11,417 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Wang H, Ardura MI, Oyeniran SJ et al. · 2026 · ASM case reports
Background Cytomegalovirus (CMV) continues to be a significant cause of morbidity and mortality in immunocompromised patients. Nucleic acid amplification tests (NAATs) are the preferred method for both diagnosing CMV infection and…
View details →Hinoshita M, Maeda Y, Kawai A et al. · 2026 · The Journal of toxicological sciences
The modified electron spin resonance (ESR)-based photosafety test (ESR-PT) is a non-animal prediction test using ESR spectroscopy that is applicable to hydrophobic and colored chemicals and the results show high concordance with existing…
View details →Christopher-Stine L · 2026 · The Journal of rheumatology
Although statin-induced muscle toxicity was recognized, a subset of patients presented with severe, persistent necrotizing myopathy despite statin withdrawal. Recognized initially through the serendipitous aggregation of cases in the…
View details →Alvarez AM, Vega M, Valencia-Shelton F et al. · 2026 · Cureus
Background The evaluation of neonatal herpes simplex virus (HSV) includes HSV culture and/or polymerase chain reaction (PCR) of different surfaces, cerebrospinal fluid (CSF), and blood. However, the impact of blood HSV PCR for the…
View details →Dellbrügge F, Schaumann N, Kruppa M et al. · 2026 · Pneumologie (Stuttgart, Germany)
Abstract We present the case of a 39-year-old Indian female patient diagnosed with tuberculous mastitis and lymph node tuberculosis. The patient had a history of tuberculosis infection treatment as a newborn. She initially presented with…
View details →Li X, Huang Y, Hao J et al. · 2026 · Current HIV research
Background Married Men who have Sex with Men (MSM) constitute a bridge population for HIV diffusion into low-risk groups, with spousal non-disclosure rates exceeding 60% in China. It will increase the risk of secondary transmission within…
View details →Tsang SM, Merino Gutierrez V, Yu J et al. · 2026 · Veterinary sciences
Canine babesiosis caused by Babesia gibsoni is prevalent in Hong Kong. While molecular diagnosis via PCR is highly sensitive, it typically requires reference laboratory access, delaying clinical decisions. This study evaluated the…
View details →Hijaze E, Razi T, Arbel R et al. · 2026 · Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases
Objective To evaluate the diagnostic performance of BioPlex 2200 multiplex immunoassay (BI) for detecting antinuclear antibodies (ANA), compared with the gold standard, the indirect immunofluorescence assay (IIF), as a screening…
View details →Tri PM, Hung NT, Liet DH et al. · 2026 · Emergency radiology
Purpose To assess the diagnostic performance of computed tomography (CT) for predicting main pancreatic duct injury in surgically explored patients with distal pancreatic trauma. Methods We conducted a prospective single-center diagnostic…
View details →Wei XT, Zhu LY, Wu YL et al. · 2026 · Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi
Objective: To evaluate the screening performance and related factors of ultrasound for hepatic steatosis in community-based elderly populations using controlled attenuation parameter (CAP) measured by transient elastography as the…
View details →Zorlutuna Kaymak N, Pekel İ, Demir Tekol S et al. · 2026 · BMC ophthalmology
Purpose To evaluate the diagnostic utility and real-world clinical impact of polymerase chain reaction (PCR) analysis of aqueous humor (AH) and vitreous samples in patients with uveitis including suspected infectious and mixed…
View details →Mangiameli G, Brascia D, Re Cecconi E et al. · 2026 · Updates in surgery
The role of surgery in malignant pleural mesothelioma (MPM) remains controversial, particularly after the negative results of the MARS 1 and 2 trials. Lung-sparing cytoreductive procedures such as extended pleurectomy/decortication (eP/D)…
View details →Feng Q, Liu B, Liu H et al. · 2025 · Frontiers in microbiology
Background Accurately diagnosing central nervous system (CNS) infections remains challenging. This study aimed to evaluate the effectiveness of metagenomic next-generation sequencing (mNGS) in diagnosing suspected CNS infections and its…
View details →Tsutsumi Y, Nagasaki T, Muraki M et al. · 2026 · Internal medicine (Tokyo, Japan)
Rapid molecular and immunological assays for tuberculosis, including loop-mediated isothermal amplification (LAMP) and T-SPOT.TB assays, may yield false-negative results. We herein report a 62-year-old immunocompetent man with a productive…
View details →Novy E, Schaeffer A, Nguyen M et al. · 2026 · Critical care (London, England)
BACKGROUND: Intra-abdominal candidiasis (IAC) is a severe form of invasive candidiasis that affects critically ill patients and is associated with a high mortality rate and persistent diagnostic delays. Conventional fungal culture from…
View details →Tomlinson J, Roberson E, Klee V et al. · 2026 · Amyotrophic lateral sclerosis & frontotemporal degeneration
Objective: Assess the accuracy of ALS patient recall of genetic testing results and evaluate comprehension of key implications of results. Methods: Participants were recruited from the Center for Disease Control's National ALS Registry. A…
View details →Alvarez Mulett S, Molina Garcia S, Abu Saleh O et al. · 2026 · Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Background Central nervous system (CNS) infections are significant causes of morbidity and mortality, especially when diagnosis is delayed. Traditional cerebrospinal fluid diagnostic methods for CNS infections have limited sensitivity.…
View details →Lükewille L, Wiegand S, Fazel A et al. · 2026 · Journal of cancer research and clinical oncology
Purpose Sentinel lymph node biopsy (SLNB) is a standard procedure for nodal staging in cutaneous melanoma. However, its diagnostic performance in the head and neck region remains limited due to complex lymphatic drainage patterns. This…
View details →Zhang J, Su M, Zhang Y et al. · 2025 · Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics
Objective To explore the reasons for false negative results by Optical genome mapping (OGM) analysis of three cases and propose strategies for handling them. Methods Three patients presented at the Affiliated Hospital of Nantong University…
View details →Pantazis JC, Palmer AC · 2026 · Molecular cancer therapeutics
The phase III study of romidepsin plus CHOP for peripheral T-cell lymphoma (PTCL) yielded negative results in the overall analysis and showed that outcomes were only improved in the T follicular helper (TFH) subgroup of PTCL, with no…
View details →Genetic And Metabolic Disorders Screening Subgroup Of The Birth Defects Prevention And Control Committee Chinese Preventive Medicine Association, Rare Diseases Branch Of Shandong Medical Association, Genetic Metabolism Branch Of Shandong Provincial Rare Disease Association et al. · 2026 · Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics
High-throughput sequencing technology has recently been used in neonatal disease screening. To address the issues related to the screening process, interpretation of screening results, and recall of positive cases in neonatal genetic…
View details →Ruiz-Tagle C, Seguel R, Villarroel L et al. · 2026 · Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Background The duration of infectiousness following pulmonary tuberculosis treatment initiation remains uncertain. We aimed to assess whether a bundled intervention designed to decrease respiratory exposure was feasible and would reduce…
View details →Ringer AJ, Hanel RA, Baig AA et al. · 2025 · Journal of neurointerventional surgery
Background The optimal duration for dual antiplatelet therapy (DAPT) after stent-assisted coiling (SAC) of intracranial aneurysms is unclear. Longer-term therapy may reduce thrombotic complications but increase the risk of bleeding…
View details →Bierer JD, Stanzel R, Henderson M et al. · 2026 · The Annals of thoracic surgery
Background Pediatric cardiac surgery with cardiopulmonary bypass (CPB) is associated with systemic inflammation. This trial aimed to determine whether continuous high-exchange ultrafiltration during CPB has a clinical immunomodulatory…
View details →Khueangchiangkhwang S, Oida Y, Taguchi A et al. · 2026 · Parasitology international
Trichinella is a nematode that causes chronic infection via its larvae in muscle cells and remains a global health concern. Drug sensitivity, including to ivermectin (IVM), differs between intestinal adult worms (AW) and muscle larvae…
View details →Dunkel K, Moroz MS, Suares B et al. · 2025 · The Journal of dairy research
This research article aimed to evaluate the effect of a commercial nutraceutical additive in milk replacer on the health and weight gain of dairy calves during the pre-weaning phase. A total of 126 female Holstein calves were randomly…
View details →Meves V, Chamieh A, Mohamed M et al. · 2026 · Endoscopy international open
Background and study aims Previous studies in esophagogastroduodenoscopy or colonoscopy have demonstrated positive effects of music on patient anxiety and comfort. This study prospectively evaluated the effect of functional music on…
View details →Kashtiara A, Pauptit J, Thijs D et al. · 2025 · European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society
Objectives Enhanced Recovery After Surgery (ERAS) protocols aim to improve surgical outcomes, by mitigating postoperative stress through multimodal perioperative care. In spinal surgery, such protocols may reduce pain, hospital length of…
View details →Sielski W, Osęka T, Antolak A et al. · 2026 · Frontiers in endocrinology
Background Parathyroid preservation during total thyroidectomy with central neck dissection in papillary thyroid carcinoma remains challenging due to the glands' delicate vascular anatomy and risk of inadvertent devascularization or…
View details →Palmier M, Ghorayeb G, Arhant G et al. · 2026 · Annals of vascular surgery
Background Supraceliac aortic cross-clamping can induce remote organ injury, particularly affecting the lungs through ischemia-reperfusion mechanisms. Pulmonary endothelial dysfunction plays a central role in acute lung injury, potentially…
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