e-ISSN: Pending
WASTE Journal

Browse the failure-mode index

11,317 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Pooling Alzheimer's disease clinical trial data to develop personalized medicine approaches is easier said than done: A proof-of-principle study and call to action.

Dubbelman MA, Vromen EM, Tijms BM et al. · 2024 · Alzheimer's & dementia (New York, N. Y.)

With the advent of the first generation of disease-modifying treatments for Alzheimer's disease, it is clearer now more than ever that the field needs to move toward personalized medicine. Pooling data from past trials may help identify…

View details →
Negative / Null Result ReportMedicine

A Randomized Trial of Direct Instruction Language for Learning in Children With Autism Spectrum Disorder.

Scahill L, Shillingsburg MA, Ousley O et al. · 2022 · Journal of the American Academy of Child and Adolescent Psychiatry

Objective To compare Direct Instruction Language for Learning (DI) plus treatment as usual (TAU) with TAU alone in children with autism spectrum disorder and moderate language delay. Method In this study, 83 children (age range, 4 years to…

View details →
Negative / Null Result ReportOpen accessMedicine

Assessment of Skin in Patients With Systemic Sclerosis Using High-Frequency Ultrasound and Shear Wave Elastography: A Comparative Study With Histology, Molecular, and Clinical Parameters.

Desai R, Tan F, Wu M et al. · 2026 · Arthritis care & research

Objective Ultrasound (US) has been proposed as a potential tool for assessing skin fibrosis in systemic sclerosis (SSc). However, a large-scale comparison of US-based assessment with histologic markers of skin fibrosis has not been…

View details →
Negative / Null Result ReportMedicine

ALSUntangled #62: vitamin C.

Bedlack R, Barkhaus P, Carter G et al. · 2022 · Amyotrophic lateral sclerosis & frontotemporal degeneration

Vitamin C is one of the most common supplements taken by people with ALS. As an antioxidant, it has a plausible mechanism for slowing disease progression and there are some flawed pre-clinical studies and case reports suggesting benefit.…

View details →
Negative / Null Result ReportOpen accessMedicine

Treat-to-Target in Axial Spondyloarthritis: Are we there yet?

Aouad K, El-Zorkany B · 2022 · Mediterranean journal of rheumatology

The Treat-to-target (T2T) strategy in axial spondyloarthritis (axSpA) stipulates that treatment should reach a predefined target and if not reached, intensification of therapy is implemented aiming at best future outcomes. Clinical…

View details →
Negative / Null Result ReportMedicine

Drug profile: galcanezumab for prevention of cluster headache.

Mudugal D, Monteith TS · 2021 · Expert review of neurotherapeutics

Introduction : Cluster headache [CH] is a severely disabling trigeminal autonomic cephalalgia [TAC]. Approximately 1 in 1,000 adults are affected by CH. Calcitonin gene-related peptide [CGRP] is an important mediator in the pathophysiology…

View details →
Negative / Null Result ReportMedicine

Reexamination of the Embolic Stroke of Undetermined Source Concept.

Albers GW, Bernstein R, Brachmann J et al. · 2021 · Stroke

Occult atrial fibrillation (AF) is a leading cause of stroke of unclear cause. The optimal approach to secondary stroke prevention for these patients remains elusive. The term embolic stroke of undetermined source (ESUS) was coined to…

View details →
Negative / Null Result ReportOpen accessMedicine

SAFFRON-301: a randomised phase III study of sitravatinib in combination with tislelizumab in patients with locally advanced or metastatic non-small cell lung cancer.

Zhou Q, Gao B, Hu J et al. · 2026 · BMJ oncology

Background Many patients with non-small cell lung cancer (NSCLC) have tumours that are either refractory or develop resistance following an initial response to anti-programmed cell death protein (ligand)-1 (PD-(L)1)-based treatment,…

View details →
Negative / Null Result ReportOpen accessMedicine

Autoimmune Bullous Diseases: Therapeutic Update.

Kasperkiewicz M, van Beek N, Schmidt E · 2026 · Drugs

Autoimmune blistering diseases (AIBDs) are a heterogeneous group of at least a dozen disorders characterized by autoantibodies against structural proteins of desmosomes in the skin and surface-close epithelia in pemphigus and of the…

View details →
Negative / Null Result ReportMedicine

RETRACTED: F173. Negative Trial of Scopolamine in Major Depressive Disorder Does Not Demonstrate Neurophysiological Changes Seen With the Antidepressant Response of Ketamine.

Park L, Furey M, Nugent A et al. · 2018 · Biological psychiatry

This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our-business/policies/article-withdrawal). This conference abstract has been retracted at the request of author Maura Furey,…

View details →
Negative / Null Result ReportOpen accessMedicine

Efficacy of a tight-control and treat-to-target strategy in axial spondyloarthritis: results of the open-label, pragmatic, cluster-randomised TICOSPA trial.

Molto A, López-Medina C, Van den Bosch FE et al. · 2021 · Annals of the rheumatic diseases

Objectives To compare the benefits of a tight-control/treat-to-target strategy (TC/T2T) in axial spondyloarthritis (axSpA) with those of usual care (UC). Methods Pragmatic, prospective, cluster-randomised, controlled, open, 1-year trial…

View details →
Negative / Null Result ReportOpen accessMedicine

Biological and clinical insights from a randomized phase 2 study of an anti-oncostatin M monoclonal antibody in systemic sclerosis.

Denton CP, Del Galdo F, Khanna D et al. · 2022 · Rheumatology (Oxford, England)

Objectives The cytokine oncostatin M (OSM) is implicated in the pathology of SSc. Inhibiting OSM signalling using GSK2330811 (an anti-OSM monoclonal antibody) in patients with SSc has the potential to slow or stop the disease process.…

View details →
Negative / Null Result ReportMedicine

Evaluating the reliability of the Word-Sentence Association Paradigm (WSAP) as an interpretation bias assessment across ethnoracial groups.

Ferguson I, George G, Wu C et al. · 2025 · Cognitive therapy and research

Background The tendency to negatively interpret ambiguous situations (i.e., interpretation bias) is associated with the development and maintenance of emotional disorders. Reliable measures of this transdiagnostic construct are critical…

View details →
Negative / Null Result ReportOpen accessMedicine

In clinical hand osteoarthritis research, self-reported pain questionnaires do not reflect the patient experience.

van der Meulen C, van de Stadt LA, Kroon FPB et al. · 2025 · Rheumatology (Oxford, England)

Objective Pain in hand osteoarthritis (OA) is evaluated with repeated pain questionnaires. It is unclear whether these questionnaires adequately capture changes in pain recalled by patients. This study investigated whether changes on pain…

View details →
Negative / Null Result ReportOpen accessMedicine

Trends of Publication of Negative Trials Over Time.

Laviolle B, Locher C, Allain JS et al. · 2025 · Clinical pharmacology and therapeutics

Studies with negative results are less likely to be published than others, potentially leading to publication bias. Introduced in 2000, trial registration could have participated in decreasing the proportion of unpublished studies. We…

View details →
Negative / Null Result ReportOpen accessMedicine

Long-Term Effects of Dexmedetomidine versus Propofol During the Implantation of a Neurostimulator-A Post-Trial Follow-Up Analysis.

Ter Bruggen FFJA, Redekop WK, Stronks DL et al. · 2021 · Journal of pain research

Objective The success of neurostimulation depends partly on the amount of coverage of the neurostimulation-induced paresthesia of the painful area. This is often achieved by asking feedback from patients intraoperatively. If sedation…

View details →
Negative / Null Result ReportOpen accessMedicine

Test-retest and interrater reliability of experimental within-subject variability of pain reports as assessed by the focused analgesia selection test.

Agostinho M, Shani A, Canaipa R et al. · 2024 · Pain reports

Introduction Within-subject variability (WSV) of pain intensity reports has been shown to predict the placebo response. The focused analgesia selection test (FAST), which allows to experimentally assess WSV of pain reports, has been used…

View details →