11,319 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Zhang F, Yu Z, Pan J et al. · 2026 · Jornal de pediatria
Objective This study aimed to investigate the risk factors for acute neurological complications (ANCs) in neonates with bacterial meningitis (NBM). Methods This retrospective study analyzed 68 neonates (aged 0-28 days) with bacterial…
View details →Sanchis J, Bueno H, Martí Sánchez D et al. · 2025 · Heart (British Cardiac Society)
Background Clinical trials and meta-analyses indicate a reduced reinfarction risk with invasive management in older patients with non-ST-segment elevation myocardial infarction (NSTEMI). This study investigated whether similar benefits…
View details →Muir KJ, Maye A, McHugh MD et al. · 2025 · JAMA network open
Importance It is unknown if virtual nursing (VN) enhances care quality or improves the workload of bedside nurses in hospitals. Objective To describe what services VNs provide to patients and nurses in hospitals; to evaluate whether the…
View details →Zhang J, Suo T, Cheng Y et al. · 2026 · Journal of investigative medicine : the official publication of the American Federation for Clinical Research
Hemophagocytic lymphohistiocytosis (HLH) secondary to visceral leishmaniasis (VL-HLH) is a severe and often fatal condition marked by systemic inflammation and immune dysfunction. In this retrospective cohort study at Shanxi Children's…
View details →Smedemark SA, Jarbøl DE, Laursen CB et al. · 2026 · The lancet. Healthy longevity
Background Diagnosing acute respiratory conditions in adults older than 65 years is challenging due to age-related physiological changes, which increase diagnostic complexity and the risk of hospital admission. We investigated whether…
View details →Nakamura Y, Murata S, Yabe T et al. · 2026 · Cureus
Introduction C5 palsy is a disabling complication after posterior cervical decompression and fusion (PCDF). Whether C4/5 facetectomy reduces the incidence or improves the outcomes of C5 palsy remains uncertain. Therefore, this study aimed…
View details →Santos CMM, Mattos NM, Silva RAP et al. · 2025 · Lasers in medical science
This pilot study aimed to investigate the effects of intravascular laser irradiation of blood (ILIB) on anxiety levels and vital signs in patients undergoing third molar extraction. A randomized, placebo-controlled clinical trial was…
View details →Zhan J, Sun G, Li H et al. · 2026 · Ophthalmology. Retina
Objective To evaluate whether timing of preoperative anti-VEGF therapy given before vitrectomy for proliferative diabetic retinopathy (PDR) influences risks of postoperative vitreous hemorrhage (VH) and tractional retinal detachment (TRD).…
View details →Holland K, Gomeniouk O, Owen GS et al. · 2026 · European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
Purpose Determine if there is a difference in post-operative infection rates in patients undergoing sialendoscopy who received pre-, post-operative, both pre and post, or no antibiotics. Methods Retrospective chart review of patients who…
View details →Kipper CW, Kis P, Burleson KN et al. · 2026 · European journal of applied physiology
Objective Exercise-induced muscle damage (EIMD) compromises neuromuscular function and reduces exercise tolerance. Whether muscle oxidative capacity (MOC), an index of mitochondrial function, is reduced by EIMD or influences neuromuscular…
View details →Valle-Cruz JA, Lopiz Y, Garríguez-Pérez D et al. · 2026 · International orthopaedics
Purpose Rotational instability is a key factor in fixation failure of extracapsular hip fractures. The U-Blade (RC) lag screw was designed to improve rotational stability. This study aimed to compare mechanical complication rates between…
View details →Athan E, Greenberg RN, Baker DA et al. · 2026 · Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Background A vaccine that prevents Staphylococcus aureus skin and soft tissue infections (SA-SSTIs) would have a major impact on public health. Methods A two-part randomized study began with a phase 1, first-in-human, dose-escalation that…
View details →Carvajal-Encina F, Carvajal Rojas L · 2025 · Andes pediatrica : revista Chilena de pediatria
Prematurity is a challenge due to its high morbidity and mortality. The Explicit Health Guarantees (GES) for Premature Birth Prevention, implemented in 2005, have not been evaluated. Objective To evaluate the impact of the GES on perinatal…
View details →Chung J, Park S, Park SJ et al. · 2026 · The American journal of medicine
Objective This study aimed to evaluate the conflicting effects of weight change and smoking cessation on fracture risk in male patients with newly diagnosed type 2 diabetes mellitus (T2DM). Methods Using the National Health Insurance…
View details →Paskeviciene E, Skemiene K, Pampuscenko K et al. · 2025 · Journal of pharmacological sciences
Imeglimin, a novel oral antidiabetic drug, has been suggested to affect mitochondrial functions in some types of cells and tissues, however, it has never been investigated whether aging has an impact on its pharmacological effects in the…
View details →Streit A, Hoffmann M, Blesl A et al. · 2025 · Quality management in health care
Background Effective discharge planning is an important factor of hospital care and should follow a comprehensive assessment of patients at risk for adverse events during discharge. The study's aim was to analyze whether the use of the…
View details →Büyükbezirci G, Demiralp N, Keles S et al. · 2026 · Journal of pain research
Purpose Postherpetic neuralgia (PHN) is one of the most debilitating complications of herpes zoster and represents a major cause of chronic neuropathic pain. Increasing evidence suggests that immune dysregulation plays a critical role in…
View details →Shidara S, Ito S, Desai K et al. · 2026 · Bone
Skeletal stem/progenitor cells (SSPCs) play a fundamental role in maintaining skeletal homeostasis throughout life. Leptin receptor (Lepr)-positive cells were initially identified as SSPCs in the long bone marrow and later in the…
View details →Kim HJ, Kim N, Kim J et al. · 2025 · Scientific reports
Robot-assisted laparoscopic prostatectomy (RALP) is associated with hemodynamic shifts; patients on angiotensin receptor blockers (ARBs) are especially susceptible to intraoperative hypotension. We investigated whether induction with…
View details →Berthoud V, Nguyen M, Vinay J et al. · 2026 · Anaesthesia, critical care & pain medicine
Introduction In thoracic surgery, all respiratory muscles have a significant increase in workload, and recruitment of these muscles may be important, especially in the presence of diaphragmatic dysfunction. Evaluating diaphragmatic and…
View details →Bircher B, Aebischer P, Wimmer W et al. · 2026 · American journal of otolaryngology
Objective To evaluate the clinical implementation of preoperative, anatomy-tailored planning for electrode selection in cochlear implantation, quantify planning accuracy under routine conditions, and identify factors associated with…
View details →Hao X, Zhang Z, Cai C et al. · 2026 · International journal of surgery (London, England)
Background Dexmedetomidine was widely used in anesthesia management during cardiac surgery. The purpose was to evaluate the safety and efficacy of intraoperative dexmedetomidine in the treatment of postoperative depression in adult…
View details →Wittberg DM, Admassu F, Aragie S et al. · 2026 · Tropical medicine & international health : TM & IH
Objectives Few randomised trials have been done to assess the impact of hygiene interventions on trachoma even though hygiene improvements feature prominently in the strategy for global elimination of trachoma. This study's aim was to…
View details →Liu C, Deng G, Wang Y et al. · 2026 · Stroke and vascular neurology
Background Transradial access has become an increasingly preferred approach for cerebral angiography. However, embolic events, often clinically silent, remain a frequent concern. Despite routine use, the efficacy and safety of heparin…
View details →Jiang C, Zhao Z, Yang Z et al. · 2026 · Circulation
Background Observational studies have suggested that SGLT2 (sodium-glucose cotransporter 2) inhibitors are associated with a lower risk of atrial fibrillation (AF) recurrence after catheter ablation in patients with AF with concomitant…
View details →Krzyżaniak M, Warmiński K, Olba-Zięty E et al. · 2025 · Industrial Crops & Products
Camelina sativa (L. Crantz) is an annual oilseed crop cultivated for industrial and food purposes. To expand camelina's cultivation area, improve yields, and reduce weed pressure, the crop can be grown in intercropping system. The aim of…
View details →Perez-Valero I, Corona Mata D, Crussells Canales MJ et al. · 2026 · International journal of antimicrobial agents
Objective To evaluate if switching from dolutegravir/lamivudine (DTG/3TC) to bictegravir/emtricitabine/tenofovir alafenamide (BIC/FTC/TAF) improves neuropsychiatric tolerability in suppressed adults with stable neuropsychiatric…
View details →Zhang F, Zhong Y, Li Q et al. · 2025 · High altitude medicine & biology
Zhang, Fengying, Yang Zhong, Qiuyue Li, Doudou Hao, Zhiyou Shi, Suying Zhu, Qian Zhang, and Yunhong Wu. Does Hydrogen-Rich Water Reduce Oxidative Stress in Patients with Chronic Mountain Sickness? A Randomized, Blinded, Controlled Trial.…
View details →Crawford AM, Striano BM, Schoenfeld AJ et al. · 2026 · Spine
Study design Retrospective multicenter cohort study. Objective To compare the safety and efficacy of venous thromboembolism prophylaxis (VTE) strategies between two high-volume spine centers with distinct protocols. Summary of background…
View details →Kinsella A, Gilligan P · 2025 · Irish medical journal
Aim Admission rate is a key performance indicator for Emergency Departments (EDs). Senior hospital management advised that, if discharge by on-call teams was possible within 24 hours, a patient should be termed 'ambulatory' and remain in…
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