11,317 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Konishi K · 2024 · Entropy (Basel, Switzerland)
We comment on the so-called negative result experiments (also known as null measurements, interaction-free measurements, and so on) in quantum mechanics (QM), in the light of the new general understanding of the quantum-measurement…
View details →Yarnall S, Saben JL, Sun N et al. · 2025 · Journal of genetic counseling
This observational study aimed to capture patients' experiences after reviewing carrier screening (CS) and/or noninvasive prenatal cell-free DNA testing (NIPT) results with Natera's Educational Virtual Assistant (NEVA). Patients, partners…
View details →Van Der Pol B, Ippolito J, Gao R et al. · 2026 · Sexually transmitted diseases
Background Extragenital (oropharyngeal and anorectal) Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (or gonococci [GC]) infections are underdiagnosed. Here we report sensitivity and specificity estimates that were obtained from the…
View details →Ding JJ, Chiu CF, Su YT et al. · 2025 · Pediatric research
Background Maternal hypercalcemia is a rare but potentially serious cause of late-onset neonatal hypocalcemia. Data on the clinical characteristics and outcomes of mother-baby couplets with maternal hypercalcemia and subsequent neonatal…
View details →Džafić F, Ahmetović A, Čoloman N et al. · 2026 · International archives of allergy and immunology
Introduction Allergic rhinitis (AR) is a prevalent health concern. In Europe, 20-40% of the population is affected. Diagnostic methods include skin tests, measurement of serum immunoglobulin E (IgE), nasal smear for eosinophils, and…
View details →Kohan R, Gil-Campesino H, García Rodríguez IO et al. · 2026 · Emerging infectious diseases
We report 2 cases of donor-derived Strongyloides stercoralis infection in renal transplant recipients. Despite initial negative serologic testing in donor samples, retrospective testing confirmed transmission. This report underscores the…
View details →Le Duc W, Butler CR, Argyropoulos GPD et al. · 2025 · PLoS biology
Rodent and human data implicate the hippocampus in the arbitration of approach-avoidance conflict (AAC), which arises when an organism is confronted with a stimulus associated simultaneously with reward and punishment. Yet, the precise…
View details →Kim CK, Lee YR, Ong L et al. · 2022 · Journal of Alzheimer's disease : JAD
Given the acknowledged lack of success in Alzheimer's disease (AD) drug development over the past two decades, the objective of this review was to derive key insights from the myriad failures to inform future drug development. A systematic…
View details →Li W, Bunch CM, Zackariya S et al. · 2025 · Scientific reports
Disordered hemostasis associated with life-threatening hemorrhage commonly afflicts patients in the emergency department, critical care unit, and perioperative settings. Rapid and sensitive hemostasis phenotyping is needed to guide…
View details →Shepard S, Anderson JM, Heigle B et al. · 2023 · Journal of orthopaedic surgery and research
Purpose To our knowledge, no study has quantified the rate of discontinuation and nonpublication of randomized controlled trials (RCTs) regarding upper and lower extremity fractures. Methods We searched ClinicalTrials.gov on September 9th,…
View details →Bajwa MS, Jackson R, Dhanda J et al. · 2023 · Cancers
Objectives High-quality randomised controlled trials (RCT) to support the use of Fibrin Sealants (FS) in neck dissection (ND) are lacking. The DEFeND trial assessed critical pilot/feasibility questions and signals from clinical outcomes to…
View details →Howland RH · 2015 · Journal of psychosocial nursing and mental health services
Seven topics previously described in this column are revisited. The use of quantitative electroencephalography has been shown in a prospective study to be effective for predicting antidepressant treatment response. A novel antidepressant…
View details →Ford KL, Sawyer MB, Ghosh S et al. · 2024 · ESMO open
Background Low muscle mass (MM) predicts unfavorable outcomes in cancer. Protein intake supports muscle health, but oncologic recommendations are not well characterized. The objectives of this study were to evaluate the feasibility of…
View details →Wulff KC, Miller FG, Pearson SD · 2011 · Health affairs (Project Hope)
To attain the anticipated benefits of increased investments in comparative effectiveness research, the results must translate into improved medical practice and policy. In this article we present an analysis of a case study of percutaneous…
View details →Komiya T, Huang CH · 2018 · Frontiers in oncology
Recent application of immunotherapy in clinical oncology revolutionized our management of advanced human cancers. Check point inhibitors targeting CTLA4 and PD-1/PD-L1 axis are immunotherapeutic agents currently available to treat a…
View details →Ponizovsky AM, Rosca P, Aronovich E et al. · 2015 · Journal of substance abuse treatment
Background Limited clinical trials and case-reports yielded conflicting results regarding the efficacy of baclofen (a GABAB agonist) in the treatment of alcohol dependence. The aim of this study was to test the efficacy and tolerability of…
View details →Park L, Furey M, Nugent AC et al. · 2019 · The international journal of neuropsychopharmacology
Background This randomized, placebo-controlled, crossover trial examined the antidepressant efficacy of the muscarinic antagonist scopolamine in major depressive disorder subjects with more severe and refractory forms of major depressive…
View details →Wu CC, Wolfe JM · 2022 · Vision research
During a visual search for a target among distractors, observers do not fixate every location in the search array. Rather processing is thought to occur within a Functional Visual Field (FVF) surrounding each fixation. We argue that there…
View details →Pramhas S, Thalhammer T, Terner S et al. · 2023 · The Lancet regional health. Europe
Background Painful knee osteoarthritis (KOA) is common, pharmacological treatment, however, is often hampered by limited tolerability. Cannabidiol, which preclinically showed anti-inflammatory, analgesic activity, could supplement…
View details →Finlay CJ, Jackson MJ, Fisher R et al. · 2024 · Journal of Parkinson's disease
Background Increased activity across corticostriatal glutamatergic synapses may contribute to L-DOPA-induced dyskinesia in Parkinson's disease. Given the weak efficacy and side-effect profile of amantadine, alternative strategies to reduce…
View details →Ghomrawi HMK, Marx RG, Pan TJ et al. · 2018 · Contemporary clinical trials communications
Publication of 2 (negative) randomized clinical trials (RCTs) in 2002 and 2008 demonstrating inefficacy of arthroscopic debridement of the knee (ADK) for osteoarthritis, and a 2004 national non-coverage Medicare determination, have…
View details →Pochon C, Laroye C, Kimmoun A et al. · 2023 · Frontiers in medicine
Background The COVID-19 pandemic caused a wave of acute respiratory distress syndrome (ARDS) with a high in-hospital mortality, especially in patients requiring invasive mechanical ventilation. Wharton Jelly-derived Mesenchymal Stromal…
View details →Goudman L, Jansen J, Vets N et al. · 2021 · Journal of clinical medicine
The increased awareness of discrepancies between self-reporting outcome measurements and objective outcome measurements within the field of neuromodulation has accelerated the search towards more objective measurements. The aim of this…
View details →Sanderson C, Hardy J, Spruyt O et al. · 2013 · Journal of pain and symptom management
Placebo and nocebo effects are known to contribute significantly to the response to symptom control, including analgesia. Clinical trial methodologies using placebo controls are designed to identify the magnitude of these effects in the…
View details →Farooqi AS, Guadagnolo BA, Mitra D et al. · 2023 · Current oncology (Toronto, Ont.)
Locoregional recurrence (LRR) is the predominant pattern of relapse and often the cause of death in patients with retroperitoneal sarcomas (RPS). As a result, reducing LRR is a critical objective for RPS patients. However, unlike soft…
View details →Ou SL, Luo J, Wei H et al. · 2023 · Frontiers in pharmacology
Background: Evidence of efficacy and safety of programmed cell death 1 (PD-1) and programmed death ligand-1 (PD-L1) checkpoint inhibitors in oesophageal cancer (EC), gastric cancer (GC) and colorectal cancer (CRC) was inconsistent,…
View details →Petrylak DP, Ratta R, Matsubara N et al. · 2025 · Journal of clinical oncology : official journal of the American Society of Clinical Oncology
Purpose The standard of care for metastatic castration-resistant prostate cancer (mCRPC) after second-generation androgen receptor pathway inhibitor (ARPI) therapy is still docetaxel. The randomized, double-blind, phase III KEYNOTE-921…
View details →Mitting RB, Ray S, Raffles M et al. · 2019 · PloS one
Background Methylprednisolone remains a commonly used ancillary therapy for paediatric acute respiratory distress syndrome (PARDS), despite a lack of level 1 evidence to justify its use. When planning prospective trials it is useful to…
View details →Brustad N, Garland J, Thorsen J et al. · 2020 · JAMA pediatrics
Importance Studies suggest an association between maternal vitamin D status during pregnancy and offspring anthropometry and bone mineralization, but investigations are few and with mixed results. Objective To investigate the effect of a…
View details →Wu Y, Tan KC, Shiu SW et al. · 2022 · Journal of diabetes investigation
Aims/introduction To examine the association between cholesterol efflux capacity (CEC) of serum high-density lipoprotein (HDL) and cognitive function and brain structures in older people with diabetes mellitus. Materials and methods…
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