11,319 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Hovgaard HL, Vistisen ST, Enevoldsen J et al. · 2026 · Anesthesiology
Background Esophagectomy is a key treatment for esophageal cancer but carries a high risk of postoperative complications, some of which are potentially preventable through optimized hemodynamic management. Goal-directed fluid therapy…
View details →Yan CL, Erben A, Sarmiento K et al. · 2025 · Quality management in health care
Background Heart failure (HF) readmission rates at our institution were often higher than the expected levels for our institution type. Social work post-discharge telephone calls were identified as an opportunity to address reasons for HF…
View details →Vafaei A, Manavi MA, Toutounchian S et al. · 2025 · Neurochemical research
Status epilepticus (SE) is a severe neurological condition with high morbidity and mortality rates. Despite the availability of treatments, many cases remain refractory to standard therapies. In this study we investigated the possible…
View details →Shoubridge AP, Brass A, Crotty M et al. · 2025 · JAMA internal medicine
Importance Infectious outbreaks of respiratory viruses within long-term care facilities (LTCFs) for older adults are associated with high rates of hospitalization and death. Despite evidence that airborne transmission contributes…
View details →Qiao W, Liu L, Zhang X et al. · 2025 · BMC anesthesiology
Background Subarachnoid anesthesia is the primary anesthetic method for elective cesarean section surgery, characterized by rapidly taking effect and reliable analgesia. However, subarachnoid anesthesia is prone to cause a high block…
View details →Tomazini BM, Besen BAMP, Gales AC et al. · 2026 · Lancet regional health. Americas
Background Critically ill patients are at risk of nosocomial infections, acquisition of multidrug-resistant pathogens, and substantial antimicrobial consumption. We assessed whether bathing with chlorhexidine reduces these outcomes…
View details →Beerse M, Bigelow KE, Barrios JA · 2025 · Exp Brain Res
The uncontrolled manifold analysis (UCM) is a useful technique for motor learning research enabling the classification of movement variability into solutions and errors. Less explored methodological considerations within the UCM framework…
View details →Hald JD, Weir CJ, Keerie C et al. · 2026 · JAMA
Importance Osteogenesis imperfecta causes multiple fractures throughout life, causing substantial morbidity. Objective To determine whether the parathyroid hormone analogue teriparatide followed by zoledronic acid reduces the risk of…
View details →Cancellier EL, Degryse F, da Silva RC et al. · 2025 · The Science of the total environment
The use of petroleum-based coatings in controlled-release fertilizers (CRFs) raises environmental concerns and it is unclear if, and to what extent, CRFs can improve P use efficiency. This study explored the synthesis of bio-based…
View details →van den Brink DP, Hilderink BN, Kleinveld DJB et al. · 2026 · British journal of anaesthesia
Background During shock, neutrophil-mediated glycocalyx degradation can lead to exposure of the procoagulant endothelial surface and consequent organ injury. Resuscitation using crystalloid fluids may augment this endothelial damage, while…
View details →Lopes LF, Favoretto VR, Evangelista AG et al. · 2025 · European food research & technology.
This study evaluated the efficacy of gaseous allyl isothiocyanate (AITC) in inhibiting Aspergillus parasiticus growth and aflatoxin production in soybeans and beans stored at 85% relative humidity for 35d. Samples of 50 g of soybeans or…
View details →Elzawahry S, Elhilali H, Awadein A et al. · 2026 · Journal of pediatric ophthalmology and strabismus
Purpose To investigate whether using an enhanced monofocal intraocular lens (IOL) in the pediatric age group can improve the visual performance at varying distances in comparison to standard monofocal lenses. Methods Forty-five eyes of…
View details →Saint-Etienne A, Hardy A, Miele A et al. · 2025 · Journal of clinical medicine
Background: Arthrofibrosis requiring arthrolysis is a relevant complication after anterior cruciate ligament (ACL) reconstruction. It has been suggested that intercondylar notch impingement may contribute to this outcome. The aim of this…
View details →Alarifi M, Luo J, Jabour A et al. · 2026 · Journal of clinical medicine
Background/Objectives : Immediate patient access to radiology reports has increased the need for communication that patients can understand, yet it remains unclear whether simplifying report language improves comprehension without…
View details →Wisén E, Pivodic A, Skagervik A et al. · 2026 · British journal of anaesthesia
Background Blood loss and blood transfusion are associated with negative short-term and long-term outcomes in hepatic resection. Vasopressin decreases portal blood flow and could reduce bleeding during liver surgery. We compared the…
View details →Malik A, Martin GS · 2024 · Annals of internal medicine
Source citation Turgeon AF, Fergusson DA, Clayton L, et al; HEMOTION Trial Investigators on behalf of the Canadian Critical Care Trials Group, the Canadian Perioperative Anesthesia Clinical Trials Group, and the Canadian Traumatic Brain…
View details →Tran TN, Kerkhof M, Le TT et al. · 2026 · The journal of allergy and clinical immunology. In practice
Background Real-world data on the benefit of high-dose inhaled corticosteroid (ICS) after exacerbation are limited. Objective To investigate whether stepping up to high-dose ICS after severe exacerbation reduces future asthma exacerbation…
View details →Raynaud Q, Dardano T, Oliveira R et al. · 2026 · NMR in biomedicine
Maps of the transverse relaxation rate R 2 * and magnetic susceptibility (χ) are computed from gradient-echo data and are sensitive to signal instabilities induced by cardiac pulsation. Here, we introduce two k-space sampling strategies…
View details →Santoro S, Mota FC, de Aquino CGG et al. · 2025 · Updates in surgery
To present and analyze the results of sleeve gastrectomy with transit bipartition (SG + TB) with three different lengths of common channel (CC) and its implications for the weight loss and signals of residual malabsorption. A total of 790…
View details →Shu W, Wan J, Xu H et al. · 2025 · Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]
Background Although previous studies have shown the potential advantages of albumin administration in critically ill patients, it has not been tested in patients with severe acute pancreatitis. Methods In this single-center trial, we…
View details →Uhrbrand CG, Carlé N, Valancius K et al. · 2025 · Spine
Study design A randomized blinded trial with three groups. Objective To evaluate whether a single intraoperative methadone dose reduces postoperative opioid requirements and pain intensity in patients undergoing lumbar fusion surgery.…
View details →Nageswaran S, Easterling D, Skaar JE et al. · 2025 · Pediatrics
Background and objectives Improving home health (HH) care for children with medical complexity (CMC) is critical. We developed ICollab, a care model involving collaboration between a children's hospital's complex care clinicians, HH…
View details →Nahmias J, Stopenski S, Jebbia M et al. · 2025 · JAMA surgery
Importance Traumatic rib fractures are associated with significant morbidity, including pulmonary complications and prolonged opioid use. Identifying adjunctive treatments that can reduce opioid consumption without compromising safety…
View details →Cariou B, Thys A, Oliveira AR et al. · 2025 · Diabetes, obesity & metabolism
Aims Postprandial hyperlipidaemia (PPL), characterized by elevated triglyceride (TG) concentrations after a meal, is common in type 2 diabetes (T2D) and is often recognized as an independent cardiovascular risk factor. Here, we aimed to…
View details →Wynberg E, Mishra A, Liverani M et al. · 2026 · International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
Objectives Poorly targeted antibiotic use in primary care is a driver of antimicrobial resistance. Electronic clinical decision support algorithms (eCDSAs) integrating point-of-care tests may improve prescribing. We evaluated the impact of…
View details →Larsen M, Underdal M, Salvesen Ø et al. · 2025 · Sexual & reproductive healthcare : official journal of the Swedish Association of Midwives
Objective Long latent phase of labor with subsequent prolonged total labor duration increases the risk of obstetric interventions and complications. We explored whether Proactive Support of Labor (PSL) compared to Standard Support of Labor…
View details →Fujii T, Kitadani Y, Tanaka A et al. · 2025 · Journal of pediatric surgery
Background The effectiveness of prophylactic antibiotics in pediatric inguinal hernia repair remains unclear. As the procedure is considered clean, the necessity of prophylactic antibiotics is debated. Methods We conducted a retrospective…
View details →de Souza Freire T, Kawakami MD, de Almeida MF et al. · 2026 · Jornal de pediatria
Objective To determine whether the use of an electrocardiogram monitor in newborns receiving positive pressure ventilation (PPV) at birth affects the frequency of tracheal intubation in the delivery room. Methods Retrospective cohort of…
View details →Veale JP, Shawdon A, D'Alessandro P et al. · 2025 · Sports (Basel, Switzerland)
A history of anterior cruciate ligament reconstruction (ACLR) during the Australian Football (AF) talent pathway may impact draft prospects and increase the risk of a second injury during a professional career. This study investigated…
View details →Meer R, Xu JY, Newsom SP et al. · 2026 · The American journal of clinical nutrition
Background Medial arterial calcification (MAC) and increased arterial stiffness contribute to cardiovascular disease risk in type 2 diabetes mellitus (T2DM). Experimental studies suggest that magnesium supplementation may halt arterial…
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