e-ISSN: Pending
WASTE Journal

Browse the failure-mode index

11,417 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

The effect of negative randomized trials and surgeon volume on the rates of arthroscopy for patients with knee OA.

Ghomrawi HMK, Marx RG, Pan TJ et al. · 2018 · Contemporary clinical trials communications

Publication of 2 (negative) randomized clinical trials (RCTs) in 2002 and 2008 demonstrating inefficacy of arthroscopic debridement of the knee (ADK) for osteoarthritis, and a 2004 national non-coverage Medicare determination, have…

View details →
Negative / Null Result ReportOpen accessMedicine

Efficacy of Wharton Jelly Mesenchymal Stromal Cells infusions in moderate to severe SARS-Cov-2 related acute respiratory distress syndrome: a phase 2a double-blind randomized controlled trial.

Pochon C, Laroye C, Kimmoun A et al. · 2023 · Frontiers in medicine

Background The COVID-19 pandemic caused a wave of acute respiratory distress syndrome (ARDS) with a high in-hospital mortality, especially in patients requiring invasive mechanical ventilation. Wharton Jelly-derived Mesenchymal Stromal…

View details →
Negative / Null Result ReportOpen accessMedicine

Exhaled-Breath Testing Using an Electronic Nose during Spinal Cord Stimulation in Patients with Failed Back Surgery Syndrome: An Experimental Pilot Study.

Goudman L, Jansen J, Vets N et al. · 2021 · Journal of clinical medicine

The increased awareness of discrepancies between self-reporting outcome measurements and objective outcome measurements within the field of neuromodulation has accelerated the search towards more objective measurements. The aim of this…

View details →
Negative / Null Result ReportOpen accessMedicine

Radiation Therapy for Retroperitoneal Sarcomas: A Strass-Ful Situation.

Farooqi AS, Guadagnolo BA, Mitra D et al. · 2023 · Current oncology (Toronto, Ont.)

Locoregional recurrence (LRR) is the predominant pattern of relapse and often the cause of death in patients with retroperitoneal sarcomas (RPS). As a result, reducing LRR is a critical objective for RPS patients. However, unlike soft…

View details →
Negative / Null Result ReportOpen accessMedicine

Pembrolizumab Plus Docetaxel Versus Docetaxel for Previously Treated Metastatic Castration-Resistant Prostate Cancer: The Randomized, Double-Blind, Phase III KEYNOTE-921 Trial.

Petrylak DP, Ratta R, Matsubara N et al. · 2025 · Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Purpose The standard of care for metastatic castration-resistant prostate cancer (mCRPC) after second-generation androgen receptor pathway inhibitor (ARPI) therapy is still docetaxel. The randomized, double-blind, phase III KEYNOTE-921…

View details →
Negative / Null Result ReportMedicine

Effect of High-Dose vs Standard-Dose Vitamin D Supplementation in Pregnancy on Bone Mineralization in Offspring Until Age 6 Years: A Prespecified Secondary Analysis of a Double-Blinded, Randomized Clinical Trial.

Brustad N, Garland J, Thorsen J et al. · 2020 · JAMA pediatrics

Importance Studies suggest an association between maternal vitamin D status during pregnancy and offspring anthropometry and bone mineralization, but investigations are few and with mixed results. Objective To investigate the effect of a…

View details →
Negative / Null Result ReportOpen accessMedicine

Cholesterol efflux capacity of high-density lipoprotein was not associated with cognitive decline and brain structures in older people with diabetes mellitus.

Wu Y, Tan KC, Shiu SW et al. · 2022 · Journal of diabetes investigation

Aims/introduction To examine the association between cholesterol efflux capacity (CEC) of serum high-density lipoprotein (HDL) and cognitive function and brain structures in older people with diabetes mellitus. Materials and methods…

View details →
Negative / Null Result ReportMedicine

Three ways to find a fluke: Evaluating diagnostic methods for Fasciola hepatica surveillance in Swedish sheep.

Felländer M, Grandi G, Juremalm M et al. · 2026 · Veterinary parasitology, regional studies and reports

Infections with Fasciola hepatica are most prevalent in south-western Sweden, but climate change may facilitate further spread, as both the parasite and its snail host thrive in humid, mild conditions. Sheep are particularly susceptible,…

View details →
Negative / Null Result ReportMedicine

Genetic analysis of a fetus with mosaic trisomy 15 with false-negative result in prenatal amniotic fluid karyotype analysis.

Li X, Peng Y, Liu W et al. · 2025 · Taiwanese journal of obstetrics & gynecology

Objective To investigate the cause of a false-negative result in prenatal amniotic fluid karyotype analysis for a fetus with mosaic trisomy 15, and to propose a cytomolecular genetic strategy for detecting mosaicism in amniotic fluid. Case…

View details →
Negative / Null Result ReportMedicine

The moderating role of parental cognitive perceptions in the link between children's cancer predisposition genetic testing results and parent psychological adjustment.

Sachner L, Flynn JS, Hsu CW et al. · 2026 · Journal of pediatric psychology

Objective Children with cancer increasingly undergo germline genetic testing to identify genetic predispositions and inform clinical care options. Parents of children with pathogenic/likely pathogenic (P/LP) germline results have reported…

View details →
Negative / Null Result ReportMedicine

[The challenge of delabeling antibiotic allergy in Colombian children: do parents trust the negative result of the drug provocation test with the implicated antibiotic?]

Rincón-González AM, Galeano-Tamayo DC, Zuluaga LSD · 2025 · Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993)

Objective To explore the factors associated with the use of the antibiotic implicated in an adverse reaction following a negative challenge test in pediatric patients in a clinical allergology service of a health institution in Medellin.…

View details →
Negative / Null Result ReportMedicine

Cervical length and fetal fibronectin for the identification of true spontaneous onset of labor.

Warintaksa P, Youkhong C, Trikasemmart M et al. · 2026 · The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians

Introduction True labor is characterized by regular uterine contractions and cervical changes. However, the precise diagnosis of the "onset" of true labor is challenging, as the examination of cervical changes requires multiple timepoints,…

View details →
Negative / Null Result ReportMedicine

Suspicious bands in serum and urine protein immunofixation electrophoresis tests in patients with and without a history of monoclonal gammopathies: a retrospective database study.

Dincer M, Aydin O, Karakus V et al. · 2026 · Laboratory medicine

Introduction Electrophoresis tests are reported as negative, positive, or-rarely-as suspicious for monoclonal band (SfMB). This study aimed to determine the fate of patients with SfMB findings in long-term follow-up. Methods Patients with…

View details →
Negative / Null Result ReportOpen accessMedicine

Stage IV Rectal Adenocarcinoma After Negative Multitarget Stool DNA-Fecal Immunochemical Test in a Symptomatic Patient: Misapplication of a Screening Test in a Diagnostic Context.

Omari Y, Nohomovich B, Sallam D et al. · 2026 · Cureus

Multitarget stool DNA-fecal immunochemical testing (mt-sDNA-FIT) is validated for colorectal cancer (CRC) screening in asymptomatic, average-risk adults. However, its application in symptomatic patients represents a misuse of a screening…

View details →