Chen B et al. · 2026 · The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons

Background To compare the superthin (3-5 mm) versus conventional (≥10 mm) anterolateral thigh (ALT) flap for post-traumatic ankle reconstruction. Methods Retrospective cohort (2020-2024): superthin ALT (n=26) vs conventional ALT (n=34).…

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Negative / Null Result ReportMedicine

Assessing the Clinical Performance of a Presymptomatic Acute Graft-Versus-Host Disease Biomarker Test in Hematopoietic Stem Cell Transplant Recipients.

Wang L, Pulgrossi RC, Anderson J et al. · 2026 · The journal of applied laboratory medicine

Background Acute graft-versus-host disease (aGVHD) is a common complication of allogenic hematopoietic cell transplantation (HCT). The aGVHD presymptomatic algorithm is comprised of 2 serum biomarkers, suppression of tumorigenicity 2 and…

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Negative / Null Result ReportMedicine

Combined therapy with nebulized and intravenous colistin for the treatment of multidrug resistance pneumonia in burn patients: experience from a third referral burn care center in Mexico City.

Delaye-Martínez MA, Aguilar-Rodea BP, Cardona-Ortiz AF et al. · 2026 · European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology

Purpose Nebulized colistin has shown promise in treating ventilator-associated pneumonia (VAP) due to carbapenem-resistant strains; evidence in burn patients is limited. This study evaluated the efficacy of nebulized colistin as an adjunct…

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Negative / Null Result ReportMedicine

Leading large language models on a periodontology knowledge test.

Rusa AM, Schmidlin PR, Sarkar P et al. · 2026 · Swiss dental journal

Large language models (LLMs) are increasingly used in clinical and educational settings. However, there is a paucity of data on LLMs' performance in specialized dental domains. This study assessed the performance of four LLMs, including…

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Negative / Null Result ReportMedicine

PD-1/PD-L1 inhibitors plus chemotherapy versus chemotherapy alone for ARPI-pretreated and chemotherapy-naive metastatic castration-resistant prostate cancer: a pooled analysis of KEYNOTE-921 and CheckMate 7DX trials.

Zou Q, Huang Q, Li J et al. · 2026 · International urology and nephrology

Background The optimal treatment strategy for androgen receptor pathway inhibitor (ARPI)-pretreated and chemotherapy-naïve metastatic castration-resistant prostate cancer (mCRPC) remains unclear. Chemotherapy has limited efficacy as a…

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Negative / Null Result ReportMedicine

The Value of Oxygenation Vital Signs in Machine Learning Prediction of Neurodevelopmental Outcomes in Preterm Infants.

van Boven M, Bennis F, Onland W et al. · 2025 · IEEE journal of biomedical and health informatics

Machine learning models predicting neurodevelopmental outcome in preterm infants have great potential, but have often relied on inaccessible brain magnetic resonance imaging measurements. This study aimed to build models using readily…

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Negative / Null Result ReportMedicine

Effect of a Drug Dosing Safety Bundle Initiative to Improve Pediatric Drug Dosing by Paramedics. Results of the Michigan Pediatric EMS Error Reduction Study (MI-PEERS).

Hoyle JD Jr, Ekblad G, Dunwoody S et al. · 2026 · Prehospital emergency care

Objectives We sought to decrease pediatric prehospital dosing errors by implementing a bundled drug dosing safety system (DDSS). Multiple studies have demonstrated that pediatric prehospital drug-dosing errors occur at rates of > 30% for…

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Negative / Null Result ReportMedicine

[Mandibular donor site healing after bone graft harvesting in cleft patients: a comparative study of rotary bur and piezoelectric osteotomy techniques].

Ivanov AL, Reshetnyak EI, Sukacheva SA · 2026 · Stomatologiia

Objective To evaluate mandibular donor site healing after cortical bone graft harvesting in cleft patients, comparing outcomes of osteotomies performed with rotary burs and piezosurgery. Material and methods Fifty-three patients (64 bone…

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Negative / Null Result ReportMedicine

Motivational Interviewing and Cognitive Behavioural Therapy in the Auckland Cardiac Rehabilitation Programme: A Propensity Score-Matched Study.

Marshall PW, Benatar JR, O'Halloran P et al. · 2026 · Heart, lung & circulation

Aim Suboptimal enrolment and engagement in cardiac rehabilitation remains a persistent issue worldwide. This study evaluated the impact of a nurse-specialist-delivered motivational interviewing (MI) and cognitive behavioural therapy (CBT)…

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Negative / Null Result ReportMedicine

Exploring iridotrabecular contact index and related factors in primary angle closure disease: a swept-source anterior segment OCT study.

Jeong Y, Park KH, Jeoung JW · 2026 · The British journal of ophthalmology

Background/aims This study evaluates the relationship between the iridotrabecular contact (ITC) index and various anterior segment parameters, with a particular focus on lens-related parameters, given their clinical relevance in primary…

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Negative / Null Result ReportOpen accessMedicine

Lamotrigine serum concentrations as longitudinal biomarkers for seizure risk prediction in pregnant women with epilepsy: a secondary analysis of the EMPiRE study.

Allotey J, Junaid F, Peréz T et al. · 2026 · BMJ neurology open

Background Serum lamotrigine concentrations fall during pregnancy, and therapeutic drug monitoring is often used to guide dose adjustment. We do not know whether serial antenatal measurements improve prediction of seizure risk in pregnant…

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