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Browse the failure-mode index

11,417 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Examining the profile of couples attending a violence prevention intervention: A dyadic latent profile analysis.

Bhardwaj A, Musci RJ, Blackwell A et al. · 2025 · International health trends and perspectives

Objective Existing research points to how increasing male engagement in public health interventions without addressing gender inequities can perpetuate power imbalances in a relationship which may lead to increased stress and anxiety for…

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Negative / Null Result ReportOpen accessMedicine

No evidence that sociosexual orientation moderates effects of conception probability on women's preferences for male facial masculinity.

Lee AJ, Jones BC, Zietsch BP et al. · 2023 · Scientific reports

Although many researchers have proposed that women will show stronger preferences for male facial masculinity when conception probability is high, empirical tests of this hypothesis have produced mixed results. One possible explanation for…

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Negative / Null Result ReportMedicine

Gastrointestinal tract exposure to particles and DNA damage in animals: A review of studies before, during and after the peak of nanotoxicology.

Møller P, Roursgaard M · 2024 · Mutation research. Reviews in mutation research

Humans ingest particles and fibers on daily basis. Non-digestible carbohydrates are beneficial to health and food additives are considered safe. However, titanium dioxide (E171) has been banned in the European Union because the European…

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Negative / Null Result ReportOpen accessMedicine

Pro-inflammatory dietary patterns and their association with cardiovascular disease and pancreatic cancer in a hospital population: a cross-sectional study.

Jin Q, Liu Y, Tong Q et al. · 2025 · Frontiers in nutrition

Objective To examine whether a concise, clinic-feasible Patient Inflammatory Diet Score (PIDS) relates to prevalent pancreatic cancer and cardiovascular disease (CVD) in a hospital population, and to explore associations with systemic…

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Negative / Null Result ReportMedicine

Learning to draw parametric faces.

Davidenko N, Day J · 2025 · Memory & cognition

Humans' ability to draw faces accurately from memory is extremely rare. One source of difficulty is the drawing process itself, which requires converting a complex, three-dimensional mental representation to a two-dimensional drawing. To…

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Negative / Null Result ReportOpen accessMedicine

No Genetic Causal Relationship Between HIV Infection and Insulin Resistance, Diabetes: A Bidirectional Mendelian Randomization Analysis.

Liu P, Zeng Q · 2025 · Journal of multidisciplinary healthcare

Background The causal relationship between HIV infection and insulin resistance, as well as diabetes mellitus, remains uncertain. This study explores these associations using genome-wide association study data and Mendelian randomization…

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Negative / Null Result ReportOpen accessMedicine

In the eastern Mediterranean, the rat lungworm Angiostrongylus cantonensis is absent or extremely rare according to recent surveys.

Anettová L, Šipková A, Cibulka P et al. · 2025 · Parasitology research

This study summarizes the findings of a comprehensive field investigation into the presence of Angiostrongylus cantonensis, a zoonotic nematode responsible for meningitis, in selected regions of the eastern Mediterranean. Samples were…

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Negative / Null Result ReportMedicine

College Student Video Gaming: Risk or Resilience for Mental Health?

Vengurlekar IN, Thudi KR · 2025 · Psychological reports

Video gaming has become a popular method of entertainment for college students. Previous work indicates mixed results regarding the link between video gaming and mental health outcomes. However, little research has addressed how different…

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Negative / Null Result ReportMedicine

Post-occlusive reactive hyperemia in habituated caffeine users: Effects of abstaining versus consuming typical doses.

Chatlaong MA, Stanford DM, Miller WM et al. · 2024 · Clinical hemorheology and microcirculation

Background Post-occlusive reactive hyperemia (PORH) typically requires caffeine abstinence. For habitual users, it is unknown if abstinence affects PORH. Objective Compare PORH after habitual users consume or abstain from caffeine. Methods…

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Negative / Null Result ReportOpen accessMedicine

Intake of the Total, Classes, and Subclasses of (Poly)phenols and Breast Cancer Risk: A Prospective Analysis of the EPIC Study.

López-Padilla MF, Seoane-Miraz D, Guiñón-Fort D et al. · 2026 · Antioxidants (Basel, Switzerland)

Polyphenols represent the largest and most diverse class of dietary antioxidants. Epidemiological evidence linking specific (poly)phenol classes, such as flavonoids and lignans, to breast cancer (BC) risk remains limited and largely…

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Negative / Null Result ReportOpen accessMedicine

Early and later susceptibility to effects of parenting: Exploring Frankenhuis and Panchanathan's (2011) evolutionary commitment hypothesis.

Zhang X, Machlin L, McLaughlin K et al. · 2025 · Developmental psychology

This study tests Frankenhuis and Panchanathan's (2011) evolutionary commitment hypothesis by examining individual differences in susceptibility to the effects of parenting during early and late childhood. Drawing from the Future of…

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Negative / Null Result ReportOpen accessMedicine

Musical groove listening does not enhance primary motor cortex activation.

O'Connell SR, Wilson GE, Berkowitz DH et al. · 2026 · Imaging neuroscience (Cambridge, Mass.)

Groove is the pleasurable urge to move to the beat of music, a universally experienced human phenomenon. Because listeners are often inspired to move to music with groove, we asked whether high-groove music would promote greater motor…

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Negative / Null Result ReportOpen accessMedicine

Psychobehavioral profiles of eating risk: schema-emotion regulation patterns differ in central adiposity with genotype (FTO rs9939609) as external validator-a pilot study.

Obara-Gołębiowska M · 2026 · Eating and weight disorders : EWD

Purpose To identify person-centered psychological profiles of eating-related risk based on early maladaptive schemas (EMS), emotion regulation difficulties, and eating behaviors, and to examine their external validation using…

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Negative / Null Result ReportOpen accessMedicine

Effect of a Pragmatic eHealth Behavioral Gestational Weight Gain Intervention on Household Chaos in Pregnant People of Lower Socioeconomic Status: Randomized Controlled Trial.

Kracht CL, Falkenhain K, Flanagan EW et al. · 2026 · JMIR mental health

Background Household chaos is an emerging risk factor for childhood obesity development, especially in families with lower socioeconomic status (SES). It is unclear if changes in household chaos, especially in pregnancy, may mediate the…

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