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Browse the failure-mode index

11,319 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Efficacy of topical hydrophilic gel of paromomycin combined with systemic or locally administered leishmanicidal drugs for treatment of experimental leishmaniasis caused by Leishmania (Viannia) braziliensis.

Alves LL, Pinheiro Rosa DC, Freire ML et al. · 2025 · The Journal of antimicrobial chemotherapy

Objective This study aimed at evaluating the combination of a topical hydrophilic gel of paromomycin (PA) with intralesion meglumine antimoniate (Glu IL) or systemic administration of liposomal amphotericin B (AmphLipo) for the treatment…

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Negative / Null Result ReportOpen accessMedicine

Diaryl-Aminoindazole with Extensive In Vitro Mycobactericidal Activity Dependent on Exposure to Reactive Nitrogen Species.

Warrier T, Martínez-Hoyos M, Porras De Francisco E et al. · 2026 · ACS infectious diseases

A bromoindazole was reported with the ability to rapidly and extensively kill Mycobacterium tuberculosis (Mtb) in vitro, but only in the presence of sublethal levels of reactive nitrogen species (RNS) (Warrier et al., ACS Infectious…

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Negative / Null Result ReportMedicine

Impact of daily adaptive head and neck radiotherapy on toxicity and quality of life: results of the DARTBOARD phase II randomized trial.

Sher DJ, Avkshtol V, Lin MH et al. · 2025 · Journal of the National Cancer Institute

Background The utility of adaptive radiotherapy (ART) for head and neck squamous cell carcinoma (HNSCC) remains poorly defined. Daily ART (DART) promises both anatomic adaptation and planning target volume (PTV) reduction. In this…

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Negative / Null Result ReportMedicine

The Moderating Effect of Social Skills and Social Support on the Association Between Poverty Ratio and Health Promotion Behaviors in Adolescence.

Furman CR, Worth IA, Zhang JD et al. · 2025 · Behavioral medicine (Washington, D.C.)

Eating and exercise habits established in adolescence are associated with immediate and long-term health outcomes. These habits may be influenced by adolescents' socioeconomic status (SES), such that low SES households often experience…

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Negative / Null Result ReportMedicine

Aortic Arch Morphology and Cerebrovascular Accidents After Transfemoral Transcatheter Aortic Valve Implantation.

Baltruskeviciute L, Moccetti F, Wolfrum M et al. · 2026 · The American journal of cardiology

Cerebrovascular accidents (CVA) after transcatheter aortic valve implantation (TAVI) remain a major concern. However, the impact of aortic arch morphology has not been investigated in this context. To address this gap, consecutive patients…

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Negative / Null Result ReportOpen accessMedicine

Impact of an Educational Programme in Primary Care for mothers With Infant Colic Babies: Quasi-Experimental Study.

Martínez-Lentisco MDM, Carreño-Segura S, León-Morillas F et al. · 2026 · Clinical pediatrics

This quasi-experimental study assessed the impact of a postpartum educational programme on health care utilization and maternal stress in mothers of infants with colic. A total of 84 mothers took part in 2 individual sessions, 15 days…

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Negative / Null Result ReportMedicine

Prophylactic norepinephrine infusion to reduce severe hypotension during induction of anaesthesia in patients undergoing cardiac surgery: a randomised controlled single-centre clinical trial.

Gaillard C, Breul L, Foucher A et al. · 2026 · British journal of anaesthesia

Background The EPITUBE trial aimed to determine whether a prophylactic infusion of norepinephrine reduced severe hypotension after induction of general anaesthesia and tracheal intubation in patients undergoing cardiac surgery. Methods We…

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Negative / Null Result ReportMedicine

Low dose of landiolol does not prevent postoperative atrial fibrillation after cardiac surgery in non-Asian patients: a multicentre randomised study.

Amour J, Naudin C, Besnard A et al. · 2026 · British journal of anaesthesia

Background Postoperative atrial fibrillation (POAF) affects 30% of patients undergoing cardiac surgery with cardiopulmonary bypass (CPB). Beta-blockers are the first-line agents recommended for POAF prevention. Landiolol, an…

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Negative / Null Result ReportMedicine

Effect of use of virtual reality on morphine-sparing in patients with sickle cell disease for main management of vaso-occlusive crises in an adult emergency department.

Dubreucq Guerif E, Agut S, Rousseau A et al. · 2026 · European journal of emergency medicine : official journal of the European Society for Emergency Medicine

Background and importance Vaso-occlusive crisis is the main reason for emergency department (ED) visits for patients with sickle cell disease. Therapeutic management involves multimodal analgesia, which often comprises the administration…

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Negative / Null Result ReportMedicine

Medial and Lateral Column Load Distribution After In Situ Subtalar/Talonavicular Fusion With and Without Calcaneocuboid Fusion: A Cadaveric Study.

Alkaramany E, Gallagher BP, Abbasi P et al. · 2025 · Foot & ankle international

Background Previous investigations have speculated that stiffening the lateral column of the hindfoot in triple arthrodesis can increase lateral plantar pressure with resulting lateral column pain. It is unclear whether sparing of the…

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Negative / Null Result ReportMedicine

Turning the tide: A randomized controlled trial of a brief digital mindfulness intervention to reduce immediate and delayed negative interpretation bias.

Wang Y, Wang S, Lin J et al. · 2026 · Journal of affective disorders

Objective The current study aimed to explore the effectiveness and mechanisms of mindfulness on alleviating both immediate and delayed negative interpretation biases (NIB). Method A total of 105 college students (female: 84.62 %, age:…

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Negative / Null Result ReportMedicine

Effect of standard wound dressing versus prophylactic closed incision negative-pressure therapy on surgical-site infection after open incisional hernia repair: multicentre randomized clinical trial.

Marckmann M, Henriksen NA, Krarup PM et al. · 2025 · The British journal of surgery

Background The benefit of closed incision negative-pressure therapy (ciNPT) after open incisional hernia repair in reducing surgical-site infection (SSI) is uncertain. Methods The PROPRESS multicentre RCT was conducted from 1 March 2023 to…

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Negative / Null Result ReportMedicine

Magnesium sulfate does not reduce propofol requirements but contributes to lower opioid consumption in bitches undergoing ovariohysterectomy.

Boff GA, Iepsen LB, Serighelli-Junior G et al. · 2025 · Veterinary research communications

This study aimed to evaluate the effects of magnesium sulfate on propofol requirements and perioperative analgesia in dogs undergoing ovariohysterectomy. Fourteen female dogs (2 ± 1 years, 17 ± 5 kg) were enrolled in this randomized and…

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Negative / Null Result ReportMedicine

The effects of marine fatty acid omega-3 supplements on incident fractures and bone mineral density in generally healthy adults.

LeBoff MS, Chou SH, Ratnarajah DM et al. · 2026 · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Although preclinical studies suggest that omega-3 fatty acids may benefit skeletal health, there are few randomized controlled trials investigating effects of supplemental omega-3 on bone outcomes. This VITamin D and OmegA-3 TriaL (VITAL)…

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Negative / Null Result ReportMedicine

Left Ventricular Unloading in Anterior ST-Segment Elevation Myocardial Infarction Without Shock: The ST-Segment Elevation Myocardial Infarction Door to Unload Randomized Controlled Trial.

Kapur NK, Mangner N, Aghili N et al. · 2026 · Journal of the American College of Cardiology

Background Despite rapid percutaneous coronary intervention (PCI) for ST-segment elevation myocardial infarction (STEMI), large infarcts contribute to heart failure and mortality. Left ventricular (LV) wall tension and load are major…

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