11,417 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Hiredesai AN, Martinez CJ, Hinckley NB et al. · 2026 · Cureus
Purpose Shear wave elastography (SWE) is a non-invasive technique for assessing median nerve (MN) stiffness in carpal tunnel syndrome (CTS). This study evaluated whether SWE measurements of the MN improve after corticosteroid injection…
View details →Pater WJ, Buller LT, Ziemba-Davis M et al. · 2026 · Arthroplasty today
Background Tourniquet use in revision total knee arthroplasty (rTKA) enhances visualization and improves cement penetration. However, concerns exist about muscle injury, pain, wound complications, and venous thromboembolism (VTE). This…
View details →El Alam A, Fleifel M, Nassani BM · 2026 · Cureus
Background Meal frequency takes a large focus when people enter a weight-loss program. Objective The primary aim of this study was to compare fat percentage and muscle percentage across three self-reported meal-frequency patterns,…
View details →El-Enbaby H, Hollingsworth B, Maystadt JF et al. · 2024 · Economics and human biology
The relationship between poverty and mental health is complex. Conditional cash transfers are seen as an important policy tool in reducing poverty and fostering social protection. Evidence on the impact of cash transfers on mental health…
View details →Kransberg J, Sjøli Bråthen AC, Falch ES et al. · 2026 · Imaging neuroscience (Cambridge, Mass.)
Grid cells in the human entorhinal cortex (EC) play a critical role in spatial navigation and memory. The EC is also one of the first regions affected by ageing and Alzheimer's disease. This pre-registered functional magnetic resonance…
View details →Wenzel K, Thomas J, Carrano J et al. · 2025 · Drug and alcohol dependence reports
Substance use disorders (SUDs) including opioid use disorder (OUD) and alcohol use disorder (AUD) contribute to significant morbidity and mortality in the United States. Pharmacotherapy treatment, including extended-release naltrexone…
View details →Liu X, Zhu Z, Chawes B et al. · 2026 · Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology
Background Vitamin D may play a role in early lung development, yet epidemiologic evidence on its association with later asthma risk is mixed. We aimed to investigate the associations of neonatal 25-hydroxyvitamin D (25(OH)D) and vitamin…
View details →Chatila ZK, Duggan MR, Silberberg E et al. · 2026 · Alzheimer's & dementia : the journal of the Alzheimer's Association
While a growing body of literature suggests a role for infections in Alzheimer's disease (AD), microbial contributions to AD remains a contentious topic, in part due to challenges in reconciling the positive evidence with studies reporting…
View details →Helac A, Uchino BN · 2025 · Acta psychologica
General perceived social support is important because it is linked to significant health outcomes. Most research examining perceived social support and health behaviors has not formally modeled the influence of interdependence in a dyad.…
View details →Gao S, Gross AL, Aksman LM et al. · 2026 · Journal of Alzheimer's disease : JAD
BackgroundPlasma neurodegenerative biomarkers are a potential low-cost tool for studying Alzheimer's disease and dementia in population-based research, especially in low- and middle-income countries. However, their associations with…
View details →Atkinson A, Marschall J, Burnham JP · 2025 · Antimicrobial resistance and infection control
Background Air changes per hour (ACH) in operating rooms (ORs) are energy intensive, and optimal air change settings are not known. Objectives We sought to explore whether there is a relationship between surgical site infections (SSIs)…
View details →Perales-Puchalt J, Yang FM, Townley R · 2025 · Alzheimer disease and associated disorders
We tested the efficacy of docosahexaenoic acid (DHA) supplementation on aggressive behavior among people with dementia. We used secondary data from a randomized, double-blind, placebo-controlled trial. Analyses included 402 individuals…
View details →Sheng Y, Han Y, Xue Y · 2026 · Medicine
Beta-blockers are recommended for post-myocardial infarction (MI) care, but their long-term impact on all-cause mortality in real-world settings remains unclear. This study investigates the association using propensity score methods in a…
View details →Watkins K, Ladabaum U, Olsen E et al. · 2024 · iGIE : innovation, investigation and insights
Background and aims The progress of artificial intelligence (AI) in endoscopy is at a crossroads. The positive results of randomized controlled trials of computer-aided detection (CADe) have not been replicated in multiple pragmatic CADe…
View details →Kusztor A, Mulay N, Yamada M et al. · 2025 · Neuroscience of consciousness
During an acute episode of depersonalization/derealization (DP/DR), people report a complex and idiosyncratic change in their perceptual experience. Specifically, derealisation describes the experience of detachment from the external world…
View details →Beaver JN, Nicodemus MM, Spalding IR et al. · 2025 · eNeuro
Mice offer a wealth of opportunities for investigating brain circuits regulating multiple behaviors, largely due to their genetic tractability. Social behaviors are translationally relevant, considering both mice and humans are highly…
View details →Kraft VM, Jones DR, Smyth JM et al. · 2026 · Emotion (Washington, D.C.)
Variability in daily emotional experiences may be important for both mental and physical health and may be influenced by individual differences such as age, gender, race, and ethnicity. Research on individual differences in affect…
View details →Coppeto DJ, Martin JS, Ringen EJ et al. · 2024 · Peptides
The neurohormones oxytocin (OT) and arginine vasopressin (AVP) are involved in social behaviors and psychiatric conditions. However, more research on nonhuman primates with complex social behaviors is needed. We studied two closely-related…
View details →Shapouri S, Rafiee Y · 2024 · Human nature (Hawthorne, N.Y.)
Considering the role of human interactions in infectious disease outbreaks and cooperation in mitigating natural disasters consequences, ecological threats to human survival have been among proposed drivers of collectivism. Utilizing…
View details →Sarfraz S, Fouad Elganainy M, Waris U et al. · 2026 · Proceedings (Baylor University. Medical Center)
Background Secondhand smoke (SHS) is a major cardiovascular risk factor, but its relationship with resting tachycardia, a marker of autonomic imbalance and adverse prognosis, remains unclear in young adults. Methods We analyzed adults aged…
View details →Roozenbeek J, Lasser J, Marks M et al. · 2025 · Royal Society open science
The spread of misinformation on social media continues to pose challenges. While prior research has shown some success in reducing susceptibility to misinformation at scale, how individual-level interventions impact the quality of content…
View details →Wei Y, Li J · 2025 · Discover oncology
Background Non-alcoholic fatty liver disease (NAFLD) has been increasingly associated with hepatocellular carcinoma (HCC) risk in observational studies, yet the causal nature of this relationship and its impact on systemic lipid metabolism…
View details →Zhou C, Dong X, Chen G et al. · 2025 · Nature medicine
After the global approval of atezolizumab plus bevacizumab and chemotherapy as first-line metastatic nonsquamous non-small-cell lung cancer (nsqNSCLC) treatment, the IMpower151 ( NCT04194203 ) trial was conducted in China to address…
View details →Esparragosa Vazquez I, Sanson M, Chinot OL et al. · 2024 · Neuro-oncology advances
Background Based on preclinical studies showing that IDH-mutant (IDHm) gliomas could be vulnerable to PARP inhibition we launched a multicenter phase 2 study to test the efficacy of olaparib monotherapy in this population. Methods Adults…
View details →Zumla A, Rosenthal PJ, Sam-Agudu NA et al. · 2025 · The American journal of tropical medicine and hygiene
On August 14, 2024, following a regional declaration by the Africa Centres for Disease Control and Prevention, the World Health Organization declared mpox a Public Health Emergency of International Concern, marking the second such…
View details →Yuan H, Curran JG, Keith SW et al. · 2021 · Headache
Objective To evaluate the efficacy and safety of intravenous (IV) Ibuprofen for acute treatment of migraine. Background IV nonsteroidal anti-inflammatory drugs (NSAIDs) are an alternative to oral NSAIDs, especially in patients with severe…
View details →Singer JM, Wing JJ, Klein EG et al. · 2026 · Journal of public health policy
In the United States certain groups, such as African Americans (AA) and sexual minorities (SM) have disproportionately high rates of flavored tobacco use. Policies restricting flavored tobacco may especially benefit these groups and lead…
View details →Dragan KL · 2026 · Journal of policy analysis and management : [the journal of the Association for Public Policy Analysis and Management]
Low-income housing is often of substandard quality. Health care payers like Medicaid and Medicare are piloting reimbursement for housing quality improvement with the rationale of reducing expenses from acute care use, but little is known…
View details →Zevallos-Morales A, Romani-Huacani E, Psoter KJ et al. · 2025 · Frontiers in public health
Background Peru has one of the highest burdens of asthma in the world, as well as large gaps in access to evidence-based treatments. Studies often overlook the ways in which the research context and data collection activities interact and…
View details →Jónsdóttir LK, Forslund T, Frick MA et al. · 2024 · Developmental science
Previous research and theory indicate an importance of the quality of the early caregiving environment in the development of self-regulation. However, it is unclear how attachment security and maternal sensitivity, two related but distinct…
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