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Browse the failure-mode index

11,417 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Is it necessary for patients with a positive urine culture to achieve a negative result after antimicrobial treatment before undergoing percutaneous nephrolithotomy?

Zheng J, Guo Q, Yue G et al. · 2025 · World journal of urology

Objective There is ongoing debate regarding whether patients with a positive urine culture (UC) need to wait for the culture to turn negative following antimicrobial treatment before undergoing percutaneous nephrolithotomy (PCNL). This…

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Negative / Null Result ReportMedicine

Association between sleep disturbances and gray matter volume in individuals at clinical high-risk for psychosis and healthy controls: A longitudinal MRI study (NAPLS-3).

Wezenberg BN, Koster M, van Wingen G et al. · 2025 · Schizophrenia research

Objective Sleep disturbances and brain alterations are common in psychotic disorders and individuals at clinical high risk for psychosis (CHR-P). It remains unclear whether gray matter volume changes are inherent to psychosis or partly…

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Negative / Null Result ReportOpen accessMedicine

Evaluating algorithmic approaches to rare disease case-finding: a retrospective validation study using electronic health records.

Boardman-Pretty F, Kumar J, Grant C et al. · 2026 · Orphanet journal of rare diseases

BACKGROUND: Accurate and early diagnosis to optimise rare disease care is a global priority. With recent developments in artificial intelligence (AI)-based solutions, a promising area to improve rare disease diagnosis is the application of…

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Negative / Null Result ReportMedicine

Diagnostic discrepancies: A retrospective analysis of two antinuclear antibody platforms.

Ali M, Baban Y, Kumar G · 2026 · Journal of investigative medicine : the official publication of the American Federation for Clinical Research

To retrospectively examine the outcome of the antinuclear antibody (ANA) screen by comparing the performance of BioPlex 2200 and immunofluorescence assay (IFA). We reviewed the ANA screening results performed on the BioPlex 2200 using…

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Negative / Null Result ReportOpen accessMedicine

Characteristics of healthcare workers and health facilities associated with inaccurate recording of malaria rapid diagnostic test results: a multi-country study.

Atobatele S, Mpimbaza A, Ngufor C et al. · 2025 · Malaria journal

Background Malaria rapid diagnostic tests (RDTs) have improved case management and surveillance across sub-Saharan Africa by reducing presumptive treatment and enhancing diagnostic specificity. However, healthcare workers' (HCWs) concerns…

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Negative / Null Result ReportMedicine

Retrospective Evaluation of the Correlation Between Somatostatin Receptor PET/CT and Histopathology in Patients with Suspected Intracranial Meningiomas.

Ebner R, Braach J, Rübenthaler J et al. · 2025 · Journal of nuclear medicine : official publication, Society of Nuclear Medicine

The aim of this retrospective study was to evaluate the correlation between findings from somatostatin receptor (SSTR) PET/CT and histopathology in patients with suspected intracranial meningiomas. Methods: We conducted a retrospective…

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Negative / Null Result ReportOpen accessMedicine

Evaluation of standard and modified two-tiered testing algorithms using well-characterized early Lyme disease samples.

Horn EJ, Menefee B, Schotthoefer AM et al. · 2026 · Journal of clinical microbiology

Current laboratory testing for Lyme disease (LD) relies on serology. We evaluated the performance of standard two-tiered testing (STTT) and modified two-tiered testing (MTTT) algorithms using samples obtained from well-characterized…

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Negative / Null Result ReportOpen accessMedicine

Long bones after suspected "grave robbery": a comparison of different methods for the estimation of the post mortem interval.

Baumgarten J, Stephan E, Ohlwärther TEN et al. · 2026 · Forensic science, medicine, and pathology

Estimation of the postmortem interval (PMI) of found bones is an important and challenging part of forensic osteology assessments. This study examined human long bones that had been taken from cemeteries and hoarded by a "bone collector".…

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Negative / Null Result ReportMedicine

Low-Dose Aspirin Continuation During Gastric Endoscopic Submucosal Dissection in Patients With Low Thrombotic Risk: A Randomized Trial.

Uedo N, Gotoda T, Takizawa K et al. · 2026 · The American journal of gastroenterology

Introduction The recommendation to discontinue low-dose aspirin (LDA) during the periprocedural period of endoscopic submucosal dissection (ESD) for early gastric cancer (EGC) remains controversial in patients at low thrombotic risk. If…

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Negative / Null Result ReportOpen accessMedicine

Seasonality and clinical characteristics of influenza-like illness and severe acute respiratory infection in children under 5 years in Cox's Bazar, Bangladesh (2021-2023).

Zabir MOH, Habib MA, Monalisa et al. · 2026 · IJID regions

Objectives Acute respiratory infections (ARIs) such as influenza-like illness (ILI) and severe acute respiratory infection (SARI) are leading causes of morbidity among children aged under 5 years (under-5) in Bangladesh. In Cox's Bazar,…

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Negative / Null Result ReportMedicine

[Analysis of a twin pregnancy with false negative result for 22q11.2 deletion syndrome by expanded non-invasive prenatal testing].

Zhao G, Jiao Z, Dai P et al. · 2023 · Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics

Objective To explore the cause for a twin pregnancy with false negative result for 22q11.2 deletion syndrome by expanded non-invasive prenatal testing (NIPT-plus). Methods A pregnant woman with twin pregnancy through in-vitro fertilization…

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Negative / Null Result ReportOpen accessMedicine

Blood-based biomarkers GFAP/UCH-L1 for the diagnosis of mild traumatic brain injury (mTBI): a single-center implementation experience.

Maegele M, Breidenbach L, Kaufmann J et al. · 2026 · European journal of trauma and emergency surgery : official publication of the European Trauma Society

Introduction Mild traumatic brain injuries (mTBI) affect millions of people worldwide every year as one of the most common clinical presentations in the emergency department. Diagnosis is mainly based on clinical criteria and computed…

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Negative / Null Result ReportOpen accessMedicine

Abnormal Ultrasonography Overcomes NIPT's Inherent Limitations: Revealing Two Cases of NIPT False Negatives Caused by Trisomy 21 Mosaicism and a Literature Review.

Mu Y, Jing Y, Liu X et al. · 2026 · International journal of women's health

Background Non-invasive prenatal testing (NIPT) is widely adopted for its high sensitivity in detecting chromosomal abnormalities, but its accuracy for placental and fetal mosaicism is limited due to reliance on placental DNA, leading to…

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Negative / Null Result ReportOpen accessMedicine

Correlation between controlled-pressure provocative test duration and electrodiagnostic severity in carpal tunnel syndrome.

Iamchaimongkol A, Leeareekun K, Chira-Adisai W et al. · 2026 · Journal of rehabilitation medicine

Objective To assess the correlation between controlled-pressure provocative test duration and electrodiagnostic severity in carpal tunnel syndrome. Design Cross-sectional correlational study. Patients Patients with clinical symptoms…

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Negative / Null Result ReportOpen accessMedicine

The discrepancy of somatic BRCA1/2 pathogenic variants from two different platforms in epithelial ovarian, fallopian tube, and peritoneal cancer.

Kim JH, Shin JY, Park SY et al. · 2024 · Scientific reports

The somatic BRCA1 or BRCA2 Pathogenic Variant (PV)/Likely PV (LPV) from Next Generation Sequencing (NGS) is the most important biomarker for PARP inhibitor use and maintenance-targeted therapies. A discrepancy in the detection rates of…

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